OPN1MW cDNA ORF clone, Homo sapiens(human)

Increasing the Stability of Recombinant Human Green Cone Pigment.
Owen TS, Salom D, Sun W, Palczewski K
Biochemistry(2018 Jan)

Structural and functional alterations associated with deutan N94K and R330Q mutations of green cone opsin.
Srinivasan S, Fern?ndez-Sampedro MA, Ramon E, Garriga P
Biochimica et biophysica acta1863(7)1840-1847(2017 Jul)

Data suggest that OPN1MW exhibits a conserved Pro-Pro motif in extracellular loop 2 as observed in monostable visual G-protein-coupled receptors; comparison of deuterium uptake between inactive and active states of OPN1MW suggests a reduced solvent accessibility of the extracellular N-terminal region and an increased accessibility of the chromophore binding site.
Title: Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.

Data suggest that insights into dimerization interface of red cone opsin should aid investigations of the structure and function of GPCR cell signaling.
Title: A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins.

Findings show that mutation in OPN1MW underlie the cone dysfunction in all of the subjects tested, the color vision defect can be caused either by the same mutation or a gene rearrangement at the same locus.
Title: Cone Photoreceptor Structure in Patients With X-Linked Cone Dysfunction and Red-Green Color Vision Deficiency.

The study reports on a different regeneration mechanism among red and green cone opsins with retinal analogs using UV-Vis/fluorescence spectroscopic analyses, molecular modeling and site-directed mutagenesis.
Title: Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration.

We identified 76 individuals with an L-M array. Four had exonic mutations, but the other 72 had no mutation in the exons or flanking introns. Sixty-nine of the 72 individuals had a -71A>C substitution in the M gene promoter.
Title: A new subset of deutan colour vision defect associated with an L/M visual pigment gene array of normal order and -71C substitution in the Japanese population.