ZNHIT3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZNHIT3
Entrez Gene ID	9326
Full Name	zinc finger HIT-type containing 3
Synonyms	PEHO,TRIP3
General protein information	Preferred Names zinc finger HIT-type containing 3 Names zinc finger HIT domain-containing protein 3 HNF-4a coactivator TR-interacting protein 3 TRIP-3 thyroid hormone receptor interactor 3 thyroid receptor interacting protein 3 zinc finger, HIT domain containing 3 zinc finger, HIT type 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Disorder MIM:	604500
Disorder Html:	PEHO syndrome, 260565 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004773.3	NP_004764.1	zinc finger HIT domain-containing protein 3 isoform 1
NM_001281434.1	NP_001268363.1	zinc finger HIT domain-containing protein 3 isoform 3
NM_004773.4	NP_004764.1	zinc finger HIT domain-containing protein 3 isoform 1
NM_001281432.1	NP_001268361.1	zinc finger HIT domain-containing protein 3 isoform 2
NM_001281432.2	NP_001268361.1	zinc finger HIT domain-containing protein 3 isoform 2
NM_001281433.1	NP_001268362.1	zinc finger HIT domain-containing protein 3 isoform 4

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011858	XP_320662.3
Homo sapiens (human)	ZNHIT3	NP_004764.1
Canis lupus familiaris (dog)	ZNHIT3	XP_003639345.1
Rattus norvegicus (Norway rat)	Znhit3	XP_573169.3
Danio rerio (zebrafish)	znhit3	NP_956567.1
Pan troglodytes (chimpanzee)	ZNHIT3	NP_001181858.1
	ZNHIT3	XP_001111068.1
Gallus gallus (chicken)	ZNHIT3	XP_003642459.2
Drosophila melanogaster (fruit fly)	CG8204	NP_611050.1
Xenopus tropicalis (tropical clawed frog)	znhit3	NP_001039046.1
	LOC707869	XP_001096419.1
Bos taurus (cattle)	ZNHIT3	NP_001039360.1
Mus musculus (house mouse)	Znhit3	NP_001005223.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.
Anttonen AK, Laari A, Kousi M, Yang YJ, J??skel?inen T, Somer M, Siintola E, Jakkula E, Muona M, Tegelberg S, L?nnqvist T, Pihko H, Valanne L, Paetau A, Lun MP, H?stbacka J, Kopra O, Joensuu T, Katsanis N, Lehtinen MK, Palvimo JJ, Lehesjoki AE
Brain : a journal of neurology140(5)1267-1279(2017 05)

Structural Features of the Box C/D snoRNP Pre-assembly Process Are Conserved through Species.
Quinternet M, Chagot ME, Roth? B, Tiotiu D, Charpentier B, Manival X
Structure (London, England : 1993)24(10)1693-1706(2016 Oct)

Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.
Roth? B, Saliou JM, Quinternet M, Back R, Tiotiu D, Jacquemin C, Loegler C, Schlotter F, Pe?a V, Eckert K, Mor?ra S, Dorsselaer AV, Branlant C, Massenet S, Sanglier-Cianf?rani S, Manival X, Charpentier B
Nucleic acids research42(16)10731-47(2014)

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.
Koppen A, Houtman R, Pijnenburg D, Jeninga EH, Ruijtenbeek R, Kalkhoven E
Molecular & cellular proteomics : MCP8(10)2212-26(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that loss-of-function missense mutation of znhit3 underlies PEHO syndrome.
Title: ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.

Results solve the structure of a complex resulting from interaction between protein fragments of human NUFIP1 and its cofactor ZNHIT3, and emphasize their imbrication. Also, it seems that the complexes involving NUFIP1, ZNHIT3, and SNU13 share strong structural similarities between human and yeast, suggesting that the initial steps of the box C/D snoRNP assembly process are conserved among species.
Title: Structural Features of the Box C/D snoRNP Pre-assembly Process Are Conserved through Species.

Results identify TRIP3 as a novel regulator of PPARgamma-mediated adipocyte differentiation.
Title: Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

A high GYPC gene expression is associated with an unfavorable outcome, in contrast, a high TRIP3 gene expression is associated with a favorable outcome in childhood ALL.
Title: [Relationship between expression of GYPC and TRIP3 genes and prognosis of acute lymphoblastic leukemia in children].

