CAPN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAPN6
Entrez Gene ID	827
Full Name	calpain 6
Synonyms	CANPX,CAPNX,CalpM,DJ914P14.1
General protein information	Preferred Names calpain 6 Names calpain-6 calpain-like protease X-linked calpamodulin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq23
Summary	Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009].
Disorder MIM:	300146

mRNA and Protein(s)

mRNA	Protein	Name
NM_014289.4	NP_055104.2	calpain-6
NM_014289.3	NP_055104.2	calpain-6

Pathways from BioSystems

Homologies

Homo sapiens (human)	CAPN6	NP_055104.2
	LOC706434	XP_002808592.1
Canis lupus familiaris (dog)	CAPN6	XP_549188.2
Bos taurus (cattle)	CAPN6	NP_001179160.1
Rattus norvegicus (Norway rat)	Capn6	NP_113996.1
Gallus gallus (chicken)	CAPN6	XP_420313.2
Pan troglodytes (chimpanzee)	CAPN6	XP_001146965.1
Mus musculus (house mouse)	Capn6	NP_031629.3

Gene Ontology
Bibliography

Related articles in PubMed

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
The Journal of clinical investigation126(9)3417-32(2016 Sep)

miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.
Liu Y, Wang Y, Sun X, Mei C, Wang L, Li Z, Zha X
Oncotarget7(12)13491-501(2016 Mar)

Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
Marion A, Dieudonn? FX, Pati?o-Garcia A, Lecanda F, Marie PJ, Modrowski D
International journal of cancer130(11)2514-25(2012 Jun)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Family-based association study for bipolar affective disorder.
Secolin R, Banzato CE, Oliveira MC, Bittar MF, Santos ML, Dalgalarrondo P, Lopes-Cendes I
Psychiatric genetics20(3)126-9(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CAPN6 promotes atherogenicity in inflamed macrophages by disturbing CWC22/EJC systems.
Title: Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.

High CAPN6 expression is associated with liver cancer.
Title: miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.

syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6.
Title: Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Family-based association study for bipolar affective disorder.

The following CAPN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAPN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18668	NM_014289.4 Latest version!	Homo sapiens calpain 6 (CAPN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18668	NM_014289.3	Homo sapiens calpain 6 (CAPN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAPN6 ( NM_014289.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055104.2 Homo sapiens calpain 6 (CAPN6), mRNA.

