Gldc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gldc
Entrez Gene ID	104174
Full Name	glycine decarboxylase
Synonyms	D030049L12Rik,D19Wsu57e,b2b2679Clo
General protein information	Preferred Names glycine decarboxylase Names glycine dehydrogenase (decarboxylating), mitochondrial glycine cleavage system P protein glycine dehydrogenase (aminomethyl-transferring) glycine dehydrogenase [decarboxylating], mitochondrial
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C1\|19 24.87 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_138595.2	NP_613061.1	glycine dehydrogenase (decarboxylating), mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GLDC	NP_000161.2
Danio rerio (zebrafish)	gldc	NP_955848.1
Saccharomyces cerevisiae (baker's yeast)	GCV2	NP_013914.1
Magnaporthe oryzae (rice blast fungus)	MGG_15038	XP_003720581.1
Canis lupus familiaris (dog)	GLDC	XP_538655.2
Rattus norvegicus (Norway rat)	Gldc	NP_001101053.1
Caenorhabditis elegans (roundworm)	R12C12.1	NP_495209.1
Kluyveromyces lactis	KLLA0D12738g	XP_453630.1
Xenopus tropicalis (tropical clawed frog)	gldc	XP_002934225.2
Pan troglodytes (chimpanzee)	GLDC	XP_001143144.1
	GLDC	XP_001112651.1
Mus musculus (house mouse)	Gldc	NP_613061.1
Arabidopsis thaliana (thale cress)	GLDP2	NP_180178.1
Oryza sativa (rice)	Os01g0711400	NP_001044046.1
Drosophila melanogaster (fruit fly)	CG3999	NP_649989.1
Neurospora crassa	NCU02475	XP_965069.2
Bos taurus (cattle)	GLDC	NP_001179880.1
Gallus gallus (chicken)	GLDC	NP_989653.1
Schizosaccharomyces pombe (fission yeast)	gcv2	NP_592832.2
Arabidopsis thaliana (thale cress)	GLDP1	NP_195027.1

Gene Ontology
Bibliography

Related articles in PubMed

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.
Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE
Cell reports21(7)1795-1808(2017 Nov)

Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.
Autuori MC, Pai YJ, Stuckey DJ, Savery D, Marconi AM, Massa V, Lythgoe MF, Copp AJ, David AL, Greene ND
Prenatal diagnosis37(3)273-281(2017 Mar)

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.
Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND
Nature communications66388(2015 Mar)

Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.
Li X, Cui C, Guo Y, Yang G
Oncology research and treatment38(11)586-9(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Exencephaly and ventriculomegaly were detectable by High-frequency ultrasound in homozygous Gldc-deficient mouse embryos indicating this to be an effective tool to study CNS development.
Title: Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice through limiting supply of one-carbon units from mitochondrial folate metabolism.
Title: Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.

These studies support a direct relationship between p53 mutations and GLDC expression in B cell lymphoma.
Title: Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.

Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system.
Title: Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.

The following Gldc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gldc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14008	NM_138595.2 Latest version!	Mus musculus glycine decarboxylase (Gldc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$601.30 $859.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gldc ( NM_138595.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_613061.1 Mus musculus glycine decarboxylase (Gldc), mRNA.

