Gene Symbol | Tgfbr1 |
Entrez Gene ID | 21812 |
Full Name | transforming growth factor, beta receptor I |
Synonyms | ALK5,AU017191,Alk-5,ESK2,TGFR-1,TbetaR-I,TbetaRI |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. |