Price & Availability↑

CloneID	OHu18668
Clone ID Related Accession (Same CDS sequence)	NM_014289.4 , NM_014289.3
Accession Version	NM_014289.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	calpain-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031117.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014289.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ000388.1, AF029232.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324068.2/ ENSP00000317214.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAATACC AGGAACTGAA GCAGGAATGC 
ATCAAAGACA GCAGACTTTT CTGTGATCCA ACATTTCTGC CTGAGAATGA TTCTCTTTTC 
TACAACCGAC TGCTTCCTGG AAAGGTGGTG TGGAAACGTC CCCAGGACAT CTGTGATGAC 
CCCCATCTGA TTGTGGGCAA CATTAGCAAC CACCAGCTGA CCCAAGGGAG ACTGGGGCAC 
AAGCCAATGG TTTCTGCATT TTCCTGTTTG GCTGTTCAGG AGTCTCATTG GACAAAGACA 
ATTCCCAACC ATAAGGAACA GGAATGGGAC CCTCAAAAAA CAGAAAAATA CGCTGGGATA 
TTTCACTTTC GTTTCTGGCA TTTTGGAGAA TGGACTGAAG TGGTGATTGA TGACTTGTTG 
CCCACCATTA ACGGAGATCT GGTCTTCTCT TTCTCCACTT CCATGAATGA GTTTTGGAAT 
GCTCTGCTGG AAAAAGCTTA TGCAAAGCTG CTAGGCTGTT ATGAGGCCCT GGATGGTTTG 
ACCATCACTG ATATTATTGT GGACTTCACG GGCACATTGG CTGAAACTGT TGACATGCAG 
AAAGGAAGAT ACACTGAGCT TGTTGAGGAG AAGTACAAGC TATTCGGAGA ACTGTACAAA 
ACATTTACCA AAGGTGGTCT GATCTGCTGT TCCATTGAGT CTCCCAATCA GGAGGAGCAA 
GAAGTTGAAA CTGATTGGGG TCTGCTGAAG GGCCATACCT ATACCATGAC TGATATTCGC 
AAAATTCGTC TTGGAGAGAG ACTTGTGGAA GTCTTCAGTG CTGAGAAGGT GTATATGGTT 
CGCCTGAGAA ACCCCTTGGG AAGACAGGAA TGGAGTGGCC CCTGGAGTGA AATTTCTGAA 
GAGTGGCAGC AACTGACTGC ATCAGATCGC AAGAACCTGG GGCTTGTTAT GTCTGATGAT 
GGAGAGTTTT GGATGAGCTT GGAGGACTTT TGCCGCAACT TTCACAAACT GAATGTCTGC 
CGCAATGTGA ACAACCCTAT TTTTGGCCGA AAGGAGCTGG AATCGGTGTT GGGATGCTGG 
ACTGTGGATG ATGATCCCCT GATGAACCGC TCAGGAGGCT GCTATAACAA CCGTGATACC 
TTCCTGCAGA ATCCCCAGTA CATCTTCACT GTGCCTGAGG ATGGGCACAA GGTCATTATG 
TCACTGCAGC AGAAGGACCT GCGCACTTAC CGCCGAATGG GAAGACCTGA CAATTACATC 
ATTGGCTTTG AGCTCTTCAA GGTGGAGATG AACCGCAAAT TCCGCCTCCA CCACCTCTAC 
ATCCAGGAGC GTGCTGGGAC TTCCACCTAT ATTGACACCC GCACAGTGTT TCTGAGCAAG 
TACCTGAAGA AGGGCAACTA TGTGCTTGTC CCAACCATGT TCCAGCATGG TCGCACCAGC 
GAGTTTCTCC TGAGAATCTT CTCTGAAGTG CCTGTCCAGC TCAGGGAACT GACTCTGGAC 
ATGCCCAAAA TGTCCTGCTG GAACCTGGCT CGTGGCTACC CGAAAGTAGT TACTCAGATC 
ACTGTTCACA GTGCTGAGGA CCTGGAGAAG AAGTATGCCA ATGAAACTGT AAACCCATAT 
TTGGTCATCA AATGTGGAAA GGAGGAAGTC CGTTCTCCTG TCCAGAAGAA TACAGTTCAT 
GCCATTTTTG ACACCCAGGC CATTTTCTAC AGAAGGACCA CTGACATTCC TATTATAGTA 
CAGGTCTGGA ACAGCCGAAA ATTCTGTGAT CAGTTCTTGG GGCAGGTTAC TCTGGATGCT 
GACCCCAGCG ACTGCCGTGA TCTGAAGTCT CTGTACCTGC GTAAGAAGGG TGGTCCAACT 
GCCAAAGTCA AGCAAGGCCA CATCAGCTTC AAGGTTATTT CCAGCGATGA TCTCACTGAG 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055104.2
CDS	129..2054
Translation	MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

Target ORF information:

RefSeq Version	NM_014289.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calpain 6 (CAPN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014289.4

ORF Insert Sequence:

ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAATACC AGGAACTGAA GCAGGAATGC 
ATCAAAGACA GCAGACTTTT CTGTGATCCA ACATTTCTGC CTGAGAATGA TTCTCTTTTC 
TACAACCGAC TGCTTCCTGG AAAGGTGGTG TGGAAACGTC CCCAGGACAT CTGTGATGAC 
CCCCATCTGA TTGTGGGCAA CATTAGCAAC CACCAGCTGA CCCAAGGGAG ACTGGGGCAC 
AAGCCAATGG TTTCTGCATT TTCCTGTTTG GCTGTTCAGG AGTCTCATTG GACAAAGACA 
ATTCCCAACC ATAAGGAACA GGAATGGGAC CCTCAAAAAA CAGAAAAATA CGCTGGGATA 
TTTCACTTTC GTTTCTGGCA TTTTGGAGAA TGGACTGAAG TGGTGATTGA TGACTTGTTG 
CCCACCATTA ACGGAGATCT GGTCTTCTCT TTCTCCACTT CCATGAATGA GTTTTGGAAT 
GCTCTGCTGG AAAAAGCTTA TGCAAAGCTG CTAGGCTGTT ATGAGGCCCT GGATGGTTTG 
ACCATCACTG ATATTATTGT GGACTTCACG GGCACATTGG CTGAAACTGT TGACATGCAG 
AAAGGAAGAT ACACTGAGCT TGTTGAGGAG AAGTACAAGC TATTCGGAGA ACTGTACAAA 
ACATTTACCA AAGGTGGTCT GATCTGCTGT TCCATTGAGT CTCCCAATCA GGAGGAGCAA 
GAAGTTGAAA CTGATTGGGG TCTGCTGAAG GGCCATACCT ATACCATGAC TGATATTCGC 
AAAATTCGTC TTGGAGAGAG ACTTGTGGAA GTCTTCAGTG CTGAGAAGGT GTATATGGTT 
CGCCTGAGAA ACCCCTTGGG AAGACAGGAA TGGAGTGGCC CCTGGAGTGA AATTTCTGAA 
GAGTGGCAGC AACTGACTGC ATCAGATCGC AAGAACCTGG GGCTTGTTAT GTCTGATGAT 
GGAGAGTTTT GGATGAGCTT GGAGGACTTT TGCCGCAACT TTCACAAACT GAATGTCTGC 
CGCAATGTGA ACAACCCTAT TTTTGGCCGA AAGGAGCTGG AATCGGTGTT GGGATGCTGG 
ACTGTGGATG ATGATCCCCT GATGAACCGC TCAGGAGGCT GCTATAACAA CCGTGATACC 
TTCCTGCAGA ATCCCCAGTA CATCTTCACT GTGCCTGAGG ATGGGCACAA GGTCATTATG 
TCACTGCAGC AGAAGGACCT GCGCACTTAC CGCCGAATGG GAAGACCTGA CAATTACATC 
ATTGGCTTTG AGCTCTTCAA GGTGGAGATG AACCGCAAAT TCCGCCTCCA CCACCTCTAC 
ATCCAGGAGC GTGCTGGGAC TTCCACCTAT ATTGACACCC GCACAGTGTT TCTGAGCAAG 
TACCTGAAGA AGGGCAACTA TGTGCTTGTC CCAACCATGT TCCAGCATGG TCGCACCAGC 
GAGTTTCTCC TGAGAATCTT CTCTGAAGTG CCTGTCCAGC TCAGGGAACT GACTCTGGAC 
ATGCCCAAAA TGTCCTGCTG GAACCTGGCT CGTGGCTACC CGAAAGTAGT TACTCAGATC 
ACTGTTCACA GTGCTGAGGA CCTGGAGAAG AAGTATGCCA ATGAAACTGT AAACCCATAT 
TTGGTCATCA AATGTGGAAA GGAGGAAGTC CGTTCTCCTG TCCAGAAGAA TACAGTTCAT 
GCCATTTTTG ACACCCAGGC CATTTTCTAC AGAAGGACCA CTGACATTCC TATTATAGTA 
CAGGTCTGGA ACAGCCGAAA ATTCTGTGAT CAGTTCTTGG GGCAGGTTAC TCTGGATGCT 
GACCCCAGCG ACTGCCGTGA TCTGAAGTCT CTGTACCTGC GTAAGAAGGG TGGTCCAACT 
GCCAAAGTCA AGCAAGGCCA CATCAGCTTC AAGGTTATTT CCAGCGATGA TCTCACTGAG 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAPN6 ( NM_014289.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055104.2 Homo sapiens calpain 6 (CAPN6), mRNA.

