SMPD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMPD2
Entrez Gene ID	6610
Full Name	sphingomyelin phosphodiesterase 2
Synonyms	ISC1,NSMASE,NSMASE1
General protein information	Preferred Names sphingomyelin phosphodiesterase 2 Names sphingomyelin phosphodiesterase 2 N-SMase lyso-PAF-PLC lyso-platelet-activating factor-phospholipase C neutral sphingomyelinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q21
Summary	This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009].
Disorder MIM:	603498

mRNA and Protein(s)

mRNA	Protein	Name
XM_024446526.1	XP_024302294.1	sphingomyelin phosphodiesterase 2 isoform X1
XM_011536079.1	XP_011534381.1	sphingomyelin phosphodiesterase 2 isoform X2
NM_003080.2	NP_003071.2	sphingomyelin phosphodiesterase 2
NM_003080.3	NP_003071.2	sphingomyelin phosphodiesterase 2
XM_005267109.1	XP_005267166.1	sphingomyelin phosphodiesterase 2 isoform X3
XM_024446527.1	XP_024302295.1	sphingomyelin phosphodiesterase 2 isoform X3

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	smpd2a	NP_001025390.1
Danio rerio (zebrafish)	LOC797914	XP_001338369.2
Pan troglodytes (chimpanzee)	SMPD2	XP_001152001.1
Rattus norvegicus (Norway rat)	Smpd2	NP_112650.1
Gallus gallus (chicken)	SMPD2	XP_001232516.1
Caenorhabditis elegans (roundworm)	T27F6.6	NP_493169.2
	SMPD2	XP_001090569.1
Drosophila melanogaster (fruit fly)	CG12034	NP_647790.1
Xenopus tropicalis (tropical clawed frog)	smpd2	NP_001120209.1
Homo sapiens (human)	SMPD2	NP_003071.2
Bos taurus (cattle)	SMPD2	NP_001068851.2
Mus musculus (house mouse)	Smpd2	NP_033239.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008053	XP_001689028.1
Canis lupus familiaris (dog)	SMPD2	XP_005627754.1

Gene Ontology
Bibliography

Related articles in PubMed

Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae.
Faulstich M, Hagen F, Avota E, Kozjak-Pavlovic V, Winkler AC, Xian Y, Schneider-Schaulies S, Rudel T
Cellular microbiology17(2)241-53(2015 Feb)

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.
Yabu T, Shiba H, Shibasaki Y, Nakanishi T, Imamura S, Touhata K, Yamashita M
Cell death and differentiation22(2)258-73(2015 Feb)

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
Kihara A, Mitsutake S, Mizutani Y, Igarashi Y
Progress in lipid research46(2)126-44(2007 Mar)

Ceramide synthesis and metabolism as a target for cancer therapy.
Reynolds CP, Maurer BJ, Kolesnick RN
Cancer letters206(2)169-80(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interestingly, neutral but not acid sphingomyelinase was mandatory for PorBIA -mediated Neisseria gonorrhoeae invasion into host cells.
Title: Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae.

nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2)has a common central role in ceramide signaling during the stress and cytokine responses and apoptosis.
Title: Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.

These data suggest that Ox-LDL activates N-SMase-ceramide signaling pathway, and stimulates phosphorylation of p38 MAPK, leading to apoptosis in vascular smooth muscle cells, which initiates VSMC calcification.
Title: Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling.

NSM2 plays a key role in the cellular response to hyperosmolar stress, and its activity regulates both cytokine secretion and lipid droplet formation.
Title: Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2.

cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5.
Title: Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.

The following SMPD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMPD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30447	NM_003080.3 Latest version!	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu40944	XM_005267109.1 Latest version!	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu40944	XM_024446527.1 Latest version!	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu60649	XM_011536079.1 Latest version!	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu105829	XM_024446526.1 Latest version!	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu30447	NM_003080.2	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMPD2 ( NM_003080.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003071.2 Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), mRNA.

