Clpx cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clpx
Entrez Gene ID	270166
Full Name	caseinolytic mitochondrial matrix peptidase chaperone subunit
Synonyms	AU014732,E330029I21
General protein information	Preferred Names caseinolytic mitochondrial matrix peptidase chaperone subunit Names ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial caseinolytic peptidase X caseinolytic protease X
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 C\|9 35.22 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001044389.2	NP_001037854.1	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform 2
NM_011802.3	NP_035932.2	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLPX	NP_006651.2
Canis lupus familiaris (dog)	CLPX	XP_852508.1
Gallus gallus (chicken)	CLPX	NP_001025723.1
Danio rerio (zebrafish)	clpxa	NP_001004581.1
Drosophila melanogaster (fruit fly)	CG4538	NP_650843.1
Mus musculus (house mouse)	Clpx	NP_035932.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002996	XP_003436341.1
Neurospora crassa	NCU05427	XP_963250.2
Bos taurus (cattle)	CLPX	XP_002690567.1
Rattus norvegicus (Norway rat)	Clpx	NP_001007804.1
Pan troglodytes (chimpanzee)	CLPX	XP_001174382.1
	CLPX	XP_001108768.1
Kluyveromyces lactis	KLLA0F09691g	XP_455520.1
Caenorhabditis elegans (roundworm)	D2030.2	NP_001021076.1
Saccharomyces cerevisiae (baker's yeast)	MCX1	NP_009786.1
Magnaporthe oryzae (rice blast fungus)	MGG_03187	XP_003716802.1

Gene Ontology
Bibliography

Related articles in PubMed

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.
Al-Furoukh N, Ianni A, Nolte H, H?lper S, Kr?ger M, Wanrooij S, Braun T
Biochimica et biophysica acta1853(10 Pt A)2580-91(2015 Oct)

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Gispert S, Parganlija D, Klinkenberg M, Dr?se S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, B?chel F, Adler T, Hrab? de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G
Human molecular genetics22(24)4871-87(2013 Dec)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

Proteomic analysis of the mouse liver mitochondrial inner membrane.
Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA, Martinou JC
The Journal of biological chemistry278(42)41566-71(2003 Oct)

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y
Genome research13(6B)1273-89(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results illustrate that ClpX overexpression is a good and simple model to study the underlying mechanisms of the UPRmt in mammalian cells.
Title: ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Title: Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.

