HSP90B1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSP90B1
Entrez Gene ID	7184
Full Name	heat shock protein 90 beta family member 1
Synonyms	ECGP,GP96,GRP94,HEL-S-125m,HEL35,TRA1
General protein information	Preferred Names heat shock protein 90 beta family member 1 Names endoplasmin 94 kDa glucose-regulated protein endothelial cell (HBMEC) glycoprotein epididymis luminal protein 35 epididymis secretory sperm binding protein Li 125m heat shock protein 90 kDa beta member 1 heat shock protein 90kDa beta (Grp94), member 1 heat shock protein 90kDa beta family member 1 stress-inducible tumor rejection antigen gp96 tumor rejection antigen (gp96) 1 tumor rejection antigen 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q23.3
Summary	This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012].
Disorder MIM:	191175

mRNA and Protein(s)

mRNA	Protein	Name
NM_003299.3	NP_003290.1	endoplasmin precursor
NM_003299.2	NP_003290.1	endoplasmin precursor

Pathways from BioSystems

Homologies

	HSP90B1	XP_001095189.1
Mus musculus (house mouse)	Hsp90b1	NP_035761.1
Rattus norvegicus (Norway rat)	Hsp90b1	NP_001012197.2
Homo sapiens (human)	HSP90B1	NP_003290.1
Canis lupus familiaris (dog)	HSP90B1	NP_001003327.1
Bos taurus (cattle)	HSP90B1	NP_777125.1
Oryza sativa (rice)	Os06g0716700	NP_001058590.1
Gallus gallus (chicken)	HSP90B1	NP_989620.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001424	XP_321706.5
Caenorhabditis elegans (roundworm)	CELE_T05E11.3	NP_001255536.1
Danio rerio (zebrafish)	hsp90b1	NP_937853.1
Drosophila melanogaster (fruit fly)	Gp93	NP_651601.1
Arabidopsis thaliana (thale cress)	SHD	NP_974606.1
Xenopus tropicalis (tropical clawed frog)	hsp90b1	NP_001039228.1
Pan troglodytes (chimpanzee)	HSP90B1	NP_001233416.1

Gene Ontology
Bibliography

Related articles in PubMed

Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.
Cai Q, Lin J, Zhang L, Lin J, Wang L, Chen D, Peng J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695015(2017 Mar)

Immuno-Stimulating Peptide Derived from HMGB1 is More Effective Than the N-Terminal Domain of Gp96 as an Endogenous Adjuvant for Improvement of Protein Vaccines.
Talebi S, Bolhassani A, Azad TM, Arashkia A, Modaresi MH
Protein and peptide letters24(3)190-196(2017)

Hsp90 and co-chaperones twist the functions of diverse client proteins.
Zuehlke A, Johnson JL
Biopolymers93(3)211-7(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In this instance, the ATP5B/CALR/HSP90B1/HSPB1/HSPD1-signaling network was revealed as the predominant target which was associated with the majority of the observed protein-protein interactions. As a result, the identified targets may be useful in explaining the anticancer mechanisms of ursolic acid and as potential targets for colorectal cancer therapy.
Title: Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.

Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines.
Title: Immuno-Stimulating Peptide Derived from HMGB1 is More Effective Than the N-Terminal Domain of Gp96 as an Endogenous Adjuvant for Improvement of Protein Vaccines.

High HSP90B1 expression is associated with non-small-cell lung cancer.
Title: HSP90B1 overexpression predicts poor prognosis in NSCLC patients.

These data demonstrate the essential role of the gp96-TLR interaction in priming T cell immunity and provide further molecular basis for the coupling of gp96-mediated innate with adaptive immunity.
Title: Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response.

These results demonstrated the pivotal role of HSP90B1 in the proliferation and survival of ovarian cells, suggesting a critical role for HSP90B1 in the pathogenesis of PCOS.
Title: The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome.

The following HSP90B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSP90B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20475	NM_003299.3 Latest version!	Homo sapiens heat shock protein 90 beta family member 1 (HSP90B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu20475	NM_003299.2	Homo sapiens heat shock protein 90 beta family member 1 (HSP90B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSP90B1 ( NM_003299.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003290.1 Homo sapiens heat shock protein 90 beta family member 1 (HSP90B1), mRNA.