Price & Availability↑

CloneID	OHu30447
Clone ID Related Accession (Same CDS sequence)	NM_003080.2 , NM_003080.3
Accession Version	NM_003080.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sphingomyelin phosphodiesterase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA672570.1, AJ222801.1 and CA314251.1. On Apr 19, 2006 this sequence version replaced NM_003080.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313515.1, SRR1163657.401007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCCCA ACTTCTCCCT GCGACTGCGG ATCTTCAACC TCAACTGCTG GGGCATTCCG 
TACTTGAGCA AGCACCGGGC CGACCGCATG AGGCGCCTGG GAGACTTTCT GAACCAGGAG 
AGCTTCGACC TGGCTTTGCT GGAGGAGGTG TGGAGTGAGC AGGACTTCCA GTACCTGAGA 
CAGAAGCTGT CACCTACCTA CCCAGCTGCA CACCACTTCC GGAGCGGAAT CATTGGCAGT 
GGCCTCTGTG TCTTCTCCAA ACATCCAATC CAGGAGCTTA CCCAGCACAT CTACACTCTC 
AATGGCTACC CCTACATGAT CCATCATGGT GACTGGTTCA GTGGGAAGGC TGTGGGGCTG 
CTGGTGCTCC ATCTAAGTGG CATGGTGCTC AACGCCTATG TGACCCATCT CCATGCCGAA 
TACAATCGAC AGAAGGACAT CTACCTAGCA CATCGTGTGG CCCAAGCTTG GGAATTGGCC 
CAGTTCATCC ACCACACATC CAAGAAGGCA GACGTGGTTC TGTTGTGTGG AGACCTCAAC 
ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003071.2
CDS	395..1666
Translation	MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Target ORF information:

RefSeq Version	NM_003080.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003080.2

ORF Insert Sequence:

ATGAAGCCCA ACTTCTCCCT GCGACTGCGG ATCTTCAACC TCAACTGCTG GGGCATTCCG 
TACTTGAGCA AGCACCGGGC CGACCGCATG AGGCGCCTGG GAGACTTTCT GAACCAGGAG 
AGCTTCGACC TGGCTTTGCT GGAGGAGGTG TGGAGTGAGC AGGACTTCCA GTACCTGAGA 
CAGAAGCTGT CACCTACCTA CCCAGCTGCA CACCACTTCC GGAGCGGAAT CATTGGCAGT 
GGCCTCTGTG TCTTCTCCAA ACATCCAATC CAGGAGCTTA CCCAGCACAT CTACACTCTC 
AATGGCTACC CCTACATGAT CCATCATGGT GACTGGTTCA GTGGGAAGGC TGTGGGGCTG 
CTGGTGCTCC ATCTAAGTGG CATGGTGCTC AACGCCTATG TGACCCATCT CCATGCCGAA 
TACAATCGAC AGAAGGACAT CTACCTAGCA CATCGTGTGG CCCAAGCTTG GGAATTGGCC 
CAGTTCATCC ACCACACATC CAAGAAGGCA GACGTGGTTC TGTTGTGTGG AGACCTCAAC 
ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMPD2 ( NM_003080.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003071.2 Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), mRNA.

Price & Availability↑

CloneID	OHu30447
Clone ID Related Accession (Same CDS sequence)	NM_003080.2 , NM_003080.3
Accession Version	NM_003080.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-10
Organism	Homo sapiens(human)
Product	sphingomyelin phosphodiesterase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL109947.19, DA672570.1, AJ222801.1 and CA314251.1. On Nov 23, 2018 this sequence version replaced NM_003080.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.339385.1, AK313515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258052.8/ ENSP00000258052.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCCCA ACTTCTCCCT GCGACTGCGG ATCTTCAACC TCAACTGCTG GGGCATTCCG 
TACTTGAGCA AGCACCGGGC CGACCGCATG AGGCGCCTGG GAGACTTTCT GAACCAGGAG 
AGCTTCGACC TGGCTTTGCT GGAGGAGGTG TGGAGTGAGC AGGACTTCCA GTACCTGAGA 
CAGAAGCTGT CACCTACCTA CCCAGCTGCA CACCACTTCC GGAGCGGAAT CATTGGCAGT 
GGCCTCTGTG TCTTCTCCAA ACATCCAATC CAGGAGCTTA CCCAGCACAT CTACACTCTC 
AATGGCTACC CCTACATGAT CCATCATGGT GACTGGTTCA GTGGGAAGGC TGTGGGGCTG 
CTGGTGCTCC ATCTAAGTGG CATGGTGCTC AACGCCTATG TGACCCATCT CCATGCCGAA 
TACAATCGAC AGAAGGACAT CTACCTAGCA CATCGTGTGG CCCAAGCTTG GGAATTGGCC 
CAGTTCATCC ACCACACATC CAAGAAGGCA GACGTGGTTC TGTTGTGTGG AGACCTCAAC 
ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003071.2
CDS	399..1670
Translation	MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Target ORF information:

