Oaz1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oaz1
Entrez Gene ID	18245
Full Name	ornithine decarboxylase antizyme 1
Synonyms	AZ-1,AZ1,Antizyme,ODC-Az,Oaz
General protein information	Preferred Names ornithine decarboxylase antizyme 1 Names ornithine decarboxylase antizyme 1 antizyme 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.72 cM
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301034.1	NP_001287963.1	ornithine decarboxylase antizyme 1 isoform 2
NM_008753.4	NP_032779.2	ornithine decarboxylase antizyme 1 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OAZ1	NP_001120840.1
	OAZ1	NP_001128372.1
Canis lupus familiaris (dog)	OAZ1	NP_001120706.1
Rattus norvegicus (Norway rat)	Oaz1	NP_620781.1
Bos taurus (cattle)	OAZ1	NP_001120715.1
Homo sapiens (human)	OAZ1	NP_004143.1
Mus musculus (house mouse)	Oaz1	NP_032779.2
Gallus gallus (chicken)	OAZ1	NP_990247.1
Danio rerio (zebrafish)	oaz1a	NP_919240.2
Xenopus tropicalis (tropical clawed frog)	oaz1	NP_988880.2

Gene Ontology
Bibliography

Related articles in PubMed

Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
Ray RM, Bavaria M, Johnson LR
Cellular signalling27(9)1850-9(2015 Sep)

miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6.
Franzoni E, Booker SA, Parthasarathy S, Rehfeld F, Grosser S, Srivatsa S, Fuchs HR, Tarabykin V, Vida I, Wulczyn FG
eLife4(2015 Jan)

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2.
Ramos-Molina B, Lambertos A, Lopez-Contreras AJ, Kasprzak JM, Czerwoniec A, Bujnicki JM, Cremades A, Pe?afiel R
FEBS open bio4510-21(2014)

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Gandre S, Bercovich Z, Kahana C
Mitochondrion2(4)245-56(2003 Mar)

Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit.
Ivanov IP, Gesteland RF, Atkins JF
Nucleic acids research28(17)3185-96(2000 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
Title: Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).

we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences
Title: Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis.

Ornithine decarboxylase antizyme expression reduces tumor incidence, multiplicity and size even in the absence of p53.
Title: Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.

These data together demonstrate the existence of a c-Jun-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress.
Title: The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.

The activity of AZ1 was low in the virgin and involuting stages, but increased markedly during late pregnancy and early lactation.
Title: Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland.

The following Oaz1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oaz1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu83567	NM_008753.4 Latest version!	Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu83466	NM_001301034.1 Latest version!	Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oaz1 ( NM_008753.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032779.2 Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu83567
Clone ID Related Accession (Same CDS sequence)	NM_008753.4
Accession Version	NM_008753.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	ornithine decarboxylase antizyme 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY112600.1, AK146571.1 and AI838943.1. On Apr 21, 2006 this sequence version replaced NM_008753.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146571.1, BC024902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: PMID: 9210404 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGCCACT GCTTCGCCAG AGAGAAGGAA 
GGGGACAAAC GCAGCGCCAC GCTTCACGCC AGCCGCACCA TGCCGCTTCT TAGTCAGCAC 
AGCCGCGGCG GCTGCAGCAG CGAGAGTTCT AGGGTTGCCC TTAATTGCTG TAGTAACCTG 
GGTCCGGGGC CTCGGTGGTG CTCCGATGTC CCTCACCCAC CCCTGAAGAT CCCAGGTGGG 
CGAGGGAACA GTCAGCGGGA TCACAGTCTT TCAGCTAGCA TCCTGTACTC CGACGAGCGG 
CTGAATGTGA CAGAGGAGCC GACGTCTAAC GACAAGACCA GGGTCCTGAG CATCCAGTCC 
ACGCTCACGG AGGCCAAGCA GGTCACCTGG AGGGCGGTGT GGAGTGGTGG TGGCCTCTAC 
ATCGAGCTCC CAGCTGGACC TCTGCCTGAG GGCAGTAAGG ACAGTTTTGC AGCTCTCCTA 
GAGTTCGCAG AGGAGCAACT CCAGGCTGAC CACGTTTTCA TCTGCTTCCC CAAGAACCGT 
GAGGACAGAG CCGCCCTACT CCGAACCTTC AGCTTTCTTG GCTTTGAGAT TGTGAGACCC 
GGGCATCCCC TTGTCCCCAA GAGACCCGAC GCTTGCTTCA TGGTCTACAC TCTGGAGAGA 
GAGGACCCGG GTGAGGAGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032779.2
CDS	join(105..308,310..789)
Translation	MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED

Target ORF information:

RefSeq Version	NM_008753.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008753.4