Price & Availability↑

CloneID	OHu20475
Clone ID Related Accession (Same CDS sequence)	NM_003299.3 , NM_003299.2
Accession Version	NM_003299.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2412bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	endoplasmin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC078819.24, X15187.1 and CA419931.1. On Nov 23, 2018 this sequence version replaced NM_003299.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ900941.1, AJ890084.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299767.10/ ENSP00000299767.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGCCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTCGGTCAGA 
GCTGACGATG AAGTTGATGT GGATGGTACA GTAGAAGAGG ATCTGGGTAA AAGTAGAGAA 
GGATCAAGGA CGGATGATGA AGTAGTACAG AGAGAGGAAG AAGCTATTCA GTTGGATGGA 
TTAAATGCAT CACAAATAAG AGAACTTAGA GAGAAGTCGG AAAAGTTTGC CTTCCAAGCC 
GAAGTTAACA GAATGATGAA ACTTATCATC AATTCATTGT ATAAAAATAA AGAGATTTTC 
CTGAGAGAAC TGATTTCAAA TGCTTCTGAT GCTTTAGATA AGATAAGGCT AATATCACTG 
ACTGATGAAA ATGCTCTTTC TGGAAATGAG GAACTAACAG TCAAAATTAA GTGTGATAAG 
GAGAAGAACC TGCTGCATGT CACAGACACC GGTGTAGGAA TGACCAGAGA AGAGTTGGTT 
AAAAACCTTG GTACCATAGC CAAATCTGGG ACAAGCGAGT TTTTAAACAA AATGACTGAA 
GCACAGGAAG ATGGCCAGTC AACTTCTGAA TTGATTGGCC AGTTTGGTGT CGGTTTCTAT 
TCCGCCTTCC TTGTAGCAGA TAAGGTTATT GTCACTTCAA AACACAACAA CGATACCCAG 
CACATCTGGG AGTCTGACTC CAATGAATTT TCTGTAATTG CTGACCCAAG AGGAAACACT 
CTAGGACGGG GAACGACAAT TACCCTTGTC TTAAAAGAAG AAGCATCTGA TTACCTTGAA 
TTGGATACAA TTAAAAATCT CGTCAAAAAA TATTCACAGT TCATAAACTT TCCTATTTAT 
GTATGGAGCA GCAAGACTGA AACTGTTGAG GAGCCCATGG AGGAAGAAGA AGCAGCCAAA 
GAAGAGAAAG AAGAATCTGA TGATGAAGCT GCAGTAGAGG AAGAAGAAGA AGAAAAGAAA 
CCAAAGACTA AAAAAGTTGA AAAAACTGTC TGGGACTGGG AACTTATGAA TGATATCAAA 
