EVA1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EVA1A
Entrez Gene ID	84141
Full Name	eva-1 homolog A, regulator of programmed cell death
Synonyms	FAM176A,TMEM166
General protein information	Preferred Names eva-1 homolog A, regulator of programmed cell death Names protein eva-1 homolog A family with sequence similarity 176, member A protein FAM176A transmembrane protein 166
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135032.1	NP_001128504.1	protein eva-1 homolog A
NM_001135032.2	NP_001128504.1	protein eva-1 homolog A
NM_001369525.1	NP_001356454.1	protein eva-1 homolog A
NM_001369524.1	NP_001356453.1	protein eva-1 homolog A
NM_032181.2	NP_115557.1	protein eva-1 homolog A
NM_032181.3	NP_115557.1	protein eva-1 homolog A

Pathways from BioSystems

Homologies

	FAM176A	XP_001111854.2
Canis lupus familiaris (dog)	FAM176A	XP_005630565.1
Mus musculus (house mouse)	Eva1a	NP_663545.2
Pan troglodytes (chimpanzee)	FAM176A	XP_003949867.1
Bos taurus (cattle)	LOC528994	XP_002691320.2
Danio rerio (zebrafish)	eva1a	NP_001070055.2
Danio rerio (zebrafish)	LOC100331241	XP_002665825.2
Homo sapiens (human)	EVA1A	NP_001128504.1
Rattus norvegicus (Norway rat)	Eva1a	NP_001102713.1
Xenopus tropicalis (tropical clawed frog)	eva1a	NP_001096270.2

Gene Ontology
Bibliography

Related articles in PubMed

EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis.
Shen X, Kan S, Liu Z, Lu G, Zhang X, Chen Y, Bai Y
Experimental cell research352(1)130-138(2017 03)

TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death.
Hu J, Li G, Qu L, Li N, Liu W, Xia D, Hongdu B, Lin X, Xu C, Lou Y, He Q, Ma D, Chen Y
Cell death & disease7(8)e2323(2016 Aug)

CCAAT/enhancer binding protein ? predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma.
Lu GD, Ang YH, Zhou J, Tamilarasi J, Yan B, Lim YC, Srivastava S, Salto-Tellez M, Hui KM, Shen HM, Nguyen LN, Tan BC, Silver DL, Hooi SC
Hepatology (Baltimore, Md.)61(3)965-78(2015 Mar)

Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells.
Xie H, Hu J, Pan H, Lou Y, Lv P, Chen Y
BMB reports47(2)104-9(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low EVA1A expression is associated with glioblastoma.
Title: EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis.

EVA1A interacts with the WD repeats of ATG16L1 through its C-terminal and promotes ATG12-ATG5/ATG16L1 complex recruitment to the autophagic membrane and enhances the formation of the autophagosome.
Title: TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death.

The adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells.
Title: Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells.

TMEM166 expression was widely down-regulated in the cancer tissues.
Title: Expression of TMEM166 protein in human normal and tumor tissues.

Low TMEM166 mRNA and protein expression is associated with esophageal squamous cell carcinoma.
Title: Transmembrane protein 166 expression in esophageal squamous cell carcinoma in Xinjiang, China.

The following EVA1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EVA1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07233	NM_001135032.2 Latest version!	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07233	NM_001369525.1 Latest version!	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07233	NM_032181.3 Latest version!	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07233	NM_001369524.1 Latest version!	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu07233	NM_001135032.1	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07233	NM_032181.2	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EVA1A ( NM_001135032.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128504.1 Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07233
Clone ID Related Accession (Same CDS sequence)	NM_001135032.1 , NM_001135032.2 , NM_001369525.1 , NM_001369524.1 , NM_032181.2 , NM_032181.3
Accession Version	NM_001135032.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	protein eva-1 homolog A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP276065.1, BE892427.1, BC016157.1 and AW016395.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016157.1, BU526860.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968832, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END##

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128504.1
CDS	479..937
Translation	MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Target ORF information:

RefSeq Version	NM_001135032.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135032.1

ORF Insert Sequence:

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EVA1A ( NM_001135032.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128504.1 Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07233
Clone ID Related Accession (Same CDS sequence)	NM_001135032.1 , NM_001135032.2 , NM_001369525.1 , NM_001369524.1 , NM_032181.2 , NM_032181.3
Accession Version	NM_001135032.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	protein eva-1 homolog A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP276065.1, BE892427.1, BC016157.1 and AW016395.1. On Nov 22, 2018 this sequence version replaced NM_001135032.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016157.1, BU526860.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968832, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000393913.8/ ENSP00000377490.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128504.1
CDS	452..910
Translation	MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Target ORF information:

RefSeq Version	NM_001135032.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135032.2

