NECTIN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NECTIN4
Entrez Gene ID	81607
Full Name	nectin cell adhesion molecule 4
Synonyms	EDSS1,LNIR,PRR4,PVRL4,nectin-4
General protein information	Preferred Names nectin cell adhesion molecule 4 Names nectin-4 Ig superfamily receptor LNIR nectin 4 poliovirus receptor-related 4 poliovirus receptor-related protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].
Disorder MIM:	609607
Disorder Html:	Ectodermal dysplasia-syndactyly syndrome 1, 613573 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011510023.1	XP_011508325.1	nectin-4 isoform X4
XM_011510022.2	XP_011508324.1	nectin-4 isoform X2
NM_030916.2	NP_112178.2	nectin-4 precursor
XM_011510021.2	XP_011508323.1	nectin-4 isoform X1
XM_005245508.3	XP_005245565.1	nectin-4 isoform X3
NM_030916.3	NP_112178.2	nectin-4 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PVRL4	XP_005641000.1
Mus musculus (house mouse)	Pvrl4	NP_082169.2
	PVRL4	XP_001117709.1
Rattus norvegicus (Norway rat)	Pvrl4	NP_001102546.1
Bos taurus (cattle)	PVRL4	NP_001019665.1
Danio rerio (zebrafish)	LOC560512	XP_005172277.1
Homo sapiens (human)	PVRL4	NP_112178.2
Pan troglodytes (chimpanzee)	PVRL4	XP_003308602.1
Danio rerio (zebrafish)	pvrl4	XP_001334985.4

Gene Ontology
Bibliography

Related articles in PubMed

Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway.
Zhang Y, Chen P, Yin W, Ji Y, Shen Q, Ni Q
Human pathology(2017 Dec)

Prognostic role of Nectin-4 expression in luminal B (HER2 negative) breast cancer.
Rajc J, Gugi? D, Fr?hlich I, Marjanovi? K, Dumen?i? B
Pathology, research and practice213(9)1102-1108(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nectin-4 is not only a BCSC marker but also a breast cancer metastasis marker
Title: Nectin-4 is a breast cancer stem cell marker that induces WNT/?-catenin signaling via Pi3k/Akt axis.

We show that Measles virus gains entry into MCF7, DLD-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase and kinase involved.
Title: Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway.

Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers
Title: Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer.

ADAM17 and ADAM10 cleave Nectin-4 and release soluble Nectin-4 (sN4).
Title: Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17.

nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway
Title: Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.

The following NECTIN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NECTIN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28639	NM_030916.3 Latest version!	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu34722	XM_005245508.3 Latest version!	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu72944	XM_011510022.2 Latest version!	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu72945	XM_011510023.1 Latest version!	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu72943	XM_011510021.2 Latest version!	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu28639	NM_030916.2	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NECTIN4 ( NM_030916.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_112178.2 Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), mRNA.

Price & Availability↑

CloneID	OHu28639
Clone ID Related Accession (Same CDS sequence)	NM_030916.2 , NM_030916.3
Accession Version	NM_030916.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1533bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-29
Organism	Homo sapiens(human)
Product	nectin-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB223835.1, BC010423.1, BC013892.2 and CF529301.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2009 this sequence version replaced NM_030916.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB105191.1, AK027753.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END##

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG ACCCCCAGGA AGACTCTGGG 
AAGCAGGTGG ACCTAGTGTC AGCCTCGGTG GTGGTGGTGG GTGTGATCGC CGCACTCTTG 
TTCTGCCTTC TGGTGGTGGT GGTGGTGCTC ATGTCCCGAT ACCATCGGCG CAAGGCCCAG 
CAGATGACCC AGAAATATGA GGAGGAGCTG ACCCTGACCA GGGAGAACTC CATCCGGAGG 
CTGCATTCCC ATCACACGGA CCCCAGGAGC CAGCCGGAGG AGAGTGTAGG GCTGAGAGCC 
GAGGGCCACC CTGATAGTCT CAAGGACAAC AGTAGCTGCT CTGTGATGAG TGAAGAGCCC 
GAGGGCCGCA GTTACTCCAC GCTGACCACG GTGAGGGAGA TAGAAACACA GACTGAACTG 
CTGTCTCCAG GCTCTGGGCG GGCCGAGGAG GAGGAAGATC AGGATGAAGG CATCAAACAG 
GCCATGAACC ATTTTGTTCA GGAGAATGGG ACCCTACGGG CCAAGCCCAC GGGCAATGGC 
ATCTACATCA ATGGGCGGGG ACACCTGGTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112178.2
CDS	300..1832
Translation	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Target ORF information:

RefSeq Version	NM_030916.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030916.2

ORF Insert Sequence:

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG ACCCCCAGGA AGACTCTGGG 
AAGCAGGTGG ACCTAGTGTC AGCCTCGGTG GTGGTGGTGG GTGTGATCGC CGCACTCTTG 
TTCTGCCTTC TGGTGGTGGT GGTGGTGCTC ATGTCCCGAT ACCATCGGCG CAAGGCCCAG 
CAGATGACCC AGAAATATGA GGAGGAGCTG ACCCTGACCA GGGAGAACTC CATCCGGAGG 
CTGCATTCCC ATCACACGGA CCCCAGGAGC CAGCCGGAGG AGAGTGTAGG GCTGAGAGCC 
GAGGGCCACC CTGATAGTCT CAAGGACAAC AGTAGCTGCT CTGTGATGAG TGAAGAGCCC 
GAGGGCCGCA GTTACTCCAC GCTGACCACG GTGAGGGAGA TAGAAACACA GACTGAACTG 
CTGTCTCCAG GCTCTGGGCG GGCCGAGGAG GAGGAAGATC AGGATGAAGG CATCAAACAG 
GCCATGAACC ATTTTGTTCA GGAGAATGGG ACCCTACGGG CCAAGCCCAC GGGCAATGGC 
ATCTACATCA ATGGGCGGGG ACACCTGGTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NECTIN4 ( NM_030916.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_112178.2 Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), mRNA.

Price & Availability↑

CloneID	OHu28639
Clone ID Related Accession (Same CDS sequence)	NM_030916.2 , NM_030916.3
Accession Version	NM_030916.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1533bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nectin-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB223835.1, BC010423.1, BC013892.2 and CF529301.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_030916.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB105191.1, AK027753.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368012.4/ ENSP00000356991.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG ACCCCCAGGA AGACTCTGGG 
AAGCAGGTGG ACCTAGTGTC AGCCTCGGTG GTGGTGGTGG GTGTGATCGC CGCACTCTTG 
TTCTGCCTTC TGGTGGTGGT GGTGGTGCTC ATGTCCCGAT ACCATCGGCG CAAGGCCCAG 
CAGATGACCC AGAAATATGA GGAGGAGCTG ACCCTGACCA GGGAGAACTC CATCCGGAGG 
CTGCATTCCC ATCACACGGA CCCCAGGAGC CAGCCGGAGG AGAGTGTAGG GCTGAGAGCC 
GAGGGCCACC CTGATAGTCT CAAGGACAAC AGTAGCTGCT CTGTGATGAG TGAAGAGCCC 
GAGGGCCGCA GTTACTCCAC GCTGACCACG GTGAGGGAGA TAGAAACACA GACTGAACTG 
CTGTCTCCAG GCTCTGGGCG GGCCGAGGAG GAGGAAGATC AGGATGAAGG CATCAAACAG 
GCCATGAACC ATTTTGTTCA GGAGAATGGG ACCCTACGGG CCAAGCCCAC GGGCAATGGC 
ATCTACATCA ATGGGCGGGG ACACCTGGTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112178.2
CDS	263..1795
Translation	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Target ORF information:

RefSeq Version	NM_030916.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030916.3

ORF Insert Sequence:

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG ACCCCCAGGA AGACTCTGGG 
AAGCAGGTGG ACCTAGTGTC AGCCTCGGTG GTGGTGGTGG GTGTGATCGC CGCACTCTTG 
TTCTGCCTTC TGGTGGTGGT GGTGGTGCTC ATGTCCCGAT ACCATCGGCG CAAGGCCCAG 
CAGATGACCC AGAAATATGA GGAGGAGCTG ACCCTGACCA GGGAGAACTC CATCCGGAGG 
CTGCATTCCC ATCACACGGA CCCCAGGAGC CAGCCGGAGG AGAGTGTAGG GCTGAGAGCC 
GAGGGCCACC CTGATAGTCT CAAGGACAAC AGTAGCTGCT CTGTGATGAG TGAAGAGCCC 
GAGGGCCGCA GTTACTCCAC GCTGACCACG GTGAGGGAGA TAGAAACACA GACTGAACTG 
CTGTCTCCAG GCTCTGGGCG GGCCGAGGAG GAGGAAGATC AGGATGAAGG CATCAAACAG 
GCCATGAACC ATTTTGTTCA GGAGAATGGG ACCCTACGGG CCAAGCCCAC GGGCAATGGC 
ATCTACATCA ATGGGCGGGG ACACCTGGTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NECTIN4 ( XM_005245508.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005245565.1 Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu34722
Clone ID Related Accession (Same CDS sequence)	XM_005245508.3
Accession Version	XM_005245508.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nectin-4 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005245508.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG ACCCCCAGGA AGACTCTGGG 
AAGCAGGTGG ACCTAGTGTC AGCCTCGGTG GTGGTGGTGG GTGTGATCGC CGCACTCTTG 
TTCTGCCTTC TGGTGGTGGT GGTGGTGCTC ATGTCCCGAT ACCATCGGCG CAAGGCCCAG 
CAGATGACCC AGAAATATGA GGAGGAGCTG ACCCTGACCA GGGAGAACTC CATCCGGAGG 
CTGCATTCCC ATCACACGGA CCCCAGGAGC CAGAGTGAAG AGCCCGAGGG CCGCAGTTAC 
TCCACGCTGA CCACGGTGAG GGAGATAGAA ACACAGACTG AACTGCTGTC TCCAGGCTCT 
GGGCGGGCCG AGGAGGAGGA AGATCAGGAT GAAGGCATCA AACAGGCCAT GAACCATTTT 
GTTCAGGAGA ATGGGACCCT ACGGGCCAAG CCCACGGGCA ATGGCATCTA CATCAATGGG 
CGGGGACACC TGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005245565.1
CDS	271..1728
Translation	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Target ORF information:

RefSeq Version	XM_005245508.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005245508.3

ORF Insert Sequence:

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG ACCCCCAGGA AGACTCTGGG 
AAGCAGGTGG ACCTAGTGTC AGCCTCGGTG GTGGTGGTGG GTGTGATCGC CGCACTCTTG 
TTCTGCCTTC TGGTGGTGGT GGTGGTGCTC ATGTCCCGAT ACCATCGGCG CAAGGCCCAG 
CAGATGACCC AGAAATATGA GGAGGAGCTG ACCCTGACCA GGGAGAACTC CATCCGGAGG 
CTGCATTCCC ATCACACGGA CCCCAGGAGC CAGAGTGAAG AGCCCGAGGG CCGCAGTTAC 
TCCACGCTGA CCACGGTGAG GGAGATAGAA ACACAGACTG AACTGCTGTC TCCAGGCTCT 
GGGCGGGCCG AGGAGGAGGA AGATCAGGAT GAAGGCATCA AACAGGCCAT GAACCATTTT 
GTTCAGGAGA ATGGGACCCT ACGGGCCAAG CCCACGGGCA ATGGCATCTA CATCAATGGG 
CGGGGACACC TGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NECTIN4 ( XM_011510022.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508324.1 Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X2, mRNA.

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CloneID	OHu72944
Clone ID Related Accession (Same CDS sequence)	XM_011510022.2
Accession Version	XM_011510022.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nectin-4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510022.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG CAGACCCCCA GGAAGACTCT 
GGGAAGCAGG TGGACCTAGT GTCAGCCTCG GTGGTGGTGG TGGGTGTGAT CGCCGCACTC 
TTGTTCTGCC TTCTGGTGGT GGTGGTGGTG CTCATGTCCC GATACCATCG GCGCAAGGCC 
CAGCAGATGA CCCAGAAATA TGAGGAGGAG CTGACCCTGA CCAGGGAGAA CTCCATCCGG 
AGGCTGCATT CCCATCACAC GGACCCCAGG AGCCAGAGTG AAGAGCCCGA GGGCCGCAGT 
TACTCCACGC TGACCACGGT GAGGGAGATA GAAACACAGA CTGAACTGCT GTCTCCAGGC 
TCTGGGCGGG CCGAGGAGGA GGAAGATCAG GATGAAGGCA TCAAACAGGC CATGAACCAT 
TTTGTTCAGG AGAATGGGAC CCTACGGGCC AAGCCCACGG GCAATGGCAT CTACATCAAT 
GGGCGGGGAC ACCTGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508324.1
CDS	271..1731
Translation	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Target ORF information:

RefSeq Version	XM_011510022.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510022.2

ORF Insert Sequence:

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG CAGACCCCCA GGAAGACTCT 
GGGAAGCAGG TGGACCTAGT GTCAGCCTCG GTGGTGGTGG TGGGTGTGAT CGCCGCACTC 
TTGTTCTGCC TTCTGGTGGT GGTGGTGGTG CTCATGTCCC GATACCATCG GCGCAAGGCC 
CAGCAGATGA CCCAGAAATA TGAGGAGGAG CTGACCCTGA CCAGGGAGAA CTCCATCCGG 
AGGCTGCATT CCCATCACAC GGACCCCAGG AGCCAGAGTG AAGAGCCCGA GGGCCGCAGT 
TACTCCACGC TGACCACGGT GAGGGAGATA GAAACACAGA CTGAACTGCT GTCTCCAGGC 
TCTGGGCGGG CCGAGGAGGA GGAAGATCAG GATGAAGGCA TCAAACAGGC CATGAACCAT 
TTTGTTCAGG AGAATGGGAC CCTACGGGCC AAGCCCACGG GCAATGGCAT CTACATCAAT 
GGGCGGGGAC ACCTGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NECTIN4 ( XM_011510023.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508325.1 Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X4, mRNA.

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CloneID	OHu72945
Clone ID Related Accession (Same CDS sequence)	XM_011510023.1
Accession Version	XM_011510023.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nectin-4 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG CAGACCCCCA GGAAGACTCT 
GGGAAGCAGG TGGACCTAGT GTCAGCCTCG GTGGTGGTGG TGGGTGTGAT CGCCGCACTC 
TTGTTCTGCC TTCTGGTGGT GGTGGTGGTG CTCATGTCCC GATACCATCG GCGCAAGGCC 
CAGCAGATGA CCCAGAAATA TGAGGAGGAG CTGACCCTGA CCAGGGAGAA CTCCATCCGG 
AGGCTGCATT CCCATCACAC GGACCCCAGG AGCCAGCCGG AGGAGAGTGT AGGGCTGAGA 
GCCGAGGGCC ACCCTGATAG TCTCAAGGAC AACAGTAGCT GCTCTGTGAT GGTGAGGCCC 
CCGGCCCCAC CGGTGTCCCC ACCACTCTCC TCGGGCCCCT GTCCTGGTCC CAGATATGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508325.1
CDS	271..1653
Translation	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMVRPPAPPVSPPLSSGPCPGPRYE

Target ORF information:

RefSeq Version	XM_011510023.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510023.1

ORF Insert Sequence:

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG CAGACCCCCA GGAAGACTCT 
GGGAAGCAGG TGGACCTAGT GTCAGCCTCG GTGGTGGTGG TGGGTGTGAT CGCCGCACTC 
TTGTTCTGCC TTCTGGTGGT GGTGGTGGTG CTCATGTCCC GATACCATCG GCGCAAGGCC 
CAGCAGATGA CCCAGAAATA TGAGGAGGAG CTGACCCTGA CCAGGGAGAA CTCCATCCGG 
AGGCTGCATT CCCATCACAC GGACCCCAGG AGCCAGCCGG AGGAGAGTGT AGGGCTGAGA 
GCCGAGGGCC ACCCTGATAG TCTCAAGGAC AACAGTAGCT GCTCTGTGAT GGTGAGGCCC 
CCGGCCCCAC CGGTGTCCCC ACCACTCTCC TCGGGCCCCT GTCCTGGTCC CAGATATGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NECTIN4 ( XM_011510021.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508323.1 Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu72943
Clone ID Related Accession (Same CDS sequence)	XM_011510021.2
Accession Version	XM_011510021.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nectin-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510021.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG CAGACCCCCA GGAAGACTCT 
GGGAAGCAGG TGGACCTAGT GTCAGCCTCG GTGGTGGTGG TGGGTGTGAT CGCCGCACTC 
TTGTTCTGCC TTCTGGTGGT GGTGGTGGTG CTCATGTCCC GATACCATCG GCGCAAGGCC 
CAGCAGATGA CCCAGAAATA TGAGGAGGAG CTGACCCTGA CCAGGGAGAA CTCCATCCGG 
AGGCTGCATT CCCATCACAC GGACCCCAGG AGCCAGCCGG AGGAGAGTGT AGGGCTGAGA 
GCCGAGGGCC ACCCTGATAG TCTCAAGGAC AACAGTAGCT GCTCTGTGAT GAGTGAAGAG 
CCCGAGGGCC GCAGTTACTC CACGCTGACC ACGGTGAGGG AGATAGAAAC ACAGACTGAA 
CTGCTGTCTC CAGGCTCTGG GCGGGCCGAG GAGGAGGAAG ATCAGGATGA AGGCATCAAA 
CAGGCCATGA ACCATTTTGT TCAGGAGAAT GGGACCCTAC GGGCCAAGCC CACGGGCAAT 
GGCATCTACA TCAATGGGCG GGGACACCTG GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508323.1
CDS	271..1806
Translation	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Target ORF information:

RefSeq Version	XM_011510021.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nectin cell adhesion molecule 4 (NECTIN4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510021.2

ORF Insert Sequence:

ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGGCCTGAGG CCTGGCTGCT GCTGCTGCTA 
CTGCTGGCAT CATTTACAGG CCGGTGCCCC GCGGGTGAGC TGGAGACCTC AGACGTGGTA 
ACTGTGGTGC TGGGCCAGGA CGCAAAACTG CCCTGCTTCT ACCGAGGGGA CTCCGGCGAG 
CAAGTGGGGC AAGTGGCATG GGCTCGGGTG GACGCGGGCG AAGGCGCCCA GGAACTAGCG 
CTACTGCACT CCAAATACGG GCTTCATGTG AGCCCGGCTT ACGAGGGCCG CGTGGAGCAG 
CCGCCGCCCC CACGCAACCC CCTGGACGGC TCAGTGCTCC TGCGCAACGC AGTGCAGGCG 
GATGAGGGCG AGTACGAGTG CCGGGTCAGC ACCTTCCCCG CCGGCAGCTT CCAGGCGCGG 
CTGCGGCTCC GAGTGCTGGT GCCTCCCCTG CCCTCACTGA ATCCTGGTCC AGCACTAGAA 
GAGGGCCAGG GCCTGACCCT GGCAGCCTCC TGCACAGCTG AGGGCAGCCC AGCCCCCAGC 
GTGACCTGGG ACACGGAGGT CAAAGGCACA ACGTCCAGCC GTTCCTTCAA GCACTCCCGC 
TCTGCTGCCG TCACCTCAGA GTTCCACTTG GTGCCTAGCC GCAGCATGAA TGGGCAGCCA 
CTGACTTGTG TGGTGTCCCA TCCTGGCCTG CTCCAGGACC AAAGGATCAC CCACATCCTC 
CACGTGTCCT TCCTTGCTGA GGCCTCTGTG AGGGGCCTTG AAGACCAAAA TCTGTGGCAC 
ATTGGCAGAG AAGGAGCTAT GCTCAAGTGC CTGAGTGAAG GGCAGCCCCC TCCCTCATAC 
AACTGGACAC GGCTGGATGG GCCTCTGCCC AGTGGGGTAC GAGTGGATGG GGACACTTTG 
GGCTTTCCCC CACTGACCAC TGAGCACAGC GGCATCTACG TCTGCCATGT CAGCAATGAG 
TTCTCCTCAA GGGATTCTCA GGTCACTGTG GATGTTCTTG CAGACCCCCA GGAAGACTCT 
GGGAAGCAGG TGGACCTAGT GTCAGCCTCG GTGGTGGTGG TGGGTGTGAT CGCCGCACTC 
TTGTTCTGCC TTCTGGTGGT GGTGGTGGTG CTCATGTCCC GATACCATCG GCGCAAGGCC 
CAGCAGATGA CCCAGAAATA TGAGGAGGAG CTGACCCTGA CCAGGGAGAA CTCCATCCGG 
AGGCTGCATT CCCATCACAC GGACCCCAGG AGCCAGCCGG AGGAGAGTGT AGGGCTGAGA 
GCCGAGGGCC ACCCTGATAG TCTCAAGGAC AACAGTAGCT GCTCTGTGAT GAGTGAAGAG 
CCCGAGGGCC GCAGTTACTC CACGCTGACC ACGGTGAGGG AGATAGAAAC ACAGACTGAA 
CTGCTGTCTC CAGGCTCTGG GCGGGCCGAG GAGGAGGAAG ATCAGGATGA AGGCATCAAA 
CAGGCCATGA ACCATTTTGT TCAGGAGAAT GGGACCCTAC GGGCCAAGCC CACGGGCAAT 
GGCATCTACA TCAATGGGCG GGGACACCTG GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway.
Human pathology(2017 Dec)
Zhang Y,Chen P,Yin W,Ji Y,Shen Q,Ni Q

Prognostic role of Nectin-4 expression in luminal B (HER2 negative) breast cancer.
Pathology, research and practice213(9)1102-1108(2017 Sep)
Rajc J,Gugi? D,Fr?hlich I,Marjanovi? K,Dumen?i? B

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NECTIN4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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