CCAATATGGC AGAGACCATC AAAAGAAGTA GAAGAAGATG AATACAAAGC TTTCTACAAA 
TCATTTTCAA AGGAAAGTGA TGACCCCATG GCTTATATTC ACTTTACTGC TGAAGGGGAA 
GTTACCTTCA AATCAATTTT ATTTGTACCC ACATCTGCTC CACGTGGTCT GTTTGACGAA 
TATGGATCTA AAAAGAGCGA TTACATTAAG CTCTATGTGC GCCGTGTATT CATCACAGAC 
GACTTCCATG ATATGATGCC TAAATACCTC AATTTTGTCA AGGGTGTGGT GGACTCAGAT 
GATCTCCCCT TGAATGTTTC CCGCGAGACT CTTCAGCAAC ATAAACTGCT TAAGGTGATT 
AGGAAGAAGC TTGTTCGTAA AACGCTGGAC ATGATCAAGA AGATTGCTGA TGATAAATAC 
AATGATACTT TTTGGAAAGA ATTTGGTACC AACATCAAGC TTGGTGTGAT TGAAGACCAC 
TCGAATCGAA CACGTCTTGC TAAACTTCTT AGGTTCCAGT CTTCTCATCA TCCAACTGAC 
ATTACTAGCC TAGACCAGTA TGTGGAAAGA ATGAAGGAAA AACAAGACAA AATCTACTTC 
ATGGCTGGGT CCAGCAGAAA AGAGGCTGAA TCTTCTCCAT TTGTTGAGCG ACTTCTGAAA 
AAGGGCTATG AAGTTATTTA CCTCACAGAA CCTGTGGATG AATACTGTAT TCAGGCCCTT 
CCCGAATTTG ATGGGAAGAG GTTCCAGAAT GTTGCCAAGG AAGGAGTGAA GTTCGATGAA 
AGTGAGAAAA CTAAGGAGAG TCGTGAAGCA GTTGAGAAAG AATTTGAGCC TCTGCTGAAT 
TGGATGAAAG ATAAAGCCCT TAAGGACAAG ATTGAAAAGG CTGTGGTGTC TCAGCGCCTG 
ACAGAATCTC CGTGTGCTTT GGTGGCCAGC CAGTACGGAT GGTCTGGCAA CATGGAGAGA 
ATCATGAAAG CACAAGCGTA CCAAACGGGC AAGGACATCT CTACAAATTA CTATGCGAGT 
CAGAAGAAAA CATTTGAAAT TAATCCCAGA CACCCGCTGA TCAGAGACAT GCTTCGACGA 
ATTAAGGAAG ATGAAGATGA TAAAACAGTT TTGGATCTTG CTGTGGTTTT GTTTGAAACA 
GCAACGCTTC GGTCAGGGTA TCTTTTACCA GACACTAAAG CATATGGAGA TAGAATAGAA 
AGAATGCTTC GCCTCAGTTT GAACATTGAC CCTGATGCAA AGGTGGAAGA AGAGCCCGAA 
GAAGAACCTG AAGAGACAGC AGAAGACACA ACAGAAGACA CAGAGCAAGA CGAAGATGAA 
GAAATGGATG TGGGAACAGA TGAAGAAGAA GAAACAGCAA AGGAATCTAC AGCTGAAAAA 
GATGAATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003290.1
CDS	107..2518
Translation	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

