Rilp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rilp
Entrez Gene ID	280408
Full Name	Rab interacting lysosomal protein
Synonyms	AI835553,Gm857
General protein information	Preferred Names Rab interacting lysosomal protein Names rab-interacting lysosomal protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B5

mRNA and Protein(s)

mRNA	Protein	Name
NM_001029938.2	NP_001025109.1	rab-interacting lysosomal protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RILP	XP_002695729.1
Mus musculus (house mouse)	Rilp	NP_001025109.1
Homo sapiens (human)	RILP	NP_113618.2
Rattus norvegicus (Norway rat)	Rilp	NP_001099281.1
Pan troglodytes (chimpanzee)	RILP	XP_001174182.2
	RILP	XP_001086142.1
Canis lupus familiaris (dog)	RILP	XP_537768.2

Gene Ontology
Bibliography

Related articles in PubMed

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD
The Journal of biological chemistry292(25)10328-10346(2017 06)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
Matsui T, Ohbayashi N, Fukuda M
The Journal of biological chemistry287(34)28619-31(2012 Aug)

Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Ohbayashi N, Maruta Y, Ishida M, Fukuda M
Journal of cell science125(Pt 6)1508-18(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The up-regulation of Rab11, Rab7, or RILP, but not its truncated form RILP-C33, rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 impaired LAMP2A trafficking.
Title: Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP.
Title: The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.

A new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes is revealed through interaction with RILP and is involved in the centripetal movement of melanosomes.
Title: Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.

CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7.
Title: Differential recruitment of CD63 and Rab7-interacting-lysosomal-protein to phagosomes containing Mycobacterium tuberculosis in macrophages.

The following Rilp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rilp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14015	NM_001029938.2 Latest version!	Mus musculus Rab interacting lysosomal protein (Rilp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rilp ( NM_001029938.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001025109.1 Mus musculus Rab interacting lysosomal protein (Rilp), mRNA.

Price & Availability↑

CloneID	OMu14015
Clone ID Related Accession (Same CDS sequence)	NM_001029938.2
Accession Version	NM_001029938.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	rab-interacting lysosomal protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW012811.1, AK139016.1, AK160517.1 and BC038146.1. On Jan 25, 2013 this sequence version replaced NM_001029938.1. ##Evidence-Data-START## Transcript exon combination :: AK139016.1, BC116750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCA GGAGGGCAGC GCCCAGGCTA CCCAGTCAGG CCTCTTCTTC AGTGGGCGCA 
GGGTCAGCCG CCGAGCTCGT GTACCATCTA GCGGGGGCTC TGGGCACTGA GCTACAGGGG 
CTGGCACGCC GCTTCGGACC CGACGCGGCG GCTGGGCTGG TGCCACTAGT CGTGCGGGCG 
CTGGAGCTCT TGGAAAAGGC CGCCGTGGGG CCGGCTCCGG ACTCGCTGCA GGTGTCCGCA 
CAGCAGGCAG AAGTGGAGCT GCGGCGGCTG CGCGAGGAGA ACCAACGCCT CCGCCAGGAG 
CTAGGCTCCG GGCCGCAGGA GGAGCGCGCG CTGCTCCGAC AGCTCAAGGA GGTGACAGAC 
AGACAGCGGG ATGAGCTTCG GGCACACAAC CGAGATCTGC AGCGCCGAAG CCAAGAGACC 
GAAGCGCTGC AGGAACAGCT ACAGCGCCTC CTGCTGATCA ACTCTGAGCT GCGGCACAAG 
CTGGCTGCAG TGCAGACCCA GTTGAGGGCC GCCCAGGACC GGGAGAGGGA GCGCCAGATA 
GCTCAGGATG GCTCCAGCCA GCTGGCTAAA GAACAGAGCT TGGAACCTGA TGCGGCAACC 
TCAGATGACC CGGTGGATAC TCAGAAGCAG CCAGGGAACC TTCCAGAAGC TGTCCAGTGT 
GGATTCAGCA GGGAAGAGCT TAAGCAAATC CTTCAGGAGC GGAATGAGCT CAAAGCCAAC 
GTGTTCTTGC TCAAGGAGGA GTTGGCGTAC TTCCAGCGAG AGCTGCTCAC AGATCACCGT 
GTTCCTGGGC TTCTGCTTGA AGCCATGAAG GTGGCAGTCA AGAAACAGAG GAGGAAGATC 
AAGGCCAAGA TGTTAGGGAC ACCTGAAGAA GCAGAGAGCA GTGAGGATGA GGATGGCTCG 
TGGCTCCTGC TCTCCAACGA CAAGGAAGAT GTTCCCCTAG TTCCTGAGTC CAGAATCCAG 
AATTTCTTTG GCTTATGGTA TCGGGGTGAA ACTGAGGCCC CTGAAGCCGA GACCAGCAAC 
CCAGCTTCCA GCAGCCTACA GAAAGGAGAA GAGACCCCAC AGCAACCCCA CCTGCAGCCT 
GTGAACAGCC CTCCAGCCCC CAACTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025109.1
CDS	55..1164
Translation	MEPRRAAPRLPSQASSSVGAGSAAELVYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELLEKAAVGPAPDSLQVSAQQAEVELRRLREENQRLRQELGSGPQEERALLRQLKEVTDRQRDELRAHNRDLQRRSQETEALQEQLQRLLLINSELRHKLAAVQTQLRAAQDRERERQIAQDGSSQLAKEQSLEPDAATSDDPVDTQKQPGNLPEAVQCGFSREELKQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVKKQRRKIKAKMLGTPEEAESSEDEDGSWLLLSNDKEDVPLVPESRIQNFFGLWYRGETEAPEAETSNPASSSLQKGEETPQQPHLQPVNSPPAPNS

