OPN1MW2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPN1MW2
Entrez Gene ID	728458
Full Name	opsin 1, medium wave sensitive 2
Synonyms	GOP
General protein information	Preferred Names opsin 1, medium wave sensitive 2 Names medium-wave-sensitive opsin 1 green cone photoreceptor pigment green-sensitive opsin opsin 1 (cone pigments), medium-wave-sensitive 2 opsin 1 cone pigments medium-wave-sensitive 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001048181.2	NP_001041646.1	medium-wave-sensitive opsin 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LOC101060233	XP_003960138.1
Homo sapiens (human)	OPN1MW	NP_000504.1
Homo sapiens (human)	OPN1MW2	NP_001041646.1

Gene Ontology
Bibliography

Related articles in PubMed

Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.
Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K
Biochemistry56(17)2338-2348(2017 05)

G protein-coupled receptors participate in cytokinesis.
Zhang X, Bedigian AV, Wang W, Eggert US
Cytoskeleton (Hoboken, N.J.)69(10)810-8(2012 Oct)

X-linked cone dystrophy caused by mutation of the red and green cone opsins.
Gardner JC, Webb TR, Kanuga N, Robson AG, Holder GE, Stockman A, Ripamonti C, Ebenezer ND, Ogun O, Devery S, Wright GA, Maher ER, Cheetham ME, Moore AT, Michaelides M, Hardcastle AJ
American journal of human genetics87(1)26-39(2010 Jul)

Expressions of rod and cone photoreceptor-like proteins in human epidermis.
Tsutsumi M, Ikeyama K, Denda S, Nakanishi J, Fuziwara S, Aoki H, Denda M
Experimental dermatology18(6)567-70(2009 Jun)

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Luttrell LM
Molecular biotechnology39(3)239-64(2008 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Immunoreactivity to anti-OPN1LW antibodies was seen in the basal layer of human epidermis & reconstructed skin. The opsin mRNA was seen in total RNA from human skin. Neither immunoreactivity nor mRNA expression was seen in cultured human keratinocytes.
Title: Expressions of rod and cone photoreceptor-like proteins in human epidermis.

The following OPN1MW2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPN1MW2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu01811	NM_001048181.2 Latest version!	Homo sapiens opsin 1, medium wave sensitive 2 (OPN1MW2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPN1MW2 ( NM_001048181.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001041646.1 Homo sapiens opsin 1, medium wave sensitive 2 (OPN1MW2), mRNA.

Price & Availability↑

CloneID	OHu01811
Clone ID Related Accession (Same CDS sequence)	NM_001048181.2
Accession Version	NM_001048181.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	medium-wave-sensitive opsin 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC244097.3. On Mar 11, 2009 this sequence version replaced NM_001048181.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC 
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG 
ATCTTTGTGG TCATTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG 
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTG 
GCAGAGACCG TCATCGCCAG CACTATCAGC GTTGTGAACC AGGTCTATGG CTACTTCGTG 
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT 
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC 
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG 
ATTGTCCTCA TGGTCACCTG CTGCATCACC CCACTCAGCA TCATCGTGCT CTGCTACCTC 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG 
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGG TCCTGGCATT CTGCTTCTGC 
TGGGGACCCT ACGCCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGCTA CCCCTTCCAC 
CCTTTGATGG CTGCCCTGCC GGCCTTCTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT 
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG 
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG 
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041646.1
CDS	83..1177
Translation	MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA

Target ORF information:

RefSeq Version	NM_001048181.2
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 1, medium wave sensitive 2 (OPN1MW2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048181.2

ORF Insert Sequence:

ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC 
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG 
ATCTTTGTGG TCATTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG 
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTG 
GCAGAGACCG TCATCGCCAG CACTATCAGC GTTGTGAACC AGGTCTATGG CTACTTCGTG 
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT 
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC 
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG 
ATTGTCCTCA TGGTCACCTG CTGCATCACC CCACTCAGCA TCATCGTGCT CTGCTACCTC 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG 
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGG TCCTGGCATT CTGCTTCTGC 
TGGGGACCCT ACGCCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGCTA CCCCTTCCAC 
CCTTTGATGG CTGCCCTGCC GGCCTTCTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT 
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG 
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG 
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.
Biochemistry56(17)2338-2348(2017 05)
Hofmann L,Alexander NS,Sun W,Zhang J,Orban T,Palczewski K

G protein-coupled receptors participate in cytokinesis.
Cytoskeleton (Hoboken, N.J.)69(10)810-8(2012 Oct)
Zhang X,Bedigian AV,Wang W,Eggert US

X-linked cone dystrophy caused by mutation of the red and green cone opsins.
American journal of human genetics87(1)26-39(2010 Jul)
Gardner JC,Webb TR,Kanuga N,Robson AG,Holder GE,Stockman A,Ripamonti C,Ebenezer ND,Ogun O,Devery S,Wright GA,Maher ER,Cheetham ME,Moore AT,Michaelides M,Hardcastle AJ

Expressions of rod and cone photoreceptor-like proteins in human epidermis.
Experimental dermatology18(6)567-70(2009 Jun)
Tsutsumi M,Ikeyama K,Denda S,Nakanishi J,Fuziwara S,Aoki H,Denda M

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Molecular biotechnology39(3)239-64(2008 Jul)
Luttrell LM

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OPN1MW2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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