FATE1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FATE1
Entrez Gene ID	89885
Full Name	fetal and adult testis expressed 1
Synonyms	CT43,FATE
General protein information	Preferred Names fetal and adult testis expressed 1 Names fetal and adult testis-expressed transcript protein BJ-HCC-2 antigen cancer/testis antigen 43 tumor antigen BJ-HCC-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010].
Disorder MIM:	300450

mRNA and Protein(s)

mRNA	Protein	Name
NM_033085.2	NP_149076.1	fetal and adult testis-expressed transcript protein
NM_033085.3	NP_149076.1	fetal and adult testis-expressed transcript protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FATE1	XP_001136508.1
Canis lupus familiaris (dog)	FATE1	XP_538196.1
Homo sapiens (human)	FATE1	NP_149076.1
	FATE1	XP_001092724.1

Gene Ontology
Bibliography

Related articles in PubMed

FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria.
Doghman-Bouguerra M, Granatiero V, Sbiera S, Sbiera I, Lacas-Gervais S, Brau F, Fassnacht M, Rizzuto R, Lalli E
EMBO reports17(9)1264-80(2016 09)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.
Maxfield KE, Taus PJ, Corcoran K, Wooten J, Macion J, Zhou Y, Borromeo M, Kollipara RK, Yan J, Xie Y, Xie XJ, Whitehurst AW
Nature communications68840(2015 Nov)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In patients with ACC, FATE1 expression in their tumor is inversely correlated with their overall survival. the ER-mitochondria uncoupling activity of FATE1 is harnessed by cancer cells to escape apoptotic death and resist the action of chemotherapeutic drugs.
Title: FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria.

FATE1 is a key survival factor in multiple oncogenic backgrounds. FATE1 prevents the accumulation of the stress-sensing BH3-only protein, BCL-2-Interacting Killer (BIK), thereby permitting viability in the presence of toxic stimuli.
Title: Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.

This study has shown that only 1.4% of infertile men have mutations in the FATE gene, and that some of these mutations do not singly cause infertility.
Title: Mutational analysis of the human FATE gene in 144 infertile men.

The following FATE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FATE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18689	NM_033085.3 Latest version!	Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18689	NM_033085.2	Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FATE1 ( NM_033085.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_149076.1 Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.

Price & Availability↑

CloneID	OHu18689
Clone ID Related Accession (Same CDS sequence)	NM_033085.2 , NM_033085.3
Accession Version	NM_033085.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	fetal and adult testis-expressed transcript protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY101182.1. This sequence is a reference standard in the RefSeqGene project. On Jan 27, 2004 this sequence version replaced NM_033085.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF249872.1, BC022064.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCAGGAG GCCCTCCCAA CACCAAGGCG GAGATGGAAA TGTCCCTGGC AGAAGAACTG 
AATCATGGAC GCCAAGGGGA AAACCAAGAG CACCTGGTGA TAGCAGAAAT GATGGAGCTT 
GGATCTCGGT CCCGGGGTGC CTCCCAGAAG AAGCAGAAGT TGGAACAAAA AGCTGCTGGC 
TCTGCTTCAG CCAAACGAGT TTGGAATATG ACTGCCACCC GACCCAAGAA AATGGGGTCC 
CAGCTGCCAA AGCCCAGAAT GCTGAGAGAA TCAGGCCATG GGGATGCCCA TCTCCAGGAG 
TACGCTGGCA ATTTCCAAGG CATACGTTTC CATTATGATC GCAACCCAGG GACAGATGCA 
GTGGCGCAGA CTAGCCTGGA AGAGTTCAAT GTACTGGAGA TGGAAGTCAT GAGAAGACAG 
CTGTATGCAG TCAACCGGCG TCTGCGCGCC CTGGAGGAAC AGGGCGCCAC CTGGCGCCAC 
AGGGAGACCC TGATCATCGC CGTGCTGGTG TCGGCCAGCA TTGCCAACCT GTGGCTGTGG 
ATGAACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149076.1
CDS	85..636
Translation	MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRSRGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYAGNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRHRETLIIAVLVSASIANLWLWMNQ

Target ORF information:

RefSeq Version	NM_033085.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033085.2

ORF Insert Sequence:

ATGGCAGGAG GCCCTCCCAA CACCAAGGCG GAGATGGAAA TGTCCCTGGC AGAAGAACTG 
AATCATGGAC GCCAAGGGGA AAACCAAGAG CACCTGGTGA TAGCAGAAAT GATGGAGCTT 
GGATCTCGGT CCCGGGGTGC CTCCCAGAAG AAGCAGAAGT TGGAACAAAA AGCTGCTGGC 
TCTGCTTCAG CCAAACGAGT TTGGAATATG ACTGCCACCC GACCCAAGAA AATGGGGTCC 
CAGCTGCCAA AGCCCAGAAT GCTGAGAGAA TCAGGCCATG GGGATGCCCA TCTCCAGGAG 
TACGCTGGCA ATTTCCAAGG CATACGTTTC CATTATGATC GCAACCCAGG GACAGATGCA 
GTGGCGCAGA CTAGCCTGGA AGAGTTCAAT GTACTGGAGA TGGAAGTCAT GAGAAGACAG 
CTGTATGCAG TCAACCGGCG TCTGCGCGCC CTGGAGGAAC AGGGCGCCAC CTGGCGCCAC 
AGGGAGACCC TGATCATCGC CGTGCTGGTG TCGGCCAGCA TTGCCAACCT GTGGCTGTGG 
ATGAACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FATE1 ( NM_033085.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_149076.1 Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.

Price & Availability↑

CloneID	OHu18689
Clone ID Related Accession (Same CDS sequence)	NM_033085.2 , NM_033085.3
Accession Version	NM_033085.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	fetal and adult testis-expressed transcript protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF002992.2 and AY101182.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_033085.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022064.2, SRR5189652.72397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370350.7/ ENSP00000359375.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGAG GCCCTCCCAA CACCAAGGCG GAGATGGAAA TGTCCCTGGC AGAAGAACTG 
AATCATGGAC GCCAAGGGGA AAACCAAGAG CACCTGGTGA TAGCAGAAAT GATGGAGCTT 
GGATCTCGGT CCCGGGGTGC CTCCCAGAAG AAGCAGAAGT TGGAACAAAA AGCTGCTGGC 
TCTGCTTCAG CCAAACGAGT TTGGAATATG ACTGCCACCC GACCCAAGAA AATGGGGTCC 
CAGCTGCCAA AGCCCAGAAT GCTGAGAGAA TCAGGCCATG GGGATGCCCA TCTCCAGGAG 
TACGCTGGCA ATTTCCAAGG CATACGTTTC CATTATGATC GCAACCCAGG GACAGATGCA 
GTGGCGCAGA CTAGCCTGGA AGAGTTCAAT GTACTGGAGA TGGAAGTCAT GAGAAGACAG 
CTGTATGCAG TCAACCGGCG TCTGCGCGCC CTGGAGGAAC AGGGCGCCAC CTGGCGCCAC 
AGGGAGACCC TGATCATCGC CGTGCTGGTG TCGGCCAGCA TTGCCAACCT GTGGCTGTGG 
ATGAACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149076.1
CDS	86..637
Translation	MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRSRGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYAGNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRHRETLIIAVLVSASIANLWLWMNQ

Target ORF information:

RefSeq Version	NM_033085.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fetal and adult testis expressed 1 (FATE1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033085.3

ORF Insert Sequence:

ATGGCAGGAG GCCCTCCCAA CACCAAGGCG GAGATGGAAA TGTCCCTGGC AGAAGAACTG 
AATCATGGAC GCCAAGGGGA AAACCAAGAG CACCTGGTGA TAGCAGAAAT GATGGAGCTT 
GGATCTCGGT CCCGGGGTGC CTCCCAGAAG AAGCAGAAGT TGGAACAAAA AGCTGCTGGC 
TCTGCTTCAG CCAAACGAGT TTGGAATATG ACTGCCACCC GACCCAAGAA AATGGGGTCC 
CAGCTGCCAA AGCCCAGAAT GCTGAGAGAA TCAGGCCATG GGGATGCCCA TCTCCAGGAG 
TACGCTGGCA ATTTCCAAGG CATACGTTTC CATTATGATC GCAACCCAGG GACAGATGCA 
GTGGCGCAGA CTAGCCTGGA AGAGTTCAAT GTACTGGAGA TGGAAGTCAT GAGAAGACAG 
CTGTATGCAG TCAACCGGCG TCTGCGCGCC CTGGAGGAAC AGGGCGCCAC CTGGCGCCAC 
AGGGAGACCC TGATCATCGC CGTGCTGGTG TCGGCCAGCA TTGCCAACCT GTGGCTGTGG 
ATGAACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria.
EMBO reports17(9)1264-80(2016 09)
Doghman-Bouguerra M,Granatiero V,Sbiera S,Sbiera I,Lacas-Gervais S,Brau F,Fassnacht M,Rizzuto R,Lalli E

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.
Nature communications68840(2015 Nov)
Maxfield KE,Taus PJ,Corcoran K,Wooten J,Macion J,Zhou Y,Borromeo M,Kollipara RK,Yan J,Xie Y,Xie XJ,Whitehurst AW

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

FATE1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報