RefSeq Version	NM_003080.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003080.3

ORF Insert Sequence:

ATGAAGCCCA ACTTCTCCCT GCGACTGCGG ATCTTCAACC TCAACTGCTG GGGCATTCCG 
TACTTGAGCA AGCACCGGGC CGACCGCATG AGGCGCCTGG GAGACTTTCT GAACCAGGAG 
AGCTTCGACC TGGCTTTGCT GGAGGAGGTG TGGAGTGAGC AGGACTTCCA GTACCTGAGA 
CAGAAGCTGT CACCTACCTA CCCAGCTGCA CACCACTTCC GGAGCGGAAT CATTGGCAGT 
GGCCTCTGTG TCTTCTCCAA ACATCCAATC CAGGAGCTTA CCCAGCACAT CTACACTCTC 
AATGGCTACC CCTACATGAT CCATCATGGT GACTGGTTCA GTGGGAAGGC TGTGGGGCTG 
CTGGTGCTCC ATCTAAGTGG CATGGTGCTC AACGCCTATG TGACCCATCT CCATGCCGAA 
TACAATCGAC AGAAGGACAT CTACCTAGCA CATCGTGTGG CCCAAGCTTG GGAATTGGCC 
CAGTTCATCC ACCACACATC CAAGAAGGCA GACGTGGTTC TGTTGTGTGG AGACCTCAAC 
ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMPD2 ( XM_005267109.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005267166.1 Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu40944
Clone ID Related Accession (Same CDS sequence)	XM_005267109.1 , XM_024446527.1
Accession Version	XM_005267109.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingomyelin phosphodiesterase 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005267166.1
CDS	472..1203
Translation	MHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Target ORF information:

RefSeq Version	XM_005267109.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005267109.1

ORF Insert Sequence:

ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMPD2 ( XM_024446527.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302295.1 Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X4, mRNA.

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CloneID	OHu40944
Clone ID Related Accession (Same CDS sequence)	XM_005267109.1 , XM_024446527.1
Accession Version	XM_024446527.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingomyelin phosphodiesterase 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302295.1
CDS	1274..2005
Translation	MHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Target ORF information:

RefSeq Version	XM_024446527.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446527.1

ORF Insert Sequence:

ATGCACCCAG AAGACCTGGG CTGCTGCCTG CTGAAGGAGT GGACAGGGCT TCATGATGCC 
TATCTTGAAA CTCGGGACTT CAAGGGCTCT GAGGAAGGCA ACACAATGGT ACCCAAGAAC 
TGCTACGTCA GCCAGCAGGA GCTGAAGCCA TTTCCCTTTG GTGTCCGCAT TGACTACGTG 
CTTTACAAGG CAGTTTCTGG GTTTTACATC TCCTGTAAGA GTTTTGAAAC CACTACAGGC 
TTTGACCCTC ACAGGGGCAC CCCCCTCTCT GATCATGAAG CCCTGATGGC TACTCTGTTT 
GTGAGGCACA GCCCCCCACA GCAGAACCCC AGCTCTACCC ACGGACCAGC AGAGAGGTCG 
CCGTTGATGT GTGTGCTAAA GGAGGCCTGG ACGGAGCTGG GTCTGGGCAT GGCTCAGGCT 
CGCTGGTGGG CCACCTTCGC TAGCTATGTG ATTGGCCTGG GGCTGCTTCT CCTGGCACTG 
CTGTGTGTCC TGGCGGCTGG AGGAGGGGCC GGGGAAGCTG CCATACTGCT CTGGACCCCC 
AGTGTAGGGC TGGTGCTGTG GGCAGGTGCA TTCTACCTCT TCCACGTACA GGAGGTCAAT 
GGCTTATATA GGGCCCAGGC TGAGCTCCAG CATGTGCTAG GAAGGGCAAG GGAGGCCCAG 
GATCTGGGCC CAGAGCCTCA GCCAGCCCTA CTCCTGGGGC AGCAGGAGGG GGACAGAACT 
AAAGAACAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMPD2 ( XM_011536079.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011534381.1 Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu60649
Clone ID Related Accession (Same CDS sequence)	XM_011536079.1
Accession Version	XM_011536079.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingomyelin phosphodiesterase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATCCATC ATGGTGACTG GTTCAGTGGG AAGGCTGTGG GGCTGCTGGT GCTCCATCTA 
AGTGGCATGG TGCTCAACGC CTATGTGACC CATCTCCATG CCGAATACAA TCGACAGAAG 
GACATCTACC TAGCACATCG TGTGGCCCAA GCTTGGGAAT TGGCCCAGTT CATCCACCAC 
ACATCCAAGA AGGCAGACGT GGTTCTGTTG TGTGGAGACC TCAACATGCA CCCAGAAGAC 
CTGGGCTGCT GCCTGCTGAA GGAGTGGACA GGGCTTCATG ATGCCTATCT TGAAACTCGG 
GACTTCAAGG GCTCTGAGGA AGGCAACACA ATGGTACCCA AGAACTGCTA CGTCAGCCAG 
CAGGAGCTGA AGCCATTTCC CTTTGGTGTC CGCATTGACT ACGTGCTTTA CAAGGCAGTT 
TCTGGGTTTT ACATCTCCTG TAAGAGTTTT GAAACCACTA CAGGCTTTGA CCCTCACAGG 
GGCACCCCCC TCTCTGATCA TGAAGCCCTG ATGGCTACTC TGTTTGTGAG GCACAGCCCC 
CCACAGCAGA ACCCCAGCTC TACCCACGGA CCAGCAGAGA GGTCGCCGTT GATGTGTGTG 
CTAAAGGAGG CCTGGACGGA GCTGGGTCTG GGCATGGCTC AGGCTCGCTG GTGGGCCACC 
TTCGCTAGCT ATGTGATTGG CCTGGGGCTG CTTCTCCTGG CACTGCTGTG TGTCCTGGCG 
GCTGGAGGAG GGGCCGGGGA AGCTGCCATA CTGCTCTGGA CCCCCAGTGT AGGGCTGGTG 
CTGTGGGCAG GTGCATTCTA CCTCTTCCAC GTACAGGAGG TCAATGGCTT ATATAGGGCC 
CAGGCTGAGC TCCAGCATGT GCTAGGAAGG GCAAGGGAGG CCCAGGATCT GGGCCCAGAG 
CCTCAGCCAG CCCTACTCCT GGGGCAGCAG GAGGGGGACA GAACTAAAGA ACAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011534381.1
CDS	183..1139
Translation	MIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Target ORF information:

RefSeq Version	XM_011536079.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011536079.1

ORF Insert Sequence:

