Capn3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Capn3
Entrez Gene ID	12335
Full Name	calpain 3
Synonyms	AI323605,Capa-3,Capa3,Lp82,p94
General protein information	Preferred Names calpain 3 Names calpain-3 CANP 3 calcium-activated neutral proteinase 3 calpain L3 calpain p94 muscle-specific calcium-activated neutral protease 3 skeletal muscle specific calpain p94
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 E5\|2 60.31 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109761.2	NP_001103231.1	calpain-3 isoform b
NM_007601.3	NP_031627.2	calpain-3 isoform a
NM_001177799.1	NP_001171270.1	calpain-3 isoform c

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100497532	XP_002935381.2
Homo sapiens (human)	CAPN3	NP_000061.1
Mus musculus (house mouse)	Capn3	NP_031627.2
Rattus norvegicus (Norway rat)	Capn3	NP_058813.1
Canis lupus familiaris (dog)	CAPN3	XP_005638349.1
Gallus gallus (chicken)	CAPN3	NP_001004405.1
	CAPN3	XP_001103220.1
Danio rerio (zebrafish)	capn3a	NP_001004571.1
Bos taurus (cattle)	CAPN3	NP_776685.1

Gene Ontology
Bibliography

Related articles in PubMed

Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis.
Yalvac ME, Amornvit J, Braganza C, Chen L, Hussain SA, Shontz KM, Montgomery CL, Flanigan KM, Lewis S, Sahenk Z
Skeletal muscle7(1)27(2017 Dec)

Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy).
Kramerova I, Ermolova N, Eskin A, Hevener A, Quehenberger O, Armando AM, Haller R, Romain N, Nelson SF, Spencer MJ
Human molecular genetics25(11)2194-2207(2016 06)

Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.
Toral-Ojeda I, Aldanondo G, Lasa-Elgarresta J, Lasa-Fern?ndez H, Fern?ndez-Torr?n R, L?pez de Munain A, Vallejo-Illarramendi A
Expert reviews in molecular medicine18e7(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Destabilization of PGC1a is attributable to decreased p38 MAPK activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation
Title: Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy).

CAPN3 deficiency leads to degradation of SERCA proteins and Ca2+ dysregulation in the skeletal muscle.
Title: Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.

Cleavage of C-terminal titin by CAPN3 is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.
Title: CAPN3-mediated processing of C-terminal titin replaced by pathological cleavage in titinopathy.

these studies reveal a novel interaction between CAPN3 and CaM and identify CaM as the first positive regulator of CAPN3 activity.
Title: Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein.

data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner
Title: skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity.

The following Capn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Capn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20313	NM_007601.3 Latest version!	Mus musculus calpain 3 (Capn3), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu20322	NM_001109761.2 Latest version!	Mus musculus calpain 3 (Capn3), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00
OMu20505	NM_001177799.1 Latest version!	Mus musculus calpain 3 (Capn3), transcript variant c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Capn3 ( NM_007601.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031627.2 Mus musculus calpain 3 (Capn3), transcript variant a, mRNA.

