OAZ1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ1
Entrez Gene ID	721477
Full Name	ornithine decarboxylase antizyme 1
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134900.2	NP_001128372.1	ornithine decarboxylase antizyme 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OAZ1	NP_001120840.1
	OAZ1	NP_001128372.1
Canis lupus familiaris (dog)	OAZ1	NP_001120706.1
Rattus norvegicus (Norway rat)	Oaz1	NP_620781.1
Bos taurus (cattle)	OAZ1	NP_001120715.1
Homo sapiens (human)	OAZ1	NP_004143.1
Mus musculus (house mouse)	Oaz1	NP_032779.2
Gallus gallus (chicken)	OAZ1	NP_990247.1
Danio rerio (zebrafish)	oaz1a	NP_919240.2
Xenopus tropicalis (tropical clawed frog)	oaz1	NP_988880.2

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.
Magness CL, Fellin PC, Thomas MJ, Korth MJ, Agy MB, Proll SC, Fitzgibbon M, Scherer CA, Miner DG, Katze MG, Iadonato SP
Genome biology6(7)R60(2005)

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Gandre S, Bercovich Z, Kahana C
Mitochondrion2(4)245-56(2003 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb57572	NM_001134900.2 Latest version!	Macaca mulatta ornithine decarboxylase antizyme 1 (OAZ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ1 ( NM_001134900.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001128372.1 Macaca mulatta ornithine decarboxylase antizyme 1 (OAZ1), mRNA.

Price & Availability↑

CloneID	OMb57572
Clone ID Related Accession (Same CDS sequence)	NM_001134900.2
Accession Version	NM_001134900.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-11
Organism	Macaca mulatta(Rhesus monkey)
Product	ornithine decarboxylase antizyme 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from QNVO02000224.1, CO644742.1, CB553280.1, CB310088.1 and CN642200.1. On Jul 17, 2014 this sequence version replaced NM_001134900.1. ##Evidence-Data-START## Transcript exon combination :: SRR3476739.643301.1, SRR5038768.538559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688315, SAMEA4688316 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AATAGCCACT GCTTCGCCAG AGAGAAGGAA 
AGGGATAAAC CCAGCGCCAC CATCCACGCC AGCCGCACCA TGCCGCTTCT AAGCCTGCAC 
AGCCGCGGAG GCAGCAGCAG TGAGAGTTCC AGGGTCTCCC TCCGCTGCTG TAGTAACCCG 
GGTCCGGGGC CTCGGTGGTG CTCCGATGCC CCTCACCCAC CCCTGAAGAT CCCAGGTGGG 
CGAGGGAATA GTCAGAGGGA TCACAATCTT TCAGCTAACT TATTCTACTC CGATGATCGG 
CTGAATGTAA CAGAGGAACT AACGTCCAAC GACAAGACGA GGATTCTCAA CGTCCAGTCC 
AGGCTCACAG ACGCCAAACG CATTAATTGG CGAACAGTGC TGAGTGGAGG CAGCCTCTAC 
ATCGAGATCC CGGGCGGCGC GCTGCCTGAG GGGAGCAAGG ACAGCTTTGC AGTTCTCCTG 
GAATTCGCTG AGGAGCAGCT GCGAGCCGAC CATGTCTTCA TTTGCTTCCA CAAGAACCGC 
GAGGACAGAG CCGCCTTGCT CCGAACCTTC AGCTTTTTGG GCTTTGAGAT TGTGAGACCG 
GGGCATCCCC TTGTCCCCAA GAGACCCGAC GCTTGCTTCA TGGCCTACAC GTTCGAGAGA 
GAGTCTTCGG GAGAGGAGGA GGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128372.1
CDS	join(80..283,285..767)
Translation	MVKSSLQRILNSHCFAREKERDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLRCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE

Target ORF information:

RefSeq Version	NM_001134900.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta ornithine decarboxylase antizyme 1 (OAZ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134900.2

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AATAGCCACT GCTTCGCCAG AGAGAAGGAA 
AGGGATAAAC CCAGCGCCAC CATCCACGCC AGCCGCACCA TGCCGCTTCT AAGCCTGCAC 
AGCCGCGGAG GCAGCAGCAG TGAGAGTTCC AGGGTCTCCC TCCGCTGCTG TAGTAACCCG 
GGTCCGGGGC CTCGGTGGTG CTCCGATGCC CCTCACCCAC CCCTGAAGAT CCCAGGTGGG 
CGAGGGAATA GTCAGAGGGA TCACAATCTT TCAGCTAACT TATTCTACTC CGATGATCGG 
CTGAATGTAA CAGAGGAACT AACGTCCAAC GACAAGACGA GGATTCTCAA CGTCCAGTCC 
AGGCTCACAG ACGCCAAACG CATTAATTGG CGAACAGTGC TGAGTGGAGG CAGCCTCTAC 
ATCGAGATCC CGGGCGGCGC GCTGCCTGAG GGGAGCAAGG ACAGCTTTGC AGTTCTCCTG 
GAATTCGCTG AGGAGCAGCT GCGAGCCGAC CATGTCTTCA TTTGCTTCCA CAAGAACCGC 
GAGGACAGAG CCGCCTTGCT CCGAACCTTC AGCTTTTTGG GCTTTGAGAT TGTGAGACCG 
GGGCATCCCC TTGTCCCCAA GAGACCCGAC GCTTGCTTCA TGGCCTACAC GTTCGAGAGA 
GAGTCTTCGG GAGAGGAGGA GGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.
Genome biology6(7)R60(2005)
Magness CL,Fellin PC,Thomas MJ,Korth MJ,Agy MB,Proll SC,Fitzgibbon M,Scherer CA,Miner DG,Katze MG,Iadonato SP

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Mitochondrion2(4)245-56(2003 Mar)
Gandre S,Bercovich Z,Kahana C

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OAZ1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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