The following Clpx gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clpx cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23377	NM_001044389.2 Latest version!	Mus musculus caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu23379	NM_011802.3 Latest version!	Mus musculus caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clpx ( NM_001044389.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001037854.1 Mus musculus caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu23377
Clone ID Related Accession (Same CDS sequence)	NM_001044389.2
Accession Version	NM_001044389.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110235.13, BC061153.1, AK087848.1 and AV237409.1. On Nov 8, 2013 this sequence version replaced NM_001044389.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC061153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTT GCGGCGCTTG TACCTGCGGC GCTGCGGCCG CCCGGCTTCT CACCACTTCG 
CTCACCTCCG CGCAGAGAGG TATTTCGTGT GGGCGAATCC ATGTGCCAGT GTTAGGAAGA 
CTGGGGACGA CCTTGGACGC TCAGGCTCTG CGCAGAGCTC CTCTTAGAAC CTTTTCAGAA 
ACACCAGCAT ACTTTGCCTC AAAAGACGGG GCAAACAAGG ATGGCTCCGG AGATGGAAAT 
AAGAAATCAG TGACTGAAGG AAGCAGTAAG AAATCAGGCT CTGGGAATTC TGGGAAAGGT 
GGAAACCAGC TTCGCTGTCC TAAATGTGGT GATTTGTGTA CACACGTGGA GACCTTTGTG 
TCTTCCACGC GTTTTGTTAA GTGTGAAAAA TGTCATCATT TTTTTGTGGT GCTGTCGGAA 
GCAGACTCAA AGAAAAGCAT AATTAAGGAA CCCGAGTCCG CTGCAGAGGC TGTGAAGTTG 
GCATTCCAGC AGAAGCCACC TCCGCCCCCC AAAAAGATTT ATAACTACCT CGACAAGTAT 
GTTGTTGGCC AGTCGTTTGC TAAGAAAGTG CTTTCAGTTG CCGTGTATAA TCATTATAAG 
AGAATATATA ATAATATTCC AGCTAATCTG AGACAGCAAG CAGAGGCTGA GAAGCAGACA 
TCACTAACAC CTAGAGAGTT GCTTCAGATC GCTGGGATCA GCCCACACGG CAATGCCTTG 
GGAGCCTCTA TGCAGCAGCA GGTAAACCAG CAAATGCCTC AGGAGAAAAG AGGAGGTGAA 
GTGTTGGACT CTTCTCAAGA TGATATAAAA CTGGAAAAAA GTAATATTTT GCTGCTTGGA 
CCAACTGGGT CAGGTAAAAC CCTTCTGGCA CAAACTTTAG CTAAATGCCT TGATGTTCCT 
TTTGCTATCT GTGACTGTAC AACTTTGACC CAGGCTGGAT ATGTAGGTGA AGATATTGAA 
TCTGTGATTG CCAAACTACT CCAAGATGCC AATTACAATG TAGAGAAAGC ACAACAAGGA 
ATTGTCTTTC TGGATGAAGT AGATAAGATT GGCAGTGTGC CAGGCATTCA TCAATTACGG 
GATGTAGGTG GAGAAGGCGT TCAGCAAGGT TTATTAAAAC TTCTAGAAGG CACAATAGTC 
AATGTTCCAG AAAAGAATTC TCGAAAACTA CGTGGAGAGA CAGTTCAAGT TGATACAACA 
AATGTCTTGT TTGTGGCATC TGGTGCCTTT AATGGCTTAG ACAGAATCAT CAGCAGGAGG 
AAAAATGAAA AGTATCTCGG CTTTGGAACA CCATCTAACC TGGGAAAGGG CAGAAGGGCT 
GCAGCTGCAG CGGATCTTGC TAACCGAAGT GGGGAATCTA ACACTCATCA GGACATTGAG 
GAGAAAGACC GGTTACTCCG CCATGTGGAA GCCAGAGATC TTATTGAGTT TGGCATGATA 
CCAGAGTTTG TGGGACGGTT GCCTGTGGTG GTTCCTTTGC ACAGCCTAGA TGAGAAGACA 
CTTGTACAAA TACTGACCGA GCCACGGAAT GCTGTTATTC CTCAGTATCA GGCCTTGTTC 
AGCATGGATA AGTGTGAGCT GAATGTTACT GAGGATGCTC TGAAAGCCAT AGCGAGATTG 
GCCCTGGAAA GAAAAACAGG TGCACGAGGC CTTCGGTCTA TAATGGAAAA GCTGTTACTA 
GAACCAATGT TCGAAGTTCC TAATTCTGAC ATTGTATGTG TGGAAGTTGA CAAAGAAGTA 
GTAGAAGGCA AAAAGGAACC AGGATACATT CGGGCACCCT CAAAAGAGTC CTCTGAAGAG 
GAATATGACT CTGGAGTGGA GGAGGATGGA TGGCCTCGTC AAGCGGATGC TGCAAACAGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001037854.1
CDS	228..2090
Translation	MSSCGACTCGAAAARLLTTSLTSAQRGISCGRIHVPVLGRLGTTLDAQALRRAPLRTFSETPAYFASKDGANKDGSGDGNKKSVTEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEAEKQTSLTPRELLQIAGISPHGNALGASMQQQVNQQMPQEKRGGEVLDSSQDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNVLFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPSKESSEEEYDSGVEEDGWPRQADAANS

Target ORF information:

RefSeq Version	NM_001044389.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044389.2

ORF Insert Sequence:

ATGTCCAGTT GCGGCGCTTG TACCTGCGGC GCTGCGGCCG CCCGGCTTCT CACCACTTCG 
CTCACCTCCG CGCAGAGAGG TATTTCGTGT GGGCGAATCC ATGTGCCAGT GTTAGGAAGA 
CTGGGGACGA CCTTGGACGC TCAGGCTCTG CGCAGAGCTC CTCTTAGAAC CTTTTCAGAA 
ACACCAGCAT ACTTTGCCTC AAAAGACGGG GCAAACAAGG ATGGCTCCGG AGATGGAAAT 
AAGAAATCAG TGACTGAAGG AAGCAGTAAG AAATCAGGCT CTGGGAATTC TGGGAAAGGT 
GGAAACCAGC TTCGCTGTCC TAAATGTGGT GATTTGTGTA CACACGTGGA GACCTTTGTG 
TCTTCCACGC GTTTTGTTAA GTGTGAAAAA TGTCATCATT TTTTTGTGGT GCTGTCGGAA 
GCAGACTCAA AGAAAAGCAT AATTAAGGAA CCCGAGTCCG CTGCAGAGGC TGTGAAGTTG 
GCATTCCAGC AGAAGCCACC TCCGCCCCCC AAAAAGATTT ATAACTACCT CGACAAGTAT 
GTTGTTGGCC AGTCGTTTGC TAAGAAAGTG CTTTCAGTTG CCGTGTATAA TCATTATAAG 
AGAATATATA ATAATATTCC AGCTAATCTG AGACAGCAAG CAGAGGCTGA GAAGCAGACA 
TCACTAACAC CTAGAGAGTT GCTTCAGATC GCTGGGATCA GCCCACACGG CAATGCCTTG 
GGAGCCTCTA TGCAGCAGCA GGTAAACCAG CAAATGCCTC AGGAGAAAAG AGGAGGTGAA 
GTGTTGGACT CTTCTCAAGA TGATATAAAA CTGGAAAAAA GTAATATTTT GCTGCTTGGA 
CCAACTGGGT CAGGTAAAAC CCTTCTGGCA CAAACTTTAG CTAAATGCCT TGATGTTCCT 
TTTGCTATCT GTGACTGTAC AACTTTGACC CAGGCTGGAT ATGTAGGTGA AGATATTGAA 
TCTGTGATTG CCAAACTACT CCAAGATGCC AATTACAATG TAGAGAAAGC ACAACAAGGA 
ATTGTCTTTC TGGATGAAGT AGATAAGATT GGCAGTGTGC CAGGCATTCA TCAATTACGG 
GATGTAGGTG GAGAAGGCGT TCAGCAAGGT TTATTAAAAC TTCTAGAAGG CACAATAGTC 
AATGTTCCAG AAAAGAATTC TCGAAAACTA CGTGGAGAGA CAGTTCAAGT TGATACAACA 
AATGTCTTGT TTGTGGCATC TGGTGCCTTT AATGGCTTAG ACAGAATCAT CAGCAGGAGG 
AAAAATGAAA AGTATCTCGG CTTTGGAACA CCATCTAACC TGGGAAAGGG CAGAAGGGCT 
GCAGCTGCAG CGGATCTTGC TAACCGAAGT GGGGAATCTA ACACTCATCA GGACATTGAG 
GAGAAAGACC GGTTACTCCG CCATGTGGAA GCCAGAGATC TTATTGAGTT TGGCATGATA 
CCAGAGTTTG TGGGACGGTT GCCTGTGGTG GTTCCTTTGC ACAGCCTAGA TGAGAAGACA 
CTTGTACAAA TACTGACCGA GCCACGGAAT GCTGTTATTC CTCAGTATCA GGCCTTGTTC 
AGCATGGATA AGTGTGAGCT GAATGTTACT GAGGATGCTC TGAAAGCCAT AGCGAGATTG 
GCCCTGGAAA GAAAAACAGG TGCACGAGGC CTTCGGTCTA TAATGGAAAA GCTGTTACTA 
GAACCAATGT TCGAAGTTCC TAATTCTGAC ATTGTATGTG TGGAAGTTGA CAAAGAAGTA 
GTAGAAGGCA AAAAGGAACC AGGATACATT CGGGCACCCT CAAAAGAGTC CTCTGAAGAG 
GAATATGACT CTGGAGTGGA GGAGGATGGA TGGCCTCGTC AAGCGGATGC TGCAAACAGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clpx ( NM_011802.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035932.2 Mus musculus caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23379
Clone ID Related Accession (Same CDS sequence)	NM_011802.3
Accession Version	NM_011802.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110235.13, AK080339.1, AK087848.1 and AV237409.1. On Nov 8, 2013 this sequence version replaced NM_011802.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK087848.1, AF134983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTT GCGGCGCTTG TACCTGCGGC GCTGCGGCCG CCCGGCTTCT CACCACTTCG 