Target ORF information:

RefSeq Version	NM_003299.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein 90 beta family member 1 (HSP90B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003299.3

ORF Insert Sequence:

ATGAGGGCCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTCGGTCAGA 
GCTGACGATG AAGTTGATGT GGATGGTACA GTAGAAGAGG ATCTGGGTAA AAGTAGAGAA 
GGATCAAGGA CGGATGATGA AGTAGTACAG AGAGAGGAAG AAGCTATTCA GTTGGATGGA 
TTAAATGCAT CACAAATAAG AGAACTTAGA GAGAAGTCGG AAAAGTTTGC CTTCCAAGCC 
GAAGTTAACA GAATGATGAA ACTTATCATC AATTCATTGT ATAAAAATAA AGAGATTTTC 
CTGAGAGAAC TGATTTCAAA TGCTTCTGAT GCTTTAGATA AGATAAGGCT AATATCACTG 
ACTGATGAAA ATGCTCTTTC TGGAAATGAG GAACTAACAG TCAAAATTAA GTGTGATAAG 
GAGAAGAACC TGCTGCATGT CACAGACACC GGTGTAGGAA TGACCAGAGA AGAGTTGGTT 
AAAAACCTTG GTACCATAGC CAAATCTGGG ACAAGCGAGT TTTTAAACAA AATGACTGAA 
GCACAGGAAG ATGGCCAGTC AACTTCTGAA TTGATTGGCC AGTTTGGTGT CGGTTTCTAT 
TCCGCCTTCC TTGTAGCAGA TAAGGTTATT GTCACTTCAA AACACAACAA CGATACCCAG 
CACATCTGGG AGTCTGACTC CAATGAATTT TCTGTAATTG CTGACCCAAG AGGAAACACT 
CTAGGACGGG GAACGACAAT TACCCTTGTC TTAAAAGAAG AAGCATCTGA TTACCTTGAA 
TTGGATACAA TTAAAAATCT CGTCAAAAAA TATTCACAGT TCATAAACTT TCCTATTTAT 
GTATGGAGCA GCAAGACTGA AACTGTTGAG GAGCCCATGG AGGAAGAAGA AGCAGCCAAA 
GAAGAGAAAG AAGAATCTGA TGATGAAGCT GCAGTAGAGG AAGAAGAAGA AGAAAAGAAA 
CCAAAGACTA AAAAAGTTGA AAAAACTGTC TGGGACTGGG AACTTATGAA TGATATCAAA 
CCAATATGGC AGAGACCATC AAAAGAAGTA GAAGAAGATG AATACAAAGC TTTCTACAAA 
TCATTTTCAA AGGAAAGTGA TGACCCCATG GCTTATATTC ACTTTACTGC TGAAGGGGAA 
GTTACCTTCA AATCAATTTT ATTTGTACCC ACATCTGCTC CACGTGGTCT GTTTGACGAA 
TATGGATCTA AAAAGAGCGA TTACATTAAG CTCTATGTGC GCCGTGTATT CATCACAGAC 
GACTTCCATG ATATGATGCC TAAATACCTC AATTTTGTCA AGGGTGTGGT GGACTCAGAT 
GATCTCCCCT TGAATGTTTC CCGCGAGACT CTTCAGCAAC ATAAACTGCT TAAGGTGATT 
AGGAAGAAGC TTGTTCGTAA AACGCTGGAC ATGATCAAGA AGATTGCTGA TGATAAATAC 
AATGATACTT TTTGGAAAGA ATTTGGTACC AACATCAAGC TTGGTGTGAT TGAAGACCAC 
TCGAATCGAA CACGTCTTGC TAAACTTCTT AGGTTCCAGT CTTCTCATCA TCCAACTGAC 
ATTACTAGCC TAGACCAGTA TGTGGAAAGA ATGAAGGAAA AACAAGACAA AATCTACTTC 
ATGGCTGGGT CCAGCAGAAA AGAGGCTGAA TCTTCTCCAT TTGTTGAGCG ACTTCTGAAA 
AAGGGCTATG AAGTTATTTA CCTCACAGAA CCTGTGGATG AATACTGTAT TCAGGCCCTT 
CCCGAATTTG ATGGGAAGAG GTTCCAGAAT GTTGCCAAGG AAGGAGTGAA GTTCGATGAA 
AGTGAGAAAA CTAAGGAGAG TCGTGAAGCA GTTGAGAAAG AATTTGAGCC TCTGCTGAAT 
TGGATGAAAG ATAAAGCCCT TAAGGACAAG ATTGAAAAGG CTGTGGTGTC TCAGCGCCTG 
ACAGAATCTC CGTGTGCTTT GGTGGCCAGC CAGTACGGAT GGTCTGGCAA CATGGAGAGA 
ATCATGAAAG CACAAGCGTA CCAAACGGGC AAGGACATCT CTACAAATTA CTATGCGAGT 
CAGAAGAAAA CATTTGAAAT TAATCCCAGA CACCCGCTGA TCAGAGACAT GCTTCGACGA 
ATTAAGGAAG ATGAAGATGA TAAAACAGTT TTGGATCTTG CTGTGGTTTT GTTTGAAACA 
GCAACGCTTC GGTCAGGGTA TCTTTTACCA GACACTAAAG CATATGGAGA TAGAATAGAA 
AGAATGCTTC GCCTCAGTTT GAACATTGAC CCTGATGCAA AGGTGGAAGA AGAGCCCGAA 
GAAGAACCTG AAGAGACAGC AGAAGACACA ACAGAAGACA CAGAGCAAGA CGAAGATGAA 
GAAATGGATG TGGGAACAGA TGAAGAAGAA GAAACAGCAA AGGAATCTAC AGCTGAAAAA 
GATGAATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSP90B1 ( NM_003299.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003290.1 Homo sapiens heat shock protein 90 beta family member 1 (HSP90B1), mRNA.