Target ORF information:

RefSeq Version	NM_001029938.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rab interacting lysosomal protein (Rilp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029938.2

ORF Insert Sequence:

ATGGAGCCCA GGAGGGCAGC GCCCAGGCTA CCCAGTCAGG CCTCTTCTTC AGTGGGCGCA 
GGGTCAGCCG CCGAGCTCGT GTACCATCTA GCGGGGGCTC TGGGCACTGA GCTACAGGGG 
CTGGCACGCC GCTTCGGACC CGACGCGGCG GCTGGGCTGG TGCCACTAGT CGTGCGGGCG 
CTGGAGCTCT TGGAAAAGGC CGCCGTGGGG CCGGCTCCGG ACTCGCTGCA GGTGTCCGCA 
CAGCAGGCAG AAGTGGAGCT GCGGCGGCTG CGCGAGGAGA ACCAACGCCT CCGCCAGGAG 
CTAGGCTCCG GGCCGCAGGA GGAGCGCGCG CTGCTCCGAC AGCTCAAGGA GGTGACAGAC 
AGACAGCGGG ATGAGCTTCG GGCACACAAC CGAGATCTGC AGCGCCGAAG CCAAGAGACC 
GAAGCGCTGC AGGAACAGCT ACAGCGCCTC CTGCTGATCA ACTCTGAGCT GCGGCACAAG 
CTGGCTGCAG TGCAGACCCA GTTGAGGGCC GCCCAGGACC GGGAGAGGGA GCGCCAGATA 
GCTCAGGATG GCTCCAGCCA GCTGGCTAAA GAACAGAGCT TGGAACCTGA TGCGGCAACC 
TCAGATGACC CGGTGGATAC TCAGAAGCAG CCAGGGAACC TTCCAGAAGC TGTCCAGTGT 
GGATTCAGCA GGGAAGAGCT TAAGCAAATC CTTCAGGAGC GGAATGAGCT CAAAGCCAAC 
GTGTTCTTGC TCAAGGAGGA GTTGGCGTAC TTCCAGCGAG AGCTGCTCAC AGATCACCGT 
GTTCCTGGGC TTCTGCTTGA AGCCATGAAG GTGGCAGTCA AGAAACAGAG GAGGAAGATC 
AAGGCCAAGA TGTTAGGGAC ACCTGAAGAA GCAGAGAGCA GTGAGGATGA GGATGGCTCG 
TGGCTCCTGC TCTCCAACGA CAAGGAAGAT GTTCCCCTAG TTCCTGAGTC CAGAATCCAG 
AATTTCTTTG GCTTATGGTA TCGGGGTGAA ACTGAGGCCC CTGAAGCCGA GACCAGCAAC 
CCAGCTTCCA GCAGCCTACA GAAAGGAGAA GAGACCCCAC AGCAACCCCA CCTGCAGCCT 
GTGAACAGCC CTCCAGCCCC CAACTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
The Journal of biological chemistry292(25)10328-10346(2017 06)
Zhang J,Johnson JL,He J,Napolitano G,Ramadass M,Rocca C,Kiosses WB,Bucci C,Xin Q,Gavathiotis E,Cuervo AM,Cherqui S,Catz SD

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
The Journal of biological chemistry287(34)28619-31(2012 Aug)
Matsui T,Ohbayashi N,Fukuda M

Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Journal of cell science125(Pt 6)1508-18(2012 Mar)
Ohbayashi N,Maruta Y,Ishida M,Fukuda M

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Rilp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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