GLDC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GLDC
Entrez Gene ID	2731
Full Name	glycine decarboxylase
Synonyms	GCE,GCSP,HYGN1
General protein information	Preferred Names glycine decarboxylase Names glycine dehydrogenase (decarboxylating), mitochondrial glycine cleavage system protein P glycine decarboxylase P-protein glycine dehydrogenase (aminomethyl-transferring) glycine dehydrogenase [decarboxylating], mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p24.1
Summary	Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010].
Disorder MIM:	238300
Disorder Html:	Glycine encephalopathy, 605899 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000170.3	NP_000161.2	glycine dehydrogenase (decarboxylating), mitochondrial precursor
NM_000170.2	NP_000161.2	glycine dehydrogenase (decarboxylating), mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GLDC	NP_000161.2
Danio rerio (zebrafish)	gldc	NP_955848.1
Saccharomyces cerevisiae (baker's yeast)	GCV2	NP_013914.1
Magnaporthe oryzae (rice blast fungus)	MGG_15038	XP_003720581.1
Canis lupus familiaris (dog)	GLDC	XP_538655.2
Rattus norvegicus (Norway rat)	Gldc	NP_001101053.1
Caenorhabditis elegans (roundworm)	R12C12.1	NP_495209.1
Kluyveromyces lactis	KLLA0D12738g	XP_453630.1
Xenopus tropicalis (tropical clawed frog)	gldc	XP_002934225.2
Pan troglodytes (chimpanzee)	GLDC	XP_001143144.1
	GLDC	XP_001112651.1
Mus musculus (house mouse)	Gldc	NP_613061.1
Arabidopsis thaliana (thale cress)	GLDP2	NP_180178.1
Oryza sativa (rice)	Os01g0711400	NP_001044046.1
Drosophila melanogaster (fruit fly)	CG3999	NP_649989.1
Neurospora crassa	NCU02475	XP_965069.2
Bos taurus (cattle)	GLDC	NP_001179880.1
Gallus gallus (chicken)	GLDC	NP_989653.1
Schizosaccharomyces pombe (fission yeast)	gcv2	NP_592832.2
Arabidopsis thaliana (thale cress)	GLDP1	NP_195027.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel compound heterozygous variant identified in GLDC gene in a Chinese family with non-ketotic hyperglycinemia.
Lin Y, Zheng Z, Sun W, Fu Q
BMC medical genetics19(1)5(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We show that the combination of GLDC and HIF-1alpha expression is an independent prognostic factor in early-stage lung non-small cell cancer
Title: Glycine decarboxylase and HIF-1? expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer.

The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT
Title: The genetic basis of classic nonketotic hyperglycinemia due to mutations in GLDC and AMT.

Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population.
Title: Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy.

study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths
Title: A novel glycine decarboxylase gene mutation in an Indian family with nonketotic hyperglycinemia.

Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer.
Title: Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

The following GLDC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GLDC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18167	NM_000170.3 Latest version!	Homo sapiens glycine decarboxylase (GLDC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OHu18167	NM_000170.2	Homo sapiens glycine decarboxylase (GLDC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GLDC ( NM_000170.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000161.2 Homo sapiens glycine decarboxylase (GLDC), mRNA.