Price & Availability↑

CloneID	OMu20313
Clone ID Related Accession (Same CDS sequence)	NM_007601.3
Accession Version	NM_007601.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2466bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	calpain-3 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY142198.1, CN664345.1, BC139790.1, AL935121.9, BC090661.1 and BB202194.1. On Apr 28, 2010 this sequence version replaced NM_007601.2. Transcript Variant: This variant (a) is the longest transcript and it encodes the longest protein (isoform a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC139790.1, X92523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAACTG TTATTAGTCC AACTGTGGCC CCAAGGACGG GGGCTGAGCC CAGGTCCCCA 
GGGCCAGTTC CTCACCCAGC TCAAGGCAAG ACCACCGAGG CTGGAGGTGG ACACCCAAGT 
GGCATCTATT CGGCCATCAT TAGCCGCAAT TTTCCGATCA TCGGTGTGAA AGAGAAGACA 
TTTGAGCAGC TCCGCAGGAA GTGCCTAGAG AAGAAAGTTC TTTATCTAGA CCCCGAGTTC 
CCACCGGATG AGACCTCTCT CTTTTACAGT CAGAAGTTCC CCATCCAGTT CGTCTGGAAG 
AGACCTCCGG AAATTTGTGA GAATCCCCGG TTTATCATTG GTGGAGCCAA CAGGACTGAC 
ATCTGCCAAG GAGATCTAGG GGACTGCTGG TTTCTTGCAG CCATCGCCTG CCTGACCCTG 
AATGAGCGGC TGCTTTTCCG AGTTATACCC CATGATCAAA GTTTCACTGA AAACTACGCA 
GGGATCTTCC ACTTCCAGTT CTGGCGCTAT GGAGACTGGG TAGATGTGGT CATTGACGAC 
TGTCTGCCAA CATACAACAA TCAGCTGGTT TTCACCAAAT CCAACCACCG CAATGAGTTC 
TGGAGTGCTC TCCTTGAGAA GGCTTATGCC AAGCTCCATG GCTCCTATGA AGCTCTGAAA 
GGTGGGAATA CCACAGAAGC CATGGAGGAC TTCACAGGAG GGGTGACAGA GTTTTTTGAG 
ATCAAGGATG CTCCGAGTGA CATGTACAAG ATTATGAGGA AAGCTATCGA GAGAGGCTCC 
CTCATGGGCT GCTCCATTGA CGATGGCACG AACATGACTT ATGGAACCTC TCCTTCTGGT 
CTGAACATGG GGGAGTTGAT TGCACGGATG GTGAGAAATA TGGATAACTC GCTGCTCAGA 
GACTCAGACC TGGACCCCAG GGGCTCAGAT GACAGACCGT CACGGACAAT TGTTCCAGTG 
CAGTATGAAA CAAGAATGGC CTGTGGGTTG GTGAAAGGGC ATGCCTATTC AGTCACTGGG 
CTGGAGGAGG CCCTGTTCAA AGGTGAGAAG GTGAAGTTGG TGCGGCTGCG GAACCCCTGG 
GGCCAGGTGG AGTGGAACGG CTCTTGGAGT GATGGTTGGA AGGACTGGAG CTTTGTAGAC 
AAAGATGAGA AGGCCCGTCT ACAGCACCAG GTTACTGAGG ATGGAGAGTT CTGGATGTCA 
TATGATGACT TCGTCTACCA TTTCACGAAG CTGGAGATCT GCAACCTCAC AGCTGACGCC 
