SYNGR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SYNGR1
Entrez Gene ID	9145
Full Name	synaptogyrin 1
General protein information	Preferred Names synaptogyrin 1 Names synaptogyrin-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.1
Summary	This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	603925

mRNA and Protein(s)

mRNA	Protein	Name
NM_145738.2	NP_663791.1	synaptogyrin-1 isoform 1c
NM_004711.5	NP_004702.2	synaptogyrin-1 isoform 1a
NM_004711.4	NP_004702.2	synaptogyrin-1 isoform 1a
NM_145731.3	NP_663783.1	synaptogyrin-1 isoform 1b

Pathways from BioSystems

Homologies

Homo sapiens (human)	SYNGR1	NP_004702.2
Drosophila melanogaster (fruit fly)	synaptogyrin	NP_610908.1
Gallus gallus (chicken)	SYNGR1	NP_001239207.1
Danio rerio (zebrafish)	syngr1a	NP_001006067.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011318	XP_309332.4
	SYNGR1	XP_002798400.1
Mus musculus (house mouse)	Syngr1	NP_997591.1
Rattus norvegicus (Norway rat)	Syngr1	NP_062039.1
Caenorhabditis elegans (roundworm)	sng-1	NP_509239.1
Xenopus tropicalis (tropical clawed frog)	syngr1	NP_001016195.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
Cobb J, Cule E, Moncrieffe H, Hinks A, Ursu S, Patrick F, Kassoumeri L, Flynn E, Bulatovi? M, Wulffraat N, van Zelst B, de Jonge R, Bohm M, Dolezalova P, Hirani S, Newman S, Whitworth P, Southwood TR, De Iorio M, , , , Wedderburn LR, Thomson W
The pharmacogenomics journal14(4)356-64(2014 Aug)

Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieud? P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantap??-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, , , Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM
Nature506(7488)376-81(2014 Feb)

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)

Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.
L?w C, Jegersch?ld C, Kovermann M, Moberg P, Nordlund P
PloS one7(6)e38244(2012)

No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.
Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L, Li S
Psychiatry research169(2)167-8(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SYNGR1 was soluble and stable in a variety of mild detergents and multiple biophysical methods confirmed the folded state of the protein.
Title: Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia.

A case-control study with synaptogyrin 1 was conducted in 506 bipolar disorder patients and 507 healthy individuals from the Han Chinese population. No association was found in this study.
Title: No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.

These mutations were not found in 507 control subjects, suggesting further functional assays are warranted to verify their relevance to the pathogenesis of schizophrenia.
Title: Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia.

Observational study of gene-disease association. (HuGE Navigator)
Title: SYNGR1 is associated with schizophrenia and bipolar disorder in southern India.

The following SYNGR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SYNGR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04557	NM_004711.5 Latest version!	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu31734	NM_145731.3 Latest version!	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31970	NM_145738.2 Latest version!	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1c, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu04557	NM_004711.4	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SYNGR1 ( NM_004711.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004702.2 Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1a, mRNA.

Price & Availability↑

CloneID	OHu04557
Clone ID Related Accession (Same CDS sequence)	NM_004711.5 , NM_004711.4
Accession Version	NM_004711.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	synaptogyrin-1 isoform 1a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI667990.1, AJ002305.1, BC000731.2, DA337769.1, BX501388.1 and AA412350.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004711.4. Transcript Variant: This variant (1a) represents the longest transcript and encodes the longest predominantly expressed isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ002305.1, SRR1660807.24951.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328933.10/ ENSP00000332287.5 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAAGGGG GTGCGTACGG AGCGGGCAAA GCCGGGGGCG CCTTCGACCC CTACACCCTG 
GTCCGGCAGC CGCACACCAT CCTGCGCGTC GTGTCTTGGC TGTTCTCCAT AGTGGTGTTC 
GGCTCCATCG TGAACGAGGG CTACCTCAAC AGCGCCTCCG AGGGGGAGGA GTTCTGCATC 
TACAACCGCA ACCCCAACGC CTGCAGCTAT GGCGTGGCCG TGGGCGTGCT CGCCTTCCTC 
ACCTGCCTGC TGTACCTGGC CCTGGACGTG TACTTCCCGC AGATCAGCAG CGTCAAGGAC 
CGCAAGAAAG CCGTCCTGTC CGACATCGGT GTCTCGGCCT TCTGGGCTTT CCTCTGGTTC 
GTGGGATTCT GCTACCTGGC CAACCAGTGG CAGGTCTCCA AGCCCAAGGA CAACCCACTG 
AACGAAGGGA CGGACGCAGC CCGGGCCGCC ATCGCCTTCT CCTTTTTCTC CATCTTCACC 
TGGGCGGGCC AGGCTGTGCT GGCCTTCCAG CGGTACCAGA TTGGCGCCGA CTCGGCCCTC 
TTCTCCCAGG ACTACATGGA CCCCAGCCAG GACTCCAGCA TGCCTTACGC GCCCTACGTG 
GAGCCCACTG GGCCGGATCC CGCCGGTATG GGCGGCACCT ACCAGCAGCC GGCCAACACC 
TTCGACACCG AGCCCCAGGG CTACCAGTCG CAGGGCTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004702.2
CDS	21..722
Translation	MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPTGPDPAGMGGTYQQPANTFDTEPQGYQSQGY

