SNAPC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNAPC2
Entrez Gene ID	6618
Full Name	small nuclear RNA activating complex polypeptide 2
Synonyms	PTFDELTA,SNAP45
General protein information	Preferred Names small nuclear RNA activating complex polypeptide 2 Names snRNA-activating protein complex subunit 2 PSE-binding factor subunit delta PTF subunit delta SNAPC 45 kDa subunit SNAPc subunit 2 proximal sequence element-binding transcription factor subunit delta small nuclear RNA activating complex, polypeptide 2, 45kD small nuclear RNA activating complex, polypeptide 2, 45kDa snRNA-activating protein complex 45 kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
Disorder MIM:	605076

mRNA and Protein(s)

mRNA	Protein	Name
NM_003083.3	NP_003074.1	snRNA-activating protein complex subunit 2
NM_003083.4	NP_003074.1	snRNA-activating protein complex subunit 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SNAPC2	NP_001238815.1
Xenopus tropicalis (tropical clawed frog)	LOC101731544	XP_004919450.1
	SNAPC2	XP_001093136.1
Canis lupus familiaris (dog)	SNAPC2	XP_854344.2
Danio rerio (zebrafish)	LOC566292	XP_001923727.1
Bos taurus (cattle)	SNAPC2	NP_001029688.1
Mus musculus (house mouse)	Snapc2	NP_598729.1
Homo sapiens (human)	SNAPC2	NP_003074.1
Rattus norvegicus (Norway rat)	Snapc2	NP_001013139.1

Gene Ontology
Bibliography

Related articles in PubMed

Replication stress induces 53BP1-containing OPT domains in G1 cells.
Harrigan JA, Belotserkovskaya R, Coates J, Dimitrova DS, Polo SE, Bradshaw CR, Fraser P, Jackson SP
The Journal of cell biology193(1)97-108(2011 Apr)

Mitotic functions for SNAP45, a subunit of the small nuclear RNA-activating protein complex SNAPc.
Shanmugam M, Hernandez N
The Journal of biological chemistry283(21)14845-56(2008 May)

A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes.
Emran F, Florens L, Ma B, Swanson SK, Washburn MP, Hernandez N
Gene37796-108(2006 Aug)

The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.
Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW
The Journal of biological chemistry278(20)18649-57(2003 May)

A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.
Acierno JS Jr, Kennedy JC, Falardeau JL, Leyne M, Bromley MC, Colman MW, Sun M, Bove C, Ashworth LK, Chadwick LH, Schiripo T, Ma S, Goldin E, Schiffmann R, Slaugenhaupt SA
Genomics73(2)203-10(2001 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings invoke a model wherein incomplete DNA synthesis during S phase leads to a DNA damage response and formation of 53BP1-OPT domains in the subsequent G1.
Title: Replication stress induces 53BP1-containing OPT domains in G1 cells.

SNAP45 plays two roles in the cell, one as a subunit of the transcription factor SNAP(c) and another as a factor required for proper mitotic progression
Title: Mitotic functions for SNAP45, a subunit of the small nuclear RNA-activating protein complex SNAPc.