CTGGAGTCCG ATAAGCTTCA GACCTGGACG GTGTCTGTAA ACGAGGGCCG CTGGGTGAGG 
GGCTGTTCTG CTGGAGGCTG CCGAAACTTC CCAGACACTT TCTGGACCAA CCCGCAGTAC 
CGTCTCAAGC TTCTGGAGGA AGACGATGAC CCTGAGGACT CTGAGGTAAT CTGCAGCTTC 
CTCGTGGCTC TGATGCAGAA GAACCGGCGC AAGGACCGGA AGCTGGGGGC CAACCTCTTC 
ACTATTGGCT TCGCCATCTA CGAGGTTCCC AAAGAGATGC ACGGGAATAA GCAACACCTG 
CAGAAGGACT TCTTCTTGTA CAACGCCTCC AAGGCCAGAA GCAAAACCTA CATCAACATG 
CGGGAGGTGT CCCAGCGCTT CCGCCTGCCA CCCAGCGAGT ATGTCATCGT ACCCTCCACC 
TACGAGCCCC ACCAGGAGGG GGAATTCATC CTCCGAGTCT TCTCCGAAAA GAGGAATCTC 
TCTGAGGAAG CTGAAAATAC AATCTCTGTG GATCGGCCAG TGAAAAAGAA AAAAAACAAG 
CCCATCATCT TCGTTTCTGA CAGAGCAAAC AGCAACAAGG AGCTGGGTGT GGACCAGGAG 
GCAGAGGAGG GCAAAGACAA AGCAGGGCCC GAGAAACGAG GGGAAACCCC ACAGCCAAGG 
CCTGGCCACA CAGACCAGGA AAGTGAGGAG CAGCAGCAAT TCCGGAACAT CTTCAGGCAG 
ATCGCAGGCG ACGACATGGA GATCTGTGCA GATGAACTCA AGAATGTCCT CAACACAGTG 
GTGAACAAAC ACAAGGACCT GAAGACACAA GGGTTCACGC TGGAGTCCTG CAGAAGCATG 
ATAGCTCTCA TGGATACAGA TGGCTCTGGA AGACTGAATC TTCAAGAGTT CCATCACCTC 
TGGAAAAAGA TCAAGGCCTG GCAGAAAATC TTCAAGCACT ATGACACAGA CCATTCCGGT 
ACCATCAATA GCTATGAGAT GCGAAATGCA GTCAATGATG CAGGCTTCCA TCTCAACAGC 
CAACTCTATG ACATCATCAC CATGCGCTAT GCGGACAAAC ACATGAACAT CGACTTTGAC 
AGCTTCATCT GCTGCTTCGT CAGGCTGGAA GGGATGTTCA GAGCTTTTAA CGCATTTGAC 
AAGGATGGCG ATGGTATCAT CAAACTGAAT GTACTTGAGT GGCTGCAGCT TACCATGTAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031627.2
CDS	281..2746
Translation	MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPSGIYSAIISRNFPIIGVKEKTFEQLRRKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDLDPRGSDDRPSRTIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLVRLRNPWGQVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAENTISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKAGPEKRGETPQPRPGHTDQESEEQQQFRNIFRQIAGDDMEICADELKNVLNTVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA

Target ORF information:

RefSeq Version	NM_007601.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus calpain 3 (Capn3), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007601.3

ORF Insert Sequence:

ATGCCAACTG TTATTAGTCC AACTGTGGCC CCAAGGACGG GGGCTGAGCC CAGGTCCCCA 
GGGCCAGTTC CTCACCCAGC TCAAGGCAAG ACCACCGAGG CTGGAGGTGG ACACCCAAGT 
GGCATCTATT CGGCCATCAT TAGCCGCAAT TTTCCGATCA TCGGTGTGAA AGAGAAGACA 
TTTGAGCAGC TCCGCAGGAA GTGCCTAGAG AAGAAAGTTC TTTATCTAGA CCCCGAGTTC 
CCACCGGATG AGACCTCTCT CTTTTACAGT CAGAAGTTCC CCATCCAGTT CGTCTGGAAG 
AGACCTCCGG AAATTTGTGA GAATCCCCGG TTTATCATTG GTGGAGCCAA CAGGACTGAC 
ATCTGCCAAG GAGATCTAGG GGACTGCTGG TTTCTTGCAG CCATCGCCTG CCTGACCCTG 
AATGAGCGGC TGCTTTTCCG AGTTATACCC CATGATCAAA GTTTCACTGA AAACTACGCA 
GGGATCTTCC ACTTCCAGTT CTGGCGCTAT GGAGACTGGG TAGATGTGGT CATTGACGAC 
TGTCTGCCAA CATACAACAA TCAGCTGGTT TTCACCAAAT CCAACCACCG CAATGAGTTC 
TGGAGTGCTC TCCTTGAGAA GGCTTATGCC AAGCTCCATG GCTCCTATGA AGCTCTGAAA 
GGTGGGAATA CCACAGAAGC CATGGAGGAC TTCACAGGAG GGGTGACAGA GTTTTTTGAG 
ATCAAGGATG CTCCGAGTGA CATGTACAAG ATTATGAGGA AAGCTATCGA GAGAGGCTCC 
CTCATGGGCT GCTCCATTGA CGATGGCACG AACATGACTT ATGGAACCTC TCCTTCTGGT 
CTGAACATGG GGGAGTTGAT TGCACGGATG GTGAGAAATA TGGATAACTC GCTGCTCAGA 
GACTCAGACC TGGACCCCAG GGGCTCAGAT GACAGACCGT CACGGACAAT TGTTCCAGTG 
CAGTATGAAA CAAGAATGGC CTGTGGGTTG GTGAAAGGGC ATGCCTATTC AGTCACTGGG 
CTGGAGGAGG CCCTGTTCAA AGGTGAGAAG GTGAAGTTGG TGCGGCTGCG GAACCCCTGG 
GGCCAGGTGG AGTGGAACGG CTCTTGGAGT GATGGTTGGA AGGACTGGAG CTTTGTAGAC 
AAAGATGAGA AGGCCCGTCT ACAGCACCAG GTTACTGAGG ATGGAGAGTT CTGGATGTCA 
TATGATGACT TCGTCTACCA TTTCACGAAG CTGGAGATCT GCAACCTCAC AGCTGACGCC 
CTGGAGTCCG ATAAGCTTCA GACCTGGACG GTGTCTGTAA ACGAGGGCCG CTGGGTGAGG 
GGCTGTTCTG CTGGAGGCTG CCGAAACTTC CCAGACACTT TCTGGACCAA CCCGCAGTAC 
CGTCTCAAGC TTCTGGAGGA AGACGATGAC CCTGAGGACT CTGAGGTAAT CTGCAGCTTC 
CTCGTGGCTC TGATGCAGAA GAACCGGCGC AAGGACCGGA AGCTGGGGGC CAACCTCTTC 
ACTATTGGCT TCGCCATCTA CGAGGTTCCC AAAGAGATGC ACGGGAATAA GCAACACCTG 
CAGAAGGACT TCTTCTTGTA CAACGCCTCC AAGGCCAGAA GCAAAACCTA CATCAACATG 
CGGGAGGTGT CCCAGCGCTT CCGCCTGCCA CCCAGCGAGT ATGTCATCGT ACCCTCCACC 
TACGAGCCCC ACCAGGAGGG GGAATTCATC CTCCGAGTCT TCTCCGAAAA GAGGAATCTC 
TCTGAGGAAG CTGAAAATAC AATCTCTGTG GATCGGCCAG TGAAAAAGAA AAAAAACAAG 
CCCATCATCT TCGTTTCTGA CAGAGCAAAC AGCAACAAGG AGCTGGGTGT GGACCAGGAG 
GCAGAGGAGG GCAAAGACAA AGCAGGGCCC GAGAAACGAG GGGAAACCCC ACAGCCAAGG 
CCTGGCCACA CAGACCAGGA AAGTGAGGAG CAGCAGCAAT TCCGGAACAT CTTCAGGCAG 
ATCGCAGGCG ACGACATGGA GATCTGTGCA GATGAACTCA AGAATGTCCT CAACACAGTG 
GTGAACAAAC ACAAGGACCT GAAGACACAA GGGTTCACGC TGGAGTCCTG CAGAAGCATG 
ATAGCTCTCA TGGATACAGA TGGCTCTGGA AGACTGAATC TTCAAGAGTT CCATCACCTC 
TGGAAAAAGA TCAAGGCCTG GCAGAAAATC TTCAAGCACT ATGACACAGA CCATTCCGGT 
ACCATCAATA GCTATGAGAT GCGAAATGCA GTCAATGATG CAGGCTTCCA TCTCAACAGC 
CAACTCTATG ACATCATCAC CATGCGCTAT GCGGACAAAC ACATGAACAT CGACTTTGAC 
AGCTTCATCT GCTGCTTCGT CAGGCTGGAA GGGATGTTCA GAGCTTTTAA CGCATTTGAC 
AAGGATGGCG ATGGTATCAT CAAACTGAAT GTACTTGAGT GGCTGCAGCT TACCATGTAT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Capn3 ( NM_001109761.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001103231.1 Mus musculus calpain 3 (Capn3), transcript variant b, mRNA.