Price & Availability↑

CloneID	OHu20475
Clone ID Related Accession (Same CDS sequence)	NM_003299.3 , NM_003299.2
Accession Version	NM_003299.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2412bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	endoplasmin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC078819.24, X15187.1 and CA419931.1. On Aug 7, 2012 this sequence version replaced NM_003299.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.112156.1, SRR1660809.42246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGCCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTCGGTCAGA 
GCTGACGATG AAGTTGATGT GGATGGTACA GTAGAAGAGG ATCTGGGTAA AAGTAGAGAA 
GGATCAAGGA CGGATGATGA AGTAGTACAG AGAGAGGAAG AAGCTATTCA GTTGGATGGA 
TTAAATGCAT CACAAATAAG AGAACTTAGA GAGAAGTCGG AAAAGTTTGC CTTCCAAGCC 
GAAGTTAACA GAATGATGAA ACTTATCATC AATTCATTGT ATAAAAATAA AGAGATTTTC 
CTGAGAGAAC TGATTTCAAA TGCTTCTGAT GCTTTAGATA AGATAAGGCT AATATCACTG 
ACTGATGAAA ATGCTCTTTC TGGAAATGAG GAACTAACAG TCAAAATTAA GTGTGATAAG 
GAGAAGAACC TGCTGCATGT CACAGACACC GGTGTAGGAA TGACCAGAGA AGAGTTGGTT 
AAAAACCTTG GTACCATAGC CAAATCTGGG ACAAGCGAGT TTTTAAACAA AATGACTGAA 
GCACAGGAAG ATGGCCAGTC AACTTCTGAA TTGATTGGCC AGTTTGGTGT CGGTTTCTAT 
TCCGCCTTCC TTGTAGCAGA TAAGGTTATT GTCACTTCAA AACACAACAA CGATACCCAG 
CACATCTGGG AGTCTGACTC CAATGAATTT TCTGTAATTG CTGACCCAAG AGGAAACACT 
CTAGGACGGG GAACGACAAT TACCCTTGTC TTAAAAGAAG AAGCATCTGA TTACCTTGAA 
TTGGATACAA TTAAAAATCT CGTCAAAAAA TATTCACAGT TCATAAACTT TCCTATTTAT 
GTATGGAGCA GCAAGACTGA AACTGTTGAG GAGCCCATGG AGGAAGAAGA AGCAGCCAAA 
GAAGAGAAAG AAGAATCTGA TGATGAAGCT GCAGTAGAGG AAGAAGAAGA AGAAAAGAAA 
CCAAAGACTA AAAAAGTTGA AAAAACTGTC TGGGACTGGG AACTTATGAA TGATATCAAA 
CCAATATGGC AGAGACCATC AAAAGAAGTA GAAGAAGATG AATACAAAGC TTTCTACAAA 
TCATTTTCAA AGGAAAGTGA TGACCCCATG GCTTATATTC ACTTTACTGC TGAAGGGGAA 
GTTACCTTCA AATCAATTTT ATTTGTACCC ACATCTGCTC CACGTGGTCT GTTTGACGAA 
TATGGATCTA AAAAGAGCGA TTACATTAAG CTCTATGTGC GCCGTGTATT CATCACAGAC 
GACTTCCATG ATATGATGCC TAAATACCTC AATTTTGTCA AGGGTGTGGT GGACTCAGAT 
GATCTCCCCT TGAATGTTTC CCGCGAGACT CTTCAGCAAC ATAAACTGCT TAAGGTGATT 
AGGAAGAAGC TTGTTCGTAA AACGCTGGAC ATGATCAAGA AGATTGCTGA TGATAAATAC 
AATGATACTT TTTGGAAAGA ATTTGGTACC AACATCAAGC TTGGTGTGAT TGAAGACCAC 
TCGAATCGAA CACGTCTTGC TAAACTTCTT AGGTTCCAGT CTTCTCATCA TCCAACTGAC 
ATTACTAGCC TAGACCAGTA TGTGGAAAGA ATGAAGGAAA AACAAGACAA AATCTACTTC 
ATGGCTGGGT CCAGCAGAAA AGAGGCTGAA TCTTCTCCAT TTGTTGAGCG ACTTCTGAAA 
AAGGGCTATG AAGTTATTTA CCTCACAGAA CCTGTGGATG AATACTGTAT TCAGGCCCTT 
CCCGAATTTG ATGGGAAGAG GTTCCAGAAT GTTGCCAAGG AAGGAGTGAA GTTCGATGAA 
AGTGAGAAAA CTAAGGAGAG TCGTGAAGCA GTTGAGAAAG AATTTGAGCC TCTGCTGAAT 
TGGATGAAAG ATAAAGCCCT TAAGGACAAG ATTGAAAAGG CTGTGGTGTC TCAGCGCCTG 
ACAGAATCTC CGTGTGCTTT GGTGGCCAGC CAGTACGGAT GGTCTGGCAA CATGGAGAGA 
ATCATGAAAG CACAAGCGTA CCAAACGGGC AAGGACATCT CTACAAATTA CTATGCGAGT 
CAGAAGAAAA CATTTGAAAT TAATCCCAGA CACCCGCTGA TCAGAGACAT GCTTCGACGA 
ATTAAGGAAG ATGAAGATGA TAAAACAGTT TTGGATCTTG CTGTGGTTTT GTTTGAAACA 
GCAACGCTTC GGTCAGGGTA TCTTTTACCA GACACTAAAG CATATGGAGA TAGAATAGAA 
AGAATGCTTC GCCTCAGTTT GAACATTGAC CCTGATGCAA AGGTGGAAGA AGAGCCCGAA 
GAAGAACCTG AAGAGACAGC AGAAGACACA ACAGAAGACA CAGAGCAAGA CGAAGATGAA 
GAAATGGATG TGGGAACAGA TGAAGAAGAA GAAACAGCAA AGGAATCTAC AGCTGAAAAA 
GATGAATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003290.1
CDS	183..2594
Translation	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

