DDX39B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DDX39B
Entrez Gene ID	7919
Full Name	DExD-box helicase 39B
Synonyms	BAT1,D6S81E,UAP56
General protein information	Preferred Names DExD-box helicase 39B Names spliceosome RNA helicase DDX39B 56 kDa U2AF65-associated protein ATP-dependent RNA helicase p47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B DEAD-box helicase 39B HLA-B-associated transcript 1 protein nuclear RNA helicase (DEAD family) spliceosome RNA helicase BAT1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011].
Disorder MIM:	142560

mRNA and Protein(s)

mRNA	Protein	Name
NM_080598.5	NP_542165.1	spliceosome RNA helicase DDX39B
NM_004640.7	NP_004631.1	spliceosome RNA helicase DDX39B
NM_004640.6	NP_004631.1	spliceosome RNA helicase DDX39B
NM_080598.6	NP_542165.1	spliceosome RNA helicase DDX39B

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ddx39b	NP_579834.2
Danio rerio (zebrafish)	bat1	NP_957237.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009075	XP_319825.4
Oryza sativa (rice)	Os01g0550000	NP_001043298.1
Homo sapiens (human)	DDX39B	NP_004631.1
Canis lupus familiaris (dog)	DDX39B	NP_001014399.1
Pan troglodytes (chimpanzee)	DDX39B	NP_001107635.1
	DDX39B	NP_001040608.1
Kluyveromyces lactis	KLLA0E21935g	XP_454944.1
Arabidopsis thaliana (thale cress)	AT5G11170	NP_568244.2
Xenopus tropicalis (tropical clawed frog)	ddx39b	NP_989072.1
Bos taurus (cattle)	DDX39B	NP_001028801.1
Mus musculus (house mouse)	Ddx39b	NP_001239386.1
Drosophila melanogaster (fruit fly)	Hel25E	NP_723089.1
Schizosaccharomyces pombe (fission yeast)	uap56	NP_594261.1
Magnaporthe oryzae (rice blast fungus)	MGG_02806	XP_003720935.1
Neurospora crassa	NCU09076	XP_964893.2
Saccharomyces cerevisiae (baker's yeast)	SUB2	NP_010199.1
Eremothecium gossypii	AGOS_ADR260C	NP_984356.1
Oryza sativa (rice)	Os01g0549700	NP_001043297.1

Gene Ontology
Bibliography

Related articles in PubMed

Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi.
Bittencourt IA, Serpeloni M, Hiraiwa PM, de Arruda Campos Brasil de Souza T, ?vila AR
International journal of biological macromolecules98793-801(2017 May)

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.
Galarza-Mu?oz G, Briggs FBS, Evsyukova I, Schott-Lerner G, Kennedy EM, Nyanhete T, Wang L, Bergamaschi L, Widen SG, Tomaras GD, Ko DC, Bradrick SS, Barcellos LF, Gregory SG, Garcia-Blanco MA
Cell169(1)72-84.e13(2017 Mar)

The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.
Nakata D, Nakao S, Nakayama K, Araki S, Nakayama Y, Aparicio S, Hara T, Nakanishi A
Biochemical and biophysical research communications483(1)271-276(2017 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Distinct features of RNA influence and ATPase efficiency between UAP56 and TcSub2 may reflect distinct structures for functional sites of TcSub2. For this reason, ligand-based or structure-based methodologies can be applied to investigate the potential of TcSub2 as a target for new drugs.
Title: Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi.

Study showed that a genetic variant in the 5' UTR of DDX39B reduces translation of DDX39B mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.
Title: Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.

DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation
Title: The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.

However, no significant association was observed between the DDX39B -22 G/C polymorphism in the cases and controls. Furthermore, it is clarified that the protective effect of IL-4 -590 is independent from APOE protective genotypes
Title: Association Study of IL-4 -590 C/T and DDX39B -22 G/C Polymorphisms with the Risk of Late-Onset Alzheimer's Disease in ian Population.

The G allele of DDX39B-22C > G was associated with absent or decreased manifestations of vivax malaria and the C allele was a risk factor for disease complications.
Title: DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria.

The following DDX39B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DDX39B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04514	NM_080598.6 Latest version!	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu04514	NM_004640.7 Latest version!	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu04514	NM_004640.6	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu04514	NM_080598.5	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DDX39B ( NM_080598.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_542165.1 Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04514
Clone ID Related Accession (Same CDS sequence)	NM_080598.5 , NM_004640.7 , NM_004640.6 , NM_080598.6
Accession Version	NM_080598.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	spliceosome RNA helicase DDX39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA048099.1, DA272922.1, BC000361.2, AL662801.7 and BM993499.1. On Feb 11, 2011 this sequence version replaced NM_080598.4. Transcript Variant: This variant (2) uses an alternative splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.254887.1, SRR1163657.32399.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542165.1
CDS	529..1815
Translation	MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR

Target ORF information:

RefSeq Version	NM_080598.5
Organism	Homo sapiens(human)
Definition	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080598.5

ORF Insert Sequence:

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DDX39B ( NM_004640.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_004631.1 Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04514
Clone ID Related Accession (Same CDS sequence)	NM_080598.5 , NM_004640.7 , NM_004640.6 , NM_080598.6
Accession Version	NM_004640.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	spliceosome RNA helicase DDX39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA272922.1, Z37166.1 and BM993499.1. On Nov 23, 2018 this sequence version replaced NM_004640.6. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222912.1, SRR5189661.39354.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396172.6/ ENSP00000379475.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004631.1
CDS	187..1473
Translation	MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR

Target ORF information:

RefSeq Version	NM_004640.7
Organism	Homo sapiens(human)
Definition	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004640.7

ORF Insert Sequence:

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DDX39B ( NM_004640.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_004631.1 Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04514
Clone ID Related Accession (Same CDS sequence)	NM_080598.5 , NM_004640.7 , NM_004640.6 , NM_080598.6
Accession Version	NM_004640.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	spliceosome RNA helicase DDX39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA048099.1, DA272922.1, Z37166.1 and BM993499.1. On Feb 11, 2011 this sequence version replaced NM_004640.5. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.97143.1, AK222912.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004631.1
CDS	659..1945
Translation	MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR

Target ORF information:

RefSeq Version	NM_004640.6
Organism	Homo sapiens(human)
Definition	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004640.6

ORF Insert Sequence:

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DDX39B ( NM_080598.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_542165.1 Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2, mRNA.

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CloneID	OHu04514
Clone ID Related Accession (Same CDS sequence)	NM_080598.5 , NM_004640.7 , NM_004640.6 , NM_080598.6
Accession Version	NM_080598.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	spliceosome RNA helicase DDX39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA272922.1, BC000361.2, AL662801.7 and BM993499.1. On Jun 1, 2019 this sequence version replaced NM_080598.5. Transcript Variant: This variant (2) uses an alternative splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.571067.1, BC000361.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542165.1
CDS	57..1343
Translation	MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR

Target ORF information:

RefSeq Version	NM_080598.6
Organism	Homo sapiens(human)
Definition	Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080598.6

ORF Insert Sequence:

ATGGCAGAGA ACGATGTGGA CAATGAGCTC TTGGACTATG AAGATGATGA GGTGGAGACA 
GCAGCTGGGG GAGATGGGGC TGAGGCCCCT GCCAAGAAGG ATGTCAAGGG CTCCTATGTC 
TCCATCCACA GCTCTGGCTT TCGTGACTTC CTGCTCAAGC CAGAGTTGCT CCGGGCCATT 
GTCGACTGTG GCTTTGAGCA TCCGTCAGAA GTCCAGCATG AGTGCATCCC TCAGGCCATT 
CTGGGAATGG ATGTCCTGTG CCAGGCCAAG TCGGGCATGG GAAAGACAGC AGTGTTTGTC 
TTGGCCACAC TGCAACAGCT GGAGCCAGTT ACTGGGCAGG TGTCTGTACT GGTGATGTGT 
CACACTCGGG AGTTGGCTTT TCAGATCAGC AAGGAATATG AGCGCTTCTC TAAATACATG 
CCCAATGTCA AGGTTGCTGT TTTTTTTGGT GGTCTGTCTA TCAAGAAGGA TGAAGAGGTG 
CTGAAGAAGA ACTGCCCGCA TATCGTCGTG GGGACTCCAG GCCGTATCCT AGCCCTGGCT 
CGAAATAAGA GCCTCAACCT CAAACACATT AAACACTTTA TTTTGGATGA ATGTGATAAG 
ATGCTTGAAC AGCTCGACAT GCGTCGGGAT GTCCAGGAAA TTTTTCGCAT GACCCCCCAC 
GAGAAGCAGG TCATGATGTT CAGTGCTACC TTGAGCAAAG AGATCCGTCC AGTCTGCCGC 
AAGTTCATGC AAGATCCAAT GGAGATCTTC GTGGATGATG AGACGAAGTT GACGCTGCAT 
GGGTTGCAGC AGTACTACGT GAAACTGAAG GACAACGAGA AGAACCGGAA GCTCTTTGAC 
CTTCTGGATG TCCTTGAGTT CAACCAGGTG GTGATCTTTG TGAAGTCTGT GCAGCGGTGC 
ATTGCCTTGG CCCAGCTACT AGTGGAGCAG AACTTCCCAG CCATTGCCAT CCACCGTGGG 
ATGCCCCAGG AGGAGAGGCT TTCTCGGTAT CAGCAGTTTA AAGATTTTCA ACGACGAATT 
CTTGTGGCTA CCAACCTATT TGGCCGAGGC ATGGACATCG AGCGGGTGAA CATTGCTTTT 
AATTATGACA TGCCTGAGGA TTCTGACACC TACCTGCATC GGGTGGCCAG AGCAGGCCGG 
TTTGGCACCA AGGGCTTGGC TATCACATTT GTGTCCGATG AGAATGATGC CAAGATCCTC 
AATGATGTGC AGGATCGCTT TGAGGTCAAT ATTAGTGAGC TGCCTGATGA GATAGACATC 
TCCTCCTACA TTGAACAGAC ACGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi.
International journal of biological macromolecules98793-801(2017 May)
Bittencourt IA,Serpeloni M,Hiraiwa PM,de Arruda Campos Brasil de Souza T,?vila AR

Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.
Cell169(1)72-84.e13(2017 Mar)
Galarza-Mu?oz G,Briggs FBS,Evsyukova I,Schott-Lerner G,Kennedy EM,Nyanhete T,Wang L,Bergamaschi L,Widen SG,Tomaras GD,Ko DC,Bradrick SS,Barcellos LF,Gregory SG,Garcia-Blanco MA

The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.
Biochemical and biophysical research communications483(1)271-276(2017 01)
Nakata D,Nakao S,Nakayama K,Araki S,Nakayama Y,Aparicio S,Hara T,Nakanishi A

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DDX39B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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