Price & Availability↑

CloneID	OMu20322
Clone ID Related Accession (Same CDS sequence)	NM_001109761.2
Accession Version	NM_001109761.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2130bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	calpain-3 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC090661.1 and BB202194.1. On Apr 28, 2010 this sequence version replaced NM_001109761.1. Transcript Variant: This variant (b) has multiple differences, compared to variant a. The resulting protein (isoform b) is shorter and has a distinct N-terminus when it is compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC090661.1, AF091998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCTACC TGCTGCCGGG ATTCTTCTGT GACAGGGTGA TCCGAGAAAG GGACAGGAGA 
AATGGAGAGG GCACTGTCTC ACAACCTCTC AAGTTTGAGG GGCAGGATTT TGTCGTTCTC 
AAACAACAGT GTCTGGCTCA GAAGTGCCTC TTTGAAGACC GTGTCTTCCC AGCAGGTGTG 
CAGGCCCTTG GCTCCCATGA GCTGAGCCAG AAAGCCAAGA TGAAGGCCAT CACTTGGAAG 
AGGCCAAAGG AAATTTGTGA GAATCCCCGG TTTATCATTG GTGGAGCCAA CAGGACTGAC 
ATCTGCCAAG GAGATCTAGG GGACTGCTGG TTTCTTGCAG CCATCGCCTG CCTGACCCTG 
AATGAGCGGC TGCTTTTCCG AGTTATACCC CATGATCAAA GTTTCACTGA AAACTACGCA 
GGGATCTTCC ACTTCCAGTT CTGGCGCTAT GGAGACTGGG TAGATGTGGT CATTGACGAC 
TGTCTGCCAA CATACAACAA TCAGCTGGTT TTCACCAAAT CCAACCACCG CAATGAGTTC 
TGGAGTGCTC TCCTTGAGAA GGCTTATGCC AAGCTCCATG GCTCCTATGA AGCTCTGAAA 
GGTGGGAATA CCACAGAAGC CATGGAGGAC TTCACAGGAG GGGTGACAGA GTTTTTTGAG 
ATCAAGGATG CTCCGAGTGA CATGTACAAG ATTATGAGGA AAGCTATCGA GAGAGGCTCC 
CTCATGGGCT GCTCCATTGA CACAATTGTT CCAGTGCAGT ATGAAACAAG AATGGCCTGT 
GGGTTGGTGA AAGGGCATGC CTATTCAGTC ACTGGGCTGG AGGAGGCCCT GTTCAAAGGT 
GAGAAGGTGA AGTTGGTGCG GCTGCGGAAC CCCTGGGGCC AGGTGGAGTG GAACGGCTCT 
TGGAGTGATG GTTGGAAGGA CTGGAGCTTT GTAGACAAAG ATGAGAAGGC CCGTCTACAG 
CACCAGGTTA CTGAGGATGG AGAGTTCTGG ATGTCATATG ATGACTTCGT CTACCATTTC 
ACGAAGCTGG AGATCTGCAA CCTCACAGCT GACGCCCTGG AGTCCGATAA GCTTCAGACC 
TGGACGGTGT CTGTAAACGA GGGCCGCTGG GTGAGGGGCT GTTCTGCTGG AGGCTGCCGA 
AACTTCCCAG ACACTTTCTG GACCAACCCG CAGTACCGTC TCAAGCTTCT GGAGGAAGAC 
GATGACCCTG AGGACTCTGA GGTAATCTGC AGCTTCCTCG TGGCTCTGAT GCAGAAGAAC 
CGGCGCAAGG ACCGGAAGCT GGGGGCCAAC CTCTTCACTA TTGGCTTCGC CATCTACGAG 
GTTCCCAAAG AGATGCACGG GAATAAGCAA CACCTGCAGA AGGACTTCTT CTTGTACAAC 
GCCTCCAAGG CCAGAAGCAA AACCTACATC AACATGCGGG AGGTGTCCCA GCGCTTCCGC 
CTGCCACCCA GCGAGTATGT CATCGTACCC TCCACCTACG AGCCCCACCA GGAGGGGGAA 
TTCATCCTCC GAGTCTTCTC CGAAAAGAGG AATCTCTCTG AGGAAGCTGA AAATACAATC 
TCTGTGGATC GGCCAGTGCC AAGGCCTGGC CACACAGACC AGGAAAGTGA GGAGCAGCAG 
CAATTCCGGA ACATCTTCAG GCAGATCGCA GGCGACGACA TGGAGATCTG TGCAGATGAA 
CTCAAGAATG TCCTCAACAC AGTGGTGAAC AAACACAAGG ACCTGAAGAC ACAAGGGTTC 
ACGCTGGAGT CCTGCAGAAG CATGATAGCT CTCATGGATA CAGATGGCTC TGGAAGACTG 
AATCTTCAAG AGTTCCATCA CCTCTGGAAA AAGATCAAGG CCTGGCAGAA AATCTTCAAG 
CACTATGACA CAGACCATTC CGGTACCATC AATAGCTATG AGATGCGAAA TGCAGTCAAT 
GATGCAGGCT TCCATCTCAA CAGCCAACTC TATGACATCA TCACCATGCG CTATGCGGAC 
AAACACATGA ACATCGACTT TGACAGCTTC ATCTGCTGCT TCGTCAGGCT GGAAGGGATG 
TTCAGAGCTT TTAACGCATT TGACAAGGAT GGCGATGGTA TCATCAAACT GAATGTACTT 
GAGTGGCTGC AGCTTACCAT GTATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103231.1
CDS	74..2203
Translation	MPYLLPGFFCDRVIRERDRRNGEGTVSQPLKFEGQDFVVLKQQCLAQKCLFEDRVFPAGVQALGSHELSQKAKMKAITWKRPKEICENPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKDAPSDMYKIMRKAIERGSLMGCSIDTIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLVRLRNPWGQVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAENTISVDRPVPRPGHTDQESEEQQQFRNIFRQIAGDDMEICADELKNVLNTVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA

Target ORF information:

RefSeq Version	NM_001109761.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calpain 3 (Capn3), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109761.2

ORF Insert Sequence:

ATGCCCTACC TGCTGCCGGG ATTCTTCTGT GACAGGGTGA TCCGAGAAAG GGACAGGAGA 
AATGGAGAGG GCACTGTCTC ACAACCTCTC AAGTTTGAGG GGCAGGATTT TGTCGTTCTC 
AAACAACAGT GTCTGGCTCA GAAGTGCCTC TTTGAAGACC GTGTCTTCCC AGCAGGTGTG 
CAGGCCCTTG GCTCCCATGA GCTGAGCCAG AAAGCCAAGA TGAAGGCCAT CACTTGGAAG 
AGGCCAAAGG AAATTTGTGA GAATCCCCGG TTTATCATTG GTGGAGCCAA CAGGACTGAC 
ATCTGCCAAG GAGATCTAGG GGACTGCTGG TTTCTTGCAG CCATCGCCTG CCTGACCCTG 
AATGAGCGGC TGCTTTTCCG AGTTATACCC CATGATCAAA GTTTCACTGA AAACTACGCA 
GGGATCTTCC ACTTCCAGTT CTGGCGCTAT GGAGACTGGG TAGATGTGGT CATTGACGAC 
TGTCTGCCAA CATACAACAA TCAGCTGGTT TTCACCAAAT CCAACCACCG CAATGAGTTC 
TGGAGTGCTC TCCTTGAGAA GGCTTATGCC AAGCTCCATG GCTCCTATGA AGCTCTGAAA 
GGTGGGAATA CCACAGAAGC CATGGAGGAC TTCACAGGAG GGGTGACAGA GTTTTTTGAG 
ATCAAGGATG CTCCGAGTGA CATGTACAAG ATTATGAGGA AAGCTATCGA GAGAGGCTCC 
CTCATGGGCT GCTCCATTGA CACAATTGTT CCAGTGCAGT ATGAAACAAG AATGGCCTGT 
GGGTTGGTGA AAGGGCATGC CTATTCAGTC ACTGGGCTGG AGGAGGCCCT GTTCAAAGGT 
GAGAAGGTGA AGTTGGTGCG GCTGCGGAAC CCCTGGGGCC AGGTGGAGTG GAACGGCTCT 
TGGAGTGATG GTTGGAAGGA CTGGAGCTTT GTAGACAAAG ATGAGAAGGC CCGTCTACAG 
CACCAGGTTA CTGAGGATGG AGAGTTCTGG ATGTCATATG ATGACTTCGT CTACCATTTC 
ACGAAGCTGG AGATCTGCAA CCTCACAGCT GACGCCCTGG AGTCCGATAA GCTTCAGACC 
TGGACGGTGT CTGTAAACGA GGGCCGCTGG GTGAGGGGCT GTTCTGCTGG AGGCTGCCGA 
AACTTCCCAG ACACTTTCTG GACCAACCCG CAGTACCGTC TCAAGCTTCT GGAGGAAGAC 
GATGACCCTG AGGACTCTGA GGTAATCTGC AGCTTCCTCG TGGCTCTGAT GCAGAAGAAC 
CGGCGCAAGG ACCGGAAGCT GGGGGCCAAC CTCTTCACTA TTGGCTTCGC CATCTACGAG 
GTTCCCAAAG AGATGCACGG GAATAAGCAA CACCTGCAGA AGGACTTCTT CTTGTACAAC 
GCCTCCAAGG CCAGAAGCAA AACCTACATC AACATGCGGG AGGTGTCCCA GCGCTTCCGC 
CTGCCACCCA GCGAGTATGT CATCGTACCC TCCACCTACG AGCCCCACCA GGAGGGGGAA 
TTCATCCTCC GAGTCTTCTC CGAAAAGAGG AATCTCTCTG AGGAAGCTGA AAATACAATC 
TCTGTGGATC GGCCAGTGCC AAGGCCTGGC CACACAGACC AGGAAAGTGA GGAGCAGCAG 
CAATTCCGGA ACATCTTCAG GCAGATCGCA GGCGACGACA TGGAGATCTG TGCAGATGAA 
CTCAAGAATG TCCTCAACAC AGTGGTGAAC AAACACAAGG ACCTGAAGAC ACAAGGGTTC 
ACGCTGGAGT CCTGCAGAAG CATGATAGCT CTCATGGATA CAGATGGCTC TGGAAGACTG 
AATCTTCAAG AGTTCCATCA CCTCTGGAAA AAGATCAAGG CCTGGCAGAA AATCTTCAAG 
CACTATGACA CAGACCATTC CGGTACCATC AATAGCTATG AGATGCGAAA TGCAGTCAAT 
GATGCAGGCT TCCATCTCAA CAGCCAACTC TATGACATCA TCACCATGCG CTATGCGGAC 
AAACACATGA ACATCGACTT TGACAGCTTC ATCTGCTGCT TCGTCAGGCT GGAAGGGATG 
TTCAGAGCTT TTAACGCATT TGACAAGGAT GGCGATGGTA TCATCAAACT GAATGTACTT 
GAGTGGCTGC AGCTTACCAT GTATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Capn3 ( NM_001177799.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001171270.1 Mus musculus calpain 3 (Capn3), transcript variant c, mRNA.

