oaz1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	oaz1
Entrez Gene ID	394475
Full Name	ornithine decarboxylase antizyme 1
Synonyms	ODC-Az,azi,oaz
General protein information	Preferred Names ornithine decarboxylase antizyme 1 Names ornithine decarboxylase antizyme 1
Gene Type	protein-coding
Organism	Xenopus tropicalis(tropical clawed frog)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jul 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_203549.2	NP_988880.3	ornithine decarboxylase antizyme 1 isoform 2
NM_001300762.1	NP_001287691.1	ornithine decarboxylase antizyme 1 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OAZ1	NP_001120840.1
	OAZ1	NP_001128372.1
Canis lupus familiaris (dog)	OAZ1	NP_001120706.1
Rattus norvegicus (Norway rat)	Oaz1	NP_620781.1
Bos taurus (cattle)	OAZ1	NP_001120715.1
Homo sapiens (human)	OAZ1	NP_004143.1
Mus musculus (house mouse)	Oaz1	NP_032779.2
Gallus gallus (chicken)	OAZ1	NP_990247.1
Danio rerio (zebrafish)	oaz1a	NP_919240.2
Xenopus tropicalis (tropical clawed frog)	oaz1	NP_988880.2

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Gandre S, Bercovich Z, Kahana C
Mitochondrion2(4)245-56(2003 Mar)

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)

Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.
Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins JF, Gesteland RF, Hayashi S
Cell80(1)51-60(1995 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following oaz1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the oaz1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OXa47194	NM_001300762.1 Latest version!	Xenopus tropicalis ornithine decarboxylase antizyme 1 (oaz1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
OXa47195	NM_203549.2 Latest version!	Xenopus tropicalis ornithine decarboxylase antizyme 1 (oaz1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

oaz1 ( NM_001300762.1 ) cDNA ORF clone, Xenopus tropicalis(tropical clawed frog) -> NP_001287691.1 Xenopus tropicalis ornithine decarboxylase antizyme 1 (oaz1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OXa47194
Clone ID Related Accession (Same CDS sequence)	NM_001300762.1
Accession Version	NM_001300762.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Xenopus tropicalis(tropical clawed frog)
Product	ornithine decarboxylase antizyme 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL641155.2, CX741301.1, DR838823.1, DN008994.1 and BG885707.1. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AL875288.2, BX716913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00861986, SAMN00861988 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT CCTCCCTCCA GCGGATACTC AATAGCCATT GCTTTGCCAG AGAAAAAGAA 
GGAAATAAAA GAAACTGCGC CATGCCTCTT CTGAGTATAC CCAGTAGTAG TGAAAGTTCC 
AGAGTTTCTT TCAATTGCTG TAGTAACCTG GGTCCCGGGC CTCGGTGGTG TTCCGATGTC 
CCTCACCCAC CCCTGAAGAT CCCAGGTGGG CGAGGGAATA GTCAGAGGGA TCACAATCTT 
TCAGCTAATT TATTTTATTC TGATAATAGG CTGAACATAA CAGAAGAGCT TACATCCAAT 
AACAGGACCA GAATACTCAA TGTCCAATCA AGTCTGACAG ACGGCAAACA AGTGAGTTGG 
AGAGCTGTGC TAAACAATAA CAACCTCTAT ATAGAAATCC CGACTGGCAC TCTACCTGAT 
GGCAGCAAAG ACAGCTTTGC AATTGTACTA GAATATGCAG AAGAGCAACT CCAAGTGGGT 
CATGTCTTTA TCTGCTTCCA CAAGAACAGG GATGATAGAG CCATGCTTCT CCGAACATTC 
AGATTCTTGG GCTTTGAGAT TGTGATACCT GGACATCCCC TTGTCCCTAA GAGACCAGAT 
GCTTGCTTTA TGGCTTACAC CTTTGAAAGA GATTCTTCTG ATGAAGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287691.1
CDS	join(127..300,302..778)
Translation	MVKSSLQRILNSHCFAREKEGNKRNCAMPLLSIPSSSESSRVSFNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNITEELTSNNRTRILNVQSSLTDGKQVSWRAVLNNNNLYIEIPTGTLPDGSKDSFAIVLEYAEEQLQVGHVFICFHKNRDDRAMLLRTFRFLGFEIVIPGHPLVPKRPDACFMAYTFERDSSDED

Target ORF information:

RefSeq Version	NM_001300762.1
Organism	Xenopus tropicalis(tropical clawed frog)
Definition	Xenopus tropicalis ornithine decarboxylase antizyme 1 (oaz1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300762.1