Price & Availability↑

CloneID	OHu18167
Clone ID Related Accession (Same CDS sequence)	NM_000170.3 , NM_000170.2
Accession Version	NM_000170.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3063bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	glycine dehydrogenase (decarboxylating), mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL162411.23, DA741442.1, DR002916.1, BC111993.1, AW593954.1 and AI480362.1. On Dec 4, 2019 this sequence version replaced NM_000170.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D90239.1, M63635.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGTCCT GTGCCAGGGC GTGGGGGCTG CGCCTGGGCC GCGGGGTCGG GGGCGGCCGC 
CGCCTGGCTG GGGGATCGGG GCCGTGCTGG GCGCCGCGGA GCCGGGACAG CAGCAGTGGC 
GGCGGGGACA GCGCCGCGGC TGGGGCCTCG CGCCTCCTGG AGCGCCTTCT GCCCAGACAC 
GACGACTTCG CTCGGAGGCA CATCGGCCCT GGGGACAAAG ACCAGAGAGA GATGCTGCAG 
ACCTTGGGGC TGGCGAGCAT TGATGAATTG ATCGAGAAGA CGGTCCCTGC CAACATCCGT 
TTGAAAAGAC CCTTGAAAAT GGAAGACCCT GTTTGTGAAA ATGAAATCCT TGCAACTCTG 
CATGCCATTT CAAGCAAAAA CCAGATCTGG AGATCGTATA TTGGCATGGG CTATTATAAC 
TGCTCAGTGC CACAGACGAT TTTGCGGAAC TTACTGGAGA ACTCAGGATG GATCACCCAG 
TATACTCCAT ACCAGCCTGA GGTGTCTCAG GGGAGGCTGG AGAGTTTACT CAACTACCAG 
ACCATGGTGT GTGACATCAC AGGCCTGGAC ATGGCCAATG CATCCCTGCT GGATGAGGGG 
ACTGCAGCCG CAGAGGCACT GCAGCTGTGC TACAGACACA ACAAGAGGAG GAAATTTCTC 
GTTGATCCCC GTTGCCACCC ACAGACAATA GCTGTTGTCC AGACTCGAGC CAAATATACT 
GGAGTCCTCA CTGAGCTGAA GTTACCCTGT GAAATGGACT TCAGTGGAAA AGATGTCAGT 
GGAGTGTTGT TCCAGTACCC AGACACGGAG GGGAAGGTGG AAGACTTTAC GGAACTCGTG 
GAGAGAGCTC ATCAGAGTGG GAGCCTGGCC TGCTGTGCTA CTGACCTTTT AGCTTTGTGC 
ATCTTGAGGC CACCTGGAGA ATTTGGGGTA GACATCGCCC TGGGCAGCTC CCAGAGATTT 
GGAGTGCCAC TGGGCTATGG GGGACCCCAT GCAGCATTTT TTGCTGTCCG AGAAAGCTTG 
GTGAGAATGA TGCCTGGAAG AATGGTGGGG GTAACAAGAG ATGCCACTGG GAAAGAAGTG 
TATCGTCTTG CTCTTCAAAC CAGGGAGCAA CACATTCGGA GAGACAAGGC TACCAGCAAC 
ATCTGTACAG CTCAGGCCCT CTTGGCGAAT ATGGCTGCCA TGTTTGCAAT CTACCATGGT 
TCCCATGGGC TGGAGCATAT TGCTAGGAGG GTACATAATG CCACTTTGAT TTTGTCAGAA 
GGTCTCAAGC GAGCAGGGCA TCAACTCCAG CATGACCTGT TCTTTGATAC CTTGAAGATT 
CAGTGTGGCT GCTCAGTGAA GGAGGTCTTG GGCAGGGCCG CTCAGCGGCA GATCAATTTT 