Price & Availability↑

CloneID	OMu14008
Clone ID Related Accession (Same CDS sequence)	NM_138595.2
Accession Version	NM_138595.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3078bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	glycine dehydrogenase (decarboxylating), mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC157986.4, BC017135.1 and BF020198.1. On Feb 13, 2013 this sequence version replaced NM_138595.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017135.1, AK080937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCAGCTGT GTGCCAGGGC ATGGGGGCTG CGCCTGGGCC GCGGAGCCGG GGGCGGCCAC 
CGCCTGGCTC GGGGCACCGG CTTGAGTTGG GCGCAGCGAA GCCGGGACAG CAGCGGCGGC 
GGTGGCGGTG GCGGTGGCGG GGACCGCGGC GCGGCTGGGG CCTCGCGCCT TCTGGAGCGC 
CTCCTGCCCA GACACGATGA CTTCTCCCGG AGACACATCG GCCCCGGAGA CAAAGACCGG 
AGGGAGATGC TGCAGGCGCT GGGGCTGGCG AGCATTGATG AGCTCATCGA GAAGACGGTC 
CCCGCCAGCA TCCGCTTGAA GAGACCCTTG AAAATGGAAG ACCCTATTTG TGAGAATGAA 
ATCCTCGAGA CTCTGCATGC CATTGCAAGC AAGAACCAGA TCTGGAGGTC GTATATTGGC 
ATGGGCTATT ACAACTGCTC GGTGCCCCAG ACCATTTTGC GGAACTTACT GGAGAATTCT 
GGATGGGTCA CCCAGTACAC TCCGTATCAG CCAGAGGTGT CCCAGGGGAG GCTGGAGAGT 
TTACTCAACT ACCAGACCAT GGTGTCTGAC ATCACAGGCT TGGACATGGC CAACGCTTCC 
CTGCTGGATG AGGCAACCGC GGCTGCAGAG GCGATGCAAC TGTGCCACAG ACACAACAAG 
AGGAAGAAAT TTTTCGTTGA TCCTCGTTGT CACCCACAGA CGATAGCTGT TGTCCAGACT 
CGAGCCAAAT ATAGGGGGGT GCTTGTCGAG CTGAAGTTAC CCCACGAAAT GGATTTCAGT 
GGCAAAGACG TCTGTGGGGT GCTGTTCCAG TACCCAGACA CTGAGGGGAA GGTGGAGGAC 
TTCACAGAAC TTGTAGACAG AGCCCATCAG ACTGGGAGCC TGACCTGCTG TGCTACTGAC 
CTTTTAGCTC TGTGTATTTT GAGGCCACCT GGAGAGTTTG GAGTGGACAT TGCCCTGGGC 
AACTCCCAGA GATTTGGAGT GCCACTGGGC TATGGGGGAC CGCATGCGGC CTTCTTTGCT 
GTCAAAGAAA ACCTGGTGAG GATGATGCCT GGAAGGATGG TGGGGGTGAC AAGGGATGCC 
ACAGGGAAGG AAGTGTATCG CCTCGCTCTC CAGACCAGAG AACAACACAT CCGGAGAGAC 
AAAGCCACCA GCAACATCTG CACGGCTCAG GCCCTTTTAG CCAACATGGC TGCCATGTTC 
GCCATTTACC ATGGATCCCA GGGGCTGAAG CACATTGCTA AAAGGGTTCA TAATGCTACT 
TTGATTTTGT CTGAAGGGCT CAAGCGAGCA GGACACCAAC TCCAGCATGA CCTGTTCTTT 
GACACTTTGA AGGTTCAGTG TGGCTGCTCA GTGAAGGAGG TGCTGGGCAG AGCAGCTCAG 
AGGCAAATCA ACTTTCGACT CTTCGATGAC GGCACACTTG GCATTTCTTT GGATGAAACA 
GTCACTGAGA AAGATCTGGA TGATTTACTG TGGATCTTCG GCTGTGAGTC ATCTGCAGAA 
TTAGTTGCTG AAGGCATGGG AGAGGAGCGG AGAGGTCTTC TAGGGTCTTC ATTCAAGAGA 
ACCAGCCCGT TCCTCACTCA TCAGGTGTTC AACAGCTATC ACTCAGAAAC TAATCTTGTC 