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CloneID	OMu20505
Clone ID Related Accession (Same CDS sequence)	NM_001177799.1
Accession Version	NM_001177799.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	calpain-3 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY142198.1, CN664345.1, AF127766.2, BC139790.1, BC090661.1 and BB202194.1. Transcript Variant: This variant (c) lacks several alternate, in-frame coding exons, compared to variant a. The resulting protein (isoform c) is shorter when it is compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF127766.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGCCAACTG TTATTAGTCC AACTGTGGCC CCAAGGACGG GGGCTGAGCC CAGGTCCCCA 
GGGCCAGTTC CTCACCCAGC TCAAGGCAAG ACCACCGAGG CTGGAGGTGG ACACCCAAGT 
GGCATCTATT CGGCCATCAT TAGCCGCAAT TTTCCGATCA TCGGTGTGAA AGAGAAGACA 
TTTGAGCAGC TCCGCAGGAA GTGCCTAGAG AAGAAAGTTC TTTATCTAGA CCCCGAGTTC 
CCACCGGATG AGACCTCTCT CTTTTACAGT CAGAAGTTCC CCATCCAGTT CGTCTGGAAG 
AGACCTCCGG AAATTTGTGA GAATCCCCGG TTTATCATTG GTGGAGCCAA CAGGACTGAC 
ATCTGCCAAG GAGATCTAGG GGACTGCTGG TTTCTTGCAG CCATCGCCTG CCTGACCCTG 
AATGAGCGGC TGCTTTTCCG AGTTATACCC CATGATCAAA GTTTCACTGA AAACTACGCA 
GGGATCTTCC ACTTCCAGTT CTGGCGCTAT GGAGACTGGG TAGATGTGGT CATTGACGAC 
TGTCTGCCAA CATACAACAA TCAGCTGGTT TTCACCAAAT CCAACCACCG CAATGAGTTC 
TGGAGTGCTC TCCTTGAGAA GGCTTATGCC AAGCTCCATG GCTCCTATGA AGCTCTGAAA 
GGTGGGAATA CCACAGAAGC CATGGAGGAC TTCACAGGAG GGGTGACAGA GTTTTTTGAG 
ATCAAGGATG CTCCGAGTGA CATGTACAAG ATTATGAGGA AAGCTATCGA GAGAGGCTCC 
CTCATGGGCT GCTCCATTGA CACAATTGTT CCAGTGCAGT ATGAAACAAG AATGGCCTGT 
GGGTTGGTGA AAGGGCATGC CTATTCAGTC ACTGGGCTGG AGGAGGCCCT GTTCAAAGGT 
GAGAAGGTGA AGTTGGTGCG GCTGCGGAAC CCCTGGGGCC AGGTGGAGTG GAACGGCTCT 
TGGAGTGATG GTTGGAAGGA CTGGAGCTTT GTAGACAAAG ATGAGAAGGC CCGTCTACAG 
CACCAGGTTA CTGAGGATGG AGAGTTCTGG ATGTCATATG ATGACTTCGT CTACCATTTC 
ACGAAGCTGG AGATCTGCAA CCTCACAGCT GACGCCCTGG AGTCCGATAA GCTTCAGACC 
TGGACGGTGT CTGTAAACGA GGGCCGCTGG GTGAGGGGCT GTTCTGCTGG AGGCTGCCGA 
AACTTCCCAG ACACTTTCTG GACCAACCCG CAGTACCGTC TCAAGCTTCT GGAGGAAGAC 
GATGACCCTG AGGACTCTGA GGTAATCTGC AGCTTCCTCG TGGCTCTGAT GCAGAAGAAC 
CGGCGCAAGG ACCGGAAGCT GGGGGCCAAC CTCTTCACTA TTGGCTTCGC CATCTACGAG 
GTTCCCAAAG AGATGCACGG GAATAAGCAA CACCTGCAGA AGGACTTCTT CTTGTACAAC 
GCCTCCAAGG CCAGAAGCAA AACCTACATC AACATGCGGG AGGTGTCCCA GCGCTTCCGC 
CTGCCACCCA GCGAGTATGT CATCGTACCC TCCACCTACG AGCCCCACCA GGAGGGGGAA 
TTCATCCTCC GAGTCTTCTC CGAAAAGAGG AATCTCTCTG AGGAAGCTGA AAATACAATC 
TCTGTGGATC GGCCAGTGCC AAGGCCTGGC CACACAGACC AGGAAAGTGA GGAGCAGCAG 
CAATTCCGGA ACATCTTCAG GCAGATCGCA GGCGACGACA TGGAGATCTG TGCAGATGAA 
CTCAAGAATG TCCTCAACAC AGTGGTGAAC AAACACAAGG ACCTGAAGAC ACAAGGGTTC 
ACGCTGGAGT CCTGCAGAAG CATGATAGCT CTCATGGATA CAGATGGCTC TGGAAGACTG 
AATCTTCAAG AGTTCCATCA CCTCTGGAAA AAGATCAAGG CCTGGCAGAA AATCTTCAAG 
CACTATGACA CAGACCATTC CGGTACCATC AATAGCTATG AGATGCGAAA TGCAGTCAAT 
GATGCAGGCT TCCATCTCAA CAGCCAACTC TATGACATCA TCACCATGCG CTATGCGGAC 
AAACACATGA ACATCGACTT TGACAGCTTC ATCTGCTGCT TCGTCAGGCT GGAAGGGATG 
TTCAGAGCTT TTAACGCATT TGACAAGGAT GGCGATGGTA TCATCAAACT GAATGTACTT 
GAGTGGCTGC AGCTTACCAT GTATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171270.1
CDS	281..2470
Translation	MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPSGIYSAIISRNFPIIGVKEKTFEQLRRKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKDAPSDMYKIMRKAIERGSLMGCSIDTIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLVRLRNPWGQVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAENTISVDRPVPRPGHTDQESEEQQQFRNIFRQIAGDDMEICADELKNVLNTVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA

Target ORF information:

RefSeq Version	NM_001177799.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus calpain 3 (Capn3), transcript variant c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001177799.1

ORF Insert Sequence:

ATGCCAACTG TTATTAGTCC AACTGTGGCC CCAAGGACGG GGGCTGAGCC CAGGTCCCCA 
GGGCCAGTTC CTCACCCAGC TCAAGGCAAG ACCACCGAGG CTGGAGGTGG ACACCCAAGT 
GGCATCTATT CGGCCATCAT TAGCCGCAAT TTTCCGATCA TCGGTGTGAA AGAGAAGACA 
TTTGAGCAGC TCCGCAGGAA GTGCCTAGAG AAGAAAGTTC TTTATCTAGA CCCCGAGTTC 
CCACCGGATG AGACCTCTCT CTTTTACAGT CAGAAGTTCC CCATCCAGTT CGTCTGGAAG 
AGACCTCCGG AAATTTGTGA GAATCCCCGG TTTATCATTG GTGGAGCCAA CAGGACTGAC 
ATCTGCCAAG GAGATCTAGG GGACTGCTGG TTTCTTGCAG CCATCGCCTG CCTGACCCTG 
AATGAGCGGC TGCTTTTCCG AGTTATACCC CATGATCAAA GTTTCACTGA AAACTACGCA 
GGGATCTTCC ACTTCCAGTT CTGGCGCTAT GGAGACTGGG TAGATGTGGT CATTGACGAC 
TGTCTGCCAA CATACAACAA TCAGCTGGTT TTCACCAAAT CCAACCACCG CAATGAGTTC 
TGGAGTGCTC TCCTTGAGAA GGCTTATGCC AAGCTCCATG GCTCCTATGA AGCTCTGAAA 
GGTGGGAATA CCACAGAAGC CATGGAGGAC TTCACAGGAG GGGTGACAGA GTTTTTTGAG 
ATCAAGGATG CTCCGAGTGA CATGTACAAG ATTATGAGGA AAGCTATCGA GAGAGGCTCC 
CTCATGGGCT GCTCCATTGA CACAATTGTT CCAGTGCAGT ATGAAACAAG AATGGCCTGT 
GGGTTGGTGA AAGGGCATGC CTATTCAGTC ACTGGGCTGG AGGAGGCCCT GTTCAAAGGT 
GAGAAGGTGA AGTTGGTGCG GCTGCGGAAC CCCTGGGGCC AGGTGGAGTG GAACGGCTCT 
TGGAGTGATG GTTGGAAGGA CTGGAGCTTT GTAGACAAAG ATGAGAAGGC CCGTCTACAG 
CACCAGGTTA CTGAGGATGG AGAGTTCTGG ATGTCATATG ATGACTTCGT CTACCATTTC 
ACGAAGCTGG AGATCTGCAA CCTCACAGCT GACGCCCTGG AGTCCGATAA GCTTCAGACC 
TGGACGGTGT CTGTAAACGA GGGCCGCTGG GTGAGGGGCT GTTCTGCTGG AGGCTGCCGA 
AACTTCCCAG ACACTTTCTG GACCAACCCG CAGTACCGTC TCAAGCTTCT GGAGGAAGAC 
GATGACCCTG AGGACTCTGA GGTAATCTGC AGCTTCCTCG TGGCTCTGAT GCAGAAGAAC 
CGGCGCAAGG ACCGGAAGCT GGGGGCCAAC CTCTTCACTA TTGGCTTCGC CATCTACGAG 
GTTCCCAAAG AGATGCACGG GAATAAGCAA CACCTGCAGA AGGACTTCTT CTTGTACAAC 
GCCTCCAAGG CCAGAAGCAA AACCTACATC AACATGCGGG AGGTGTCCCA GCGCTTCCGC 
CTGCCACCCA GCGAGTATGT CATCGTACCC TCCACCTACG AGCCCCACCA GGAGGGGGAA 
TTCATCCTCC GAGTCTTCTC CGAAAAGAGG AATCTCTCTG AGGAAGCTGA AAATACAATC 
TCTGTGGATC GGCCAGTGCC AAGGCCTGGC CACACAGACC AGGAAAGTGA GGAGCAGCAG 
CAATTCCGGA ACATCTTCAG GCAGATCGCA GGCGACGACA TGGAGATCTG TGCAGATGAA 
CTCAAGAATG TCCTCAACAC AGTGGTGAAC AAACACAAGG ACCTGAAGAC ACAAGGGTTC 
ACGCTGGAGT CCTGCAGAAG CATGATAGCT CTCATGGATA CAGATGGCTC TGGAAGACTG 
AATCTTCAAG AGTTCCATCA CCTCTGGAAA AAGATCAAGG CCTGGCAGAA AATCTTCAAG 
CACTATGACA CAGACCATTC CGGTACCATC AATAGCTATG AGATGCGAAA TGCAGTCAAT 
GATGCAGGCT TCCATCTCAA CAGCCAACTC TATGACATCA TCACCATGCG CTATGCGGAC 
AAACACATGA ACATCGACTT TGACAGCTTC ATCTGCTGCT TCGTCAGGCT GGAAGGGATG 
TTCAGAGCTT TTAACGCATT TGACAAGGAT GGCGATGGTA TCATCAAACT GAATGTACTT 
GAGTGGCTGC AGCTTACCAT GTATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis.
Skeletal muscle7(1)27(2017 Dec)
Yalvac ME,Amornvit J,Braganza C,Chen L,Hussain SA,Shontz KM,Montgomery CL,Flanigan KM,Lewis S,Sahenk Z

Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy).
Human molecular genetics25(11)2194-2207(2016 06)
Kramerova I,Ermolova N,Eskin A,Hevener A,Quehenberger O,Armando AM,Haller R,Romain N,Nelson SF,Spencer MJ

Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.
Expert reviews in molecular medicine18e7(2016 Apr)
Toral-Ojeda I,Aldanondo G,Lasa-Elgarresta J,Lasa-Fern?ndez H,Fern?ndez-Torr?n R,L?pez de Munain A,Vallejo-Illarramendi A

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Capn3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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