Target ORF information:

RefSeq Version	NM_003299.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein 90 beta family member 1 (HSP90B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003299.2

ORF Insert Sequence:

ATGAGGGCCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTCGGTCAGA 
GCTGACGATG AAGTTGATGT GGATGGTACA GTAGAAGAGG ATCTGGGTAA AAGTAGAGAA 
GGATCAAGGA CGGATGATGA AGTAGTACAG AGAGAGGAAG AAGCTATTCA GTTGGATGGA 
TTAAATGCAT CACAAATAAG AGAACTTAGA GAGAAGTCGG AAAAGTTTGC CTTCCAAGCC 
GAAGTTAACA GAATGATGAA ACTTATCATC AATTCATTGT ATAAAAATAA AGAGATTTTC 
CTGAGAGAAC TGATTTCAAA TGCTTCTGAT GCTTTAGATA AGATAAGGCT AATATCACTG 
ACTGATGAAA ATGCTCTTTC TGGAAATGAG GAACTAACAG TCAAAATTAA GTGTGATAAG 
GAGAAGAACC TGCTGCATGT CACAGACACC GGTGTAGGAA TGACCAGAGA AGAGTTGGTT 
AAAAACCTTG GTACCATAGC CAAATCTGGG ACAAGCGAGT TTTTAAACAA AATGACTGAA 
GCACAGGAAG ATGGCCAGTC AACTTCTGAA TTGATTGGCC AGTTTGGTGT CGGTTTCTAT 
TCCGCCTTCC TTGTAGCAGA TAAGGTTATT GTCACTTCAA AACACAACAA CGATACCCAG 
CACATCTGGG AGTCTGACTC CAATGAATTT TCTGTAATTG CTGACCCAAG AGGAAACACT 
CTAGGACGGG GAACGACAAT TACCCTTGTC TTAAAAGAAG AAGCATCTGA TTACCTTGAA 
TTGGATACAA TTAAAAATCT CGTCAAAAAA TATTCACAGT TCATAAACTT TCCTATTTAT 
GTATGGAGCA GCAAGACTGA AACTGTTGAG GAGCCCATGG AGGAAGAAGA AGCAGCCAAA 
GAAGAGAAAG AAGAATCTGA TGATGAAGCT GCAGTAGAGG AAGAAGAAGA AGAAAAGAAA 
CCAAAGACTA AAAAAGTTGA AAAAACTGTC TGGGACTGGG AACTTATGAA TGATATCAAA 
CCAATATGGC AGAGACCATC AAAAGAAGTA GAAGAAGATG AATACAAAGC TTTCTACAAA 
TCATTTTCAA AGGAAAGTGA TGACCCCATG GCTTATATTC ACTTTACTGC TGAAGGGGAA 
GTTACCTTCA AATCAATTTT ATTTGTACCC ACATCTGCTC CACGTGGTCT GTTTGACGAA 
TATGGATCTA AAAAGAGCGA TTACATTAAG CTCTATGTGC GCCGTGTATT CATCACAGAC 
GACTTCCATG ATATGATGCC TAAATACCTC AATTTTGTCA AGGGTGTGGT GGACTCAGAT 
GATCTCCCCT TGAATGTTTC CCGCGAGACT CTTCAGCAAC ATAAACTGCT TAAGGTGATT 
