CCDC8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCDC8
Entrez Gene ID	83987
Full Name	coiled-coil domain containing 8
Synonyms	3M3,PPP1R20,p90
General protein information	Preferred Names coiled-coil domain containing 8 Names coiled-coil domain-containing protein 8 protein phosphatase 1, regulatory subunit 20
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011].
Disorder MIM:	614145
Disorder Html:	3-M syndrome 3, 614205 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032040.4	NP_114429.2	coiled-coil domain-containing protein 8
NM_032040.5	NP_114429.2	coiled-coil domain-containing protein 8

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCDC8	XP_001167818.1
Canis lupus familiaris (dog)	CCDC8	XP_005616471.1
Bos taurus (cattle)	CCDC8	NP_001030562.2
Rattus norvegicus (Norway rat)	Ccdc8	NP_001009533.2
Homo sapiens (human)	CCDC8	NP_114429.2
	CCDC8	XP_001111790.1
Mus musculus (house mouse)	Ccdc8	NP_001095005.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-Wide Association Study of MKI67 Expression and its Clinical Implications in HBV-Related Hepatocellular Carcinoma in Southern China.
Yang CK, Yu TD, Han CY, Qin W, Liao XW, Yu L, Liu XG, Zhu GZ, Su H, Lu SC, Chen ZW, Liu Z, Huang KT, Liu ZT, Liang Y, Huang JL, Mo ZN, Qin X, Li L, Xiao KY, Peng MH, Winkle CA, O'Brien SJ, Peng T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1342-1357(2017)

Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells.
Jiang GY, Zhang XP, Zhang Y, Xu HT, Wang L, Li QC, Wang EH
Human pathology5664-73(2016 10)

Inhibition of HIV-1 assembly by coiled-coil domain containing protein 8 in human cells.
Wei M, Zhao X, Liu M, Huang Z, Xiao Y, Niu M, Shao Y, Kleiman L
Scientific reports514724(2015 Oct)

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.
Nie J, Xu C, Jin J, Aka JA, Tempel W, Nguyen V, You L, Weist R, Min J, Pawson T, Yang XJ
Structure (London, England : 1993)23(4)700-12(2015 Apr)

Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
Hanson D, Murray PG, Coulson T, Sud A, Omokanye A, Stratta E, Sakhinia F, Bonshek C, Wilson LC, Wakeling E, Temtamy SA, Aglan M, Rosser EM, Mansour S, Carcavilla A, Nampoothiri S, Khan WI, Banerjee I, Chandler KE, Black GC, Clayton PE
Journal of molecular endocrinology49(3)267-75(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Variants near TTN and CCDC8 were associated with KI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients.
Title: Genome-Wide Association Study of MKI67 Expression and its Clinical Implications in HBV-Related Hepatocellular Carcinoma in Southern China.

CCDC8 may suppress the invasion and metastasis of non-small cell lung cancer cells.
Title: Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells.

CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR
Title: Identifying biological pathways that underlie primordial short stature using network analysis.

The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development.
Title: The 3M complex maintains microtubule and genome integrity.

Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
Title: Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.

The following CCDC8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCDC8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20268	NM_032040.5 Latest version!	Homo sapiens coiled-coil domain containing 8 (CCDC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu20268	NM_032040.4	Homo sapiens coiled-coil domain containing 8 (CCDC8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCDC8 ( NM_032040.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_114429.2 Homo sapiens coiled-coil domain containing 8 (CCDC8), mRNA.