CGGCTTTTTG AGGATGGCAC ACTTGGTATT TCTCTTGATG AAACAGTCAA TGAAAAAGAT 
CTGGACGATT TGTTGTGGAT CTTTGGTTGT GAGTCATCTG CAGAACTGGT TGCTGAAAGC 
ATGGGAGAGG AGTGCAGAGG TATTCCAGGG TCTGTGTTCA AGAGGACCAG CCCGTTCCTC 
ACCCATCAAG TGTTCAACAG CTACCACTCT GAAACAAACA TTGTCCGGTA CATGAAGAAA 
CTGGAAAATA AAGACATTTC CCTTGTTCAC AGCATGATTC CACTGGGATC CTGCACCATG 
AAACTGAACA GTTCGTCTGA ACTCGCACCT ATCACATGGA AAGAATTTGC AAACATCCAC 
CCCTTTGTGC CTCTGGATCA AGCTCAAGGA TATCAGCAGC TTTTCCGAGA GCTTGAGAAG 
GATTTGTGTG AACTCACAGG TTATGACCAG GTCTGTTTCC AGCCAAACAG CGGAGCCCAG 
GGAGAATATG CTGGACTGGC CACTATCCGA GCCTACTTAA ACCAGAAAGG AGAGGGGCAC 
AGAACGGTTT GCCTCATTCC GAAATCAGCA CATGGGACCA ACCCAGCAAG TGCCCACATG 
GCAGGCATGA AGATTCAGCC TGTGGAGGTG GATAAATATG GGAATATCGA TGCAGTTCAC 
CTCAAGGCCA TGGTGGATAA GCACAAGGAG AACCTAGCAG CTATCATGAT TACATACCCA 
TCCACCAATG GGGTGTTTGA AGAGAACATC AGTGACGTGT GTGACCTCAT CCATCAACAT 
GGAGGACAGG TCTACCTAGA CGGGGCAAAT ATGAATGCTC AGGTGGGAAT CTGTCGCCCT 
GGAGACTTCG GGTCTGATGT CTCGCACCTA AATCTTCACA AGACCTTCTG CATTCCCCAC 
GGAGGAGGTG GTCCTGGCAT GGGGCCCATC GGAGTGAAGA AACATCTCGC CCCGTTTTTG 
CCCAATCATC CCGTCATTTC ACTAAAGCGG AATGAGGATG CCTGTCCTGT GGGAACCGTC 
AGTGCGGCCC CATGGGGCTC CAGTTCCATC TTGCCCATTT CCTGGGCTTA TATCAAGATG 
ATGGGAGGCA AGGGTCTTAA ACAAGCCACG GAAACTGCGA TATTAAATGC CAACTACATG 
GCCAAGCGAT TAGAAACACA CTACAGAATT CTTTTCAGGG GTGCAAGAGG TTATGTGGGT 
CATGAATTTA TTTTGGACAC GAGACCCTTC AAAAAGTCTG CAAATATTGA GGCTGTGGAT 
GTGGCCAAGA GACTCCAGGA TTATGGATTT CACGCCCCTA CCATGTCCTG GCCTGTGGCA 
GGGACCCTCA TGGTGGAGCC CACTGAGTCG GAGGACAAGG CAGAGCTGGA CAGATTCTGT 
GATGCCATGA TCAGCATTCG GCAGGAAATT GCTGACATTG AGGAGGGCCG CATCGACCCC 
AGGGTCAATC CGCTGAAGAT GTCTCCACAC TCCCTGACCT GCGTTACATC TTCCCACTGG 
GACCGGCCTT ATTCCAGAGA GGTGGCAGCA TTCCCACTCC CCTTCGTGAA ACCAGAGAAC 
AAATTCTGGC CAACGATTGC CCGGATTGAT GACATATATG GAGATCAGCA CCTGGTTTGT 
ACCTGCCCAC CCATGGAAGT TTATGAGTCT CCATTTTCTG AACAAAAGAG GGCGTCTTCT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000161.2
CDS	231..3293
Translation	MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGASRLLERLLPRHDDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKLPCEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS

Target ORF information:

RefSeq Version	NM_000170.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine decarboxylase (GLDC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000170.3

ORF Insert Sequence:

ATGCAGTCCT GTGCCAGGGC GTGGGGGCTG CGCCTGGGCC GCGGGGTCGG GGGCGGCCGC 
CGCCTGGCTG GGGGATCGGG GCCGTGCTGG GCGCCGCGGA GCCGGGACAG CAGCAGTGGC 
GGCGGGGACA GCGCCGCGGC TGGGGCCTCG CGCCTCCTGG AGCGCCTTCT GCCCAGACAC 
GACGACTTCG CTCGGAGGCA CATCGGCCCT GGGGACAAAG ACCAGAGAGA GATGCTGCAG 
ACCTTGGGGC TGGCGAGCAT TGATGAATTG ATCGAGAAGA CGGTCCCTGC CAACATCCGT 
TTGAAAAGAC CCTTGAAAAT GGAAGACCCT GTTTGTGAAA ATGAAATCCT TGCAACTCTG 
CATGCCATTT CAAGCAAAAA CCAGATCTGG AGATCGTATA TTGGCATGGG CTATTATAAC 
TGCTCAGTGC CACAGACGAT TTTGCGGAAC TTACTGGAGA ACTCAGGATG GATCACCCAG 
TATACTCCAT ACCAGCCTGA GGTGTCTCAG GGGAGGCTGG AGAGTTTACT CAACTACCAG 
ACCATGGTGT GTGACATCAC AGGCCTGGAC ATGGCCAATG CATCCCTGCT GGATGAGGGG 
ACTGCAGCCG CAGAGGCACT GCAGCTGTGC TACAGACACA ACAAGAGGAG GAAATTTCTC 
GTTGATCCCC GTTGCCACCC ACAGACAATA GCTGTTGTCC AGACTCGAGC CAAATATACT 
GGAGTCCTCA CTGAGCTGAA GTTACCCTGT GAAATGGACT TCAGTGGAAA AGATGTCAGT 
GGAGTGTTGT TCCAGTACCC AGACACGGAG GGGAAGGTGG AAGACTTTAC GGAACTCGTG 
GAGAGAGCTC ATCAGAGTGG GAGCCTGGCC TGCTGTGCTA CTGACCTTTT AGCTTTGTGC 
ATCTTGAGGC CACCTGGAGA ATTTGGGGTA GACATCGCCC TGGGCAGCTC CCAGAGATTT 
GGAGTGCCAC TGGGCTATGG GGGACCCCAT GCAGCATTTT TTGCTGTCCG AGAAAGCTTG 
GTGAGAATGA TGCCTGGAAG AATGGTGGGG GTAACAAGAG ATGCCACTGG GAAAGAAGTG 
TATCGTCTTG CTCTTCAAAC CAGGGAGCAA CACATTCGGA GAGACAAGGC TACCAGCAAC 
ATCTGTACAG CTCAGGCCCT CTTGGCGAAT ATGGCTGCCA TGTTTGCAAT CTACCATGGT 
TCCCATGGGC TGGAGCATAT TGCTAGGAGG GTACATAATG CCACTTTGAT TTTGTCAGAA 
GGTCTCAAGC GAGCAGGGCA TCAACTCCAG CATGACCTGT TCTTTGATAC CTTGAAGATT 
CAGTGTGGCT GCTCAGTGAA GGAGGTCTTG GGCAGGGCCG CTCAGCGGCA GATCAATTTT 
CGGCTTTTTG AGGATGGCAC ACTTGGTATT TCTCTTGATG AAACAGTCAA TGAAAAAGAT 
CTGGACGATT TGTTGTGGAT CTTTGGTTGT GAGTCATCTG CAGAACTGGT TGCTGAAAGC 
ATGGGAGAGG AGTGCAGAGG TATTCCAGGG TCTGTGTTCA AGAGGACCAG CCCGTTCCTC 
ACCCATCAAG TGTTCAACAG CTACCACTCT GAAACAAACA TTGTCCGGTA CATGAAGAAA 
CTGGAAAATA AAGACATTTC CCTTGTTCAC AGCATGATTC CACTGGGATC CTGCACCATG 
AAACTGAACA GTTCGTCTGA ACTCGCACCT ATCACATGGA AAGAATTTGC AAACATCCAC 
CCCTTTGTGC CTCTGGATCA AGCTCAAGGA TATCAGCAGC TTTTCCGAGA GCTTGAGAAG 
GATTTGTGTG AACTCACAGG TTATGACCAG GTCTGTTTCC AGCCAAACAG CGGAGCCCAG 
GGAGAATATG CTGGACTGGC CACTATCCGA GCCTACTTAA ACCAGAAAGG AGAGGGGCAC 
AGAACGGTTT GCCTCATTCC GAAATCAGCA CATGGGACCA ACCCAGCAAG TGCCCACATG 
GCAGGCATGA AGATTCAGCC TGTGGAGGTG GATAAATATG GGAATATCGA TGCAGTTCAC 
CTCAAGGCCA TGGTGGATAA GCACAAGGAG AACCTAGCAG CTATCATGAT TACATACCCA 
TCCACCAATG GGGTGTTTGA AGAGAACATC AGTGACGTGT GTGACCTCAT CCATCAACAT 
GGAGGACAGG TCTACCTAGA CGGGGCAAAT ATGAATGCTC AGGTGGGAAT CTGTCGCCCT 
GGAGACTTCG GGTCTGATGT CTCGCACCTA AATCTTCACA AGACCTTCTG CATTCCCCAC 
GGAGGAGGTG GTCCTGGCAT GGGGCCCATC GGAGTGAAGA AACATCTCGC CCCGTTTTTG 
CCCAATCATC CCGTCATTTC ACTAAAGCGG AATGAGGATG CCTGTCCTGT GGGAACCGTC 
AGTGCGGCCC CATGGGGCTC CAGTTCCATC TTGCCCATTT CCTGGGCTTA TATCAAGATG 
ATGGGAGGCA AGGGTCTTAA ACAAGCCACG GAAACTGCGA TATTAAATGC CAACTACATG 
GCCAAGCGAT TAGAAACACA CTACAGAATT CTTTTCAGGG GTGCAAGAGG TTATGTGGGT 
CATGAATTTA TTTTGGACAC GAGACCCTTC AAAAAGTCTG CAAATATTGA GGCTGTGGAT 
GTGGCCAAGA GACTCCAGGA TTATGGATTT CACGCCCCTA CCATGTCCTG GCCTGTGGCA 
GGGACCCTCA TGGTGGAGCC CACTGAGTCG GAGGACAAGG CAGAGCTGGA CAGATTCTGT 
GATGCCATGA TCAGCATTCG GCAGGAAATT GCTGACATTG AGGAGGGCCG CATCGACCCC 
AGGGTCAATC CGCTGAAGAT GTCTCCACAC TCCCTGACCT GCGTTACATC TTCCCACTGG 
GACCGGCCTT ATTCCAGAGA GGTGGCAGCA TTCCCACTCC CCTTCGTGAA ACCAGAGAAC 
AAATTCTGGC CAACGATTGC CCGGATTGAT GACATATATG GAGATCAGCA CCTGGTTTGT 
ACCTGCCCAC CCATGGAAGT TTATGAGTCT CCATTTTCTG AACAAAAGAG GGCGTCTTCT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GLDC ( NM_000170.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000161.2 Homo sapiens glycine decarboxylase (GLDC), mRNA.