AGGAAGAAGC TTGTTCGTAA AACGCTGGAC ATGATCAAGA AGATTGCTGA TGATAAATAC 
AATGATACTT TTTGGAAAGA ATTTGGTACC AACATCAAGC TTGGTGTGAT TGAAGACCAC 
TCGAATCGAA CACGTCTTGC TAAACTTCTT AGGTTCCAGT CTTCTCATCA TCCAACTGAC 
ATTACTAGCC TAGACCAGTA TGTGGAAAGA ATGAAGGAAA AACAAGACAA AATCTACTTC 
ATGGCTGGGT CCAGCAGAAA AGAGGCTGAA TCTTCTCCAT TTGTTGAGCG ACTTCTGAAA 
AAGGGCTATG AAGTTATTTA CCTCACAGAA CCTGTGGATG AATACTGTAT TCAGGCCCTT 
CCCGAATTTG ATGGGAAGAG GTTCCAGAAT GTTGCCAAGG AAGGAGTGAA GTTCGATGAA 
AGTGAGAAAA CTAAGGAGAG TCGTGAAGCA GTTGAGAAAG AATTTGAGCC TCTGCTGAAT 
TGGATGAAAG ATAAAGCCCT TAAGGACAAG ATTGAAAAGG CTGTGGTGTC TCAGCGCCTG 
ACAGAATCTC CGTGTGCTTT GGTGGCCAGC CAGTACGGAT GGTCTGGCAA CATGGAGAGA 
ATCATGAAAG CACAAGCGTA CCAAACGGGC AAGGACATCT CTACAAATTA CTATGCGAGT 
CAGAAGAAAA CATTTGAAAT TAATCCCAGA CACCCGCTGA TCAGAGACAT GCTTCGACGA 
ATTAAGGAAG ATGAAGATGA TAAAACAGTT TTGGATCTTG CTGTGGTTTT GTTTGAAACA 
GCAACGCTTC GGTCAGGGTA TCTTTTACCA GACACTAAAG CATATGGAGA TAGAATAGAA 
AGAATGCTTC GCCTCAGTTT GAACATTGAC CCTGATGCAA AGGTGGAAGA AGAGCCCGAA 
GAAGAACCTG AAGAGACAGC AGAAGACACA ACAGAAGACA CAGAGCAAGA CGAAGATGAA 
GAAATGGATG TGGGAACAGA TGAAGAAGAA GAAACAGCAA AGGAATCTAC AGCTGAAAAA 
GATGAATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695015(2017 Mar)
Cai Q,Lin J,Zhang L,Lin J,Wang L,Chen D,Peng J

Immuno-Stimulating Peptide Derived from HMGB1 is More Effective Than the N-Terminal Domain of Gp96 as an Endogenous Adjuvant for Improvement of Protein Vaccines.
Protein and peptide letters24(3)190-196(2017)
Talebi S,Bolhassani A,Azad TM,Arashkia A,Modaresi MH

Hsp90 and co-chaperones twist the functions of diverse client proteins.
Biopolymers93(3)211-7(2010 Mar)
Zuehlke A,Johnson JL

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HSP90B1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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