Capn6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Capn6
Entrez Gene ID	12338
Full Name	calpain 6
General protein information	Preferred Names calpain 6 Names calpain-6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X F2

mRNA and Protein(s)

mRNA	Protein	Name
NM_007603.3	NP_031629.3	calpain-6

Pathways from BioSystems

Homologies

Homo sapiens (human)	CAPN6	NP_055104.2
	LOC706434	XP_002808592.1
Canis lupus familiaris (dog)	CAPN6	XP_549188.2
Bos taurus (cattle)	CAPN6	NP_001179160.1
Rattus norvegicus (Norway rat)	Capn6	NP_113996.1
Gallus gallus (chicken)	CAPN6	XP_420313.2
Pan troglodytes (chimpanzee)	CAPN6	XP_001146965.1
Mus musculus (house mouse)	Capn6	NP_031629.3

Gene Ontology
Bibliography

Related articles in PubMed

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
The Journal of clinical investigation126(9)3417-32(2016 Sep)

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A
Angiogenesis19(1)53-65(2016 Jan)

Sall1 balances self-renewal and differentiation of renal progenitor cells.
Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M
Development (Cambridge, England)141(5)1047-58(2014 Mar)

Calpain-6 deficiency promotes skeletal muscle development and regeneration.
Tonami K, Hata S, Ojima K, Ono Y, Kurihara Y, Amano T, Sato T, Kawamura Y, Kurihara H, Sorimachi H
PLoS genetics9(8)e1003668(2013)

Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.
Dear TN, Boehm T
Mechanisms of development89(1-2)201-9(1999 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CAPN6 promotes atherogenicity in inflamed macrophages by disturbing CWC22/EJC systems.
Title: Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.

These results collectively showed that a loss of CAPN6 promotes skeletal muscle differentiation during both development and regeneration, suggesting a novel physiological function of CAPN6 as a suppressor of skeletal muscle differentiation.
Title: Calpain-6 deficiency promotes skeletal muscle development and regeneration.

CAPN6 acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.
Title: Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1.

Capn6 promotes cytoskeletal organization and microtubule stability in osteoclasts.
Title: Calpain-6, a target molecule of glucocorticoids, regulates osteoclastic bone resorption via cytoskeletal organization and microtubule acetylation.

Capn6 is a microtubule-stabilizing protein expressed in embryonic tissues that may be involved in the regulation of microtubule dynamics and cytoskeletal organization.
Title: Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.

The following Capn6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Capn6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14861	NM_007603.3 Latest version!	Mus musculus calpain 6 (Capn6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Capn6 ( NM_007603.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031629.3 Mus musculus calpain 6 (Capn6), mRNA.