ATGATCCATC ATGGTGACTG GTTCAGTGGG AAGGCTGTGG GGCTGCTGGT GCTCCATCTA 
AGTGGCATGG TGCTCAACGC CTATGTGACC CATCTCCATG CCGAATACAA TCGACAGAAG 
GACATCTACC TAGCACATCG TGTGGCCCAA GCTTGGGAAT TGGCCCAGTT CATCCACCAC 
ACATCCAAGA AGGCAGACGT GGTTCTGTTG TGTGGAGACC TCAACATGCA CCCAGAAGAC 
CTGGGCTGCT GCCTGCTGAA GGAGTGGACA GGGCTTCATG ATGCCTATCT TGAAACTCGG 
GACTTCAAGG GCTCTGAGGA AGGCAACACA ATGGTACCCA AGAACTGCTA CGTCAGCCAG 
CAGGAGCTGA AGCCATTTCC CTTTGGTGTC CGCATTGACT ACGTGCTTTA CAAGGCAGTT 
TCTGGGTTTT ACATCTCCTG TAAGAGTTTT GAAACCACTA CAGGCTTTGA CCCTCACAGG 
GGCACCCCCC TCTCTGATCA TGAAGCCCTG ATGGCTACTC TGTTTGTGAG GCACAGCCCC 
CCACAGCAGA ACCCCAGCTC TACCCACGGA CCAGCAGAGA GGTCGCCGTT GATGTGTGTG 
CTAAAGGAGG CCTGGACGGA GCTGGGTCTG GGCATGGCTC AGGCTCGCTG GTGGGCCACC 
TTCGCTAGCT ATGTGATTGG CCTGGGGCTG CTTCTCCTGG CACTGCTGTG TGTCCTGGCG 
GCTGGAGGAG GGGCCGGGGA AGCTGCCATA CTGCTCTGGA CCCCCAGTGT AGGGCTGGTG 
CTGTGGGCAG GTGCATTCTA CCTCTTCCAC GTACAGGAGG TCAATGGCTT ATATAGGGCC 
CAGGCTGAGC TCCAGCATGT GCTAGGAAGG GCAAGGGAGG CCCAGGATCT GGGCCCAGAG 
CCTCAGCCAG CCCTACTCCT GGGGCAGCAG GAGGGGGACA GAACTAAAGA ACAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMPD2 ( XM_024446526.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302294.1 Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu105829
Clone ID Related Accession (Same CDS sequence)	XM_024446526.1
Accession Version	XM_024446526.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1398bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sphingomyelin phosphodiesterase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCCA ACTTCTCCCT GCGACTGCGG ATCTTCAACC TCAACTGCTG GGGCATTCCG 
TACTTGAGCA AGCACCGGGC CGACCGCATG AGGCGCCTGG GAGACTTTCT GAACCAGGAG 
AGCTTCGACC TGGCTTTGCT GGAGGAGGTG TGGAGTGAGC AGGACTTCCA GTACCTGAGA 
CAGAAGCTGT CACCTACCTA CCCAGCTGCA CACCACTTCC GGAGCGGAAT CATTGGCAGT 
GGCCTCTGTG TCTTCTCCAA ACATCCAATC CAGGAGCTTA CCCAGCACAT CTACACTCTC 
AATGGCTACC CCTACATGAT CCATCATGGT GACTGGTTCA GTGGGAAGGC TGTGGGGCTG 
CTGGTGCTCC ATCTAAGTGG CATGGTGCTC AACGCCTATG TGACCCATCT CCATGCCGAA 
TACAATCGAC AGAAGGACAT CTACCTAGCA CATCGTGTGG CCCAAGCTTG GGAATTGGCC 
CAGTTCATCC AGTGTGTGAG CCTGGGCTTG AAATGGGAAG TGGGATGGGA CCCAGGGGCT 
GAGGGTGAAC AAGGCCCCAG TCATGGGGAA GAGCTGGTGA TGGAAGAACT CCCGCCTCAC 
CAACCTGGTT CCCCCAGCCA CACATCCAAG AAGGCAGACG TGGTTCTGTT GTGTGGAGAC 
CTCAACATGC ACCCAGAAGA CCTGGGCTGC TGCCTGCTGA AGGAGTGGAC AGGGCTTCAT 
GATGCCTATC TTGAAACTCG GGACTTCAAG GGCTCTGAGG AAGGCAACAC AATGGTACCC 
AAGAACTGCT ACGTCAGCCA GCAGGAGCTG AAGCCATTTC CCTTTGGTGT CCGCATTGAC 
TACGTGCTTT ACAAGGCAGT TTCTGGGTTT TACATCTCCT GTAAGAGTTT TGAAACCACT 
ACAGGCTTTG ACCCTCACAG GGGCACCCCC CTCTCTGATC ATGAAGCCCT GATGGCTACT 
CTGTTTGTGA GGCACAGCCC CCCACAGCAG AACCCCAGCT CTACCCACGG ACCAGCAGAG 
AGGTCGCCGT TGATGTGTGT GCTAAAGGAG GCCTGGACGG AGCTGGGTCT GGGCATGGCT 
CAGGCTCGCT GGTGGGCCAC CTTCGCTAGC TATGTGATTG GCCTGGGGCT GCTTCTCCTG 
GCACTGCTGT GTGTCCTGGC GGCTGGAGGA GGGGCCGGGG AAGCTGCCAT ACTGCTCTGG 
ACCCCCAGTG TAGGGCTGGT GCTGTGGGCA GGTGCATTCT ACCTCTTCCA CGTACAGGAG 
GTCAATGGCT TATATAGGGC CCAGGCTGAG CTCCAGCATG TGCTAGGAAG GGCAAGGGAG 
GCCCAGGATC TGGGCCCAGA GCCTCAGCCA GCCCTACTCC TGGGGCAGCA GGAGGGGGAC 
AGAACTAAAG AACAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302294.1
CDS	402..1799
Translation	MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIQCVSLGLKWEVGWDPGAEGEQGPSHGEELVMEELPPHQPGSPSHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