CTCACCTCCG CGCAGAGAGG TATTTCGTGT GGGCGAATCC ATGTGCCAGT GTTAGGAAGA 
CTGGGGACGA CCTTGGACGC TCAGGCTCTG CGCAGAGCTC CTCTTAGAAC CTTTTCAGAA 
ACACCAGCAT ACTTTGCCTC AAAAGACGGG GCAAACAAGG ATGGCTCCGG AGATGGAAAT 
AAGAAATCAG TGACTGAAGG AAGCAGTAAG AAATCAGGCT CTGGGAATTC TGGGAAAGGT 
GGAAACCAGC TTCGCTGTCC TAAATGTGGT GATTTGTGTA CACACGTGGA GACCTTTGTG 
TCTTCCACGC GTTTTGTTAA GTGTGAAAAA TGTCATCATT TTTTTGTGGT GCTGTCGGAA 
GCAGACTCAA AGAAAAGCAT AATTAAGGAA CCCGAGTCCG CTGCAGAGGC TGTGAAGTTG 
GCATTCCAGC AGAAGCCACC TCCGCCCCCC AAAAAGATTT ATAACTACCT CGACAAGTAT 
GTTGTTGGCC AGTCGTTTGC TAAGAAAGTG CTTTCAGTTG CCGTGTATAA TCATTATAAG 
AGAATATATA ATAATATTCC AGCTAATCTG AGACAGCAAG CAGAGGCTGA GAAGCAGACA 
TCACTAACAC CTAGAGAGTT AGAAATAAGA AGACGGGAGG ATGAGTACAG ATTTACAAAG 
TTGCTTCAGA TCGCTGGGAT CAGCCCACAC GGCAATGCCT TGGGAGCCTC TATGCAGCAG 
CAGGTAAACC AGCAAATGCC TCAGGAGAAA AGAGGAGGTG AAGTGTTGGA CTCTTCTCAA 
GATGATATAA AACTGGAAAA AAGTAATATT TTGCTGCTTG GACCAACTGG GTCAGGTAAA 
ACCCTTCTGG CACAAACTTT AGCTAAATGC CTTGATGTTC CTTTTGCTAT CTGTGACTGT 
ACAACTTTGA CCCAGGCTGG ATATGTAGGT GAAGATATTG AATCTGTGAT TGCCAAACTA 
CTCCAAGATG CCAATTACAA TGTAGAGAAA GCACAACAAG GAATTGTCTT TCTGGATGAA 
GTAGATAAGA TTGGCAGTGT GCCAGGCATT CATCAATTAC GGGATGTAGG TGGAGAAGGC 
GTTCAGCAAG GTTTATTAAA ACTTCTAGAA GGCACAATAG TCAATGTTCC AGAAAAGAAT 
TCTCGAAAAC TACGTGGAGA GACAGTTCAA GTTGATACAA CAAATGTCTT GTTTGTGGCA 
TCTGGTGCCT TTAATGGCTT AGACAGAATC ATCAGCAGGA GGAAAAATGA AAAGTATCTC 
GGCTTTGGAA CACCATCTAA CCTGGGAAAG GGCAGAAGGG CTGCAGCTGC AGCGGATCTT 
GCTAACCGAA GTGGGGAATC TAACACTCAT CAGGACATTG AGGAGAAAGA CCGGTTACTC 
CGCCATGTGG AAGCCAGAGA TCTTATTGAG TTTGGCATGA TACCAGAGTT TGTGGGACGG 
TTGCCTGTGG TGGTTCCTTT GCACAGCCTA GATGAGAAGA CACTTGTACA AATACTGACC 
GAGCCACGGA ATGCTGTTAT TCCTCAGTAT CAGGCCTTGT TCAGCATGGA TAAGTGTGAG 
CTGAATGTTA CTGAGGATGC TCTGAAAGCC ATAGCGAGAT TGGCCCTGGA AAGAAAAACA 
GGTGCACGAG GCCTTCGGTC TATAATGGAA AAGCTGTTAC TAGAACCAAT GTTCGAAGTT 
CCTAATTCTG ACATTGTATG TGTGGAAGTT GACAAAGAAG TAGTAGAAGG CAAAAAGGAA 
CCAGGATACA TTCGGGCACC CTCAAAAGAG TCCTCTGAAG AGGAATATGA CTCTGGAGTG 
GAGGAGGATG GATGGCCTCG TCAAGCGGAT GCTGCAAACA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035932.2
CDS	228..2132
Translation	MSSCGACTCGAAAARLLTTSLTSAQRGISCGRIHVPVLGRLGTTLDAQALRRAPLRTFSETPAYFASKDGANKDGSGDGNKKSVTEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEAEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQMPQEKRGGEVLDSSQDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNVLFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPSKESSEEEYDSGVEEDGWPRQADAANS

