PTP4A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTP4A1
Entrez Gene ID	7803
Full Name	protein tyrosine phosphatase type IVA, member 1
Synonyms	HH72,PRL-1,PRL1,PTP(CAAX1),PTPCAAX1
General protein information	Preferred Names protein tyrosine phosphatase type IVA, member 1 Names protein tyrosine phosphatase type IVA 1 PVT1/PTP4A1 fusion phosphatase of regenerating liver 1 protein tyrosine phosphatase type IVA protein 1 protein-tyrosine phosphatase 4a1 protein-tyrosine phosphatase of regenerating liver 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q12
Summary	This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013].
Disorder MIM:	601585

mRNA and Protein(s)

mRNA	Protein	Name
XM_017011270.1	XP_016866759.1	protein tyrosine phosphatase type IVA 1 isoform X1
XM_017011271.1	XP_016866760.1	protein tyrosine phosphatase type IVA 1 isoform X1
XM_011536112.1	XP_011534414.1	protein tyrosine phosphatase type IVA 1 isoform X1
NM_003463.4	NP_003454.1	protein tyrosine phosphatase type IVA 1
XM_017011272.1	XP_016866761.1	protein tyrosine phosphatase type IVA 1 isoform X2
XM_011536111.1	XP_011534413.1	protein tyrosine phosphatase type IVA 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PTP4A1	NP_001233568.1
Rattus norvegicus (Norway rat)	Ptp4a1	NP_113767.1
	PTP4A1	XP_001083424.1
Danio rerio (zebrafish)	ptp4a1	NP_001007776.2
Bos taurus (cattle)	PTP4A1	NP_001193053.1
Gallus gallus (chicken)	PTP4A1	NP_001008461.1
Drosophila melanogaster (fruit fly)	PRL-1	NP_609780.1
Caenorhabditis elegans (roundworm)	prl-1	NP_508683.1
Xenopus tropicalis (tropical clawed frog)	ptp4a1	NP_001008023.1
Homo sapiens (human)	PTP4A1	NP_003454.1
Canis lupus familiaris (dog)	PTP4A1	XP_005627571.1
Mus musculus (house mouse)	Ptp4a1	NP_035330.1
Rattus norvegicus (Norway rat)	LOC102547074	XP_006244747.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008708	XP_314814.3

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis.
Li C, Jiang Y, Miao R, Qu K, Zhang J, Liu C
International journal of oncology52(2)536-546(2018 Feb)

MYC-containing amplicons in acute myeloid leukemia: Genomic structures, evolution, and transcriptional consequences.
?Abbate A, Tolomeo D, Cifola I, Severgnini M, Turchiano A, Augello B, Squeo G, D Addabbo P, Traversa D, Daniele G, Lonoce A, Pafundi M, Carella M, Palumbo O, Dolnik A, Muehlematter D, Schoumans J, Van Roy N, De Bellis G, Martinelli G, Merla G, Bullinger L, Haferlach C, Storlazzi CT
Leukemia(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed that SIAH1 and PTP4A1 expression was regulated by mir-944 in breast cancer cells. miR-944 binds directly the 3 UTR of their promotor region.
Title: Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells.

miR-601 inhibits growth and invasion of breast cancer cells by targeting PTP4A1.
Title: miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer.

Data indicate that protein-tyrosine-phosphatase of regenerating liver 1 (PRL1) gene was expressed much more highly in prostate cancer (PCa) than in nonneoplastic prostate samples.
Title: Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method.

We confirmed with our previous findings that PTP4A1-PHF3-EYS variants were significantly associated with alcohol dependence.
Title: Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence.

Data highlight the oncogenic function of PRL-1 in HCC invasion and metastasis.
Title: Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma.

The following PTP4A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTP4A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21249	NM_003463.4 Latest version!	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu21249	XM_017011270.1 Latest version!	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu21249	XM_011536112.1 Latest version!	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu21249	XM_017011271.1 Latest version!	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu21249	XM_011536111.1 Latest version!	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu96793	XM_017011272.1 Latest version!	Homo sapiens protein tyrosine phosphatase type IVA, member 1 (PTP4A1), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTP4A1 ( NM_003463.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003454.1 Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), mRNA.

