VAMP8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VAMP8
Entrez Gene ID	8673
Full Name	vesicle associated membrane protein 8
Synonyms	EDB,VAMP-8
General protein information	Preferred Names vesicle associated membrane protein 8 Names vesicle-associated membrane protein 8 vesicle-associated membrane protein 8 (endobrevin)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p11.2
Summary	This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010].
Disorder MIM:	603177

mRNA and Protein(s)

mRNA	Protein	Name
NM_003761.4	NP_003752.2	vesicle-associated membrane protein 8
NM_003761.5	NP_003752.2	vesicle-associated membrane protein 8
XM_017005170.1	XP_016860659.1	vesicle-associated membrane protein 8 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VAMP8	XP_003309126.1
Canis lupus familiaris (dog)	VAMP8	XP_852312.1
Mus musculus (house mouse)	Vamp8	NP_058074.2
Homo sapiens (human)	VAMP8	NP_003752.2
Rattus norvegicus (Norway rat)	Vamp8	NP_114015.1
	VAMP8	XP_001086599.1
Bos taurus (cattle)	VAMP8	NP_001029462.1
Danio rerio (zebrafish)	vamp8	NP_956053.1
Xenopus tropicalis (tropical clawed frog)	vamp8	NP_001016285.2

Gene Ontology
Bibliography

Related articles in PubMed

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.
Marshall MR, Pattu V, Halimani M, Maier-Peuschel M, M?ller ML, Becherer U, Hong W, Hoth M, Tschernig T, Bryceson YT, Rettig J
The Journal of cell biology210(1)135-51(2015 Jul)

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz LM, Li J, Vivona S, Pfuetzner RA, Brunger AT, Zhong Q
Nature520(7548)563-6(2015 Apr)

No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population.
Zhou P, Zhang S, Chen H, Chen Y, Liu X, Sun B
International journal of clinical and experimental pathology8(5)5681-7(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cytotoxic granule exocytosis is a sequential, multivesicle fusion process requiring VAMP8-mediated recycling endosome fusion before cytotoxic granule fusion.
Title: VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.

Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.
Title: Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.

Vesicle-associated membrane protein 8 as a novel oncogene by promoting cell proliferation and therapeutic resistance in glioma. Targeting VAMP8 may serve as a potential therapeutic regimen for the treatment of glioma.
Title: VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells.

our study suggested that VAMP8 gene variants might not contribute to glioma susceptibility and associated with glioma in the Chinese Han population.
Title: No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population.

Inhibition of VAMP8, but not VAMP7, significantly reduces viral entry.
Title: UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.

The following VAMP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VAMP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18035	NM_003761.5 Latest version!	Homo sapiens vesicle associated membrane protein 8 (VAMP8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu90027	XM_017005170.1 Latest version!	Homo sapiens vesicle associated membrane protein 8 (VAMP8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu18035	NM_003761.4	Homo sapiens vesicle associated membrane protein 8 (VAMP8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VAMP8 ( NM_003761.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003752.2 Homo sapiens vesicle associated membrane protein 8 (VAMP8), mRNA.

Price & Availability↑

CloneID	OHu18035
Clone ID Related Accession (Same CDS sequence)	NM_003761.4 , NM_003761.5
Accession Version	NM_003761.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	vesicle-associated membrane protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM702226.1, BC001634.1 and BX092149.1. This sequence is a reference standard in the RefSeqGene project. On Jun 13, 2010 this sequence version replaced NM_003761.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279854.376.1, SRR1163657.136254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAAG CCAGTGAAGG TGGAGGAAAT GATCGTGTGC GGAACCTGCA AAGTGAGGTG 
GAGGGAGTTA AGAATATTAT GACCCAGAAT GTGGAGCGGA TCCTGGCCCG GGGGGAAAAC 
TTGGAACATC TCCGCAACAA GACAGAGGAT CTGGAAGCCA CATCTGAGCA CTTCAAGACG 
ACATCGCAGA AGGTGGCTCG AAAATTCTGG TGGAAGAACG TGAAGATGAT TGTCCTTATC 
TGCGTGATTG TTTTTATCAT CATCCTCTTC ATTGTGCTCT TTGCCACTGG TGCCTTCTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003752.2
CDS	157..459
Translation	MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS

Target ORF information:

RefSeq Version	NM_003761.4
Organism	Homo sapiens(human)
Definition	Homo sapiens vesicle associated membrane protein 8 (VAMP8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003761.4

ORF Insert Sequence:

ATGGAGGAAG CCAGTGAAGG TGGAGGAAAT GATCGTGTGC GGAACCTGCA AAGTGAGGTG 
GAGGGAGTTA AGAATATTAT GACCCAGAAT GTGGAGCGGA TCCTGGCCCG GGGGGAAAAC 
TTGGAACATC TCCGCAACAA GACAGAGGAT CTGGAAGCCA CATCTGAGCA CTTCAAGACG 
ACATCGCAGA AGGTGGCTCG AAAATTCTGG TGGAAGAACG TGAAGATGAT TGTCCTTATC 
TGCGTGATTG TTTTTATCAT CATCCTCTTC ATTGTGCTCT TTGCCACTGG TGCCTTCTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAMP8 ( NM_003761.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003752.2 Homo sapiens vesicle associated membrane protein 8 (VAMP8), mRNA.

