Tgfbr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tgfbr1
Entrez Gene ID	29591
Full Name	transforming growth factor, beta receptor 1
Synonyms	Alk5,Skr4,Tgfr-1,tbetaR-I
General protein information	Preferred Names transforming growth factor, beta receptor 1 Names TGF-beta receptor type-1 TGF-beta receptor type I TGF-beta type I receptor activin receptor-like kinase 5 serine/threonine-protein kinase receptor R4 transforming growth factor, beta receptor I transforming growth factor-beta receptor type I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q22
Summary	forms a heteromeric receptor complex with TGF-beta type II receptor that binds TGF-beta and mediates TGF-beta signalling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006238030.3	XP_006238092.2	TGF-beta receptor type-1 isoform X1
NM_012775.2	NP_036907.2	TGF-beta receptor type-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TGFBR1	NP_004603.1
Pan troglodytes (chimpanzee)	TGFBR1	XP_001159299.1
Canis lupus familiaris (dog)	TGFBR1	XP_538750.4
Gallus gallus (chicken)	TGFBR1	NP_989577.1
Xenopus tropicalis (tropical clawed frog)	tgfbr1	NP_001015961.1
Danio rerio (zebrafish)	tgfbr1a	NP_001032772.2
Drosophila melanogaster (fruit fly)	babo	NP_476999.1
Mus musculus (house mouse)	Tgfbr1	NP_033396.1
Rattus norvegicus (Norway rat)	Tgfbr1	XP_006238215.1
Danio rerio (zebrafish)	tgfbr1b	NP_001108531.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012476	XP_307671.3
	TGFBR1	XP_001112621.1
Bos taurus (cattle)	TGFBR1	NP_777046.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008247	XP_317220.3

Gene Ontology
Bibliography

Related articles in PubMed

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-?1/ALK5/Smad pathway.
Becerra A, Rojas M, Vallejos A, Villegas V, P?rez L, Cabello-Verrugio C, Simon F
Laboratory investigation; a journal of technical methods and pathology97(9)1033-1046(2017 Sep)

Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-? receptor I (T?RI) through exosomal secretion.
Van Krieken R, Chen G, Gao B, Read J, Al Saleh HA, Li R, Al-Nedawi K, Krepinsky JC
Cellular signalling29158-167(2017 Jan)

Fluoride Regulate Osteoblastic Transforming Growth Factor-?1 Signaling by Mediating Recycling of the Type I Receptor ALK5.
Yang C, Wang Y, Xu H
PloS one12(1)e0170674(2017)

MiR-22 may Suppress Fibrogenesis by Targeting TGF?R I in Cardiac Fibroblasts.
Hong Y, Cao H, Wang Q, Ye J, Sui L, Feng J, Cai X, Song H, Zhang X, Chen X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(6)1345-1353(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studied the fibrotic actions of STAT3 suppression in endothelial cells (ECs); investigated TGF-beta1/ALK5/Smad4 signaling pathway participation; found signaling pathway involvement dependent on TGF-beta1 secretion, the ALK5 activation pathway, and Smad4 translocation into the nucleus.Conclude that suppressed STAT3 expression converts ECs into activated fibroblasts via TGF-beta1/ALK5/Smad4 signaling pathway.
Title: Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-?1/ALK5/Smad pathway.

a novel role for SREBP-1 as a cell surface retention factor for TbetaRI in mesangial cells, is reported.
Title: Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-? receptor I (T?RI) through exosomal secretion.

the expression of Runx2, ALK5 and Smad3 were influenced by SB431542 treatment. In conclusion, this preliminary study indicated that fluoride regulated osteoblastic TGFb1 signaling in bone turnover and cells differentiation via ALK5.
Title: Fluoride Regulate Osteoblastic Transforming Growth Factor-?1 Signaling by Mediating Recycling of the Type I Receptor ALK5.

This study demonstrated that Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats.
Title: Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats.

miR-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart.
Title: MiR-22 may Suppress Fibrogenesis by Targeting TGF?R I in Cardiac Fibroblasts.