Target ORF information:

RefSeq Version	XM_024446526.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sphingomyelin phosphodiesterase 2 (SMPD2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446526.1

ORF Insert Sequence:

ATGAAGCCCA ACTTCTCCCT GCGACTGCGG ATCTTCAACC TCAACTGCTG GGGCATTCCG 
TACTTGAGCA AGCACCGGGC CGACCGCATG AGGCGCCTGG GAGACTTTCT GAACCAGGAG 
AGCTTCGACC TGGCTTTGCT GGAGGAGGTG TGGAGTGAGC AGGACTTCCA GTACCTGAGA 
CAGAAGCTGT CACCTACCTA CCCAGCTGCA CACCACTTCC GGAGCGGAAT CATTGGCAGT 
GGCCTCTGTG TCTTCTCCAA ACATCCAATC CAGGAGCTTA CCCAGCACAT CTACACTCTC 
AATGGCTACC CCTACATGAT CCATCATGGT GACTGGTTCA GTGGGAAGGC TGTGGGGCTG 
CTGGTGCTCC ATCTAAGTGG CATGGTGCTC AACGCCTATG TGACCCATCT CCATGCCGAA 
TACAATCGAC AGAAGGACAT CTACCTAGCA CATCGTGTGG CCCAAGCTTG GGAATTGGCC 
CAGTTCATCC AGTGTGTGAG CCTGGGCTTG AAATGGGAAG TGGGATGGGA CCCAGGGGCT 
GAGGGTGAAC AAGGCCCCAG TCATGGGGAA GAGCTGGTGA TGGAAGAACT CCCGCCTCAC 
CAACCTGGTT CCCCCAGCCA CACATCCAAG AAGGCAGACG TGGTTCTGTT GTGTGGAGAC 
CTCAACATGC ACCCAGAAGA CCTGGGCTGC TGCCTGCTGA AGGAGTGGAC AGGGCTTCAT 
GATGCCTATC TTGAAACTCG GGACTTCAAG GGCTCTGAGG AAGGCAACAC AATGGTACCC 
AAGAACTGCT ACGTCAGCCA GCAGGAGCTG AAGCCATTTC CCTTTGGTGT CCGCATTGAC 
TACGTGCTTT ACAAGGCAGT TTCTGGGTTT TACATCTCCT GTAAGAGTTT TGAAACCACT 
ACAGGCTTTG ACCCTCACAG GGGCACCCCC CTCTCTGATC ATGAAGCCCT GATGGCTACT 
CTGTTTGTGA GGCACAGCCC CCCACAGCAG AACCCCAGCT CTACCCACGG ACCAGCAGAG 
AGGTCGCCGT TGATGTGTGT GCTAAAGGAG GCCTGGACGG AGCTGGGTCT GGGCATGGCT 
CAGGCTCGCT GGTGGGCCAC CTTCGCTAGC TATGTGATTG GCCTGGGGCT GCTTCTCCTG 
GCACTGCTGT GTGTCCTGGC GGCTGGAGGA GGGGCCGGGG AAGCTGCCAT ACTGCTCTGG 
ACCCCCAGTG TAGGGCTGGT GCTGTGGGCA GGTGCATTCT ACCTCTTCCA CGTACAGGAG 
GTCAATGGCT TATATAGGGC CCAGGCTGAG CTCCAGCATG TGCTAGGAAG GGCAAGGGAG 
GCCCAGGATC TGGGCCCAGA GCCTCAGCCA GCCCTACTCC TGGGGCAGCA GGAGGGGGAC 
AGAACTAAAG AACAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae.
Cellular microbiology17(2)241-53(2015 Feb)
Faulstich M,Hagen F,Avota E,Kozjak-Pavlovic V,Winkler AC,Xian Y,Schneider-Schaulies S,Rudel T

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.
Cell death and differentiation22(2)258-73(2015 Feb)
Yabu T,Shiba H,Shibasaki Y,Nakanishi T,Imamura S,Touhata K,Yamashita M

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
Progress in lipid research46(2)126-44(2007 Mar)
Kihara A,Mitsutake S,Mizutani Y,Igarashi Y

Ceramide synthesis and metabolism as a target for cancer therapy.
Cancer letters206(2)169-80(2004 Apr)
Reynolds CP,Maurer BJ,Kolesnick RN

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SMPD2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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