Target ORF information:

RefSeq Version	NM_004711.5
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004711.5

ORF Insert Sequence:

ATGGAAGGGG GTGCGTACGG AGCGGGCAAA GCCGGGGGCG CCTTCGACCC CTACACCCTG 
GTCCGGCAGC CGCACACCAT CCTGCGCGTC GTGTCTTGGC TGTTCTCCAT AGTGGTGTTC 
GGCTCCATCG TGAACGAGGG CTACCTCAAC AGCGCCTCCG AGGGGGAGGA GTTCTGCATC 
TACAACCGCA ACCCCAACGC CTGCAGCTAT GGCGTGGCCG TGGGCGTGCT CGCCTTCCTC 
ACCTGCCTGC TGTACCTGGC CCTGGACGTG TACTTCCCGC AGATCAGCAG CGTCAAGGAC 
CGCAAGAAAG CCGTCCTGTC CGACATCGGT GTCTCGGCCT TCTGGGCTTT CCTCTGGTTC 
GTGGGATTCT GCTACCTGGC CAACCAGTGG CAGGTCTCCA AGCCCAAGGA CAACCCACTG 
AACGAAGGGA CGGACGCAGC CCGGGCCGCC ATCGCCTTCT CCTTTTTCTC CATCTTCACC 
TGGGCGGGCC AGGCTGTGCT GGCCTTCCAG CGGTACCAGA TTGGCGCCGA CTCGGCCCTC 
TTCTCCCAGG ACTACATGGA CCCCAGCCAG GACTCCAGCA TGCCTTACGC GCCCTACGTG 
GAGCCCACTG GGCCGGATCC CGCCGGTATG GGCGGCACCT ACCAGCAGCC GGCCAACACC 
TTCGACACCG AGCCCCAGGG CTACCAGTCG CAGGGCTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYNGR1 ( NM_145731.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_663783.1 Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1b, mRNA.

Price & Availability↑

CloneID	OHu31734
Clone ID Related Accession (Same CDS sequence)	NM_145731.3
Accession Version	NM_145731.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	synaptogyrin-1 isoform 1b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI667990.1, AJ002304.1, BC000731.2 and AW304782.1. On Aug 31, 2007 this sequence version replaced NM_145731.2. Transcript Variant: This variant (1b) has a distinct 3' UTR and contains an alternate 3' coding exon, as compared to variant 1a. The encoded isoform (1b) has a distinct C-terminus, compared to isoform 1a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.272891.1, SRR1660805.24271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGGGG GTGCGTACGG AGCGGGCAAA GCCGGGGGCG CCTTCGACCC CTACACCCTG 
GTCCGGCAGC CGCACACCAT CCTGCGCGTC GTGTCTTGGC TGTTCTCCAT AGTGGTGTTC 
GGCTCCATCG TGAACGAGGG CTACCTCAAC AGCGCCTCCG AGGGGGAGGA GTTCTGCATC 
TACAACCGCA ACCCCAACGC CTGCAGCTAT GGCGTGGCCG TGGGCGTGCT CGCCTTCCTC 
ACCTGCCTGC TGTACCTGGC CCTGGACGTG TACTTCCCGC AGATCAGCAG CGTCAAGGAC 
CGCAAGAAAG CCGTCCTGTC CGACATCGGT GTCTCGGCCT TCTGGGCTTT CCTCTGGTTC 
GTGGGATTCT GCTACCTGGC CAACCAGTGG CAGGTCTCCA AGCCCAAGGA CAACCCACTG 
AACGAAGGGA CGGACGCAGC CCGGGCCGCC ATCGCCTTCT CCTTTTTCTC CATCTTCACC 
TGGAGCCTGA CCGCAGCCCT GGCCGTGCGG AGATTCAAGG ACCTAAGCTT CCAGGAGGAG 
TACAGCACAC TGTTCCCTGC CTCGGCACAG CCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663783.1
CDS	63..638
Translation	MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWSLTAALAVRRFKDLSFQEEYSTLFPASAQP

