CLPX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLPX
Entrez Gene ID	10845
Full Name	caseinolytic mitochondrial matrix peptidase chaperone subunit
General protein information	Preferred Names caseinolytic mitochondrial matrix peptidase chaperone subunit Names ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial ClpX caseinolytic peptidase X homolog ClpX caseinolytic protease X homolog energy-dependent regulator of proteolysis
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.31
Summary	The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015].
Disorder MIM:	615611

mRNA and Protein(s)

mRNA	Protein	Name
XM_011521164.2	XP_011519466.1	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1
XM_011521164.3	XP_011519466.1	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1
NM_006660.3	NP_006651.2	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor
NM_006660.4	NP_006651.2	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor
NM_006660.5	NP_006651.2	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLPX	NP_006651.2
Canis lupus familiaris (dog)	CLPX	XP_852508.1
Gallus gallus (chicken)	CLPX	NP_001025723.1
Danio rerio (zebrafish)	clpxa	NP_001004581.1
Drosophila melanogaster (fruit fly)	CG4538	NP_650843.1
Mus musculus (house mouse)	Clpx	NP_035932.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002996	XP_003436341.1
Neurospora crassa	NCU05427	XP_963250.2
Bos taurus (cattle)	CLPX	XP_002690567.1
Rattus norvegicus (Norway rat)	Clpx	NP_001007804.1
Pan troglodytes (chimpanzee)	CLPX	XP_001174382.1
	CLPX	XP_001108768.1
Kluyveromyces lactis	KLLA0F09691g	XP_455520.1
Caenorhabditis elegans (roundworm)	D2030.2	NP_001021076.1
Saccharomyces cerevisiae (baker's yeast)	MCX1	NP_009786.1
Magnaporthe oryzae (rice blast fungus)	MGG_03187	XP_003716802.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutation in human
Yien YY, Ducamp S, van der Vorm LN, Kardon JR, Manceau H, Kannengiesser C, Bergonia HA, Kafina MD, Karim Z, Gouya L, Baker TA, Puy H, Phillips JD, Nicolas G, Paw BH
Proceedings of the National Academy of Sciences of the United States of America114(38)E8045-E8052(2017 Sep)

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.
Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC
PLoS biology14(7)e1002507(2016 Jul)

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.
Al-Furoukh N, Ianni A, Nolte H, H?lper S, Kr?ger M, Wanrooij S, Braun T
Biochimica et biophysica acta1853(10 Pt A)2580-91(2015 Oct)

Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine.
Cordova JC, Olivares AO, Shin Y, Stinson BM, Calmat S, Schmitz KR, Aubin-Tam ME, Baker TA, Lang MJ, Sauer RT
Cell158(3)647-58(2014 Jul)

Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX.
Kasashima K, Sumitani M, Endo H
Experimental cell research318(18)2335-43(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence.
Title: The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

results illustrate that ClpX overexpression is a good and simple model to study the underlying mechanisms of the UPRmt in mammalian cells.
Title: ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.

Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability.
Title: Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine.

human ClpX, a novel mtDNA regulator, maintains mtDNA nucleoid distribution through TFAM function as a chaperone rather than as a protease and its involvement in mtDNA segregation.
Title: Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX.

Walker B mutation in human CLPX exhibits improved interaction with the model unfolded substrate casein and several putative physiological substrates in vitro.
Title: Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.

The following CLPX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLPX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13853	NM_006660.5 Latest version!	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit X (CLPX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu64411	XM_011521164.3 Latest version!	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit X (CLPX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu64411	XM_011521164.2	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu13853	NM_006660.3	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu13853	NM_006660.4	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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Reference Sequences (Refseq)

CLPX ( NM_006660.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006651.2 Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), mRNA.

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CloneID	OHu13853
Clone ID Related Accession (Same CDS sequence)	NM_006660.3 , NM_006660.4 , NM_006660.5
Accession Version	NM_006660.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor
Comment