Price & Availability↑

CloneID	OHu18167
Clone ID Related Accession (Same CDS sequence)	NM_000170.3 , NM_000170.2
Accession Version	NM_000170.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3063bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	glycine dehydrogenase (decarboxylating), mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA741442.1, DR002916.1, BC111993.1, AW593954.1 and AI480362.1. This sequence is a reference standard in the RefSeqGene project. On Jun 9, 2006 this sequence version replaced NM_000170.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D90239.1, M64590.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGTCCT GTGCCAGGGC GTGGGGGCTG CGCCTGGGCC GCGGGGTCGG GGGCGGCCGC 
CGCCTGGCTG GGGGATCGGG GCCGTGCTGG GCGCCGCGGA GCCGGGACAG CAGCAGTGGC 
GGCGGGGACA GCGCCGCGGC TGGGGCCTCG CGCCTCCTGG AGCGCCTTCT GCCCAGACAC 
GACGACTTCG CTCGGAGGCA CATCGGCCCT GGGGACAAAG ACCAGAGAGA GATGCTGCAG 
ACCTTGGGGC TGGCGAGCAT TGATGAATTG ATCGAGAAGA CGGTCCCTGC CAACATCCGT 
TTGAAAAGAC CCTTGAAAAT GGAAGACCCT GTTTGTGAAA ATGAAATCCT TGCAACTCTG 
CATGCCATTT CAAGCAAAAA CCAGATCTGG AGATCGTATA TTGGCATGGG CTATTATAAC 
TGCTCAGTGC CACAGACGAT TTTGCGGAAC TTACTGGAGA ACTCAGGATG GATCACCCAG 
TATACTCCAT ACCAGCCTGA GGTGTCTCAG GGGAGGCTGG AGAGTTTACT CAACTACCAG 
ACCATGGTGT GTGACATCAC AGGCCTGGAC ATGGCCAATG CATCCCTGCT GGATGAGGGG 
ACTGCAGCCG CAGAGGCACT GCAGCTGTGC TACAGACACA ACAAGAGGAG GAAATTTCTC 
GTTGATCCCC GTTGCCACCC ACAGACAATA GCTGTTGTCC AGACTCGAGC CAAATATACT 
GGAGTCCTCA CTGAGCTGAA GTTACCCTGT GAAATGGACT TCAGTGGAAA AGATGTCAGT 
GGAGTGTTGT TCCAGTACCC AGACACGGAG GGGAAGGTGG AAGACTTTAC GGAACTCGTG 
GAGAGAGCTC ATCAGAGTGG GAGCCTGGCC TGCTGTGCTA CTGACCTTTT AGCTTTGTGC 
ATCTTGAGGC CACCTGGAGA ATTTGGGGTA GACATCGCCC TGGGCAGCTC CCAGAGATTT 
GGAGTGCCAC TGGGCTATGG GGGACCCCAT GCAGCATTTT TTGCTGTCCG AGAAAGCTTG 
GTGAGAATGA TGCCTGGAAG AATGGTGGGG GTAACAAGAG ATGCCACTGG GAAAGAAGTG 
TATCGTCTTG CTCTTCAAAC CAGGGAGCAA CACATTCGGA GAGACAAGGC TACCAGCAAC 
ATCTGTACAG CTCAGGCCCT CTTGGCGAAT ATGGCTGCCA TGTTTGCAAT CTACCATGGT 
TCCCATGGGC TGGAGCATAT TGCTAGGAGG GTACATAATG CCACTTTGAT TTTGTCAGAA 
GGTCTCAAGC GAGCAGGGCA TCAACTCCAG CATGACCTGT TCTTTGATAC CTTGAAGATT 
CAGTGTGGCT GCTCAGTGAA GGAGGTCTTG GGCAGGGCCG CTCAGCGGCA GATCAATTTT 