Target ORF information:

RefSeq Version	NM_145731.3
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145731.3

ORF Insert Sequence:

ATGGAAGGGG GTGCGTACGG AGCGGGCAAA GCCGGGGGCG CCTTCGACCC CTACACCCTG 
GTCCGGCAGC CGCACACCAT CCTGCGCGTC GTGTCTTGGC TGTTCTCCAT AGTGGTGTTC 
GGCTCCATCG TGAACGAGGG CTACCTCAAC AGCGCCTCCG AGGGGGAGGA GTTCTGCATC 
TACAACCGCA ACCCCAACGC CTGCAGCTAT GGCGTGGCCG TGGGCGTGCT CGCCTTCCTC 
ACCTGCCTGC TGTACCTGGC CCTGGACGTG TACTTCCCGC AGATCAGCAG CGTCAAGGAC 
CGCAAGAAAG CCGTCCTGTC CGACATCGGT GTCTCGGCCT TCTGGGCTTT CCTCTGGTTC 
GTGGGATTCT GCTACCTGGC CAACCAGTGG CAGGTCTCCA AGCCCAAGGA CAACCCACTG 
AACGAAGGGA CGGACGCAGC CCGGGCCGCC ATCGCCTTCT CCTTTTTCTC CATCTTCACC 
TGGAGCCTGA CCGCAGCCCT GGCCGTGCGG AGATTCAAGG ACCTAAGCTT CCAGGAGGAG 
TACAGCACAC TGTTCCCTGC CTCGGCACAG CCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYNGR1 ( NM_004711.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004702.2 Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1a, mRNA.

Price & Availability↑

CloneID	OHu04557
Clone ID Related Accession (Same CDS sequence)	NM_004711.5 , NM_004711.4
Accession Version	NM_004711.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	synaptogyrin-1 isoform 1a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI667990.1, AJ002305.1, BC000731.2, DA337769.1, BX501388.1, AA412350.1 and AI278583.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2007 this sequence version replaced NM_004711.3. Transcript Variant: This variant (1a) represents the longest transcript and encodes the longest predominantly expressed isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ002305.1, SRR1660807.24951.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGGGG GTGCGTACGG AGCGGGCAAA GCCGGGGGCG CCTTCGACCC CTACACCCTG 
GTCCGGCAGC CGCACACCAT CCTGCGCGTC GTGTCTTGGC TGTTCTCCAT AGTGGTGTTC 
GGCTCCATCG TGAACGAGGG CTACCTCAAC AGCGCCTCCG AGGGGGAGGA GTTCTGCATC 
TACAACCGCA ACCCCAACGC CTGCAGCTAT GGCGTGGCCG TGGGCGTGCT CGCCTTCCTC 
ACCTGCCTGC TGTACCTGGC CCTGGACGTG TACTTCCCGC AGATCAGCAG CGTCAAGGAC 
CGCAAGAAAG CCGTCCTGTC CGACATCGGT GTCTCGGCCT TCTGGGCTTT CCTCTGGTTC 
GTGGGATTCT GCTACCTGGC CAACCAGTGG CAGGTCTCCA AGCCCAAGGA CAACCCACTG 
AACGAAGGGA CGGACGCAGC CCGGGCCGCC ATCGCCTTCT CCTTTTTCTC CATCTTCACC 
TGGGCGGGCC AGGCTGTGCT GGCCTTCCAG CGGTACCAGA TTGGCGCCGA CTCGGCCCTC 
TTCTCCCAGG ACTACATGGA CCCCAGCCAG GACTCCAGCA TGCCTTACGC GCCCTACGTG 
GAGCCCACTG GGCCGGATCC CGCCGGTATG GGCGGCACCT ACCAGCAGCC GGCCAACACC 
TTCGACACCG AGCCCCAGGG CTACCAGTCG CAGGGCTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004702.2
CDS	63..764
Translation	MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPTGPDPAGMGGTYQQPANTFDTEPQGYQSQGY