The following Tgfbr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tgfbr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13155	NM_012775.2 Latest version!	Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$293.30 $419.00
ORa43311	XM_006238030.3 Latest version!	Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tgfbr1 ( NM_012775.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036907.2 Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), mRNA.

Price & Availability↑

CloneID	ORa13155
Clone ID Related Accession (Same CDS sequence)	NM_012775.2
Accession Version	NM_012775.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Rattus norvegicus(Norway rat)
Product	TGF-beta receptor type-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB804748.1, BC087035.1 and CK844086.1. On or before Dec 15, 2013 this sequence version replaced XM_006225297.1, XM_003749940.1, XM_003754027.1, NM_012775.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087035.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCGG CGTCGGCTGC TTTGCGTCGC TGCCTGCTTC TCATCGTGTT GGTGGCGGCG 
GCGACGCTGC TCCCGGGGGC GAAGGCATTA CAGTGTTTCT GCCACCTCTG TACAAAGGAC 
AATTTTACTT GTGAGACAGA TGGTCTCTGC TTTGTCTCAG TCACCGAGAC CACAGACAAA 
GTTATACACA ATAGCATGTG TATAGCTGAA ATCGACCTAA TTCCCCGAGA CAGGCCATTT 
GTTTGTGCAC CATCTTCAAA AACAGGGGCA GTTACGTATT GCTGCAATCA GGATCACTGC 
AATAAAATAG AACTCCCAAC TACAGAAAAG CAGTCAGCTG GCCTCGGTCC TGTGGAGCTG 
GCAGCTGTCA TTGCTGGTCC AGTCTGCTTC GTCTGCATTG CACTTATGCT GATGGTCTAT 
ATCTGCCATA ACCGCACTGT CATTCACCAC CGCGTACCAA ATGAAGAGGA TCCCTCACTA 
GATCGCCCTT TCATTTCAGA GGGCACCACC TTAAAAGATT TAATTTATGA TATGACAACA 
TCAGGGTCTG GATCAGGTTT ACCACTGCTT GTTCAAAGAA CAATTGCAAG GACCATTGTG 
CTACAAGAAA GCATCGGCAA AGGTCGGTTT GGAGAAGTTT GGCGAGGCAA ATGGCGGGGA 
GAAGAAGTTG CCGTGAAGAT ATTCTCTTCT AGAGAAGAAC GTTCATGGTT CCGAGAGGCA 
GAGATTTATC AGACTGTAAT GTTACGCCAT GAAAATATCC TGGGGTTTAT AGCAGCAGAC 
AACAAAGACA ATGGTACATG GACTCAGCTG TGGTTGGTGT CGGATTATCA TGAGCATGGA 
TCCCTTTTCG ATTACTTGAA TAGATACACT GTTACTGTGG AAGGAATGAT CAAACTCGCT 
CTGTCCACGG CAAGTGGTCT TGCCCATCTT CACATGGAGA TTGTTGGTAC CCAAGGAAAA 
CCAGCTATTG CCCATAGAGA TTTGAAATCA AAGAATATCT TGGTGAAGAA AAATGGAACC 
TGTTGTATTG CAGATTTGGG ACTTGCTGTG AGACATGATT CTGCCACAGA TACAATTGAT 
ATTGCTCCAA ACCACAGAGT AGGCACTAAA AGGTATATGG CCCCTGAAGT TCTAGATGAT 
TCCATAAATA TGAAACATTT TGAATCCTTC AAACGTGCTG ACATCTATGC AATGGGCTTA 
GTATTCTGGG AAATCGCTCG ACGCTGTTCC ATTGGCGGAA TCCACGAAGA CTACCAGTTG 
CCTTACTATG ATCTTGTACC TTCTGATCCA TCCGTTGAAG AAATGAGAAA AGTAGTTTGT 
GAACAGAAGT TAAGGCCAAA TATTCCCAAC AGATGGCAGA GCTGTGAGGC CTTGAGAGTG 
ATGGCCAAAA TTATGAGAGA ATGTTGGTAT GCCAATGGAG CAGCTAGGCT GACAGCTTTG 
CGAATTAAAA AAACATTGTC ACAGCTCAGC CAACAGGAAG GCATCAAAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036907.2
CDS	83..1576
Translation	MEAASAALRRCLLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTYCCNQDHCNKIELPTTEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