CGGTATATGA AGAAACTGGA GAACAAAGAC ATCTCCCTCG TTCACAGCAT GATCCCACTG 
GGATCCTGCA CCATGAAGCT CAATAGCTCC TCCGAACTTG CACCCATCAC CTGGAGAGAA 
TTTGCCAACA TCCACCCCTT TGTGCCGCTG GACCAAGCCC AGGGATACCA ACAGCTTTTC 
CAAGGGCTGG AGAAGGATCT GTGTGAGATC ACAGGCTACG ACCGAGTCTC ATTCCAGCCA 
AACAGCGGAG CGCAGGGGGA GTACGCCGGA CTGGCCACCA TCAGAGCGTA CTTAGACCAG 
AAAGGAGAGA GACACAGAAC AGTCTGTCTC ATTCCTAAGT CAGCACATGG AACGAATCCA 
GCAAGCGCTC ACATGGCGGG CATGAAGATC CAGCCTGTGG AGGTGGACAG ATACGGGAAC 
ATCGATGTGG CTCACCTCAA GGCCATGGTG GACCAACACA AGGAGAACCT GGCCGCCATC 
ATGATCACGT ATCCATCTAC CAATGGTGTA TTTGAAGAGA ATATCGGCGA TGTGTGCGCC 
CTGATTCACC AACACGGAGG ACAGGTCTAC CTCGACGGGG CGAACATGAA TGCCCAGGTG 
GGAATCTGCC GCCCTGGGGA CTTTGGGTCA GACGTCTCTC ACCTAAATCT TCACAAGACC 
TTCTGCATTC CCCACGGAGG GGGCGGTCCT GGCATGGGGC CCATCGGAGT GAAGAAGCAC 
CTCAGCCCCT TTCTGCCCAG CCACCCCGTC ATTTCCATAA AGCCAACTGA AGGCACCTGG 
CCCGTGGGCA CTGTCAGTGC AGCCCCGTGG GGTTCCAGCT CCATCCTGCC CATTTCATGG 
GCTTACATTA AGATGATGGG TGGAAAGGGC CTCAAAGAAG CCACAGAAAT CGCCATTCTA 
AATGCCAACT ACATGGCCAA ACGACTAGAG AAACACTACA GAGTCCTCTT TAGAGGTGCA 
AGAGGGTATG TGGCTCATGA GTTTATCTTG GACACCCGAC CCTTCAAAAA GTCTGCCAAT 
GTTGAGGCTG TGGATGTTGC CAAGAGGCTC CAGGATTATG GATTTCACGC CCCTACCATG 
TCCTGGCCTG TGGCAGGGAC TCTCATGATT GAGCCCACCG AGTCAGAAGA CAAGGCAGAG 
CTCGACAGAT TCTGTGATGC TATGATCAGC ATCAGGCAAG AAATCGCTGA CATAGAGGAG 
GGCCGCATCG ACCCGAGGGT CAACCCCCTG AAGATGTCTC CACACTCCTT GACCTGTGTC 
ACATCCTCCT GCTGGGATCG GCCGTATTCT AGAGAGGTAG CAGCATTTCC ACTGCCCTTT 
GTGAAACCAG AGAACAAATT CTGGCCAACC ATTGCCCGGA TCGATGACAT CTACGGAGAT 
CAGCACTTGG TCTGCACCTG CCCGCCCATG GAGGTCTATG AGTCTCCATT TTCTGAACAG 
AAGAGGGCTT CTTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_613061.1
CDS	182..3259
Translation	MQLCARAWGLRLGRGAGGGHRLARGTGLSWAQRSRDSSGGGGGGGGGDRGAAGASRLLERLLPRHDDFSRRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKLPHEMDFSGKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCGCSVKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMGEERRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWREFANIHPFVPLDQAQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKAMVDQHKENLAAIMITYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLSPFLPSHPVISIKPTEGTWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEATEIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSCWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS

Target ORF information:

RefSeq Version	NM_138595.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycine decarboxylase (Gldc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138595.2

ORF Insert Sequence:

ATGCAGCTGT GTGCCAGGGC ATGGGGGCTG CGCCTGGGCC GCGGAGCCGG GGGCGGCCAC 
CGCCTGGCTC GGGGCACCGG CTTGAGTTGG GCGCAGCGAA GCCGGGACAG CAGCGGCGGC 
GGTGGCGGTG GCGGTGGCGG GGACCGCGGC GCGGCTGGGG CCTCGCGCCT TCTGGAGCGC 
CTCCTGCCCA GACACGATGA CTTCTCCCGG AGACACATCG GCCCCGGAGA CAAAGACCGG 
AGGGAGATGC TGCAGGCGCT GGGGCTGGCG AGCATTGATG AGCTCATCGA GAAGACGGTC 
CCCGCCAGCA TCCGCTTGAA GAGACCCTTG AAAATGGAAG ACCCTATTTG TGAGAATGAA 
ATCCTCGAGA CTCTGCATGC CATTGCAAGC AAGAACCAGA TCTGGAGGTC GTATATTGGC 
ATGGGCTATT ACAACTGCTC GGTGCCCCAG ACCATTTTGC GGAACTTACT GGAGAATTCT 
GGATGGGTCA CCCAGTACAC TCCGTATCAG CCAGAGGTGT CCCAGGGGAG GCTGGAGAGT 
TTACTCAACT ACCAGACCAT GGTGTCTGAC ATCACAGGCT TGGACATGGC CAACGCTTCC 
CTGCTGGATG AGGCAACCGC GGCTGCAGAG GCGATGCAAC TGTGCCACAG ACACAACAAG 
AGGAAGAAAT TTTTCGTTGA TCCTCGTTGT CACCCACAGA CGATAGCTGT TGTCCAGACT 
CGAGCCAAAT ATAGGGGGGT GCTTGTCGAG CTGAAGTTAC CCCACGAAAT GGATTTCAGT 
GGCAAAGACG TCTGTGGGGT GCTGTTCCAG TACCCAGACA CTGAGGGGAA GGTGGAGGAC 
TTCACAGAAC TTGTAGACAG AGCCCATCAG ACTGGGAGCC TGACCTGCTG TGCTACTGAC 
CTTTTAGCTC TGTGTATTTT GAGGCCACCT GGAGAGTTTG GAGTGGACAT TGCCCTGGGC 
AACTCCCAGA GATTTGGAGT GCCACTGGGC TATGGGGGAC CGCATGCGGC CTTCTTTGCT 
GTCAAAGAAA ACCTGGTGAG GATGATGCCT GGAAGGATGG TGGGGGTGAC AAGGGATGCC 
ACAGGGAAGG AAGTGTATCG CCTCGCTCTC CAGACCAGAG AACAACACAT CCGGAGAGAC 
AAAGCCACCA GCAACATCTG CACGGCTCAG GCCCTTTTAG CCAACATGGC TGCCATGTTC 
GCCATTTACC ATGGATCCCA GGGGCTGAAG CACATTGCTA AAAGGGTTCA TAATGCTACT 
TTGATTTTGT CTGAAGGGCT CAAGCGAGCA GGACACCAAC TCCAGCATGA CCTGTTCTTT 
GACACTTTGA AGGTTCAGTG TGGCTGCTCA GTGAAGGAGG TGCTGGGCAG AGCAGCTCAG 
AGGCAAATCA ACTTTCGACT CTTCGATGAC GGCACACTTG GCATTTCTTT GGATGAAACA 
GTCACTGAGA AAGATCTGGA TGATTTACTG TGGATCTTCG GCTGTGAGTC ATCTGCAGAA 
TTAGTTGCTG AAGGCATGGG AGAGGAGCGG AGAGGTCTTC TAGGGTCTTC ATTCAAGAGA 
ACCAGCCCGT TCCTCACTCA TCAGGTGTTC AACAGCTATC ACTCAGAAAC TAATCTTGTC 
CGGTATATGA AGAAACTGGA GAACAAAGAC ATCTCCCTCG TTCACAGCAT GATCCCACTG 
GGATCCTGCA CCATGAAGCT CAATAGCTCC TCCGAACTTG CACCCATCAC CTGGAGAGAA 
TTTGCCAACA TCCACCCCTT TGTGCCGCTG GACCAAGCCC AGGGATACCA ACAGCTTTTC 
CAAGGGCTGG AGAAGGATCT GTGTGAGATC ACAGGCTACG ACCGAGTCTC ATTCCAGCCA 
AACAGCGGAG CGCAGGGGGA GTACGCCGGA CTGGCCACCA TCAGAGCGTA CTTAGACCAG 
AAAGGAGAGA GACACAGAAC AGTCTGTCTC ATTCCTAAGT CAGCACATGG AACGAATCCA 