ORF Insert Sequence:

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EVA1A ( NM_001369525.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001356454.1 Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu07233
Clone ID Related Accession (Same CDS sequence)	NM_001135032.1 , NM_001135032.2 , NM_001369525.1 , NM_001369524.1 , NM_032181.2 , NM_032181.3
Accession Version	NM_001369525.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	protein eva-1 homolog A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP276065.1, BE892427.1, BC063016.1 and AK023453.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI837841.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END##

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356454.1
CDS	540..998
Translation	MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Target ORF information:

RefSeq Version	NM_001369525.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369525.1

ORF Insert Sequence:

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EVA1A ( NM_001369524.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001356453.1 Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07233
Clone ID Related Accession (Same CDS sequence)	NM_001135032.1 , NM_001135032.2 , NM_001369525.1 , NM_001369524.1 , NM_032181.2 , NM_032181.3
Accession Version	NM_001369524.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	protein eva-1 homolog A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF247750.1, BC063016.1, BE892427.1 and AK023453.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063016.1, BI833486.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END##

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356453.1
CDS	593..1051
Translation	MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Target ORF information:

RefSeq Version	NM_001369524.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001369524.1

ORF Insert Sequence:

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EVA1A ( NM_032181.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115557.1 Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07233
Clone ID Related Accession (Same CDS sequence)	NM_001135032.1 , NM_001135032.2 , NM_001369525.1 , NM_001369524.1 , NM_032181.2 , NM_032181.3
Accession Version	NM_032181.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	protein eva-1 homolog A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK023453.1 and AW016395.1. On Sep 19, 2008 this sequence version replaced NM_032181.1. Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023453.1, BI761625.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142853 [ECO:0000350] ##Evidence-Data-END##

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115557.1
CDS	439..897
Translation	MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Target ORF information:

RefSeq Version	NM_032181.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032181.2

ORF Insert Sequence:

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EVA1A ( NM_032181.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115557.1 Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 2, mRNA.

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CloneID	OHu07233
Clone ID Related Accession (Same CDS sequence)	NM_001135032.1 , NM_001135032.2 , NM_001369525.1 , NM_001369524.1 , NM_032181.2 , NM_032181.3
Accession Version	NM_032181.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	protein eva-1 homolog A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK023453.1. On Apr 10, 2019 this sequence version replaced NM_032181.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023453.1, BI761625.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142853 [ECO:0000350] ##Evidence-Data-END##

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115557.1
CDS	436..894
Translation	MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

Target ORF information:

RefSeq Version	NM_032181.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eva-1 homolog A, regulator of programmed cell death (EVA1A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032181.3

ORF Insert Sequence:

ATGAGGCTGC CCCTCAGCCA CAGCCCAGAG CACGTGGAGA TGGCTTTGCT CAGCAACATC 
CTAGCGGCCT ATTCCTTTGT CTCAGAAAAT CCTGAGCGAG CAGCTCTGTA CTTTGTTTCT 
GGCGTGTGCA TCGGGCTGGT GCTGACCCTG GCTGCTCTGG TGATAAGGAT CTCTTGCCAC 
ACAGACTGCA GGCGGCGTCC CGGGAAGAAG TTCCTGCAGG ACAGAGAGAG CAGCAGCGAC 
AGCAGCGACA GCGAGGATGG CAGTGAGGAC ACCGTGTCCG ATCTCTCCGT GCGGAGACAC 
CGCCGCTTCG AGAGGACTTT GAACAAGAAT GTGTTCACCT CTGCGGAGGA GCTGGAGCGC 
GCCCAGCGGC TGGAGGAGCG CGAGCGCATC ATCAGGGAGA TCTGGATGAA TGGCCAGCCT 
GAGGTGCCCG GGACCAGGAG CCTGAATCGC TACTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis.
Experimental cell research352(1)130-138(2017 03)
Shen X,Kan S,Liu Z,Lu G,Zhang X,Chen Y,Bai Y

TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death.
Cell death & disease7(8)e2323(2016 Aug)
Hu J,Li G,Qu L,Li N,Liu W,Xia D,Hongdu B,Lin X,Xu C,Lou Y,He Q,Ma D,Chen Y

CCAAT/enhancer binding protein ? predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma.
Hepatology (Baltimore, Md.)61(3)965-78(2015 Mar)
Lu GD,Ang YH,Zhou J,Tamilarasi J,Yan B,Lim YC,Srivastava S,Salto-Tellez M,Hui KM,Shen HM,Nguyen LN,Tan BC,Silver DL,Hooi SC

Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells.
BMB reports47(2)104-9(2014 Feb)
Xie H,Hu J,Pan H,Lou Y,Lv P,Chen Y

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EVA1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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