Target ORF information:

RefSeq Version	NM_011802.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011802.3

ORF Insert Sequence:

ATGTCCAGTT GCGGCGCTTG TACCTGCGGC GCTGCGGCCG CCCGGCTTCT CACCACTTCG 
CTCACCTCCG CGCAGAGAGG TATTTCGTGT GGGCGAATCC ATGTGCCAGT GTTAGGAAGA 
CTGGGGACGA CCTTGGACGC TCAGGCTCTG CGCAGAGCTC CTCTTAGAAC CTTTTCAGAA 
ACACCAGCAT ACTTTGCCTC AAAAGACGGG GCAAACAAGG ATGGCTCCGG AGATGGAAAT 
AAGAAATCAG TGACTGAAGG AAGCAGTAAG AAATCAGGCT CTGGGAATTC TGGGAAAGGT 
GGAAACCAGC TTCGCTGTCC TAAATGTGGT GATTTGTGTA CACACGTGGA GACCTTTGTG 
TCTTCCACGC GTTTTGTTAA GTGTGAAAAA TGTCATCATT TTTTTGTGGT GCTGTCGGAA 
GCAGACTCAA AGAAAAGCAT AATTAAGGAA CCCGAGTCCG CTGCAGAGGC TGTGAAGTTG 
GCATTCCAGC AGAAGCCACC TCCGCCCCCC AAAAAGATTT ATAACTACCT CGACAAGTAT 
GTTGTTGGCC AGTCGTTTGC TAAGAAAGTG CTTTCAGTTG CCGTGTATAA TCATTATAAG 
AGAATATATA ATAATATTCC AGCTAATCTG AGACAGCAAG CAGAGGCTGA GAAGCAGACA 
TCACTAACAC CTAGAGAGTT AGAAATAAGA AGACGGGAGG ATGAGTACAG ATTTACAAAG 
TTGCTTCAGA TCGCTGGGAT CAGCCCACAC GGCAATGCCT TGGGAGCCTC TATGCAGCAG 
CAGGTAAACC AGCAAATGCC TCAGGAGAAA AGAGGAGGTG AAGTGTTGGA CTCTTCTCAA 
GATGATATAA AACTGGAAAA AAGTAATATT TTGCTGCTTG GACCAACTGG GTCAGGTAAA 
ACCCTTCTGG CACAAACTTT AGCTAAATGC CTTGATGTTC CTTTTGCTAT CTGTGACTGT 
ACAACTTTGA CCCAGGCTGG ATATGTAGGT GAAGATATTG AATCTGTGAT TGCCAAACTA 
CTCCAAGATG CCAATTACAA TGTAGAGAAA GCACAACAAG GAATTGTCTT TCTGGATGAA 
GTAGATAAGA TTGGCAGTGT GCCAGGCATT CATCAATTAC GGGATGTAGG TGGAGAAGGC 
GTTCAGCAAG GTTTATTAAA ACTTCTAGAA GGCACAATAG TCAATGTTCC AGAAAAGAAT 
TCTCGAAAAC TACGTGGAGA GACAGTTCAA GTTGATACAA CAAATGTCTT GTTTGTGGCA 
TCTGGTGCCT TTAATGGCTT AGACAGAATC ATCAGCAGGA GGAAAAATGA AAAGTATCTC 
GGCTTTGGAA CACCATCTAA CCTGGGAAAG GGCAGAAGGG CTGCAGCTGC AGCGGATCTT 
GCTAACCGAA GTGGGGAATC TAACACTCAT CAGGACATTG AGGAGAAAGA CCGGTTACTC 
CGCCATGTGG AAGCCAGAGA TCTTATTGAG TTTGGCATGA TACCAGAGTT TGTGGGACGG 
TTGCCTGTGG TGGTTCCTTT GCACAGCCTA GATGAGAAGA CACTTGTACA AATACTGACC 