Target ORF information:

RefSeq Version	NM_012775.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012775.2

ORF Insert Sequence:

ATGGAGGCGG CGTCGGCTGC TTTGCGTCGC TGCCTGCTTC TCATCGTGTT GGTGGCGGCG 
GCGACGCTGC TCCCGGGGGC GAAGGCATTA CAGTGTTTCT GCCACCTCTG TACAAAGGAC 
AATTTTACTT GTGAGACAGA TGGTCTCTGC TTTGTCTCAG TCACCGAGAC CACAGACAAA 
GTTATACACA ATAGCATGTG TATAGCTGAA ATCGACCTAA TTCCCCGAGA CAGGCCATTT 
GTTTGTGCAC CATCTTCAAA AACAGGGGCA GTTACGTATT GCTGCAATCA GGATCACTGC 
AATAAAATAG AACTCCCAAC TACAGAAAAG CAGTCAGCTG GCCTCGGTCC TGTGGAGCTG 
GCAGCTGTCA TTGCTGGTCC AGTCTGCTTC GTCTGCATTG CACTTATGCT GATGGTCTAT 
ATCTGCCATA ACCGCACTGT CATTCACCAC CGCGTACCAA ATGAAGAGGA TCCCTCACTA 
GATCGCCCTT TCATTTCAGA GGGCACCACC TTAAAAGATT TAATTTATGA TATGACAACA 
TCAGGGTCTG GATCAGGTTT ACCACTGCTT GTTCAAAGAA CAATTGCAAG GACCATTGTG 
CTACAAGAAA GCATCGGCAA AGGTCGGTTT GGAGAAGTTT GGCGAGGCAA ATGGCGGGGA 
GAAGAAGTTG CCGTGAAGAT ATTCTCTTCT AGAGAAGAAC GTTCATGGTT CCGAGAGGCA 
GAGATTTATC AGACTGTAAT GTTACGCCAT GAAAATATCC TGGGGTTTAT AGCAGCAGAC 
AACAAAGACA ATGGTACATG GACTCAGCTG TGGTTGGTGT CGGATTATCA TGAGCATGGA 
TCCCTTTTCG ATTACTTGAA TAGATACACT GTTACTGTGG AAGGAATGAT CAAACTCGCT 
CTGTCCACGG CAAGTGGTCT TGCCCATCTT CACATGGAGA TTGTTGGTAC CCAAGGAAAA 
CCAGCTATTG CCCATAGAGA TTTGAAATCA AAGAATATCT TGGTGAAGAA AAATGGAACC 
TGTTGTATTG CAGATTTGGG ACTTGCTGTG AGACATGATT CTGCCACAGA TACAATTGAT 
ATTGCTCCAA ACCACAGAGT AGGCACTAAA AGGTATATGG CCCCTGAAGT TCTAGATGAT 
TCCATAAATA TGAAACATTT TGAATCCTTC AAACGTGCTG ACATCTATGC AATGGGCTTA 
GTATTCTGGG AAATCGCTCG ACGCTGTTCC ATTGGCGGAA TCCACGAAGA CTACCAGTTG 
CCTTACTATG ATCTTGTACC TTCTGATCCA TCCGTTGAAG AAATGAGAAA AGTAGTTTGT 
GAACAGAAGT TAAGGCCAAA TATTCCCAAC AGATGGCAGA GCTGTGAGGC CTTGAGAGTG 
ATGGCCAAAA TTATGAGAGA ATGTTGGTAT GCCAATGGAG CAGCTAGGCT GACAGCTTTG 
CGAATTAAAA AAACATTGTC ACAGCTCAGC CAACAGGAAG GCATCAAAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tgfbr1 ( XM_006238030.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238092.2 Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43311
Clone ID Related Accession (Same CDS sequence)	XM_006238030.3