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAGTTAGA AATAAGAAGA CGGGAGGATG AGTACAGATT TACAAAATTG 
CTTCAGATTG CTGGAATTAG CCCACATGGT AATGCTTTAG GAGCATCAAT GCAGCAACAG 
GTAAATCAAC AAATACCTCA GGAAAAACGA GGAGGTGAAG TATTGGATTC TTCTCATGAT 
GACATAAAAC TTGAAAAAAG TAATATTTTG CTGCTTGGAC CAACTGGGTC AGGTAAAACT 
CTGCTGGCAC AAACCCTAGC TAAATGCCTT GATGTCCCTT TTGCTATCTG TGACTGTACA 
ACTTTGACTC AGGCTGGATA TGTAGGCGAA GATATTGAAT CTGTGATTGC AAAACTACTC 
CAAGATGCCA ATTATAATGT GGAAAAAGCA CAACAAGGAA TTGTCTTTCT GGATGAAGTA 
GATAAGATTG GCAGTGTGCC AGGCATTCAT CAATTACGGG ATGTAGGTGG AGAAGGCGTT 
CAGCAAGGCT TATTAAAACT ACTAGAAGGC ACAATAGTCA ATGTTCCAGA AAAGAATTCC 
CGAAAGCTCC GTGGAGAAAC AGTTCAAGTT GATACAACAA ACATCCTGTT TGTGGCATCT 
GGTGCTTTCA ATGGTTTAGA CAGAATCATC AGCAGGAGGA AAAATGAAAA GTATCTTGGA 
TTTGGAACAC CATCTAATCT GGGAAAAGGC AGAAGGGCTG CAGCTGCTGC AGACCTTGCT 
AATCGAAGTG GGGAATCGAA TACTCACCAA GACATTGAAG AAAAAGATCG GTTATTGCGT 
CATGTGGAAG CCAGAGATCT GATTGAGTTT GGCATGATTC CTGAGTTTGT GGGACGGTTG 
CCTGTGGTGG TTCCATTGCA TAGCCTAGAT GAGAAAACAC TTGTACAAAT ATTAACTGAG 
CCACGAAATG CTGTTATTCC TCAGTACCAG GCCTTATTCA GCATGGATAA GTGTGAACTG 
AATGTTACTG AGGATGCTTT GAAAGCTATA GCCAGATTGG CACTAGAACG AAAAACAGGT 
GCACGAGGCC TTCGGTCCAT AATGGAAAAG CTGTTACTAG AACCAATGTT TGAAGTCCCT 
AATTCTGATA TCGTATGTGT GGAGGTTGAC AAAGAAGTAG TAGAAGGAAA AAAGGAACCA 
GGATACATCC GGGCTCCAAC AAAAGAATCC TCTGAAGAGG AGTATGACTC TGGAGTTGAA 
GAAGAAGGAT GGCCCCGCCA AGCAGATGCT GCAAACAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_006651.2

Translation

MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS

Target ORF information:

RefSeq Version	NM_006660.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006660.3

ORF Insert Sequence:

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAGTTAGA AATAAGAAGA CGGGAGGATG AGTACAGATT TACAAAATTG 
CTTCAGATTG CTGGAATTAG CCCACATGGT AATGCTTTAG GAGCATCAAT GCAGCAACAG 
GTAAATCAAC AAATACCTCA GGAAAAACGA GGAGGTGAAG TATTGGATTC TTCTCATGAT 
GACATAAAAC TTGAAAAAAG TAATATTTTG CTGCTTGGAC CAACTGGGTC AGGTAAAACT 
CTGCTGGCAC AAACCCTAGC TAAATGCCTT GATGTCCCTT TTGCTATCTG TGACTGTACA 
ACTTTGACTC AGGCTGGATA TGTAGGCGAA GATATTGAAT CTGTGATTGC AAAACTACTC 
CAAGATGCCA ATTATAATGT GGAAAAAGCA CAACAAGGAA TTGTCTTTCT GGATGAAGTA 
GATAAGATTG GCAGTGTGCC AGGCATTCAT CAATTACGGG ATGTAGGTGG AGAAGGCGTT 
CAGCAAGGCT TATTAAAACT ACTAGAAGGC ACAATAGTCA ATGTTCCAGA AAAGAATTCC 
CGAAAGCTCC GTGGAGAAAC AGTTCAAGTT GATACAACAA ACATCCTGTT TGTGGCATCT 
GGTGCTTTCA ATGGTTTAGA CAGAATCATC AGCAGGAGGA AAAATGAAAA GTATCTTGGA 
TTTGGAACAC CATCTAATCT GGGAAAAGGC AGAAGGGCTG CAGCTGCTGC AGACCTTGCT 
AATCGAAGTG GGGAATCGAA TACTCACCAA GACATTGAAG AAAAAGATCG GTTATTGCGT 
CATGTGGAAG CCAGAGATCT GATTGAGTTT GGCATGATTC CTGAGTTTGT GGGACGGTTG 
CCTGTGGTGG TTCCATTGCA TAGCCTAGAT GAGAAAACAC TTGTACAAAT ATTAACTGAG 
CCACGAAATG CTGTTATTCC TCAGTACCAG GCCTTATTCA GCATGGATAA GTGTGAACTG 
AATGTTACTG AGGATGCTTT GAAAGCTATA GCCAGATTGG CACTAGAACG AAAAACAGGT 
GCACGAGGCC TTCGGTCCAT AATGGAAAAG CTGTTACTAG AACCAATGTT TGAAGTCCCT 
AATTCTGATA TCGTATGTGT GGAGGTTGAC AAAGAAGTAG TAGAAGGAAA AAAGGAACCA 
GGATACATCC GGGCTCCAAC AAAAGAATCC TCTGAAGAGG AGTATGACTC TGGAGTTGAA 
GAAGAAGGAT GGCCCCGCCA AGCAGATGCT GCAAACAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPX ( NM_006660.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006651.2 Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13853
Clone ID Related Accession (Same CDS sequence)	NM_006660.3 , NM_006660.4 , NM_006660.5
Accession Version	NM_006660.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-25
Organism	Homo sapiens(human)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG717994.1, AJ006267.3, AC013553.14 and CA945006.1. On Nov 25, 2015 this sequence version replaced NM_006660.3. Transcript Variant: This variant (1) represents the longer, protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.117099.1, SRR1803617.227545.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAGTTAGA AATAAGAAGA CGGGAGGATG AGTACAGATT TACAAAATTG 
CTTCAGATTG CTGGAATTAG CCCACATGGT AATGCTTTAG GAGCATCAAT GCAGCAACAG 
GTAAATCAAC AAATACCTCA GGAAAAACGA GGAGGTGAAG TATTGGATTC TTCTCATGAT 
GACATAAAAC TTGAAAAAAG TAATATTTTG CTGCTTGGAC CAACTGGGTC AGGTAAAACT 
CTGCTGGCAC AAACCCTAGC TAAATGCCTT GATGTCCCTT TTGCTATCTG TGACTGTACA 
ACTTTGACTC AGGCTGGATA TGTAGGCGAA GATATTGAAT CTGTGATTGC AAAACTACTC 
CAAGATGCCA ATTATAATGT GGAAAAAGCA CAACAAGGAA TTGTCTTTCT GGATGAAGTA 
GATAAGATTG GCAGTGTGCC AGGCATTCAT CAATTACGGG ATGTAGGTGG AGAAGGCGTT 
CAGCAAGGCT TATTAAAACT ACTAGAAGGC ACAATAGTCA ATGTTCCAGA AAAGAATTCC 
CGAAAGCTCC GTGGAGAAAC AGTTCAAGTT GATACAACAA ACATCCTGTT TGTGGCATCT 
GGTGCTTTCA ATGGTTTAGA CAGAATCATC AGCAGGAGGA AAAATGAAAA GTATCTTGGA 
TTTGGAACAC CATCTAATCT GGGAAAAGGC AGAAGGGCTG CAGCTGCTGC AGACCTTGCT 
AATCGAAGTG GGGAATCGAA TACTCACCAA GACATTGAAG AAAAAGATCG GTTATTGCGT 
CATGTGGAAG CCAGAGATCT GATTGAGTTT GGCATGATTC CTGAGTTTGT GGGACGGTTG 
CCTGTGGTGG TTCCATTGCA TAGCCTAGAT GAGAAAACAC TTGTACAAAT ATTAACTGAG 
CCACGAAATG CTGTTATTCC TCAGTACCAG GCCTTATTCA GCATGGATAA GTGTGAACTG 
AATGTTACTG AGGATGCTTT GAAAGCTATA GCCAGATTGG CACTAGAACG AAAAACAGGT 
GCACGAGGCC TTCGGTCCAT AATGGAAAAG CTGTTACTAG AACCAATGTT TGAAGTCCCT 
AATTCTGATA TCGTATGTGT GGAGGTTGAC AAAGAAGTAG TAGAAGGAAA AAAGGAACCA 
GGATACATCC GGGCTCCAAC AAAAGAATCC TCTGAAGAGG AGTATGACTC TGGAGTTGAA 
GAAGAAGGAT GGCCCCGCCA AGCAGATGCT GCAAACAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006651.2
CDS	268..2169
Translation	MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS

Target ORF information:

RefSeq Version	NM_006660.4
Organism	Homo sapiens(human)
Definition	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006660.4

ORF Insert Sequence:

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAGTTAGA AATAAGAAGA CGGGAGGATG AGTACAGATT TACAAAATTG 
CTTCAGATTG CTGGAATTAG CCCACATGGT AATGCTTTAG GAGCATCAAT GCAGCAACAG 
GTAAATCAAC AAATACCTCA GGAAAAACGA GGAGGTGAAG TATTGGATTC TTCTCATGAT 
GACATAAAAC TTGAAAAAAG TAATATTTTG CTGCTTGGAC CAACTGGGTC AGGTAAAACT 
CTGCTGGCAC AAACCCTAGC TAAATGCCTT GATGTCCCTT TTGCTATCTG TGACTGTACA 
ACTTTGACTC AGGCTGGATA TGTAGGCGAA GATATTGAAT CTGTGATTGC AAAACTACTC 
CAAGATGCCA ATTATAATGT GGAAAAAGCA CAACAAGGAA TTGTCTTTCT GGATGAAGTA 
GATAAGATTG GCAGTGTGCC AGGCATTCAT CAATTACGGG ATGTAGGTGG AGAAGGCGTT 
CAGCAAGGCT TATTAAAACT ACTAGAAGGC ACAATAGTCA ATGTTCCAGA AAAGAATTCC 
CGAAAGCTCC GTGGAGAAAC AGTTCAAGTT GATACAACAA ACATCCTGTT TGTGGCATCT 
GGTGCTTTCA ATGGTTTAGA CAGAATCATC AGCAGGAGGA AAAATGAAAA GTATCTTGGA 
TTTGGAACAC CATCTAATCT GGGAAAAGGC AGAAGGGCTG CAGCTGCTGC AGACCTTGCT 
AATCGAAGTG GGGAATCGAA TACTCACCAA GACATTGAAG AAAAAGATCG GTTATTGCGT 
CATGTGGAAG CCAGAGATCT GATTGAGTTT GGCATGATTC CTGAGTTTGT GGGACGGTTG 
CCTGTGGTGG TTCCATTGCA TAGCCTAGAT GAGAAAACAC TTGTACAAAT ATTAACTGAG 
CCACGAAATG CTGTTATTCC TCAGTACCAG GCCTTATTCA GCATGGATAA GTGTGAACTG 
AATGTTACTG AGGATGCTTT GAAAGCTATA GCCAGATTGG CACTAGAACG AAAAACAGGT 
GCACGAGGCC TTCGGTCCAT AATGGAAAAG CTGTTACTAG AACCAATGTT TGAAGTCCCT 
AATTCTGATA TCGTATGTGT GGAGGTTGAC AAAGAAGTAG TAGAAGGAAA AAAGGAACCA 
GGATACATCC GGGCTCCAAC AAAAGAATCC TCTGAAGAGG AGTATGACTC TGGAGTTGAA 
GAAGAAGGAT GGCCCCGCCA AGCAGATGCT GCAAACAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPX ( NM_006660.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006651.2 Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit X (CLPX), transcript variant 1, mRNA.

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CloneID	OHu13853
Clone ID Related Accession (Same CDS sequence)	NM_006660.3 , NM_006660.4 , NM_006660.5
Accession Version	NM_006660.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG717994.1, AJ006267.3, AC013553.14 and CA945006.1. On Nov 23, 2018 this sequence version replaced NM_006660.4. Transcript Variant: This variant (1) represents the longer, protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.227545.1, SRR1803617.117099.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000300107.7/ ENSP00000300107.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAGTTAGA AATAAGAAGA CGGGAGGATG AGTACAGATT TACAAAATTG 
CTTCAGATTG CTGGAATTAG CCCACATGGT AATGCTTTAG GAGCATCAAT GCAGCAACAG 
GTAAATCAAC AAATACCTCA GGAAAAACGA GGAGGTGAAG TATTGGATTC TTCTCATGAT 
GACATAAAAC TTGAAAAAAG TAATATTTTG CTGCTTGGAC CAACTGGGTC AGGTAAAACT 
CTGCTGGCAC AAACCCTAGC TAAATGCCTT GATGTCCCTT TTGCTATCTG TGACTGTACA 
ACTTTGACTC AGGCTGGATA TGTAGGCGAA GATATTGAAT CTGTGATTGC AAAACTACTC 
CAAGATGCCA ATTATAATGT GGAAAAAGCA CAACAAGGAA TTGTCTTTCT GGATGAAGTA 
GATAAGATTG GCAGTGTGCC AGGCATTCAT CAATTACGGG ATGTAGGTGG AGAAGGCGTT 
CAGCAAGGCT TATTAAAACT ACTAGAAGGC ACAATAGTCA ATGTTCCAGA AAAGAATTCC 
CGAAAGCTCC GTGGAGAAAC AGTTCAAGTT GATACAACAA ACATCCTGTT TGTGGCATCT 
GGTGCTTTCA ATGGTTTAGA CAGAATCATC AGCAGGAGGA AAAATGAAAA GTATCTTGGA 
TTTGGAACAC CATCTAATCT GGGAAAAGGC AGAAGGGCTG CAGCTGCTGC AGACCTTGCT 
AATCGAAGTG GGGAATCGAA TACTCACCAA GACATTGAAG AAAAAGATCG GTTATTGCGT 
CATGTGGAAG CCAGAGATCT GATTGAGTTT GGCATGATTC CTGAGTTTGT GGGACGGTTG 
CCTGTGGTGG TTCCATTGCA TAGCCTAGAT GAGAAAACAC TTGTACAAAT ATTAACTGAG 
CCACGAAATG CTGTTATTCC TCAGTACCAG GCCTTATTCA GCATGGATAA GTGTGAACTG 
AATGTTACTG AGGATGCTTT GAAAGCTATA GCCAGATTGG CACTAGAACG AAAAACAGGT 
GCACGAGGCC TTCGGTCCAT AATGGAAAAG CTGTTACTAG AACCAATGTT TGAAGTCCCT 
AATTCTGATA TCGTATGTGT GGAGGTTGAC AAAGAAGTAG TAGAAGGAAA AAAGGAACCA 
GGATACATCC GGGCTCCAAC AAAAGAATCC TCTGAAGAGG AGTATGACTC TGGAGTTGAA 
GAAGAAGGAT GGCCCCGCCA AGCAGATGCT GCAAACAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006651.2
CDS	190..2091
Translation	MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS

Target ORF information:

RefSeq Version	NM_006660.5
Organism	Homo sapiens(human)
Definition	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit X (CLPX), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006660.5

ORF Insert Sequence:

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAGTTAGA AATAAGAAGA CGGGAGGATG AGTACAGATT TACAAAATTG 
CTTCAGATTG CTGGAATTAG CCCACATGGT AATGCTTTAG GAGCATCAAT GCAGCAACAG 
GTAAATCAAC AAATACCTCA GGAAAAACGA GGAGGTGAAG TATTGGATTC TTCTCATGAT 
GACATAAAAC TTGAAAAAAG TAATATTTTG CTGCTTGGAC CAACTGGGTC AGGTAAAACT 
CTGCTGGCAC AAACCCTAGC TAAATGCCTT GATGTCCCTT TTGCTATCTG TGACTGTACA 
ACTTTGACTC AGGCTGGATA TGTAGGCGAA GATATTGAAT CTGTGATTGC AAAACTACTC 
CAAGATGCCA ATTATAATGT GGAAAAAGCA CAACAAGGAA TTGTCTTTCT GGATGAAGTA 
GATAAGATTG GCAGTGTGCC AGGCATTCAT CAATTACGGG ATGTAGGTGG AGAAGGCGTT 
CAGCAAGGCT TATTAAAACT ACTAGAAGGC ACAATAGTCA ATGTTCCAGA AAAGAATTCC 
CGAAAGCTCC GTGGAGAAAC AGTTCAAGTT GATACAACAA ACATCCTGTT TGTGGCATCT 
GGTGCTTTCA ATGGTTTAGA CAGAATCATC AGCAGGAGGA AAAATGAAAA GTATCTTGGA 
TTTGGAACAC CATCTAATCT GGGAAAAGGC AGAAGGGCTG CAGCTGCTGC AGACCTTGCT 
AATCGAAGTG GGGAATCGAA TACTCACCAA GACATTGAAG AAAAAGATCG GTTATTGCGT 
CATGTGGAAG CCAGAGATCT GATTGAGTTT GGCATGATTC CTGAGTTTGT GGGACGGTTG 
CCTGTGGTGG TTCCATTGCA TAGCCTAGAT GAGAAAACAC TTGTACAAAT ATTAACTGAG 
CCACGAAATG CTGTTATTCC TCAGTACCAG GCCTTATTCA GCATGGATAA GTGTGAACTG 
AATGTTACTG AGGATGCTTT GAAAGCTATA GCCAGATTGG CACTAGAACG AAAAACAGGT 
GCACGAGGCC TTCGGTCCAT AATGGAAAAG CTGTTACTAG AACCAATGTT TGAAGTCCCT 
AATTCTGATA TCGTATGTGT GGAGGTTGAC AAAGAAGTAG TAGAAGGAAA AAAGGAACCA 
GGATACATCC GGGCTCCAAC AAAAGAATCC TCTGAAGAGG AGTATGACTC TGGAGTTGAA 
GAAGAAGGAT GGCCCCGCCA AGCAGATGCT GCAAACAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPX ( XM_011521164.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519466.1 Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), transcript variant X1, mRNA.