GAGCCACGGA ATGCTGTTAT TCCTCAGTAT CAGGCCTTGT TCAGCATGGA TAAGTGTGAG 
CTGAATGTTA CTGAGGATGC TCTGAAAGCC ATAGCGAGAT TGGCCCTGGA AAGAAAAACA 
GGTGCACGAG GCCTTCGGTC TATAATGGAA AAGCTGTTAC TAGAACCAAT GTTCGAAGTT 
CCTAATTCTG ACATTGTATG TGTGGAAGTT GACAAAGAAG TAGTAGAAGG CAAAAAGGAA 
CCAGGATACA TTCGGGCACC CTCAAAAGAG TCCTCTGAAG AGGAATATGA CTCTGGAGTG 
GAGGAGGATG GATGGCCTCG TCAAGCGGAT GCTGCAAACA GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.
Biochimica et biophysica acta1853(10 Pt A)2580-91(2015 Oct)
Al-Furoukh N,Ianni A,Nolte H,H?lper S,Kr?ger M,Wanrooij S,Braun T

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Human molecular genetics22(24)4871-87(2013 Dec)
Gispert S,Parganlija D,Klinkenberg M,Dr?se S,Wittig I,Mittelbronn M,Grzmil P,Koob S,Hamann A,Walter M,B?chel F,Adler T,Hrab? de Angelis M,Busch DH,Zell A,Reichert AS,Brandt U,Osiewacz HD,Jendrach M,Auburger G

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

Proteomic analysis of the mouse liver mitochondrial inner membrane.
The Journal of biological chemistry278(42)41566-71(2003 Oct)
Da Cruz S,Xenarios I,Langridge J,Vilbois F,Parone PA,Martinou JC

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Genome research13(6B)1273-89(2003 Jun)
Carninci P,Waki K,Shiraki T,Konno H,Shibata K,Itoh M,Aizawa K,Arakawa T,Ishii Y,Sasaki D,Bono H,Kondo S,Sugahara Y,Saito R,Osato N,Fukuda S,Sato K,Watahiki A,Hirozane-Kishikawa T,Nakamura M,Shibata Y,Yasunishi A,Kikuchi N,Yoshiki A,Kusakabe M,Gustincich S,Beisel K,Pavan W,Aidinis V,Nakagawara A,Held WA,Iwata H,Kono T,Nakauchi H,Lyons P,Wells C,Hume DA,Fagiolini M,Hensch TK,Brinkmeier M,Camper S,Hirota J,Mombaerts P,Muramatsu M,Okazaki Y,Kawai J,Hayashizaki Y

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Clpx cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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