Price & Availability↑

CloneID	OHu21249
Clone ID Related Accession (Same CDS sequence)	XM_017011270.1 , XM_017011271.1 , XM_011536112.1 , NM_003463.4 , XM_011536111.1
Accession Version	NM_003463.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase type IVA 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW136267.1, BC045571.1, BC023975.2, BP264358.1, CA427371.1 and BF436021.1. On Jul 3, 2013 this sequence version replaced NM_003463.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC045571.1, SRR1660803.178133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein regulatory uORF :: PMID: 25621764 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003454.1
CDS	1154..1675
Translation	MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Target ORF information:

RefSeq Version	NM_003463.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003463.4

ORF Insert Sequence:

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTP4A1 ( XM_017011270.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866759.1 Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu21249
Clone ID Related Accession (Same CDS sequence)	XM_017011270.1 , XM_017011271.1 , XM_011536112.1 , NM_003463.4 , XM_011536111.1
Accession Version	XM_017011270.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase type IVA 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866759.1
CDS	510..1031
Translation	MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Target ORF information:

RefSeq Version	XM_017011270.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011270.1

ORF Insert Sequence:

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTP4A1 ( XM_017011271.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866760.1 Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu21249
Clone ID Related Accession (Same CDS sequence)	XM_017011270.1 , XM_017011271.1 , XM_011536112.1 , NM_003463.4 , XM_011536111.1
Accession Version	XM_017011271.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase type IVA 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866760.1
CDS	490..1011
Translation	MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Target ORF information:

RefSeq Version	XM_017011271.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011271.1

ORF Insert Sequence:

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTP4A1 ( XM_011536112.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011534414.1 Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu21249
Clone ID Related Accession (Same CDS sequence)	XM_017011270.1 , XM_017011271.1 , XM_011536112.1 , NM_003463.4 , XM_011536111.1
Accession Version	XM_011536112.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase type IVA 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011534414.1
CDS	1252..1773
Translation	MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Target ORF information:

RefSeq Version	XM_011536112.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011536112.1

ORF Insert Sequence:

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTP4A1 ( XM_011536111.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011534413.1 Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu21249
Clone ID Related Accession (Same CDS sequence)	XM_017011270.1 , XM_017011271.1 , XM_011536112.1 , NM_003463.4 , XM_011536111.1
Accession Version	XM_011536111.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase type IVA 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011534413.1
CDS	493..1014
Translation	MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Target ORF information:

RefSeq Version	XM_011536111.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011536111.1

ORF Insert Sequence:

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 
TTTAACAGCA AGCAACTTCT GTATTTGGAG AAGTATCGTC CTAAAATGCG GCTGCGTTTC 
AAAGATTCCA ACGGTCATAG AAACAACTGT TGCATTCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTP4A1 ( XM_017011272.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866761.1 Homo sapiens protein tyrosine phosphatase type IVA, member 1 (PTP4A1), transcript variant X5, mRNA.

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CloneID	OHu96793
Clone ID Related Accession (Same CDS sequence)	XM_017011272.1
Accession Version	XM_017011272.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase type IVA 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866761.1
CDS	1154..1561
Translation	MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQ

Target ORF information:

RefSeq Version	XM_017011272.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase type IVA, member 1 (PTP4A1), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011272.1

ORF Insert Sequence:

ATGGCTCGAA TGAACCGCCC AGCTCCTGTG GAAGTCACAT ACAAGAACAT GAGATTTCTT 
ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 
GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTATG ACACTACTCT TGTGGAGAAA 
GAAGGTATCC ATGTTCTTGA TTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 
GTTGATGACT GGTTAAGTCT TGTGAAAATT AAGTTTCGTG AAGAACCTGG TTGTTGTATT 
GCTGTTCATT GCGTTGCAGG CCTTGGGAGA GCTCCAGTAC TTGTTGCCCT AGCATTAATT 
GAAGGTGGAA TGAAATACGA AGATGCAGTA CAATTCATAA GACAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis.
International journal of oncology52(2)536-546(2018 Feb)
Li C,Jiang Y,Miao R,Qu K,Zhang J,Liu C

MYC-containing amplicons in acute myeloid leukemia: Genomic structures, evolution, and transcriptional consequences.
Leukemia(2017 Nov)
?Abbate A,Tolomeo D,Cifola I,Severgnini M,Turchiano A,Augello B,Squeo G,D Addabbo P,Traversa D,Daniele G,Lonoce A,Pafundi M,Carella M,Palumbo O,Dolnik A,Muehlematter D,Schoumans J,Van Roy N,De Bellis G,Martinelli G,Merla G,Bullinger L,Haferlach C,Storlazzi CT

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PTP4A1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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