GCAAGCGCTC ACATGGCGGG CATGAAGATC CAGCCTGTGG AGGTGGACAG ATACGGGAAC 
ATCGATGTGG CTCACCTCAA GGCCATGGTG GACCAACACA AGGAGAACCT GGCCGCCATC 
ATGATCACGT ATCCATCTAC CAATGGTGTA TTTGAAGAGA ATATCGGCGA TGTGTGCGCC 
CTGATTCACC AACACGGAGG ACAGGTCTAC CTCGACGGGG CGAACATGAA TGCCCAGGTG 
GGAATCTGCC GCCCTGGGGA CTTTGGGTCA GACGTCTCTC ACCTAAATCT TCACAAGACC 
TTCTGCATTC CCCACGGAGG GGGCGGTCCT GGCATGGGGC CCATCGGAGT GAAGAAGCAC 
CTCAGCCCCT TTCTGCCCAG CCACCCCGTC ATTTCCATAA AGCCAACTGA AGGCACCTGG 
CCCGTGGGCA CTGTCAGTGC AGCCCCGTGG GGTTCCAGCT CCATCCTGCC CATTTCATGG 
GCTTACATTA AGATGATGGG TGGAAAGGGC CTCAAAGAAG CCACAGAAAT CGCCATTCTA 
AATGCCAACT ACATGGCCAA ACGACTAGAG AAACACTACA GAGTCCTCTT TAGAGGTGCA 
AGAGGGTATG TGGCTCATGA GTTTATCTTG GACACCCGAC CCTTCAAAAA GTCTGCCAAT 
GTTGAGGCTG TGGATGTTGC CAAGAGGCTC CAGGATTATG GATTTCACGC CCCTACCATG 
TCCTGGCCTG TGGCAGGGAC TCTCATGATT GAGCCCACCG AGTCAGAAGA CAAGGCAGAG 
CTCGACAGAT TCTGTGATGC TATGATCAGC ATCAGGCAAG AAATCGCTGA CATAGAGGAG 
GGCCGCATCG ACCCGAGGGT CAACCCCCTG AAGATGTCTC CACACTCCTT GACCTGTGTC 
ACATCCTCCT GCTGGGATCG GCCGTATTCT AGAGAGGTAG CAGCATTTCC ACTGCCCTTT 
GTGAAACCAG AGAACAAATT CTGGCCAACC ATTGCCCGGA TCGATGACAT CTACGGAGAT 
CAGCACTTGG TCTGCACCTG CCCGCCCATG GAGGTCTATG AGTCTCCATT TTCTGAACAG 
AAGAGGGCTT CTTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.
Cell reports21(7)1795-1808(2017 Nov)
Leung KY,Pai YJ,Chen Q,Santos C,Calvani E,Sudiwala S,Savery D,Ralser M,Gross SS,Copp AJ,Greene NDE

Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.
Prenatal diagnosis37(3)273-281(2017 Mar)
Autuori MC,Pai YJ,Stuckey DJ,Savery D,Marconi AM,Massa V,Lythgoe MF,Copp AJ,David AL,Greene ND

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Nature521(7553)520-4(2015 May)
Li Y,Klena NT,Gabriel GC,Liu X,Kim AJ,Lemke K,Chen Y,Chatterjee B,Devine W,Damerla RR,Chang C,Yagi H,San Agustin JT,Thahir M,Anderton S,Lawhead C,Vescovi A,Pratt H,Morgan J,Haynes L,Smith CL,Eppig JT,Reinholdt L,Francis R,Leatherbury L,Ganapathiraju MK,Tobita K,Pazour GJ,Lo CW

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.
Nature communications66388(2015 Mar)
Pai YJ,Leung KY,Savery D,Hutchin T,Prunty H,Heales S,Brosnan ME,Brosnan JT,Copp AJ,Greene ND

Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.
Oncology research and treatment38(11)586-9(2015)
Li X,Cui C,Guo Y,Yang G

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Gldc cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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