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGCCACT GCTTCGCCAG AGAGAAGGAA 
GGGGACAAAC GCAGCGCCAC GCTTCACGCC AGCCGCACCA TGCCGCTTCT TAGTCAGCAC 
AGCCGCGGCG GCTGCAGCAG CGAGAGTTCT AGGGTTGCCC TTAATTGCTG TAGTAACCTG 
GGTCCGGGGC CTCGGTGGTG CTCCGATGTC CCTCACCCAC CCCTGAAGAT CCCAGGTGGG 
CGAGGGAACA GTCAGCGGGA TCACAGTCTT TCAGCTAGCA TCCTGTACTC CGACGAGCGG 
CTGAATGTGA CAGAGGAGCC GACGTCTAAC GACAAGACCA GGGTCCTGAG CATCCAGTCC 
ACGCTCACGG AGGCCAAGCA GGTCACCTGG AGGGCGGTGT GGAGTGGTGG TGGCCTCTAC 
ATCGAGCTCC CAGCTGGACC TCTGCCTGAG GGCAGTAAGG ACAGTTTTGC AGCTCTCCTA 
GAGTTCGCAG AGGAGCAACT CCAGGCTGAC CACGTTTTCA TCTGCTTCCC CAAGAACCGT 
GAGGACAGAG CCGCCCTACT CCGAACCTTC AGCTTTCTTG GCTTTGAGAT TGTGAGACCC 
GGGCATCCCC TTGTCCCCAA GAGACCCGAC GCTTGCTTCA TGGTCTACAC TCTGGAGAGA 
GAGGACCCGG GTGAGGAGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Oaz1 ( NM_001301034.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001287963.1 Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83466
Clone ID Related Accession (Same CDS sequence)	NM_001301034.1
Accession Version	NM_001301034.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	ornithine decarboxylase antizyme 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY112600.1, AA270439.1, AK146571.1 and AI838943.1. Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) lacks 2 internal amino acids compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB950935.1, CB950529.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: PMID: 9210404 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGCCACT GCTTCGCCAG AGAGAAGGAA 
GGGGACAAAC GCAGCGCCAC GCTTCACGCC AGCCGCACCA TGCCGCTTCT TAGTCAGCAC 
AGCCGCGGCG GCTGCAGCAG CGAGAGGGTT GCCCTTAATT GCTGTAGTAA CCTGGGTCCG 
GGGCCTCGGT GGTGCTCCGA TGTCCCTCAC CCACCCCTGA AGATCCCAGG TGGGCGAGGG 
AACAGTCAGC GGGATCACAG TCTTTCAGCT AGCATCCTGT ACTCCGACGA GCGGCTGAAT 
GTGACAGAGG AGCCGACGTC TAACGACAAG ACCAGGGTCC TGAGCATCCA GTCCACGCTC 
ACGGAGGCCA AGCAGGTCAC CTGGAGGGCG GTGTGGAGTG GTGGTGGCCT CTACATCGAG 
CTCCCAGCTG GACCTCTGCC TGAGGGCAGT AAGGACAGTT TTGCAGCTCT CCTAGAGTTC 
GCAGAGGAGC AACTCCAGGC TGACCACGTT TTCATCTGCT TCCCCAAGAA CCGTGAGGAC 
AGAGCCGCCC TACTCCGAAC CTTCAGCTTT CTTGGCTTTG AGATTGTGAG ACCCGGGCAT 
CCCCTTGTCC CCAAGAGACC CGACGCTTGC TTCATGGTCT ACACTCTGGA GAGAGAGGAC 
CCGGGTGAGG AGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287963.1
CDS	join(105..302,304..783)
Translation	MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSERVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED

Target ORF information:

RefSeq Version	NM_001301034.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301034.1

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGCCACT GCTTCGCCAG AGAGAAGGAA 
GGGGACAAAC GCAGCGCCAC GCTTCACGCC AGCCGCACCA TGCCGCTTCT TAGTCAGCAC 
AGCCGCGGCG GCTGCAGCAG CGAGAGGGTT GCCCTTAATT GCTGTAGTAA CCTGGGTCCG 
GGGCCTCGGT GGTGCTCCGA TGTCCCTCAC CCACCCCTGA AGATCCCAGG TGGGCGAGGG 
AACAGTCAGC GGGATCACAG TCTTTCAGCT AGCATCCTGT ACTCCGACGA GCGGCTGAAT 
GTGACAGAGG AGCCGACGTC TAACGACAAG ACCAGGGTCC TGAGCATCCA GTCCACGCTC 
ACGGAGGCCA AGCAGGTCAC CTGGAGGGCG GTGTGGAGTG GTGGTGGCCT CTACATCGAG 
CTCCCAGCTG GACCTCTGCC TGAGGGCAGT AAGGACAGTT TTGCAGCTCT CCTAGAGTTC 
GCAGAGGAGC AACTCCAGGC TGACCACGTT TTCATCTGCT TCCCCAAGAA CCGTGAGGAC 
AGAGCCGCCC TACTCCGAAC CTTCAGCTTT CTTGGCTTTG AGATTGTGAG ACCCGGGCAT 
CCCCTTGTCC CCAAGAGACC CGACGCTTGC TTCATGGTCT ACACTCTGGA GAGAGAGGAC 
CCGGGTGAGG AGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
Cellular signalling27(9)1850-9(2015 Sep)
Ray RM,Bavaria M,Johnson LR

miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6.
eLife4(2015 Jan)
Franzoni E,Booker SA,Parthasarathy S,Rehfeld F,Grosser S,Srivatsa S,Fuchs HR,Tarabykin V,Vida I,Wulczyn FG

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2.
FEBS open bio4510-21(2014)
Ramos-Molina B,Lambertos A,Lopez-Contreras AJ,Kasprzak JM,Czerwoniec A,Bujnicki JM,Cremades A,Pe?afiel R

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Mitochondrion2(4)245-56(2003 Mar)
Gandre S,Bercovich Z,Kahana C

Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit.
Nucleic acids research28(17)3185-96(2000 Sep)
Ivanov IP,Gesteland RF,Atkins JF

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Oaz1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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