The following SNAPC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNAPC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26569	NM_003083.4 Latest version!	Homo sapiens small nuclear RNA activating complex polypeptide 2 (SNAPC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu26569	NM_003083.3	Homo sapiens small nuclear RNA activating complex polypeptide 2 (SNAPC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNAPC2 ( NM_003083.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003074.1 Homo sapiens small nuclear RNA activating complex polypeptide 2 (SNAPC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26569
Clone ID Related Accession (Same CDS sequence)	NM_003083.3 , NM_003083.4
Accession Version	NM_003083.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	snRNA-activating protein complex subunit 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF454397.1, U44755.1, AC010336.8 and EC481022.1. On Nov 3, 2009 this sequence version replaced NM_003083.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U44755.1, SRR1803611.65686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCAC CTCCCAGGCG GCGAGCGGCC CCGGCGCGCT ATCTGGGCGA GGTGACCGGT 
CCCGCGACCT GGAGCGCTCG CGAGAAGCGG CAGCTAGTGC GACTCCTGCA GGCGCGGCAG 
GGCCAGCCGG AGCCGGACGC CACCGAGCTG GCCCGGGAGC TGCGGGGCCG GAGCGAGGCT 
GAGATCCGGG TCTTCCTCCA GCAGCTCAAG GGCCGCGTAG CCCGGGAGGC CATTCAGAAA 
GTGCATCCGG GTGGCCTTCA GGGACCAAGG CGCCGGGAGG CACAGCCCCC AGCCCCCATA 
GAGGTCTGGA CGGATCTGGC TGAGAAGATA ACAGGGCCAC TGGAAGAAGC CCTGGCAGTG 
GCTTTCTCGC AGGTGCTCAC CATCGCGGCC ACGGAACCGG TCACCCTCCT GCACTCCAAG 
CCCCCCAAGC CCACGCAGGC CCGTGGAAAG CCTTTGCTCC TGAGCGCCCC TGGAGGACAG 
GAAGACCCCG CCCCTGAAAT ACCTAGCTCT GCCCCTGCTG CACCTAGCTC CGCACCCAGG 
ACTCCTGACC CTGCCCCTGA GAAACCTTCT GAGTCGTCGG CTGGTCCCTC CACTGAAGAA 
GACTTTGCTG TGGACTTTGA GAAGATCTAC AAGTACTTGT CCTCTGTCTC CCGAAGTGGC 
CGCAGCCCCG AGCTCTCAGC AGCTGAGTCC GCTGTGGTCC TCGACCTGCT CATGTCACTT 
CCAGAGGAGC TGCCACTCCT GCCCTGCACA GCCCTGGTTG AGCATATGAC GGAGACGTAC 
CTACGCCTGA CAGCCCCCCA GCCCATTCCC GCTGGAGGGA GCCTGGGGCC TGCAGCAGAA 
GGGGATGGGG CTGGCTCCAA GGCACCAGAG GAGACCCCCC CAGCCACCGA GAAGGCCGAG 
CACAGCGAAC TGAAATCGCC TTGGCAAGCA GCTGGGATCT GTCCCCTGAA CCCGTTCCTG 
GTGCCCCTGG AGCTTCTGGG TCGGGCAGCC ACCCCTGCCA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003074.1
CDS	59..1063
Translation	MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPEPDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLGPAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR

Target ORF information:

RefSeq Version	NM_003083.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear RNA activating complex polypeptide 2 (SNAPC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003083.3

ORF Insert Sequence:

ATGAAGCCAC CTCCCAGGCG GCGAGCGGCC CCGGCGCGCT ATCTGGGCGA GGTGACCGGT 
CCCGCGACCT GGAGCGCTCG CGAGAAGCGG CAGCTAGTGC GACTCCTGCA GGCGCGGCAG 
GGCCAGCCGG AGCCGGACGC CACCGAGCTG GCCCGGGAGC TGCGGGGCCG GAGCGAGGCT 
GAGATCCGGG TCTTCCTCCA GCAGCTCAAG GGCCGCGTAG CCCGGGAGGC CATTCAGAAA 
GTGCATCCGG GTGGCCTTCA GGGACCAAGG CGCCGGGAGG CACAGCCCCC AGCCCCCATA 
GAGGTCTGGA CGGATCTGGC TGAGAAGATA ACAGGGCCAC TGGAAGAAGC CCTGGCAGTG 
GCTTTCTCGC AGGTGCTCAC CATCGCGGCC ACGGAACCGG TCACCCTCCT GCACTCCAAG 
CCCCCCAAGC CCACGCAGGC CCGTGGAAAG CCTTTGCTCC TGAGCGCCCC TGGAGGACAG 
GAAGACCCCG CCCCTGAAAT ACCTAGCTCT GCCCCTGCTG CACCTAGCTC CGCACCCAGG 
ACTCCTGACC CTGCCCCTGA GAAACCTTCT GAGTCGTCGG CTGGTCCCTC CACTGAAGAA 
GACTTTGCTG TGGACTTTGA GAAGATCTAC AAGTACTTGT CCTCTGTCTC CCGAAGTGGC 
CGCAGCCCCG AGCTCTCAGC AGCTGAGTCC GCTGTGGTCC TCGACCTGCT CATGTCACTT 
CCAGAGGAGC TGCCACTCCT GCCCTGCACA GCCCTGGTTG AGCATATGAC GGAGACGTAC 
CTACGCCTGA CAGCCCCCCA GCCCATTCCC GCTGGAGGGA GCCTGGGGCC TGCAGCAGAA 
GGGGATGGGG CTGGCTCCAA GGCACCAGAG GAGACCCCCC CAGCCACCGA GAAGGCCGAG 
CACAGCGAAC TGAAATCGCC TTGGCAAGCA GCTGGGATCT GTCCCCTGAA CCCGTTCCTG 
GTGCCCCTGG AGCTTCTGGG TCGGGCAGCC ACCCCTGCCA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNAPC2 ( NM_003083.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003074.1 Homo sapiens small nuclear RNA activating complex polypeptide 2 (SNAPC2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26569
Clone ID Related Accession (Same CDS sequence)	NM_003083.3 , NM_003083.4
Accession Version	NM_003083.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	snRNA-activating protein complex subunit 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U44755.1 and AC010336.8. On Nov 23, 2018 this sequence version replaced NM_003083.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U44755.1, SRR3476690.130996.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221573.11/ ENSP00000221573.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCCAC CTCCCAGGCG GCGAGCGGCC CCGGCGCGCT ATCTGGGCGA GGTGACCGGT 
CCCGCGACCT GGAGCGCTCG CGAGAAGCGG CAGCTAGTGC GACTCCTGCA GGCGCGGCAG 
GGCCAGCCGG AGCCGGACGC CACCGAGCTG GCCCGGGAGC TGCGGGGCCG GAGCGAGGCT 
GAGATCCGGG TCTTCCTCCA GCAGCTCAAG GGCCGCGTAG CCCGGGAGGC CATTCAGAAA 
GTGCATCCGG GTGGCCTTCA GGGACCAAGG CGCCGGGAGG CACAGCCCCC AGCCCCCATA 
GAGGTCTGGA CGGATCTGGC TGAGAAGATA ACAGGGCCAC TGGAAGAAGC CCTGGCAGTG 
GCTTTCTCGC AGGTGCTCAC CATCGCGGCC ACGGAACCGG TCACCCTCCT GCACTCCAAG 
CCCCCCAAGC CCACGCAGGC CCGTGGAAAG CCTTTGCTCC TGAGCGCCCC TGGAGGACAG 
GAAGACCCCG CCCCTGAAAT ACCTAGCTCT GCCCCTGCTG CACCTAGCTC CGCACCCAGG 
ACTCCTGACC CTGCCCCTGA GAAACCTTCT GAGTCGTCGG CTGGTCCCTC CACTGAAGAA 
GACTTTGCTG TGGACTTTGA GAAGATCTAC AAGTACTTGT CCTCTGTCTC CCGAAGTGGC 
CGCAGCCCCG AGCTCTCAGC AGCTGAGTCC GCTGTGGTCC TCGACCTGCT CATGTCACTT 
CCAGAGGAGC TGCCACTCCT GCCCTGCACA GCCCTGGTTG AGCATATGAC GGAGACGTAC 
CTACGCCTGA CAGCCCCCCA GCCCATTCCC GCTGGAGGGA GCCTGGGGCC TGCAGCAGAA 
GGGGATGGGG CTGGCTCCAA GGCACCAGAG GAGACCCCCC CAGCCACCGA GAAGGCCGAG 
CACAGCGAAC TGAAATCGCC TTGGCAAGCA GCTGGGATCT GTCCCCTGAA CCCGTTCCTG 
GTGCCCCTGG AGCTTCTGGG TCGGGCAGCC ACCCCTGCCA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003074.1
CDS	30..1034
Translation	MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPEPDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEVWTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQEDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSRSGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLGPAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR

Target ORF information:

RefSeq Version	NM_003083.4
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear RNA activating complex polypeptide 2 (SNAPC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003083.4

ORF Insert Sequence:

ATGAAGCCAC CTCCCAGGCG GCGAGCGGCC CCGGCGCGCT ATCTGGGCGA GGTGACCGGT 
CCCGCGACCT GGAGCGCTCG CGAGAAGCGG CAGCTAGTGC GACTCCTGCA GGCGCGGCAG 
GGCCAGCCGG AGCCGGACGC CACCGAGCTG GCCCGGGAGC TGCGGGGCCG GAGCGAGGCT 
GAGATCCGGG TCTTCCTCCA GCAGCTCAAG GGCCGCGTAG CCCGGGAGGC CATTCAGAAA 
GTGCATCCGG GTGGCCTTCA GGGACCAAGG CGCCGGGAGG CACAGCCCCC AGCCCCCATA 
GAGGTCTGGA CGGATCTGGC TGAGAAGATA ACAGGGCCAC TGGAAGAAGC CCTGGCAGTG 
GCTTTCTCGC AGGTGCTCAC CATCGCGGCC ACGGAACCGG TCACCCTCCT GCACTCCAAG 
CCCCCCAAGC CCACGCAGGC CCGTGGAAAG CCTTTGCTCC TGAGCGCCCC TGGAGGACAG 
GAAGACCCCG CCCCTGAAAT ACCTAGCTCT GCCCCTGCTG CACCTAGCTC CGCACCCAGG 
ACTCCTGACC CTGCCCCTGA GAAACCTTCT GAGTCGTCGG CTGGTCCCTC CACTGAAGAA 
GACTTTGCTG TGGACTTTGA GAAGATCTAC AAGTACTTGT CCTCTGTCTC CCGAAGTGGC 
CGCAGCCCCG AGCTCTCAGC AGCTGAGTCC GCTGTGGTCC TCGACCTGCT CATGTCACTT 
CCAGAGGAGC TGCCACTCCT GCCCTGCACA GCCCTGGTTG AGCATATGAC GGAGACGTAC 
CTACGCCTGA CAGCCCCCCA GCCCATTCCC GCTGGAGGGA GCCTGGGGCC TGCAGCAGAA 
GGGGATGGGG CTGGCTCCAA GGCACCAGAG GAGACCCCCC CAGCCACCGA GAAGGCCGAG 
CACAGCGAAC TGAAATCGCC TTGGCAAGCA GCTGGGATCT GTCCCCTGAA CCCGTTCCTG 
GTGCCCCTGG AGCTTCTGGG TCGGGCAGCC ACCCCTGCCA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Replication stress induces 53BP1-containing OPT domains in G1 cells.
The Journal of cell biology193(1)97-108(2011 Apr)
Harrigan JA,Belotserkovskaya R,Coates J,Dimitrova DS,Polo SE,Bradshaw CR,Fraser P,Jackson SP

Mitotic functions for SNAP45, a subunit of the small nuclear RNA-activating protein complex SNAPc.
The Journal of biological chemistry283(21)14845-56(2008 May)
Shanmugam M,Hernandez N

A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes.
Gene37796-108(2006 Aug)
Emran F,Florens L,Ma B,Swanson SK,Washburn MP,Hernandez N

The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.
The Journal of biological chemistry278(20)18649-57(2003 May)
Hinkley CS,Hirsch HA,Gu L,LaMere B,Henry RW

A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.
Genomics73(2)203-10(2001 Apr)
Acierno JS Jr,Kennedy JC,Falardeau JL,Leyne M,Bromley MC,Colman MW,Sun M,Bove C,Ashworth LK,Chadwick LH,Schiripo T,Ma S,Goldin E,Schiffmann R,Slaugenhaupt SA

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SNAPC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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