Price & Availability↑

CloneID	OHu18035
Clone ID Related Accession (Same CDS sequence)	NM_003761.4 , NM_003761.5
Accession Version	NM_003761.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	vesicle-associated membrane protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM702226.1, BC001634.1 and BX092149.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003761.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.194331.1, SRR1163657.202340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263864.10/ ENSP00000263864.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGAAG CCAGTGAAGG TGGAGGAAAT GATCGTGTGC GGAACCTGCA AAGTGAGGTG 
GAGGGAGTTA AGAATATTAT GACCCAGAAT GTGGAGCGGA TCCTGGCCCG GGGGGAAAAC 
TTGGAACATC TCCGCAACAA GACAGAGGAT CTGGAAGCCA CATCTGAGCA CTTCAAGACG 
ACATCGCAGA AGGTGGCTCG AAAATTCTGG TGGAAGAACG TGAAGATGAT TGTCCTTATC 
TGCGTGATTG TTTTTATCAT CATCCTCTTC ATTGTGCTCT TTGCCACTGG TGCCTTCTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003752.2
CDS	62..364
Translation	MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS

Target ORF information:

RefSeq Version	NM_003761.5
Organism	Homo sapiens(human)
Definition	Homo sapiens vesicle associated membrane protein 8 (VAMP8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003761.5

ORF Insert Sequence:

ATGGAGGAAG CCAGTGAAGG TGGAGGAAAT GATCGTGTGC GGAACCTGCA AAGTGAGGTG 
GAGGGAGTTA AGAATATTAT GACCCAGAAT GTGGAGCGGA TCCTGGCCCG GGGGGAAAAC 
TTGGAACATC TCCGCAACAA GACAGAGGAT CTGGAAGCCA CATCTGAGCA CTTCAAGACG 
ACATCGCAGA AGGTGGCTCG AAAATTCTGG TGGAAGAACG TGAAGATGAT TGTCCTTATC 
TGCGTGATTG TTTTTATCAT CATCCTCTTC ATTGTGCTCT TTGCCACTGG TGCCTTCTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAMP8 ( XM_017005170.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016860659.1 Homo sapiens vesicle associated membrane protein 8 (VAMP8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu90027
Clone ID Related Accession (Same CDS sequence)	XM_017005170.1
Accession Version	XM_017005170.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 300bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	vesicle-associated membrane protein 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGAAG CCAGTGAAGG TGGAGGAAAT GATCGTGTGC GGAACCTGCA AAGTGAGGTG 
GAGGGAGTTA AGAATATTAT GACCCAGAAT GTGGAGCGGA TCCTGGCCCG GGGGGAAAAC 
TTGGAACATC TCCGCAACAA GACAGAGGAT CTGGAAGCCA CACCAGGGGC TGAGGCCAGC 
TGTTTCAGGG AGGAAGTAAC TCCAAAGTTG AGCAAAGTCT GGAGCCTCAA GTTCTGTGTT 
CAGCGGGGAG GCTGGCTCTG GCTTTCTGAG TCCTGTGTGA ACTCTTGGCT CTTGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016860659.1
CDS	113..412
Translation	MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATPGAEASCFREEVTPKLSKVWSLKFCVQRGGWLWLSESCVNSWLLV

Target ORF information:

RefSeq Version	XM_017005170.1
Organism	Homo sapiens(human)
Definition	Homo sapiens vesicle associated membrane protein 8 (VAMP8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005170.1

ORF Insert Sequence:

ATGGAGGAAG CCAGTGAAGG TGGAGGAAAT GATCGTGTGC GGAACCTGCA AAGTGAGGTG 
GAGGGAGTTA AGAATATTAT GACCCAGAAT GTGGAGCGGA TCCTGGCCCG GGGGGAAAAC 
TTGGAACATC TCCGCAACAA GACAGAGGAT CTGGAAGCCA CACCAGGGGC TGAGGCCAGC 
TGTTTCAGGG AGGAAGTAAC TCCAAAGTTG AGCAAAGTCT GGAGCCTCAA GTTCTGTGTT 
CAGCGGGGAG GCTGGCTCTG GCTTTCTGAG TCCTGTGTGA ACTCTTGGCT CTTGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.
The Journal of cell biology210(1)135-51(2015 Jul)
Marshall MR,Pattu V,Halimani M,Maier-Peuschel M,M?ller ML,Becherer U,Hong W,Hoth M,Tschernig T,Bryceson YT,Rettig J

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Nature520(7548)563-6(2015 Apr)
Diao J,Liu R,Rong Y,Zhao M,Zhang J,Lai Y,Zhou Q,Wilz LM,Li J,Vivona S,Pfuetzner RA,Brunger AT,Zhong Q

No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population.
International journal of clinical and experimental pathology8(5)5681-7(2015)
Zhou P,Zhang S,Chen H,Chen Y,Liu X,Sun B

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VAMP8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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