CGGCTTTTTG AGGATGGCAC ACTTGGTATT TCTCTTGATG AAACAGTCAA TGAAAAAGAT 
CTGGACGATT TGTTGTGGAT CTTTGGTTGT GAGTCATCTG CAGAACTGGT TGCTGAAAGC 
ATGGGAGAGG AGTGCAGAGG TATTCCAGGG TCTGTGTTCA AGAGGACCAG CCCGTTCCTC 
ACCCATCAAG TGTTCAACAG CTACCACTCT GAAACAAACA TTGTCCGGTA CATGAAGAAA 
CTGGAAAATA AAGACATTTC CCTTGTTCAC AGCATGATTC CACTGGGATC CTGCACCATG 
AAACTGAACA GTTCGTCTGA ACTCGCACCT ATCACATGGA AAGAATTTGC AAACATCCAC 
CCCTTTGTGC CTCTGGATCA AGCTCAAGGA TATCAGCAGC TTTTCCGAGA GCTTGAGAAG 
GATTTGTGTG AACTCACAGG TTATGACCAG GTCTGTTTCC AGCCAAACAG CGGAGCCCAG 
GGAGAATATG CTGGACTGGC CACTATCCGA GCCTACTTAA ACCAGAAAGG AGAGGGGCAC 
AGAACGGTTT GCCTCATTCC GAAATCAGCA CATGGGACCA ACCCAGCAAG TGCCCACATG 
GCAGGCATGA AGATTCAGCC TGTGGAGGTG GATAAATATG GGAATATCGA TGCAGTTCAC 
CTCAAGGCCA TGGTGGATAA GCACAAGGAG AACCTAGCAG CTATCATGAT TACATACCCA 
TCCACCAATG GGGTGTTTGA AGAGAACATC AGTGACGTGT GTGACCTCAT CCATCAACAT 
GGAGGACAGG TCTACCTAGA CGGGGCAAAT ATGAATGCTC AGGTGGGAAT CTGTCGCCCT 
GGAGACTTCG GGTCTGATGT CTCGCACCTA AATCTTCACA AGACCTTCTG CATTCCCCAC 
GGAGGAGGTG GTCCTGGCAT GGGGCCCATC GGAGTGAAGA AACATCTCGC CCCGTTTTTG 
CCCAATCATC CCGTCATTTC ACTAAAGCGG AATGAGGATG CCTGTCCTGT GGGAACCGTC 
AGTGCGGCCC CATGGGGCTC CAGTTCCATC TTGCCCATTT CCTGGGCTTA TATCAAGATG 
ATGGGAGGCA AGGGTCTTAA ACAAGCCACG GAAACTGCGA TATTAAATGC CAACTACATG 
GCCAAGCGAT TAGAAACACA CTACAGAATT CTTTTCAGGG GTGCAAGAGG TTATGTGGGT 
CATGAATTTA TTTTGGACAC GAGACCCTTC AAAAAGTCTG CAAATATTGA GGCTGTGGAT 
GTGGCCAAGA GACTCCAGGA TTATGGATTT CACGCCCCTA CCATGTCCTG GCCTGTGGCA 
GGGACCCTCA TGGTGGAGCC CACTGAGTCG GAGGACAAGG CAGAGCTGGA CAGATTCTGT 
GATGCCATGA TCAGCATTCG GCAGGAAATT GCTGACATTG AGGAGGGCCG CATCGACCCC 
AGGGTCAATC CGCTGAAGAT GTCTCCACAC TCCCTGACCT GCGTTACATC TTCCCACTGG 
GACCGGCCTT ATTCCAGAGA GGTGGCAGCA TTCCCACTCC CCTTCGTGAA ACCAGAGAAC 
AAATTCTGGC CAACGATTGC CCGGATTGAT GACATATATG GAGATCAGCA CCTGGTTTGT 
ACCTGCCCAC CCATGGAAGT TTATGAGTCT CCATTTTCTG AACAAAAGAG GGCGTCTTCT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000161.2
CDS	194..3256
Translation	MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGASRLLERLLPRHDDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKLPCEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS

Target ORF information:

RefSeq Version	NM_000170.2
Organism	Homo sapiens(human)
Definition	Homo sapiens glycine decarboxylase (GLDC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000170.2

ORF Insert Sequence:

ATGCAGTCCT GTGCCAGGGC GTGGGGGCTG CGCCTGGGCC GCGGGGTCGG GGGCGGCCGC 
CGCCTGGCTG GGGGATCGGG GCCGTGCTGG GCGCCGCGGA GCCGGGACAG CAGCAGTGGC 
GGCGGGGACA GCGCCGCGGC TGGGGCCTCG CGCCTCCTGG AGCGCCTTCT GCCCAGACAC 
GACGACTTCG CTCGGAGGCA CATCGGCCCT GGGGACAAAG ACCAGAGAGA GATGCTGCAG 
ACCTTGGGGC TGGCGAGCAT TGATGAATTG ATCGAGAAGA CGGTCCCTGC CAACATCCGT 
TTGAAAAGAC CCTTGAAAAT GGAAGACCCT GTTTGTGAAA ATGAAATCCT TGCAACTCTG 
CATGCCATTT CAAGCAAAAA CCAGATCTGG AGATCGTATA TTGGCATGGG CTATTATAAC 
TGCTCAGTGC CACAGACGAT TTTGCGGAAC TTACTGGAGA ACTCAGGATG GATCACCCAG 
TATACTCCAT ACCAGCCTGA GGTGTCTCAG GGGAGGCTGG AGAGTTTACT CAACTACCAG 
ACCATGGTGT GTGACATCAC AGGCCTGGAC ATGGCCAATG CATCCCTGCT GGATGAGGGG 
ACTGCAGCCG CAGAGGCACT GCAGCTGTGC TACAGACACA ACAAGAGGAG GAAATTTCTC 
GTTGATCCCC GTTGCCACCC ACAGACAATA GCTGTTGTCC AGACTCGAGC CAAATATACT 
GGAGTCCTCA CTGAGCTGAA GTTACCCTGT GAAATGGACT TCAGTGGAAA AGATGTCAGT 
GGAGTGTTGT TCCAGTACCC AGACACGGAG GGGAAGGTGG AAGACTTTAC GGAACTCGTG 
GAGAGAGCTC ATCAGAGTGG GAGCCTGGCC TGCTGTGCTA CTGACCTTTT AGCTTTGTGC 
ATCTTGAGGC CACCTGGAGA ATTTGGGGTA GACATCGCCC TGGGCAGCTC CCAGAGATTT 
GGAGTGCCAC TGGGCTATGG GGGACCCCAT GCAGCATTTT TTGCTGTCCG AGAAAGCTTG 
GTGAGAATGA TGCCTGGAAG AATGGTGGGG GTAACAAGAG ATGCCACTGG GAAAGAAGTG 
TATCGTCTTG CTCTTCAAAC CAGGGAGCAA CACATTCGGA GAGACAAGGC TACCAGCAAC 
ATCTGTACAG CTCAGGCCCT CTTGGCGAAT ATGGCTGCCA TGTTTGCAAT CTACCATGGT 
TCCCATGGGC TGGAGCATAT TGCTAGGAGG GTACATAATG CCACTTTGAT TTTGTCAGAA 
GGTCTCAAGC GAGCAGGGCA TCAACTCCAG CATGACCTGT TCTTTGATAC CTTGAAGATT 
CAGTGTGGCT GCTCAGTGAA GGAGGTCTTG GGCAGGGCCG CTCAGCGGCA GATCAATTTT 
CGGCTTTTTG AGGATGGCAC ACTTGGTATT TCTCTTGATG AAACAGTCAA TGAAAAAGAT 
CTGGACGATT TGTTGTGGAT CTTTGGTTGT GAGTCATCTG CAGAACTGGT TGCTGAAAGC 
ATGGGAGAGG AGTGCAGAGG TATTCCAGGG TCTGTGTTCA AGAGGACCAG CCCGTTCCTC 
ACCCATCAAG TGTTCAACAG CTACCACTCT GAAACAAACA TTGTCCGGTA CATGAAGAAA 