Price & Availability↑

CloneID	OHu20268
Clone ID Related Accession (Same CDS sequence)	NM_032040.4 , NM_032040.5
Accession Version	NM_032040.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG717344.1, JN703457.1, BC025243.1, AL136609.1 and AI301367.1. This sequence is a reference standard in the RefSeqGene project. On Dec 21, 2011 this sequence version replaced NM_032040.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCTGCAGA TCGGGGAGGA CGTCGACTAT TTGCTCATCC CCCGGGAGGT CAGGCTGGCT 
GGGGGCGTCT GGAGAGTCAT CTCTAAGCCC GCCACCAAGG AAGCAGAATT TCGGGAGCGG 
CTGACCCAGT TCCTGGAAGA AGAGGGCCGC ACCCTGGAGG ACGTGGCCCG CATCATGGAG 
AAGAGCACCC CGCACCCGCC CCAGCCCCCC AAAAAGCCCA AGGAGCCCCG AGTGAGGAGG 
AGAGTGCAGC AGATGGTGAC TCCTCCGCCC CGGCTGGTCG TGGGCACGTA CGACAGCAGC 
AACGCCAGCG ACAGCGAGTT CAGCGACTTC GAGACCTCCA GAGACAAGAG CCGCCAGGGC 
CCGCGGCGGG GCAAGAAGGT GCGCAAAATG CCCGTCAGCT ACCTGGGCAG CAAGTTCCTG 
GGAAGCGACC TGGAGAGTGA GGATGATGAG GAACTGGTCG AGGCCTTCCT CCGGCGACAG 
GAGAAGCAGC CCAGCGCGCC GCCTGCCCGC CGCCGCGTCA ACCTGCCAGT GCCCATGTTT 
GAGGACAACC TGGGGCCTCA GCTGTCCAAA GCGGACAGGT GGCGGGAGTA TGTCAGCCAG 
GTGTCCTGGG GGAAGCTGAA GCGGAGGGTG AAGGGTTGGG CGCCGAGGGC GGGCCCCGGG 
GTGGGCGAGG CCCGGCTGGC CTCCACCGCA GTGGAGAGCG CAGGGGTATC ATCGGCGCCA 
GAGGGCACCA GCCCGGGGGA TCGCTTGGGA AACGCGGGAG ATGTTTGTGT GCCCCAGGCT 
TCCCCTAGGC GATGGAGGCC CAAGATCAAC TGGGCCTCCT TTCGGCGCCG CAGGAAGGAG 
CAGACAGCAC CCACAGGTCA GGGGGCAGAC ATCGAGGCTG ATCAGGGGGG AGAGGCTGCA 
GATAGTCAAA GGGAAGAGGC CATAGCTGAC CAGCGGGAAG GGGCTGCAGG TAATCAGAGG 
GCAGGGGCCC CAGCTGACCA GGGGGCAGAG GCTGCAGATA ATCAGAGGGA AGAGGCTGCA 
GATAATCAGA GGGCAGGGGC CCCAGCTGAG GAGGGGGCAG AGGCTGCAGA TAACCAGAGG 
GAAGAGGCTG CAGATAATCA GAGGGCAGAG GCCCCAGCTG ACCAGAGGTC ACAGGGCACA 
GATAACCACA GGGAAGAGGC TGCAGATAAT CAGAGGGCGG AGGCCCCAGC TGACCAGGGG 
TCAGAGGTTA CAGATAATCA AAGGGAAGAG GCCGTACATG ACCAGAGGGA AAGGGCCCCA 
GCTGTCCAGG GTGCAGATAA TCAGAGGGCA CAGGCCCGGG CTGGCCAGAG GGCAGAGGCT 
GCACATAATC AGAGGGCAGG GGCCCCAGGT ATCCAGGAAG CTGAAGTCTC AGCTGCCCAA 
GGGACCACAG GAACAGCTCC AGGAGCCAGG GCCCGGAAAC AGGTCAAGAC AGTGAGGTTC 
CAGACCCCTG GACGCTTTTC GTGGTTTTGC AAGCGCCGGA GAGCCTTCTG GCACACTCCC 
CGGTTGCCAA CCCTGCCCAA GAGAGTCCCC AGGGCAGGAG AGGCCAGGAA CCTCAGGGTG 
CTGAGGGCCG AGGCCAGAGC AGAAGCTGAG CAGGGAGAGC AAGAAGACCA GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114429.2
CDS	853..2469
Translation	MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIMEKSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQGPRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMFEDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAPEGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL

Target ORF information:

RefSeq Version	NM_032040.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 8 (CCDC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032040.4

ORF Insert Sequence:

ATGCTGCAGA TCGGGGAGGA CGTCGACTAT TTGCTCATCC CCCGGGAGGT CAGGCTGGCT 
GGGGGCGTCT GGAGAGTCAT CTCTAAGCCC GCCACCAAGG AAGCAGAATT TCGGGAGCGG 
CTGACCCAGT TCCTGGAAGA AGAGGGCCGC ACCCTGGAGG ACGTGGCCCG CATCATGGAG 
AAGAGCACCC CGCACCCGCC CCAGCCCCCC AAAAAGCCCA AGGAGCCCCG AGTGAGGAGG 
AGAGTGCAGC AGATGGTGAC TCCTCCGCCC CGGCTGGTCG TGGGCACGTA CGACAGCAGC 
AACGCCAGCG ACAGCGAGTT CAGCGACTTC GAGACCTCCA GAGACAAGAG CCGCCAGGGC 
CCGCGGCGGG GCAAGAAGGT GCGCAAAATG CCCGTCAGCT ACCTGGGCAG CAAGTTCCTG 
GGAAGCGACC TGGAGAGTGA GGATGATGAG GAACTGGTCG AGGCCTTCCT CCGGCGACAG 
GAGAAGCAGC CCAGCGCGCC GCCTGCCCGC CGCCGCGTCA ACCTGCCAGT GCCCATGTTT 
GAGGACAACC TGGGGCCTCA GCTGTCCAAA GCGGACAGGT GGCGGGAGTA TGTCAGCCAG 
GTGTCCTGGG GGAAGCTGAA GCGGAGGGTG AAGGGTTGGG CGCCGAGGGC GGGCCCCGGG 
GTGGGCGAGG CCCGGCTGGC CTCCACCGCA GTGGAGAGCG CAGGGGTATC ATCGGCGCCA 
GAGGGCACCA GCCCGGGGGA TCGCTTGGGA AACGCGGGAG ATGTTTGTGT GCCCCAGGCT 
TCCCCTAGGC GATGGAGGCC CAAGATCAAC TGGGCCTCCT TTCGGCGCCG CAGGAAGGAG 
CAGACAGCAC CCACAGGTCA GGGGGCAGAC ATCGAGGCTG ATCAGGGGGG AGAGGCTGCA 
GATAGTCAAA GGGAAGAGGC CATAGCTGAC CAGCGGGAAG GGGCTGCAGG TAATCAGAGG 
GCAGGGGCCC CAGCTGACCA GGGGGCAGAG GCTGCAGATA ATCAGAGGGA AGAGGCTGCA 
GATAATCAGA GGGCAGGGGC CCCAGCTGAG GAGGGGGCAG AGGCTGCAGA TAACCAGAGG 
GAAGAGGCTG CAGATAATCA GAGGGCAGAG GCCCCAGCTG ACCAGAGGTC ACAGGGCACA 
GATAACCACA GGGAAGAGGC TGCAGATAAT CAGAGGGCGG AGGCCCCAGC TGACCAGGGG 
TCAGAGGTTA CAGATAATCA AAGGGAAGAG GCCGTACATG ACCAGAGGGA AAGGGCCCCA 
GCTGTCCAGG GTGCAGATAA TCAGAGGGCA CAGGCCCGGG CTGGCCAGAG GGCAGAGGCT 
GCACATAATC AGAGGGCAGG GGCCCCAGGT ATCCAGGAAG CTGAAGTCTC AGCTGCCCAA 
GGGACCACAG GAACAGCTCC AGGAGCCAGG GCCCGGAAAC AGGTCAAGAC AGTGAGGTTC 
CAGACCCCTG GACGCTTTTC GTGGTTTTGC AAGCGCCGGA GAGCCTTCTG GCACACTCCC 
CGGTTGCCAA CCCTGCCCAA GAGAGTCCCC AGGGCAGGAG AGGCCAGGAA CCTCAGGGTG 
CTGAGGGCCG AGGCCAGAGC AGAAGCTGAG CAGGGAGAGC AAGAAGACCA GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCDC8 ( NM_032040.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_114429.2 Homo sapiens coiled-coil domain containing 8 (CCDC8), mRNA.