Target ORF information:

RefSeq Version	NM_004711.4
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004711.4

ORF Insert Sequence:

ATGGAAGGGG GTGCGTACGG AGCGGGCAAA GCCGGGGGCG CCTTCGACCC CTACACCCTG 
GTCCGGCAGC CGCACACCAT CCTGCGCGTC GTGTCTTGGC TGTTCTCCAT AGTGGTGTTC 
GGCTCCATCG TGAACGAGGG CTACCTCAAC AGCGCCTCCG AGGGGGAGGA GTTCTGCATC 
TACAACCGCA ACCCCAACGC CTGCAGCTAT GGCGTGGCCG TGGGCGTGCT CGCCTTCCTC 
ACCTGCCTGC TGTACCTGGC CCTGGACGTG TACTTCCCGC AGATCAGCAG CGTCAAGGAC 
CGCAAGAAAG CCGTCCTGTC CGACATCGGT GTCTCGGCCT TCTGGGCTTT CCTCTGGTTC 
GTGGGATTCT GCTACCTGGC CAACCAGTGG CAGGTCTCCA AGCCCAAGGA CAACCCACTG 
AACGAAGGGA CGGACGCAGC CCGGGCCGCC ATCGCCTTCT CCTTTTTCTC CATCTTCACC 
TGGGCGGGCC AGGCTGTGCT GGCCTTCCAG CGGTACCAGA TTGGCGCCGA CTCGGCCCTC 
TTCTCCCAGG ACTACATGGA CCCCAGCCAG GACTCCAGCA TGCCTTACGC GCCCTACGTG 
GAGCCCACTG GGCCGGATCC CGCCGGTATG GGCGGCACCT ACCAGCAGCC GGCCAACACC 
TTCGACACCG AGCCCCAGGG CTACCAGTCG CAGGGCTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYNGR1 ( NM_145738.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_663791.1 Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1c, mRNA.

Price & Availability↑

CloneID	OHu31970
Clone ID Related Accession (Same CDS sequence)	NM_145738.2
Accession Version	NM_145738.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	synaptogyrin-1 isoform 1c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ002303.1, AJ002304.1 and AW304782.1. On Aug 31, 2007 this sequence version replaced NM_145738.1. Transcript Variant: This variant (1c) encodes the shortest isoform. It contains a distinct 5' UTR and 5' coding region resulting in a frameshift and downstream translation initiation site, when compared to isoform 1a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ002303.1, AA007668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGACCT TAGAGTTTGG GATTCTGGAA TTCGATCCTT CATGGATAGG CAGCTGGACA 
CAGAGGTCGT GGGTGAGCTG GAGGAGCAGG CCCGGATGTG AGCTGTTCTC CATAGTGGTG 
TTCGGCTCCA TCGTGAACGA GGGCTACCTC AACAGCGCCT CCGAGGGGGA GGAGTTCTGC 
ATCTACAACC GCAACCCCAA CGCCTGCAGC TATGGCGTGG CCGTGGGCGT GCTCGCCTTC 
CTCACCTGCC TGCTGTACCT GGCCCTGGAC GTGTACTTCC CGCAGATCAG CAGCGTCAAG 
GACCGCAAGA AAGCCGTCCT GTCCGACATC GGTGTCTCGG CCTTCTGGGC TTTCCTCTGG 
TTCGTGGGAT TCTGCTACCT GGCCAACCAG TGGCAGGTCT CCAAGCCCAA GGACAACCCA 
CTGAACGAAG GGACGGACGC AGCCCGGGCC GCCATCGCCT TCTCCTTTTT CTCCATCTTC 
ACCTGGAGCC TGACCGCAGC CCTGGCCGTG CGGAGATTCA AGGACCTAAG CTTCCAGGAG 
GAGTACAGCA CACTGTTCCC TGCCTCGGCA CAGCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663791.1
CDS	26..604
Translation	MLTLEFGILEFDPSWIGSWTQRSWVSWRSRPGCELFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWSLTAALAVRRFKDLSFQEEYSTLFPASAQP

Target ORF information:

RefSeq Version	NM_145738.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptogyrin 1 (SYNGR1), transcript variant 1c, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145738.2

ORF Insert Sequence:

ATGTTGACCT TAGAGTTTGG GATTCTGGAA TTCGATCCTT CATGGATAGG CAGCTGGACA 
CAGAGGTCGT GGGTGAGCTG GAGGAGCAGG CCCGGATGTG AGCTGTTCTC CATAGTGGTG 
TTCGGCTCCA TCGTGAACGA GGGCTACCTC AACAGCGCCT CCGAGGGGGA GGAGTTCTGC 
ATCTACAACC GCAACCCCAA CGCCTGCAGC TATGGCGTGG CCGTGGGCGT GCTCGCCTTC 
CTCACCTGCC TGCTGTACCT GGCCCTGGAC GTGTACTTCC CGCAGATCAG CAGCGTCAAG 
GACCGCAAGA AAGCCGTCCT GTCCGACATC GGTGTCTCGG CCTTCTGGGC TTTCCTCTGG 
TTCGTGGGAT TCTGCTACCT GGCCAACCAG TGGCAGGTCT CCAAGCCCAA GGACAACCCA 
CTGAACGAAG GGACGGACGC AGCCCGGGCC GCCATCGCCT TCTCCTTTTT CTCCATCTTC 
ACCTGGAGCC TGACCGCAGC CCTGGCCGTG CGGAGATTCA AGGACCTAAG CTTCCAGGAG 
GAGTACAGCA CACTGTTCCC TGCCTCGGCA CAGCCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
The pharmacogenomics journal14(4)356-64(2014 Aug)
Cobb J,Cule E,Moncrieffe H,Hinks A,Ursu S,Patrick F,Kassoumeri L,Flynn E,Bulatovi? M,Wulffraat N,van Zelst B,de Jonge R,Bohm M,Dolezalova P,Hirani S,Newman S,Whitworth P,Southwood TR,De Iorio M,,,,Wedderburn LR,Thomson W

Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Nature506(7488)376-81(2014 Feb)
Okada Y,Wu D,Trynka G,Raj T,Terao C,Ikari K,Kochi Y,Ohmura K,Suzuki A,Yoshida S,Graham RR,Manoharan A,Ortmann W,Bhangale T,Denny JC,Carroll RJ,Eyler AE,Greenberg JD,Kremer JM,Pappas DA,Jiang L,Yin J,Ye L,Su DF,Yang J,Xie G,Keystone E,Westra HJ,Esko T,Metspalu A,Zhou X,Gupta N,Mirel D,Stahl EA,Diogo D,Cui J,Liao K,Guo MH,Myouzen K,Kawaguchi T,Coenen MJ,van Riel PL,van de Laar MA,Guchelaar HJ,Huizinga TW,Dieud? P,Mariette X,Bridges SL Jr,Zhernakova A,Toes RE,Tak PP,Miceli-Richard C,Bang SY,Lee HS,Martin J,Gonzalez-Gay MA,Rodriguez-Rodriguez L,Rantap??-Dahlqvist S,Arlestig L,Choi HK,Kamatani Y,Galan P,Lathrop M,,,Eyre S,Bowes J,Barton A,de Vries N,Moreland LW,Criswell LA,Karlson EW,Taniguchi A,Yamada R,Kubo M,Liu JS,Bae SC,Worthington J,Padyukov L,Klareskog L,Gregersen PK,Raychaudhuri S,Stranger BE,De Jager PL,Franke L,Visscher PM,Brown MA,Yamanaka H,Mimori T,Takahashi A,Xu H,Behrens TW,Siminovitch KA,Momohara S,Matsuda F,Yamamoto K,Plenge RM

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
PLoS genetics9(1)e1003225(2013)
Lauc G,Huffman JE,Pu?i? M,Zgaga L,Adamczyk B,Mu?ini? A,Novokmet M,Pola?ek O,Gornik O,Kri?ti? J,Keser T,Vitart V,Scheijen B,Uh HW,Molokhia M,Patrick AL,McKeigue P,Kol?i? I,Luki? IK,Swann O,van Leeuwen FN,Ruhaak LR,Houwing-Duistermaat JJ,Slagboom PE,Beekman M,de Craen AJ,Deelder AM,Zeng Q,Wang W,Hastie ND,Gyllensten U,Wilson JF,Wuhrer M,Wright AF,Rudd PM,Hayward C,Aulchenko Y,Campbell H,Rudan I

Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.
PloS one7(6)e38244(2012)
L?w C,Jegersch?ld C,Kovermann M,Moberg P,Nordlund P

No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.
Psychiatry research169(2)167-8(2009 Sep)
Wang Y,Yu L,Zhao T,Xu J,Liu Z,Liu Y,Feng G,He L,Li S

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SYNGR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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