The following ZNHIT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZNHIT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00700	NM_004773.4 Latest version!	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00452	NM_001281434.1 Latest version!	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu04787	NM_001281432.2 Latest version!	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu04788	NM_001281433.1 Latest version!	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu00700	NM_004773.3	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04787	NM_001281432.1	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZNHIT3 ( NM_004773.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004764.1 Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00700
Clone ID Related Accession (Same CDS sequence)	NM_004773.3 , NM_004773.4
Accession Version	NM_004773.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY045632.1, AF400652.1 and BQ009986.1. On Jul 26, 2013 this sequence version replaced NM_004773.2. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163657.529517.1, BC017931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGGGGA ATCTGCAACA 
TTAAGAAGCT TATTGCTCAA TCCACACCTC AGGCAGTTGA TGGTCAACCT CGATCAGGGA 
GAAGACAAAG CAAAGCTCAT GAGAGCTTAC ATGCAAGAGC CTTTGTTTGT GGAGTTTGCA 
GACTGCTGTT TAGGAATTGT GGAGCCATCC CAGAATGAGG AGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004764.1
CDS	74..541
Translation	MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQGEDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES

Target ORF information:

RefSeq Version	NM_004773.3
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004773.3

ORF Insert Sequence:

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGGGGA ATCTGCAACA 
TTAAGAAGCT TATTGCTCAA TCCACACCTC AGGCAGTTGA TGGTCAACCT CGATCAGGGA 
GAAGACAAAG CAAAGCTCAT GAGAGCTTAC ATGCAAGAGC CTTTGTTTGT GGAGTTTGCA 
GACTGCTGTT TAGGAATTGT GGAGCCATCC CAGAATGAGG AGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT3 ( NM_004773.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004764.1 Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00700
Clone ID Related Accession (Same CDS sequence)	NM_004773.3 , NM_004773.4
Accession Version	NM_004773.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF400652.1 and BQ009986.1. On Nov 23, 2018 this sequence version replaced NM_004773.3. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR5189661.5078.1, SRR5189667.11595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000617429.5/ ENSP00000484687.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGGGGA ATCTGCAACA 
TTAAGAAGCT TATTGCTCAA TCCACACCTC AGGCAGTTGA TGGTCAACCT CGATCAGGGA 
GAAGACAAAG CAAAGCTCAT GAGAGCTTAC ATGCAAGAGC CTTTGTTTGT GGAGTTTGCA 
GACTGCTGTT TAGGAATTGT GGAGCCATCC CAGAATGAGG AGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004764.1
CDS	20..487
Translation	MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQGEDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES

Target ORF information:

RefSeq Version	NM_004773.4
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004773.4

ORF Insert Sequence:

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGGGGA ATCTGCAACA 
TTAAGAAGCT TATTGCTCAA TCCACACCTC AGGCAGTTGA TGGTCAACCT CGATCAGGGA 
GAAGACAAAG CAAAGCTCAT GAGAGCTTAC ATGCAAGAGC CTTTGTTTGT GGAGTTTGCA 
GACTGCTGTT TAGGAATTGT GGAGCCATCC CAGAATGAGG AGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT3 ( NM_001281434.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268363.1 Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu00452
Clone ID Related Accession (Same CDS sequence)	NM_001281434.1
Accession Version	NM_001281434.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 3 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY045632.1, BE260293.1, AF400652.1 and BQ009986.1. Transcript Variant: This variant (3) lacks two consecutive in-frame coding exons compared to variant 1. The resulting isoform (3) is shorter, missing an internal protein segment, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BE260293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMN02400308 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGGG 
GAATCTGCAA CATTAAGAAG CTTATTGCTC AATCCACACC TCAGGCAGTT GATGGTCAAC 
CTCGATCAGG GAGAAGACAA AGCAAAGCTC ATGAGAGCTT ACATGCAAGA GCCTTTGTTT 
GTGGAGTTTG CAGACTGCTG TTTAGGAATT GTGGAGCCAT CCCAGAATGA GGAGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268363.1
CDS	74..373
Translation	MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKGESATLRSLLLNPHLRQLMVNLDQGEDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES

Target ORF information:

RefSeq Version	NM_001281434.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281434.1

ORF Insert Sequence:

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGGG 
GAATCTGCAA CATTAAGAAG CTTATTGCTC AATCCACACC TCAGGCAGTT GATGGTCAAC 
CTCGATCAGG GAGAAGACAA AGCAAAGCTC ATGAGAGCTT ACATGCAAGA GCCTTTGTTT 
GTGGAGTTTG CAGACTGCTG TTTAGGAATT GTGGAGCCAT CCCAGAATGA GGAGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT3 ( NM_001281432.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268361.1 Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04787
Clone ID Related Accession (Same CDS sequence)	NM_001281432.1 , NM_001281432.2
Accession Version	NM_001281432.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-03
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY045632.1, BI767446.1, AK096494.1 and AK308583.1. Transcript Variant: This variant (2) contains an alternate 3' terminal exon, which results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.678674.1, SRR1660803.19825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGATGG ACTCTCGTCC 
TGTCACCCAG GCTGGAGTGC AGCGGCGCAA TCTCGGCTCA CTGCAACCTC TCCCTCCCAG 
ATTCAAGCAA TTCTCATGCC TCAGCCTCCC GAGCAGCTGG GACTACAGGC GCCTGCCACT 
ACGCCCAACC AATTTTTGTA TTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268361.1
CDS	74..520
Translation	MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLDGLSSCHPGWSAAAQSRLTATSPSQIQAILMPQPPEQLGLQAPATTPNQFLYF