Accession Version	XM_006238030.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	TGF-beta receptor type-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238030.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGCGG CGTCGGCTGC TTTGCGTCGC TGCCTGCTTC TCATCGTGTT GGTGGCGGCG 
GCGACGCTGC TCCCGGGGGC GAAGGCATTA CAGTGTTTCT GCCACCTCTG TACAAAGGAC 
AATTTTACTT GTGAGACAGA TGGTCTCTGC TTTGTCTCAG TCACCGAGAC CACAGACAAA 
GTTATACACA ATAGCATGTG TATAGCTGAA ATCGACCTAA TTCCCCGAGA CAGGCCATTT 
GTTTGTGCAC CATCTTCAAA AACAGGGGCA GTTACGTATT GCTGCAATCA GGATCACTGC 
AATAAAATAG AACTCCCAAC TACAGGACCT TTTTCAGAAA AGCAGTCAGC TGGCCTCGGT 
CCTGTGGAGC TGGCAGCTGT CATTGCTGGT CCAGTCTGCT TCGTCTGCAT TGCACTTATG 
CTGATGGTCT ATATCTGCCA TAACCGCACT GTCATTCACC ACCGCGTACC AAATGAAGAG 
GATCCCTCAC TAGATCGCCC TTTCATTTCA GAGGGCACCA CCTTAAAAGA TTTAATTTAT 
GATATGACAA CATCAGGGTC TGGATCAGGT TTACCACTGC TTGTTCAAAG AACAATTGCA 
AGGACCATTG TGCTACAAGA AAGCATCGGC AAAGGTCGGT TTGGAGAAGT TTGGCGAGGC 
AAATGGCGGG GAGAAGAAGT TGCCGTGAAG ATATTCTCTT CTAGAGAAGA ACGTTCATGG 
TTCCGAGAGG CAGAGATTTA TCAGACTGTA ATGTTACGCC ATGAAAATAT CCTGGGGTTT 
ATAGCAGCAG ACAACAAAGA CAATGGTACA TGGACTCAGC TGTGGTTGGT GTCGGATTAT 
CATGAGCATG GATCCCTTTT CGATTACTTG AATAGATACA CTGTTACTGT GGAAGGAATG 
ATCAAACTCG CTCTGTCCAC GGCAAGTGGT CTTGCCCATC TTCACATGGA GATTGTTGGT 
ACCCAAGGAA AACCAGCTAT TGCCCATAGA GATTTGAAAT CAAAGAATAT CTTGGTGAAG 
AAAAATGGAA CCTGTTGTAT TGCAGATTTG GGACTTGCTG TGAGACATGA TTCTGCCACA 
GATACAATTG ATATTGCTCC AAACCACAGA GTAGGCACTA AAAGGTATAT GGCCCCTGAA 
GTTCTAGATG ATTCCATAAA TATGAAACAT TTTGAATCCT TCAAACGTGC TGACATCTAT 
GCAATGGGCT TAGTATTCTG GGAAATCGCT CGACGCTGTT CCATTGGCGG AATCCACGAA 
GACTACCAGT TGCCTTACTA TGATCTTGTA CCTTCTGATC CATCCGTTGA AGAAATGAGA 
AAAGTAGTTT GTGAACAGAA GTTAAGGCCA AATATTCCCA ACAGATGGCA GAGCTGTGAG 
GCCTTGAGAG TGATGGCCAA AATTATGAGA GAATGTTGGT ATGCCAATGG AGCAGCTAGG 
CTGACAGCTT TGCGAATTAA AAAAACATTG TCACAGCTCA GCCAACAGGA AGGCATCAAA 
ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238092.2
CDS	93..1598
Translation	MEAASAALRRCLLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