Price & Availability↑

CloneID	OHu20268
Clone ID Related Accession (Same CDS sequence)	NM_032040.4 , NM_032040.5
Accession Version	NM_032040.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	coiled-coil domain-containing protein 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JN703457.1, BC025243.1, AL136609.1 and AI301367.1. On Jul 27, 2018 this sequence version replaced NM_032040.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: JN703457.1, AL136609.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307522.5/ ENSP00000303158.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCAGA TCGGGGAGGA CGTCGACTAT TTGCTCATCC CCCGGGAGGT CAGGCTGGCT 
GGGGGCGTCT GGAGAGTCAT CTCTAAGCCC GCCACCAAGG AAGCAGAATT TCGGGAGCGG 
CTGACCCAGT TCCTGGAAGA AGAGGGCCGC ACCCTGGAGG ACGTGGCCCG CATCATGGAG 
AAGAGCACCC CGCACCCGCC CCAGCCCCCC AAAAAGCCCA AGGAGCCCCG AGTGAGGAGG 
AGAGTGCAGC AGATGGTGAC TCCTCCGCCC CGGCTGGTCG TGGGCACGTA CGACAGCAGC 
AACGCCAGCG ACAGCGAGTT CAGCGACTTC GAGACCTCCA GAGACAAGAG CCGCCAGGGC 
CCGCGGCGGG GCAAGAAGGT GCGCAAAATG CCCGTCAGCT ACCTGGGCAG CAAGTTCCTG 
GGAAGCGACC TGGAGAGTGA GGATGATGAG GAACTGGTCG AGGCCTTCCT CCGGCGACAG 
GAGAAGCAGC CCAGCGCGCC GCCTGCCCGC CGCCGCGTCA ACCTGCCAGT GCCCATGTTT 
GAGGACAACC TGGGGCCTCA GCTGTCCAAA GCGGACAGGT GGCGGGAGTA TGTCAGCCAG 
GTGTCCTGGG GGAAGCTGAA GCGGAGGGTG AAGGGTTGGG CGCCGAGGGC GGGCCCCGGG 
GTGGGCGAGG CCCGGCTGGC CTCCACCGCA GTGGAGAGCG CAGGGGTATC ATCGGCGCCA 
GAGGGCACCA GCCCGGGGGA TCGCTTGGGA AACGCGGGAG ATGTTTGTGT GCCCCAGGCT 
TCCCCTAGGC GATGGAGGCC CAAGATCAAC TGGGCCTCCT TTCGGCGCCG CAGGAAGGAG 
CAGACAGCAC CCACAGGTCA GGGGGCAGAC ATCGAGGCTG ATCAGGGGGG AGAGGCTGCA 
GATAGTCAAA GGGAAGAGGC CATAGCTGAC CAGCGGGAAG GGGCTGCAGG TAATCAGAGG 
GCAGGGGCCC CAGCTGACCA GGGGGCAGAG GCTGCAGATA ATCAGAGGGA AGAGGCTGCA 
GATAATCAGA GGGCAGGGGC CCCAGCTGAG GAGGGGGCAG AGGCTGCAGA TAACCAGAGG 
GAAGAGGCTG CAGATAATCA GAGGGCAGAG GCCCCAGCTG ACCAGAGGTC ACAGGGCACA 
GATAACCACA GGGAAGAGGC TGCAGATAAT CAGAGGGCGG AGGCCCCAGC TGACCAGGGG 
TCAGAGGTTA CAGATAATCA AAGGGAAGAG GCCGTACATG ACCAGAGGGA AAGGGCCCCA 
GCTGTCCAGG GTGCAGATAA TCAGAGGGCA CAGGCCCGGG CTGGCCAGAG GGCAGAGGCT 
GCACATAATC AGAGGGCAGG GGCCCCAGGT ATCCAGGAAG CTGAAGTCTC AGCTGCCCAA 
GGGACCACAG GAACAGCTCC AGGAGCCAGG GCCCGGAAAC AGGTCAAGAC AGTGAGGTTC 
CAGACCCCTG GACGCTTTTC GTGGTTTTGC AAGCGCCGGA GAGCCTTCTG GCACACTCCC 
CGGTTGCCAA CCCTGCCCAA GAGAGTCCCC AGGGCAGGAG AGGCCAGGAA CCTCAGGGTG 
CTGAGGGCCG AGGCCAGAGC AGAAGCTGAG CAGGGAGAGC AAGAAGACCA GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114429.2
CDS	755..2371
Translation	MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIMEKSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQGPRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMFEDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAPEGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL

Target ORF information:

RefSeq Version	NM_032040.5
Organism	Homo sapiens(human)
Definition	Homo sapiens coiled-coil domain containing 8 (CCDC8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032040.5

ORF Insert Sequence:

ATGCTGCAGA TCGGGGAGGA CGTCGACTAT TTGCTCATCC CCCGGGAGGT CAGGCTGGCT 
GGGGGCGTCT GGAGAGTCAT CTCTAAGCCC GCCACCAAGG AAGCAGAATT TCGGGAGCGG 
CTGACCCAGT TCCTGGAAGA AGAGGGCCGC ACCCTGGAGG ACGTGGCCCG CATCATGGAG 
AAGAGCACCC CGCACCCGCC CCAGCCCCCC AAAAAGCCCA AGGAGCCCCG AGTGAGGAGG 
AGAGTGCAGC AGATGGTGAC TCCTCCGCCC CGGCTGGTCG TGGGCACGTA CGACAGCAGC 
AACGCCAGCG ACAGCGAGTT CAGCGACTTC GAGACCTCCA GAGACAAGAG CCGCCAGGGC 
CCGCGGCGGG GCAAGAAGGT GCGCAAAATG CCCGTCAGCT ACCTGGGCAG CAAGTTCCTG 
GGAAGCGACC TGGAGAGTGA GGATGATGAG GAACTGGTCG AGGCCTTCCT CCGGCGACAG 
GAGAAGCAGC CCAGCGCGCC GCCTGCCCGC CGCCGCGTCA ACCTGCCAGT GCCCATGTTT 
GAGGACAACC TGGGGCCTCA GCTGTCCAAA GCGGACAGGT GGCGGGAGTA TGTCAGCCAG 
GTGTCCTGGG GGAAGCTGAA GCGGAGGGTG AAGGGTTGGG CGCCGAGGGC GGGCCCCGGG 
GTGGGCGAGG CCCGGCTGGC CTCCACCGCA GTGGAGAGCG CAGGGGTATC ATCGGCGCCA 
GAGGGCACCA GCCCGGGGGA TCGCTTGGGA AACGCGGGAG ATGTTTGTGT GCCCCAGGCT 
TCCCCTAGGC GATGGAGGCC CAAGATCAAC TGGGCCTCCT TTCGGCGCCG CAGGAAGGAG 
CAGACAGCAC CCACAGGTCA GGGGGCAGAC ATCGAGGCTG ATCAGGGGGG AGAGGCTGCA 
GATAGTCAAA GGGAAGAGGC CATAGCTGAC CAGCGGGAAG GGGCTGCAGG TAATCAGAGG 
GCAGGGGCCC CAGCTGACCA GGGGGCAGAG GCTGCAGATA ATCAGAGGGA AGAGGCTGCA 
GATAATCAGA GGGCAGGGGC CCCAGCTGAG GAGGGGGCAG AGGCTGCAGA TAACCAGAGG 
GAAGAGGCTG CAGATAATCA GAGGGCAGAG GCCCCAGCTG ACCAGAGGTC ACAGGGCACA 
GATAACCACA GGGAAGAGGC TGCAGATAAT CAGAGGGCGG AGGCCCCAGC TGACCAGGGG 
TCAGAGGTTA CAGATAATCA AAGGGAAGAG GCCGTACATG ACCAGAGGGA AAGGGCCCCA 
GCTGTCCAGG GTGCAGATAA TCAGAGGGCA CAGGCCCGGG CTGGCCAGAG GGCAGAGGCT 
GCACATAATC AGAGGGCAGG GGCCCCAGGT ATCCAGGAAG CTGAAGTCTC AGCTGCCCAA 
GGGACCACAG GAACAGCTCC AGGAGCCAGG GCCCGGAAAC AGGTCAAGAC AGTGAGGTTC 
CAGACCCCTG GACGCTTTTC GTGGTTTTGC AAGCGCCGGA GAGCCTTCTG GCACACTCCC 
CGGTTGCCAA CCCTGCCCAA GAGAGTCCCC AGGGCAGGAG AGGCCAGGAA CCTCAGGGTG 
CTGAGGGCCG AGGCCAGAGC AGAAGCTGAG CAGGGAGAGC AAGAAGACCA GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-Wide Association Study of MKI67 Expression and its Clinical Implications in HBV-Related Hepatocellular Carcinoma in Southern China.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1342-1357(2017)
Yang CK,Yu TD,Han CY,Qin W,Liao XW,Yu L,Liu XG,Zhu GZ,Su H,Lu SC,Chen ZW,Liu Z,Huang KT,Liu ZT,Liang Y,Huang JL,Mo ZN,Qin X,Li L,Xiao KY,Peng MH,Winkle CA,O'Brien SJ,Peng T

Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells.
Human pathology5664-73(2016 10)
Jiang GY,Zhang XP,Zhang Y,Xu HT,Wang L,Li QC,Wang EH

Inhibition of HIV-1 assembly by coiled-coil domain containing protein 8 in human cells.
Scientific reports514724(2015 Oct)
Wei M,Zhao X,Liu M,Huang Z,Xiao Y,Niu M,Shao Y,Kleiman L

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.
Structure (London, England : 1993)23(4)700-12(2015 Apr)
Nie J,Xu C,Jin J,Aka JA,Tempel W,Nguyen V,You L,Weist R,Min J,Pawson T,Yang XJ

Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
Journal of molecular endocrinology49(3)267-75(2012 Dec)
Hanson D,Murray PG,Coulson T,Sud A,Omokanye A,Stratta E,Sakhinia F,Bonshek C,Wilson LC,Wakeling E,Temtamy SA,Aglan M,Rosser EM,Mansour S,Carcavilla A,Nampoothiri S,Khan WI,Banerjee I,Chandler KE,Black GC,Clayton PE

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CCDC8 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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