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CloneID	OHu64411
Clone ID Related Accession (Same CDS sequence)	XM_011521164.2 , XM_011521164.3
Accession Version	XM_011521164.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521164.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAATTGCT TCAGATTGCT GGAATTAGCC CACATGGTAA TGCTTTAGGA 
GCATCAATGC AGCAACAGGT AAATCAACAA ATACCTCAGG AAAAACGAGG AGGTGAAGTA 
TTGGATTCTT CTCATGATGA CATAAAACTT GAAAAAAGTA ATATTTTGCT GCTTGGACCA 
ACTGGGTCAG GTAAAACTCT GCTGGCACAA ACCCTAGCTA AATGCCTTGA TGTCCCTTTT 
GCTATCTGTG ACTGTACAAC TTTGACTCAG GCTGGATATG TAGGCGAAGA TATTGAATCT 
GTGATTGCAA AACTACTCCA AGATGCCAAT TATAATGTGG AAAAAGCACA ACAAGGAATT 
GTCTTTCTGG ATGAAGTAGA TAAGATTGGC AGTGTGCCAG GCATTCATCA ATTACGGGAT 
GTAGGTGGAG AAGGCGTTCA GCAAGGCTTA TTAAAACTAC TAGAAGGCAC AATAGTCAAT 
GTTCCAGAAA AGAATTCCCG AAAGCTCCGT GGAGAAACAG TTCAAGTTGA TACAACAAAC 
ATCCTGTTTG TGGCATCTGG TGCTTTCAAT GGTTTAGACA GAATCATCAG CAGGAGGAAA 
AATGAAAAGT ATCTTGGATT TGGAACACCA TCTAATCTGG GAAAAGGCAG AAGGGCTGCA 
GCTGCTGCAG ACCTTGCTAA TCGAAGTGGG GAATCGAATA CTCACCAAGA CATTGAAGAA 
AAAGATCGGT TATTGCGTCA TGTGGAAGCC AGAGATCTGA TTGAGTTTGG CATGATTCCT 
GAGTTTGTGG GACGGTTGCC TGTGGTGGTT CCATTGCATA GCCTAGATGA GAAAACACTT 
GTACAAATAT TAACTGAGCC ACGAAATGCT GTTATTCCTC AGTACCAGGC CTTATTCAGC 
ATGGATAAGT GTGAACTGAA TGTTACTGAG GATGCTTTGA AAGCTATAGC CAGATTGGCA 
CTAGAACGAA AAACAGGTGC ACGAGGCCTT CGGTCCATAA TGGAAAAGCT GTTACTAGAA 
CCAATGTTTG AAGTCCCTAA TTCTGATATC GTATGTGTGG AGGTTGACAA AGAAGTAGTA 
GAAGGAAAAA AGGAACCAGG ATACATCCGG GCTCCAACAA AAGAATCCTC TGAAGAGGAG 
TATGACTCTG GAGTTGAAGA AGAAGGATGG CCCCGCCAAG CAGATGCTGC AAACAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519466.1
CDS	252..2111
Translation	MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS

Target ORF information:

RefSeq Version	XM_011521164.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit (CLPX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521164.2

ORF Insert Sequence:

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAATTGCT TCAGATTGCT GGAATTAGCC CACATGGTAA TGCTTTAGGA 
GCATCAATGC AGCAACAGGT AAATCAACAA ATACCTCAGG AAAAACGAGG AGGTGAAGTA 
TTGGATTCTT CTCATGATGA CATAAAACTT GAAAAAAGTA ATATTTTGCT GCTTGGACCA 
ACTGGGTCAG GTAAAACTCT GCTGGCACAA ACCCTAGCTA AATGCCTTGA TGTCCCTTTT 
GCTATCTGTG ACTGTACAAC TTTGACTCAG GCTGGATATG TAGGCGAAGA TATTGAATCT 
GTGATTGCAA AACTACTCCA AGATGCCAAT TATAATGTGG AAAAAGCACA ACAAGGAATT 
GTCTTTCTGG ATGAAGTAGA TAAGATTGGC AGTGTGCCAG GCATTCATCA ATTACGGGAT 
GTAGGTGGAG AAGGCGTTCA GCAAGGCTTA TTAAAACTAC TAGAAGGCAC AATAGTCAAT 
GTTCCAGAAA AGAATTCCCG AAAGCTCCGT GGAGAAACAG TTCAAGTTGA TACAACAAAC 
ATCCTGTTTG TGGCATCTGG TGCTTTCAAT GGTTTAGACA GAATCATCAG CAGGAGGAAA 
AATGAAAAGT ATCTTGGATT TGGAACACCA TCTAATCTGG GAAAAGGCAG AAGGGCTGCA 
GCTGCTGCAG ACCTTGCTAA TCGAAGTGGG GAATCGAATA CTCACCAAGA CATTGAAGAA 
AAAGATCGGT TATTGCGTCA TGTGGAAGCC AGAGATCTGA TTGAGTTTGG CATGATTCCT 
GAGTTTGTGG GACGGTTGCC TGTGGTGGTT CCATTGCATA GCCTAGATGA GAAAACACTT 
GTACAAATAT TAACTGAGCC ACGAAATGCT GTTATTCCTC AGTACCAGGC CTTATTCAGC 
ATGGATAAGT GTGAACTGAA TGTTACTGAG GATGCTTTGA AAGCTATAGC CAGATTGGCA 
CTAGAACGAA AAACAGGTGC ACGAGGCCTT CGGTCCATAA TGGAAAAGCT GTTACTAGAA 
CCAATGTTTG AAGTCCCTAA TTCTGATATC GTATGTGTGG AGGTTGACAA AGAAGTAGTA 
GAAGGAAAAA AGGAACCAGG ATACATCCGG GCTCCAACAA AAGAATCCTC TGAAGAGGAG 
TATGACTCTG GAGTTGAAGA AGAAGGATGG CCCCGCCAAG CAGATGCTGC AAACAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLPX ( XM_011521164.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519466.1 Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit X (CLPX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64411
Clone ID Related Accession (Same CDS sequence)	XM_011521164.2 , XM_011521164.3
Accession Version	XM_011521164.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011521164.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAATTGCT TCAGATTGCT GGAATTAGCC CACATGGTAA TGCTTTAGGA 
GCATCAATGC AGCAACAGGT AAATCAACAA ATACCTCAGG AAAAACGAGG AGGTGAAGTA 
TTGGATTCTT CTCATGATGA CATAAAACTT GAAAAAAGTA ATATTTTGCT GCTTGGACCA 
ACTGGGTCAG GTAAAACTCT GCTGGCACAA ACCCTAGCTA AATGCCTTGA TGTCCCTTTT 
GCTATCTGTG ACTGTACAAC TTTGACTCAG GCTGGATATG TAGGCGAAGA TATTGAATCT 
GTGATTGCAA AACTACTCCA AGATGCCAAT TATAATGTGG AAAAAGCACA ACAAGGAATT 
GTCTTTCTGG ATGAAGTAGA TAAGATTGGC AGTGTGCCAG GCATTCATCA ATTACGGGAT 
GTAGGTGGAG AAGGCGTTCA GCAAGGCTTA TTAAAACTAC TAGAAGGCAC AATAGTCAAT 
GTTCCAGAAA AGAATTCCCG AAAGCTCCGT GGAGAAACAG TTCAAGTTGA TACAACAAAC 
ATCCTGTTTG TGGCATCTGG TGCTTTCAAT GGTTTAGACA GAATCATCAG CAGGAGGAAA 
AATGAAAAGT ATCTTGGATT TGGAACACCA TCTAATCTGG GAAAAGGCAG AAGGGCTGCA 
GCTGCTGCAG ACCTTGCTAA TCGAAGTGGG GAATCGAATA CTCACCAAGA CATTGAAGAA 
AAAGATCGGT TATTGCGTCA TGTGGAAGCC AGAGATCTGA TTGAGTTTGG CATGATTCCT 
GAGTTTGTGG GACGGTTGCC TGTGGTGGTT CCATTGCATA GCCTAGATGA GAAAACACTT 
GTACAAATAT TAACTGAGCC ACGAAATGCT GTTATTCCTC AGTACCAGGC CTTATTCAGC 
ATGGATAAGT GTGAACTGAA TGTTACTGAG GATGCTTTGA AAGCTATAGC CAGATTGGCA 
CTAGAACGAA AAACAGGTGC ACGAGGCCTT CGGTCCATAA TGGAAAAGCT GTTACTAGAA 
CCAATGTTTG AAGTCCCTAA TTCTGATATC GTATGTGTGG AGGTTGACAA AGAAGTAGTA 
GAAGGAAAAA AGGAACCAGG ATACATCCGG GCTCCAACAA AAGAATCCTC TGAAGAGGAG 
TATGACTCTG GAGTTGAAGA AGAAGGATGG CCCCGCCAAG CAGATGCTGC AAACAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519466.1
CDS	222..2081
Translation	MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS

Target ORF information:

RefSeq Version	XM_011521164.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caseinolytic mitochondrial matrix peptidase chaperone subunit X (CLPX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521164.3

ORF Insert Sequence:

ATGCCCAGCT GCGGTGCTTG TACTTGCGGC GCGGCGGCCG TCCGGCTCAT CACCTCCTCA 
CTCGCCTCCG CGCAGAGAGG TATTTCTGGT GGTCGCATTC ATATGTCAGT TTTAGGAAGG 
CTTGGGACAT TTGAAACTCA GATTCTGCAA AGAGCTCCTC TTAGATCCTT TACAGAAACA 
CCAGCATACT TTGCCTCAAA AGATGGGATA AGTAAAGATG GTTCTGGAGA TGGAAATAAG 
AAATCAGCAA GTGAGGGAAG TAGTAAGAAA TCAGGCTCTG GGAATTCTGG GAAAGGTGGA 
AACCAGCTGC GCTGTCCTAA ATGTGGCGAC TTGTGCACAC ATGTAGAGAC CTTTGTATCA 
TCCACCCGTT TTGTCAAGTG TGAAAAGTGT CATCATTTTT TTGTTGTGCT ATCTGAAGCA 
GACTCAAAGA AAAGCATAAT TAAAGAACCT GAATCAGCAG CAGAAGCTGT AAAATTGGCA 
TTCCAACAGA AACCACCACC TCCCCCTAAG AAGATTTATA ACTACCTCGA CAAGTATGTT 
GTTGGCCAGT CATTTGCTAA GAAGGTGCTT TCAGTTGCTG TGTACAATCA TTATAAGAGA 
ATATATAATA ATATCCCAGC TAATCTGAGA CAGCAAGCAG AGGTTGAGAA GCAGACATCA 
TTAACACCAA GAGAATTGCT TCAGATTGCT GGAATTAGCC CACATGGTAA TGCTTTAGGA 
GCATCAATGC AGCAACAGGT AAATCAACAA ATACCTCAGG AAAAACGAGG AGGTGAAGTA 
TTGGATTCTT CTCATGATGA CATAAAACTT GAAAAAAGTA ATATTTTGCT GCTTGGACCA 
ACTGGGTCAG GTAAAACTCT GCTGGCACAA ACCCTAGCTA AATGCCTTGA TGTCCCTTTT 
GCTATCTGTG ACTGTACAAC TTTGACTCAG GCTGGATATG TAGGCGAAGA TATTGAATCT 
GTGATTGCAA AACTACTCCA AGATGCCAAT TATAATGTGG AAAAAGCACA ACAAGGAATT 
GTCTTTCTGG ATGAAGTAGA TAAGATTGGC AGTGTGCCAG GCATTCATCA ATTACGGGAT 
GTAGGTGGAG AAGGCGTTCA GCAAGGCTTA TTAAAACTAC TAGAAGGCAC AATAGTCAAT 
GTTCCAGAAA AGAATTCCCG AAAGCTCCGT GGAGAAACAG TTCAAGTTGA TACAACAAAC 
ATCCTGTTTG TGGCATCTGG TGCTTTCAAT GGTTTAGACA GAATCATCAG CAGGAGGAAA 
AATGAAAAGT ATCTTGGATT TGGAACACCA TCTAATCTGG GAAAAGGCAG AAGGGCTGCA 
GCTGCTGCAG ACCTTGCTAA TCGAAGTGGG GAATCGAATA CTCACCAAGA CATTGAAGAA 
AAAGATCGGT TATTGCGTCA TGTGGAAGCC AGAGATCTGA TTGAGTTTGG CATGATTCCT 
GAGTTTGTGG GACGGTTGCC TGTGGTGGTT CCATTGCATA GCCTAGATGA GAAAACACTT 
GTACAAATAT TAACTGAGCC ACGAAATGCT GTTATTCCTC AGTACCAGGC CTTATTCAGC 
ATGGATAAGT GTGAACTGAA TGTTACTGAG GATGCTTTGA AAGCTATAGC CAGATTGGCA 
CTAGAACGAA AAACAGGTGC ACGAGGCCTT CGGTCCATAA TGGAAAAGCT GTTACTAGAA 
CCAATGTTTG AAGTCCCTAA TTCTGATATC GTATGTGTGG AGGTTGACAA AGAAGTAGTA 
GAAGGAAAAA AGGAACCAGG ATACATCCGG GCTCCAACAA AAGAATCCTC TGAAGAGGAG 
TATGACTCTG GAGTTGAAGA AGAAGGATGG CCCCGCCAAG CAGATGCTGC AAACAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutation in human
Proceedings of the National Academy of Sciences of the United States of America114(38)E8045-E8052(2017 Sep)
Yien YY,Ducamp S,van der Vorm LN,Kardon JR,Manceau H,Kannengiesser C,Bergonia HA,Kafina MD,Karim Z,Gouya L,Baker TA,Puy H,Phillips JD,Nicolas G,Paw BH

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.
PLoS biology14(7)e1002507(2016 Jul)
Seo JH,Rivadeneira DB,Caino MC,Chae YC,Speicher DW,Tang HY,Vaira V,Bosari S,Palleschi A,Rampini P,Kossenkov AV,Languino LR,Altieri DC

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.
Biochimica et biophysica acta1853(10 Pt A)2580-91(2015 Oct)
Al-Furoukh N,Ianni A,Nolte H,H?lper S,Kr?ger M,Wanrooij S,Braun T

Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine.
Cell158(3)647-58(2014 Jul)
Cordova JC,Olivares AO,Shin Y,Stinson BM,Calmat S,Schmitz KR,Aubin-Tam ME,Baker TA,Lang MJ,Sauer RT

Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX.
Experimental cell research318(18)2335-43(2012 Nov)
Kasashima K,Sumitani M,Endo H

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CLPX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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