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTCCA GCGGATACTC AATAGCCATT GCTTTGCCAG AGAAAAAGAA 
GGAAATAAAA GAAACTGCGC CATGCCTCTT CTGAGTATAC CCAGTAGTAG TGAAAGTTCC 
AGAGTTTCTT TCAATTGCTG TAGTAACCTG GGTCCCGGGC CTCGGTGGTG TTCCGATGTC 
CCTCACCCAC CCCTGAAGAT CCCAGGTGGG CGAGGGAATA GTCAGAGGGA TCACAATCTT 
TCAGCTAATT TATTTTATTC TGATAATAGG CTGAACATAA CAGAAGAGCT TACATCCAAT 
AACAGGACCA GAATACTCAA TGTCCAATCA AGTCTGACAG ACGGCAAACA AGTGAGTTGG 
AGAGCTGTGC TAAACAATAA CAACCTCTAT ATAGAAATCC CGACTGGCAC TCTACCTGAT 
GGCAGCAAAG ACAGCTTTGC AATTGTACTA GAATATGCAG AAGAGCAACT CCAAGTGGGT 
CATGTCTTTA TCTGCTTCCA CAAGAACAGG GATGATAGAG CCATGCTTCT CCGAACATTC 
AGATTCTTGG GCTTTGAGAT TGTGATACCT GGACATCCCC TTGTCCCTAA GAGACCAGAT 
GCTTGCTTTA TGGCTTACAC CTTTGAAAGA GATTCTTCTG ATGAAGATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

oaz1 ( NM_203549.2 ) cDNA ORF clone, Xenopus tropicalis(tropical clawed frog) -> NP_988880.3 Xenopus tropicalis ornithine decarboxylase antizyme 1 (oaz1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OXa47195
Clone ID Related Accession (Same CDS sequence)	NM_203549.2
Accession Version	NM_203549.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Xenopus tropicalis(tropical clawed frog)
Product	ornithine decarboxylase antizyme 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL641155.2, DN008994.1 and BG885707.1. On Jul 11, 2014 this sequence version replaced NM_203549.1. Transcript Variant: This variant (2) uses an alternate donor splice site at an internal exon, which causes a frameshift compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AL641155.2, BC059754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01758129 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT CCTCCCTCCA GCGGATACTC AATAGCCATT GCTTTGCCAG AGAAAAAGAA 
GGAAATAAAA GAAACTGCGC CATGCCTCTT CTGAGTATAC CCAGTAGTAG TGAAAGTTCC 
AGAGTTTCTT TCAATTGCTG TAGTAACCTG GGTCCCGGGC CTCGGTGGTG TTCCGATGTC 
CCTCACCCAC CCCTGAAGAT CCCAGGTGGG CGAGGGAATA GTCAGAGGGA TCACAATCTT 
TCAGCTAATT TATTTTATTC TGATAATAGG CTGAACATAA CAGAAGAGCT TACATCCAAT 
AACAGGACCA GAATACTCAA TGTCCAATCA AGTCTGACAG ACGGCAAACA ACTTTGCAAT 
TGTACTAGAA TATGCAGAAG AGCAACTCCA AGTGGGTCAT GTCTTTATCT GCTTCCACAA 
GAACAGGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_988880.3
CDS	join(127..300,302..559)
Translation	MVKSSLQRILNSHCFAREKEGNKRNCAMPLLSIPSSSESSRVSFNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNITEELTSNNRTRILNVQSSLTDGKQLCNCTRICRRATPSGSCLYLLPQEQG

Target ORF information:

RefSeq Version	NM_203549.2
Organism	Xenopus tropicalis(tropical clawed frog)
Definition	Xenopus tropicalis ornithine decarboxylase antizyme 1 (oaz1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203549.2

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTCCA GCGGATACTC AATAGCCATT GCTTTGCCAG AGAAAAAGAA 
GGAAATAAAA GAAACTGCGC CATGCCTCTT CTGAGTATAC CCAGTAGTAG TGAAAGTTCC 
AGAGTTTCTT TCAATTGCTG TAGTAACCTG GGTCCCGGGC CTCGGTGGTG TTCCGATGTC 
CCTCACCCAC CCCTGAAGAT CCCAGGTGGG CGAGGGAATA GTCAGAGGGA TCACAATCTT 
TCAGCTAATT TATTTTATTC TGATAATAGG CTGAACATAA CAGAAGAGCT TACATCCAAT 
AACAGGACCA GAATACTCAA TGTCCAATCA AGTCTGACAG ACGGCAAACA ACTTTGCAAT 
TGTACTAGAA TATGCAGAAG AGCAACTCCA AGTGGGTCAT GTCTTTATCT GCTTCCACAA 
GAACAGGGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Mitochondrion2(4)245-56(2003 Mar)
Gandre S,Bercovich Z,Kahana C

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P

Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.
Cell80(1)51-60(1995 Jan)
Matsufuji S,Matsufuji T,Miyazaki Y,Murakami Y,Atkins JF,Gesteland RF,Hayashi S

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oaz1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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