Target ORF information:

RefSeq Version	XM_006238030.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238030.3

ORF Insert Sequence:

ATGGAGGCGG CGTCGGCTGC TTTGCGTCGC TGCCTGCTTC TCATCGTGTT GGTGGCGGCG 
GCGACGCTGC TCCCGGGGGC GAAGGCATTA CAGTGTTTCT GCCACCTCTG TACAAAGGAC 
AATTTTACTT GTGAGACAGA TGGTCTCTGC TTTGTCTCAG TCACCGAGAC CACAGACAAA 
GTTATACACA ATAGCATGTG TATAGCTGAA ATCGACCTAA TTCCCCGAGA CAGGCCATTT 
GTTTGTGCAC CATCTTCAAA AACAGGGGCA GTTACGTATT GCTGCAATCA GGATCACTGC 
AATAAAATAG AACTCCCAAC TACAGGACCT TTTTCAGAAA AGCAGTCAGC TGGCCTCGGT 
CCTGTGGAGC TGGCAGCTGT CATTGCTGGT CCAGTCTGCT TCGTCTGCAT TGCACTTATG 
CTGATGGTCT ATATCTGCCA TAACCGCACT GTCATTCACC ACCGCGTACC AAATGAAGAG 
GATCCCTCAC TAGATCGCCC TTTCATTTCA GAGGGCACCA CCTTAAAAGA TTTAATTTAT 
GATATGACAA CATCAGGGTC TGGATCAGGT TTACCACTGC TTGTTCAAAG AACAATTGCA 
AGGACCATTG TGCTACAAGA AAGCATCGGC AAAGGTCGGT TTGGAGAAGT TTGGCGAGGC 
AAATGGCGGG GAGAAGAAGT TGCCGTGAAG ATATTCTCTT CTAGAGAAGA ACGTTCATGG 
TTCCGAGAGG CAGAGATTTA TCAGACTGTA ATGTTACGCC ATGAAAATAT CCTGGGGTTT 
ATAGCAGCAG ACAACAAAGA CAATGGTACA TGGACTCAGC TGTGGTTGGT GTCGGATTAT 
CATGAGCATG GATCCCTTTT CGATTACTTG AATAGATACA CTGTTACTGT GGAAGGAATG 
ATCAAACTCG CTCTGTCCAC GGCAAGTGGT CTTGCCCATC TTCACATGGA GATTGTTGGT 
ACCCAAGGAA AACCAGCTAT TGCCCATAGA GATTTGAAAT CAAAGAATAT CTTGGTGAAG 
AAAAATGGAA CCTGTTGTAT TGCAGATTTG GGACTTGCTG TGAGACATGA TTCTGCCACA 
GATACAATTG ATATTGCTCC AAACCACAGA GTAGGCACTA AAAGGTATAT GGCCCCTGAA 
GTTCTAGATG ATTCCATAAA TATGAAACAT TTTGAATCCT TCAAACGTGC TGACATCTAT 
GCAATGGGCT TAGTATTCTG GGAAATCGCT CGACGCTGTT CCATTGGCGG AATCCACGAA 
GACTACCAGT TGCCTTACTA TGATCTTGTA CCTTCTGATC CATCCGTTGA AGAAATGAGA 
AAAGTAGTTT GTGAACAGAA GTTAAGGCCA AATATTCCCA ACAGATGGCA GAGCTGTGAG 
GCCTTGAGAG TGATGGCCAA AATTATGAGA GAATGTTGGT ATGCCAATGG AGCAGCTAGG 
CTGACAGCTT TGCGAATTAA AAAAACATTG TCACAGCTCA GCCAACAGGA AGGCATCAAA 
ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-?1/ALK5/Smad pathway.
Laboratory investigation; a journal of technical methods and pathology97(9)1033-1046(2017 Sep)
Becerra A,Rojas M,Vallejos A,Villegas V,P?rez L,Cabello-Verrugio C,Simon F

Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-? receptor I (T?RI) through exosomal secretion.
Cellular signalling29158-167(2017 Jan)
Van Krieken R,Chen G,Gao B,Read J,Al Saleh HA,Li R,Al-Nedawi K,Krepinsky JC

Fluoride Regulate Osteoblastic Transforming Growth Factor-?1 Signaling by Mediating Recycling of the Type I Receptor ALK5.
PloS one12(1)e0170674(2017)
Yang C,Wang Y,Xu H

MiR-22 may Suppress Fibrogenesis by Targeting TGF?R I in Cardiac Fibroblasts.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(6)1345-1353(2016)
Hong Y,Cao H,Wang Q,Ye J,Sui L,Feng J,Cai X,Song H,Zhang X,Chen X

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Tgfbr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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