Target ORF information:

RefSeq Version	NM_001281432.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281432.1

ORF Insert Sequence:

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGATGG ACTCTCGTCC 
TGTCACCCAG GCTGGAGTGC AGCGGCGCAA TCTCGGCTCA CTGCAACCTC TCCCTCCCAG 
ATTCAAGCAA TTCTCATGCC TCAGCCTCCC GAGCAGCTGG GACTACAGGC GCCTGCCACT 
ACGCCCAACC AATTTTTGTA TTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT3 ( NM_001281432.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268361.1 Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04787
Clone ID Related Accession (Same CDS sequence)	NM_001281432.1 , NM_001281432.2
Accession Version	NM_001281432.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY045632.1, BI767446.1, AK096494.1, AK308583.1 and AC233698.3. On May 31, 2019 this sequence version replaced NM_001281432.1. Transcript Variant: This variant (2) contains an alternate 3' terminal exon, which results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.152882.1, SRR1660803.19825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGATGG ACTCTCGTCC 
TGTCACCCAG GCTGGAGTGC AGCGGCGCAA TCTCGGCTCA CTGCAACCTC TCCCTCCCAG 
ATTCAAGCAA TTCTCATGCC TCAGCCTCCC GAGCAGCTGG GACTACAGGC GCCTGCCACT 
ACGCCCAACC AATTTTTGTA TTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268361.1
CDS	20..466
Translation	MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLDGLSSCHPGWSAAAQSRLTATSPSQIQAILMPQPPEQLGLQAPATTPNQFLYF

Target ORF information:

RefSeq Version	NM_001281432.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281432.2

ORF Insert Sequence:

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGATGAT GATGACTCTA TAGCTGATTT TCTCAATAGT 
GATGAGGAAG AAGACAGAGT TTCTTTGCAG AATTTAAAGA ATTTAGATGG ACTCTCGTCC 
TGTCACCCAG GCTGGAGTGC AGCGGCGCAA TCTCGGCTCA CTGCAACCTC TCCCTCCCAG 
ATTCAAGCAA TTCTCATGCC TCAGCCTCCC GAGCAGCTGG GACTACAGGC GCCTGCCACT 
ACGCCCAACC AATTTTTGTA TTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNHIT3 ( NM_001281433.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268362.1 Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 4, mRNA.

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CloneID	OHu04788
Clone ID Related Accession (Same CDS sequence)	NM_001281433.1
Accession Version	NM_001281433.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	zinc finger HIT domain-containing protein 3 isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY045632.1, BG032116.1, AF400652.1 and BQ009986.1. Transcript Variant: This variant (4) uses an alternate acceptor splice site at the penultimate coding exon, which results in a frame-shift compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BG032116.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGTGATG AGGAAGAAGA CAGAGTTTCT TTGCAGAATT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268362.1
CDS	74..316
Translation	MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKVMRKKTEFLCRI

Target ORF information:

RefSeq Version	NM_001281433.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger HIT-type containing 3 (ZNHIT3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281433.1

ORF Insert Sequence:

ATGGCGTCGC TCAAATGTAG CACCGTCGTC TGCGTGATCT GCTTGGAGAA GCCCAAATAC 
CGCTGTCCAG CCTGCCGCGT GCCCTACTGC TCGGTAGTCT GCTTCCGGAA GCACAAAGAA 
CAGTGCAACC CTGAAACTCG TCCTGTTGAG AAAAAAATAA GATCAGCTCT TCCTACCAAA 
ACCGTAAAGC CTGTGGAAAA CAAAGTGATG AGGAAGAAGA CAGAGTTTCT TTGCAGAATT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.
Brain : a journal of neurology140(5)1267-1279(2017 05)
Anttonen AK,Laari A,Kousi M,Yang YJ,J??skel?inen T,Somer M,Siintola E,Jakkula E,Muona M,Tegelberg S,L?nnqvist T,Pihko H,Valanne L,Paetau A,Lun MP,H?stbacka J,Kopra O,Joensuu T,Katsanis N,Lehtinen MK,Palvimo JJ,Lehesjoki AE

Structural Features of the Box C/D snoRNP Pre-assembly Process Are Conserved through Species.
Structure (London, England : 1993)24(10)1693-1706(2016 Oct)
Quinternet M,Chagot ME,Roth? B,Tiotiu D,Charpentier B,Manival X

Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.
Nucleic acids research42(16)10731-47(2014)
Roth? B,Saliou JM,Quinternet M,Back R,Tiotiu D,Jacquemin C,Loegler C,Schlotter F,Pe?a V,Eckert K,Mor?ra S,Dorsselaer AV,Branlant C,Massenet S,Sanglier-Cianf?rani S,Manival X,Charpentier B

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.
Molecular & cellular proteomics : MCP8(10)2212-26(2009 Oct)
Koppen A,Houtman R,Pijnenburg D,Jeninga EH,Ruijtenbeek R,Kalkhoven E

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ZNHIT3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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