CTGGAAAATA AAGACATTTC CCTTGTTCAC AGCATGATTC CACTGGGATC CTGCACCATG 
AAACTGAACA GTTCGTCTGA ACTCGCACCT ATCACATGGA AAGAATTTGC AAACATCCAC 
CCCTTTGTGC CTCTGGATCA AGCTCAAGGA TATCAGCAGC TTTTCCGAGA GCTTGAGAAG 
GATTTGTGTG AACTCACAGG TTATGACCAG GTCTGTTTCC AGCCAAACAG CGGAGCCCAG 
GGAGAATATG CTGGACTGGC CACTATCCGA GCCTACTTAA ACCAGAAAGG AGAGGGGCAC 
AGAACGGTTT GCCTCATTCC GAAATCAGCA CATGGGACCA ACCCAGCAAG TGCCCACATG 
GCAGGCATGA AGATTCAGCC TGTGGAGGTG GATAAATATG GGAATATCGA TGCAGTTCAC 
CTCAAGGCCA TGGTGGATAA GCACAAGGAG AACCTAGCAG CTATCATGAT TACATACCCA 
TCCACCAATG GGGTGTTTGA AGAGAACATC AGTGACGTGT GTGACCTCAT CCATCAACAT 
GGAGGACAGG TCTACCTAGA CGGGGCAAAT ATGAATGCTC AGGTGGGAAT CTGTCGCCCT 
GGAGACTTCG GGTCTGATGT CTCGCACCTA AATCTTCACA AGACCTTCTG CATTCCCCAC 
GGAGGAGGTG GTCCTGGCAT GGGGCCCATC GGAGTGAAGA AACATCTCGC CCCGTTTTTG 
CCCAATCATC CCGTCATTTC ACTAAAGCGG AATGAGGATG CCTGTCCTGT GGGAACCGTC 
AGTGCGGCCC CATGGGGCTC CAGTTCCATC TTGCCCATTT CCTGGGCTTA TATCAAGATG 
ATGGGAGGCA AGGGTCTTAA ACAAGCCACG GAAACTGCGA TATTAAATGC CAACTACATG 
GCCAAGCGAT TAGAAACACA CTACAGAATT CTTTTCAGGG GTGCAAGAGG TTATGTGGGT 
CATGAATTTA TTTTGGACAC GAGACCCTTC AAAAAGTCTG CAAATATTGA GGCTGTGGAT 
GTGGCCAAGA GACTCCAGGA TTATGGATTT CACGCCCCTA CCATGTCCTG GCCTGTGGCA 
GGGACCCTCA TGGTGGAGCC CACTGAGTCG GAGGACAAGG CAGAGCTGGA CAGATTCTGT 
GATGCCATGA TCAGCATTCG GCAGGAAATT GCTGACATTG AGGAGGGCCG CATCGACCCC 
AGGGTCAATC CGCTGAAGAT GTCTCCACAC TCCCTGACCT GCGTTACATC TTCCCACTGG 
GACCGGCCTT ATTCCAGAGA GGTGGCAGCA TTCCCACTCC CCTTCGTGAA ACCAGAGAAC 
AAATTCTGGC CAACGATTGC CCGGATTGAT GACATATATG GAGATCAGCA CCTGGTTTGT 
ACCTGCCCAC CCATGGAAGT TTATGAGTCT CCATTTTCTG AACAAAAGAG GGCGTCTTCT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel compound heterozygous variant identified in GLDC gene in a Chinese family with non-ketotic hyperglycinemia.
BMC medical genetics19(1)5(2018 Jan)
Lin Y,Zheng Z,Sun W,Fu Q

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GLDC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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