Price & Availability↑

CloneID	OMu14861
Clone ID Related Accession (Same CDS sequence)	NM_007603.3
Accession Version	NM_007603.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	calpain-6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN700442.1, BC052167.1 and AK145116.1. On Oct 6, 2007 this sequence version replaced NM_007603.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052167.1, AK145116.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAGTACC AAGAACTGAA GCAGGAGTGC 
ATGAAGGATG GCCGCCTTTT CTGTGACCCA ACCTTCCTAC CGGAGAATGA TTCTCTGTTT 
TTCAACCGGC TGCTTCCTGG GAAGGTGGTG TGGAAGCGTC CACAGGACAT TTCTGATGAC 
CCCCACCTGA TTGTGGGCAA CATCAGCAAC CACCAGCTGA TCCAGGGCAG ATTGGGGAAC 
AAGGCAATGA TCTCTGCATT TTCCTGTTTG GCTGTTCAGG AGTCACACTG GACAAAGGCA 
ATTCCCAACC ACAAGGATCA GGAATGGGAT CCTCGAAAGC CAGAGAAATA CGCTGGAATC 
TTTCACTTCC GCTTCTGGCA TTTTGGAGAA TGGACCGAGG TGGTGATTGA TGACTTGCTT 
CCCACCATCA ACGGAGATCT GGTCTTCTCA TTCTCCACCT CCATGAATGA GTTTTGGAAT 
GCTCTACTGG AAAAAGCGTA TGCAAAGCTG CTGGGCTGTT ATGAGGCTTT GGATGGTCTG 
ACCATCACTG ATATCATCAT GGACTTCACT GGCACACTGG CTGAAATCAT TGACATGCAG 
AAAGGACGAT ACACTGATCT TGTTGAGGAG AAGTACAAGC TGTTTGGAGA ACTGTACAAA 
ACGTTCACCA AAGGAGGTCT AATTTGCTGC TCCATTGAGT CTCCCAGCCA GGAGGAACAA 
GAAGTTGAAA CAGACTGGGG ACTACTGAAG GGTTATACCT ACACCATGAC TGATATTCGC 
AAGCTCCGTC TCGGAGAAAG ACTTGTGGAA GTCTTCAGTA CTGAGAAGCT GTATATGGTT 
CGCCTAAGGA ACCCATTGGG AAGACAGGAA TGGAGTGGCC CCTGGAGTGA AATTTCAGAG 
GAGTGGCAGC AACTGACTGT AACAGATCGC AAGAACCTAG GACTTGTTAT GTCTGATGAT 
GGAGAATTTT GGATGAGTCT GGAAGATTTT TGCCACAACT TTCACAAACT GAATGTCTGC 
CGCAATGTGA ATAATCCTGT TTTTGGCCGC AAGGAGCTGG AATCAGTGGT GGGATGTTGG 
ACTGTGGATG ATGACCCTCT GATGAACCGA TCAGGAGGTT GCTATAACAA CCGTGATACC 
TTCTTGCAGA ATCCTCAGTA CATTTTCACT GTGCCCGAGG ATGGCCATAA AGTCATCATG 
TCACTGCAAC AGAAGGACCT ACGCACTTAC CGCCGAATGG GAAGACCTGA TAATTACATC 
ATTGGTTTTG AGCTCTTCAA GGTGGAGATG AACCGAAGGT TCCGTCTTCA CCATCTGTAT 
ATTCAGGAGC GTGCTGGGAC TTCCACTTAT ATCGACACCC GTACTGTGTT TCTGAGCAAG 
TATCTGAAGA AGGGCAGCTA CGTGCTTGTT CCAACCATGT TCCAACATGG CCGTACCAGT 
GAATTTCTGC TGAGGATCTT CTCTGAAGTG CCCGTCCAGC TCAGGGAACT GACCTTGGAC 
ATGCCCAAGA TGTCTTGCTG GAACCTGGCA CGTGGCTACC CAAAGGTGGT TACCCAGATC 
ACTGTCCACA GTGCTGAGGG CCTGGAGAAG AAGTATGCCA ATGAAACTGT CAATCCATAT 
CTGATCATCA AATGTGGAAA GGAGGAAGTC CGTTCCCCTG TCCAGAAGAA TACTGTGCAT 
GCCATTTTTG ACACGCAGGC CATTTTCTAC AGAAGGACCA CTGACATTCC TATTATCATC 
CAGGTGTGGA ACAGCAGAAA ATTCTGTGAT CAGTTCCTGG GGCAGGTTAC TCTCGATGCT 
GACCCCAGCG ACTGCCGTGA TCTGAAATCT CTGTACCTGC GTAAGAAGGG TGGTCCTACT 
GCCAAAGTCA AGCAAGGTCA CATCAGCTTC AAAGTTATCT CTAGCGATGA TCTCACTGAG 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031629.3
CDS	221..2146
Translation	MGPPLKLFKNQKYQELKQECMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIVGNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKDQEWDPRKPEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDWGLLKGYTYTMTDIRKLRLGERLVEVFSTEKLYMVRLRNPLGRQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

Target ORF information:

RefSeq Version	NM_007603.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus calpain 6 (Capn6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007603.3

ORF Insert Sequence:

ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAGTACC AAGAACTGAA GCAGGAGTGC 
ATGAAGGATG GCCGCCTTTT CTGTGACCCA ACCTTCCTAC CGGAGAATGA TTCTCTGTTT 
TTCAACCGGC TGCTTCCTGG GAAGGTGGTG TGGAAGCGTC CACAGGACAT TTCTGATGAC 
CCCCACCTGA TTGTGGGCAA CATCAGCAAC CACCAGCTGA TCCAGGGCAG ATTGGGGAAC 
AAGGCAATGA TCTCTGCATT TTCCTGTTTG GCTGTTCAGG AGTCACACTG GACAAAGGCA 
ATTCCCAACC ACAAGGATCA GGAATGGGAT CCTCGAAAGC CAGAGAAATA CGCTGGAATC 
TTTCACTTCC GCTTCTGGCA TTTTGGAGAA TGGACCGAGG TGGTGATTGA TGACTTGCTT 
CCCACCATCA ACGGAGATCT GGTCTTCTCA TTCTCCACCT CCATGAATGA GTTTTGGAAT 
GCTCTACTGG AAAAAGCGTA TGCAAAGCTG CTGGGCTGTT ATGAGGCTTT GGATGGTCTG 
ACCATCACTG ATATCATCAT GGACTTCACT GGCACACTGG CTGAAATCAT TGACATGCAG 
AAAGGACGAT ACACTGATCT TGTTGAGGAG AAGTACAAGC TGTTTGGAGA ACTGTACAAA 
ACGTTCACCA AAGGAGGTCT AATTTGCTGC TCCATTGAGT CTCCCAGCCA GGAGGAACAA 
GAAGTTGAAA CAGACTGGGG ACTACTGAAG GGTTATACCT ACACCATGAC TGATATTCGC 
AAGCTCCGTC TCGGAGAAAG ACTTGTGGAA GTCTTCAGTA CTGAGAAGCT GTATATGGTT 
CGCCTAAGGA ACCCATTGGG AAGACAGGAA TGGAGTGGCC CCTGGAGTGA AATTTCAGAG 
GAGTGGCAGC AACTGACTGT AACAGATCGC AAGAACCTAG GACTTGTTAT GTCTGATGAT 
GGAGAATTTT GGATGAGTCT GGAAGATTTT TGCCACAACT TTCACAAACT GAATGTCTGC 
CGCAATGTGA ATAATCCTGT TTTTGGCCGC AAGGAGCTGG AATCAGTGGT GGGATGTTGG 
ACTGTGGATG ATGACCCTCT GATGAACCGA TCAGGAGGTT GCTATAACAA CCGTGATACC 
TTCTTGCAGA ATCCTCAGTA CATTTTCACT GTGCCCGAGG ATGGCCATAA AGTCATCATG 
TCACTGCAAC AGAAGGACCT ACGCACTTAC CGCCGAATGG GAAGACCTGA TAATTACATC 
ATTGGTTTTG AGCTCTTCAA GGTGGAGATG AACCGAAGGT TCCGTCTTCA CCATCTGTAT 
ATTCAGGAGC GTGCTGGGAC TTCCACTTAT ATCGACACCC GTACTGTGTT TCTGAGCAAG 
TATCTGAAGA AGGGCAGCTA CGTGCTTGTT CCAACCATGT TCCAACATGG CCGTACCAGT 
GAATTTCTGC TGAGGATCTT CTCTGAAGTG CCCGTCCAGC TCAGGGAACT GACCTTGGAC 
ATGCCCAAGA TGTCTTGCTG GAACCTGGCA CGTGGCTACC CAAAGGTGGT TACCCAGATC 
ACTGTCCACA GTGCTGAGGG CCTGGAGAAG AAGTATGCCA ATGAAACTGT CAATCCATAT 
CTGATCATCA AATGTGGAAA GGAGGAAGTC CGTTCCCCTG TCCAGAAGAA TACTGTGCAT 
GCCATTTTTG ACACGCAGGC CATTTTCTAC AGAAGGACCA CTGACATTCC TATTATCATC 
CAGGTGTGGA ACAGCAGAAA ATTCTGTGAT CAGTTCCTGG GGCAGGTTAC TCTCGATGCT 
GACCCCAGCG ACTGCCGTGA TCTGAAATCT CTGTACCTGC GTAAGAAGGG TGGTCCTACT 
GCCAAAGTCA AGCAAGGTCA CATCAGCTTC AAAGTTATCT CTAGCGATGA TCTCACTGAG 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
The Journal of clinical investigation126(9)3417-32(2016 Sep)
Miyazaki T,Tonami K,Hata S,Aiuchi T,Ohnishi K,Lei XF,Kim-Kaneyama JR,Takeya M,Itabe H,Sorimachi H,Kurihara H,Miyazaki A

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Angiogenesis19(1)53-65(2016 Jan)
Janssen L,Dupont L,Bekhouche M,Noel A,Leduc C,Voz M,Peers B,Cataldo D,Apte SS,Dubail J,Colige A

Sall1 balances self-renewal and differentiation of renal progenitor cells.
Development (Cambridge, England)141(5)1047-58(2014 Mar)
Basta JM,Robbins L,Kiefer SM,Dorsett D,Rauchman M

Calpain-6 deficiency promotes skeletal muscle development and regeneration.
PLoS genetics9(8)e1003668(2013)
Tonami K,Hata S,Ojima K,Ono Y,Kurihara Y,Amano T,Sato T,Kawamura Y,Kurihara H,Sorimachi H

Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.
Mechanisms of development89(1-2)201-9(1999 Dec)
Dear TN,Boehm T

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Capn6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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