Price & Availability↑

CloneID	OHu18668
Clone ID Related Accession (Same CDS sequence)	NM_014289.4 , NM_014289.3
Accession Version	NM_014289.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	calpain-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA863483.1, BC000730.2 and AA368247.1. This sequence is a reference standard in the RefSeqGene project. On Nov 18, 2009 this sequence version replaced NM_014289.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ000388.1, AF029232.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAATACC AGGAACTGAA GCAGGAATGC 
ATCAAAGACA GCAGACTTTT CTGTGATCCA ACATTTCTGC CTGAGAATGA TTCTCTTTTC 
TACAACCGAC TGCTTCCTGG AAAGGTGGTG TGGAAACGTC CCCAGGACAT CTGTGATGAC 
CCCCATCTGA TTGTGGGCAA CATTAGCAAC CACCAGCTGA CCCAAGGGAG ACTGGGGCAC 
AAGCCAATGG TTTCTGCATT TTCCTGTTTG GCTGTTCAGG AGTCTCATTG GACAAAGACA 
ATTCCCAACC ATAAGGAACA GGAATGGGAC CCTCAAAAAA CAGAAAAATA CGCTGGGATA 
TTTCACTTTC GTTTCTGGCA TTTTGGAGAA TGGACTGAAG TGGTGATTGA TGACTTGTTG 
CCCACCATTA ACGGAGATCT GGTCTTCTCT TTCTCCACTT CCATGAATGA GTTTTGGAAT 
GCTCTGCTGG AAAAAGCTTA TGCAAAGCTG CTAGGCTGTT ATGAGGCCCT GGATGGTTTG 
ACCATCACTG ATATTATTGT GGACTTCACG GGCACATTGG CTGAAACTGT TGACATGCAG 
AAAGGAAGAT ACACTGAGCT TGTTGAGGAG AAGTACAAGC TATTCGGAGA ACTGTACAAA 
ACATTTACCA AAGGTGGTCT GATCTGCTGT TCCATTGAGT CTCCCAATCA GGAGGAGCAA 
GAAGTTGAAA CTGATTGGGG TCTGCTGAAG GGCCATACCT ATACCATGAC TGATATTCGC 
AAAATTCGTC TTGGAGAGAG ACTTGTGGAA GTCTTCAGTG CTGAGAAGGT GTATATGGTT 
CGCCTGAGAA ACCCCTTGGG AAGACAGGAA TGGAGTGGCC CCTGGAGTGA AATTTCTGAA 
GAGTGGCAGC AACTGACTGC ATCAGATCGC AAGAACCTGG GGCTTGTTAT GTCTGATGAT 
GGAGAGTTTT GGATGAGCTT GGAGGACTTT TGCCGCAACT TTCACAAACT GAATGTCTGC 
CGCAATGTGA ACAACCCTAT TTTTGGCCGA AAGGAGCTGG AATCGGTGTT GGGATGCTGG 
ACTGTGGATG ATGATCCCCT GATGAACCGC TCAGGAGGCT GCTATAACAA CCGTGATACC 
TTCCTGCAGA ATCCCCAGTA CATCTTCACT GTGCCTGAGG ATGGGCACAA GGTCATTATG 
TCACTGCAGC AGAAGGACCT GCGCACTTAC CGCCGAATGG GAAGACCTGA CAATTACATC 
ATTGGCTTTG AGCTCTTCAA GGTGGAGATG AACCGCAAAT TCCGCCTCCA CCACCTCTAC 
ATCCAGGAGC GTGCTGGGAC TTCCACCTAT ATTGACACCC GCACAGTGTT TCTGAGCAAG 
TACCTGAAGA AGGGCAACTA TGTGCTTGTC CCAACCATGT TCCAGCATGG TCGCACCAGC 
GAGTTTCTCC TGAGAATCTT CTCTGAAGTG CCTGTCCAGC TCAGGGAACT GACTCTGGAC 
ATGCCCAAAA TGTCCTGCTG GAACCTGGCT CGTGGCTACC CGAAAGTAGT TACTCAGATC 
ACTGTTCACA GTGCTGAGGA CCTGGAGAAG AAGTATGCCA ATGAAACTGT AAACCCATAT 
TTGGTCATCA AATGTGGAAA GGAGGAAGTC CGTTCTCCTG TCCAGAAGAA TACAGTTCAT 
GCCATTTTTG ACACCCAGGC CATTTTCTAC AGAAGGACCA CTGACATTCC TATTATAGTA 
CAGGTCTGGA ACAGCCGAAA ATTCTGTGAT CAGTTCTTGG GGCAGGTTAC TCTGGATGCT 
GACCCCAGCG ACTGCCGTGA TCTGAAGTCT CTGTACCTGC GTAAGAAGGG TGGTCCAACT 
GCCAAAGTCA AGCAAGGCCA CATCAGCTTC AAGGTTATTT CCAGCGATGA TCTCACTGAG 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055104.2
CDS	192..2117
Translation	MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

Target ORF information:

RefSeq Version	NM_014289.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calpain 6 (CAPN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014289.3

ORF Insert Sequence:

ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAATACC AGGAACTGAA GCAGGAATGC 
ATCAAAGACA GCAGACTTTT CTGTGATCCA ACATTTCTGC CTGAGAATGA TTCTCTTTTC 
TACAACCGAC TGCTTCCTGG AAAGGTGGTG TGGAAACGTC CCCAGGACAT CTGTGATGAC 
CCCCATCTGA TTGTGGGCAA CATTAGCAAC CACCAGCTGA CCCAAGGGAG ACTGGGGCAC 
AAGCCAATGG TTTCTGCATT TTCCTGTTTG GCTGTTCAGG AGTCTCATTG GACAAAGACA 
ATTCCCAACC ATAAGGAACA GGAATGGGAC CCTCAAAAAA CAGAAAAATA CGCTGGGATA 
TTTCACTTTC GTTTCTGGCA TTTTGGAGAA TGGACTGAAG TGGTGATTGA TGACTTGTTG 
CCCACCATTA ACGGAGATCT GGTCTTCTCT TTCTCCACTT CCATGAATGA GTTTTGGAAT 
GCTCTGCTGG AAAAAGCTTA TGCAAAGCTG CTAGGCTGTT ATGAGGCCCT GGATGGTTTG 
ACCATCACTG ATATTATTGT GGACTTCACG GGCACATTGG CTGAAACTGT TGACATGCAG 
AAAGGAAGAT ACACTGAGCT TGTTGAGGAG AAGTACAAGC TATTCGGAGA ACTGTACAAA 
ACATTTACCA AAGGTGGTCT GATCTGCTGT TCCATTGAGT CTCCCAATCA GGAGGAGCAA 
GAAGTTGAAA CTGATTGGGG TCTGCTGAAG GGCCATACCT ATACCATGAC TGATATTCGC 
AAAATTCGTC TTGGAGAGAG ACTTGTGGAA GTCTTCAGTG CTGAGAAGGT GTATATGGTT 
CGCCTGAGAA ACCCCTTGGG AAGACAGGAA TGGAGTGGCC CCTGGAGTGA AATTTCTGAA 
GAGTGGCAGC AACTGACTGC ATCAGATCGC AAGAACCTGG GGCTTGTTAT GTCTGATGAT 
GGAGAGTTTT GGATGAGCTT GGAGGACTTT TGCCGCAACT TTCACAAACT GAATGTCTGC 
CGCAATGTGA ACAACCCTAT TTTTGGCCGA AAGGAGCTGG AATCGGTGTT GGGATGCTGG 
ACTGTGGATG ATGATCCCCT GATGAACCGC TCAGGAGGCT GCTATAACAA CCGTGATACC 
TTCCTGCAGA ATCCCCAGTA CATCTTCACT GTGCCTGAGG ATGGGCACAA GGTCATTATG 
TCACTGCAGC AGAAGGACCT GCGCACTTAC CGCCGAATGG GAAGACCTGA CAATTACATC 
ATTGGCTTTG AGCTCTTCAA GGTGGAGATG AACCGCAAAT TCCGCCTCCA CCACCTCTAC 
ATCCAGGAGC GTGCTGGGAC TTCCACCTAT ATTGACACCC GCACAGTGTT TCTGAGCAAG 
TACCTGAAGA AGGGCAACTA TGTGCTTGTC CCAACCATGT TCCAGCATGG TCGCACCAGC 
GAGTTTCTCC TGAGAATCTT CTCTGAAGTG CCTGTCCAGC TCAGGGAACT GACTCTGGAC 
ATGCCCAAAA TGTCCTGCTG GAACCTGGCT CGTGGCTACC CGAAAGTAGT TACTCAGATC 
ACTGTTCACA GTGCTGAGGA CCTGGAGAAG AAGTATGCCA ATGAAACTGT AAACCCATAT 
TTGGTCATCA AATGTGGAAA GGAGGAAGTC CGTTCTCCTG TCCAGAAGAA TACAGTTCAT 
GCCATTTTTG ACACCCAGGC CATTTTCTAC AGAAGGACCA CTGACATTCC TATTATAGTA 
CAGGTCTGGA ACAGCCGAAA ATTCTGTGAT CAGTTCTTGG GGCAGGTTAC TCTGGATGCT 
GACCCCAGCG ACTGCCGTGA TCTGAAGTCT CTGTACCTGC GTAAGAAGGG TGGTCCAACT 
GCCAAAGTCA AGCAAGGCCA CATCAGCTTC AAGGTTATTT CCAGCGATGA TCTCACTGAG 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
The Journal of clinical investigation126(9)3417-32(2016 Sep)
Miyazaki T,Tonami K,Hata S,Aiuchi T,Ohnishi K,Lei XF,Kim-Kaneyama JR,Takeya M,Itabe H,Sorimachi H,Kurihara H,Miyazaki A

miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.
Oncotarget7(12)13491-501(2016 Mar)
Liu Y,Wang Y,Sun X,Mei C,Wang L,Li Z,Zha X

Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
International journal of cancer130(11)2514-25(2012 Jun)
Marion A,Dieudonn? FX,Pati?o-Garcia A,Lecanda F,Marie PJ,Modrowski D

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Family-based association study for bipolar affective disorder.
Psychiatric genetics20(3)126-9(2010 Jun)
Secolin R,Banzato CE,Oliveira MC,Bittar MF,Santos ML,Dalgalarrondo P,Lopes-Cendes I

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