CXCL6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL6
Entrez Gene ID	6372
Full Name	C-X-C motif chemokine ligand 6
Synonyms	CKA-3,GCP-2,GCP2,SCYB6
General protein information	Preferred Names C-X-C motif chemokine ligand 6 Names C-X-C motif chemokine 6 Small inducible cytokine subfamily B (Cys-X-Cys), member b chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) chemokine alpha 3 granulocyte chemotactic protein 2 small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2) small-inducible cytokine B6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Disorder MIM:	138965

mRNA and Protein(s)

mRNA	Protein	Name
NM_002993.3	NP_002984.1	C-X-C motif chemokine 6 precursor
NM_002993.4	NP_002984.1	C-X-C motif chemokine 6 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cxcl5	NP_033167.2
Rattus norvegicus (Norway rat)	Cxcl5	NP_071550.1
Pan troglodytes (chimpanzee)	CXCL6	XP_001156255.1
	CXCL6	XP_001103136.1
Homo sapiens (human)	CXCL6	NP_002984.1

Gene Ontology
Bibliography

Related articles in PubMed

CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p.
Li J, Tang Z, Wang H, Wu W, Zhou F, Ke H, Lu W, Zhang S, Zhang Y, Yang S, Ni S, Huang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie971182-1188(2018 Jan)

CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome.
Tor?n JL, Aguilar S, L?pez JA, Torroja C, Quintana JA, Santiago C, Abad JL, Gomes-Alves P, Gonzalez A, Bernal JA, Jim?nez-Borreguero LJ, Alves PM, R-Borlado L, V?zquez J, Bernad A
Scientific reports7(1)12490(2017 Oct)

Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
Taniguchi T, Asano Y, Nakamura K, Yamashita T, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S
The Journal of rheumatology44(8)1198-1205(2017 Aug)

Fibroblast-derived CXCL12/SDF-1? promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer.
Ma JC, Sun XW, Su H, Chen Q, Guo TK, Li Y, Chen XC, Guo J, Gong ZQ, Zhao XD, Qi JB
World journal of gastroenterology23(28)5167-5178(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure.
Title: Expression of CXCL6 and BBS5 that may be glaucoma relevant genes is regulated by PITX2.

CXCL6 level is high in the serum of chronic hepatitis B patients.CXCL6 promotes human hepatocyte proliferation through the CXCR1-NFkappaB pathway and inhibits collagen I secretion by hepatic stellate cells.
Title: CXCL6 promotes human hepatocyte proliferation through the CXCR1-NF?B pathway and inhibits collagen I secretion by hepatic stellate cells.

This is the first study to note that elevated systemic CCL5 and CXCL6 were associated with moderate/severe lumbar disc degeneration. These chemokines may be systemic biomarkers for the diagnosis and monitoring of disc degeneration.
Title: Systemic blood plasma CCL5 and CXCL6: Potential biomarkers for human lumbar disc degeneration.

The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.
Title: The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.

HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells.
Title: HIF-1? plays a role in the chemotactic migration of hepatocarcinoma cells through the modulation of CXCL6 expression.

The following CXCL6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14703	NM_002993.4 Latest version!	Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14703	NM_002993.3	Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL6 ( NM_002993.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002984.1 Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.

Price & Availability↑

CloneID	OHu14703
Clone ID Related Accession (Same CDS sequence)	NM_002993.3 , NM_002993.4
Accession Version	NM_002993.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-30
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 6 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP204144.1, AC108029.3 and U81234.1. On Jul 31, 2008 this sequence version replaced NM_002993.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U81234.1, SRR1660803.146626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCTCC CGTCCAGCCG CGCGGCCCGT GTCCCGGGTC CTTCGGGCTC CTTGTGCGCG 
CTGCTCGCGC TGCTGCTCCT GCTGACGCCG CCGGGGCCCC TCGCCAGCGC TGGTCCTGTC 
TCTGCTGTGC TGACAGAGCT GCGTTGCACT TGTTTACGCG TTACGCTGAG AGTAAACCCC 
AAAACGATTG GTAAACTGCA GGTGTTCCCC GCAGGCCCGC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGCAAGTT TGTCTGGACC CGGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACAGTGGA AACAAGAAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002984.1
CDS	196..540
Translation	MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN

Target ORF information:

RefSeq Version	NM_002993.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002993.3

ORF Insert Sequence:

ATGAGCCTCC CGTCCAGCCG CGCGGCCCGT GTCCCGGGTC CTTCGGGCTC CTTGTGCGCG 
CTGCTCGCGC TGCTGCTCCT GCTGACGCCG CCGGGGCCCC TCGCCAGCGC TGGTCCTGTC 
TCTGCTGTGC TGACAGAGCT GCGTTGCACT TGTTTACGCG TTACGCTGAG AGTAAACCCC 
AAAACGATTG GTAAACTGCA GGTGTTCCCC GCAGGCCCGC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGCAAGTT TGTCTGGACC CGGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACAGTGGA AACAAGAAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCL6 ( NM_002993.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002984.1 Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.

Price & Availability↑

CloneID	OHu14703
Clone ID Related Accession (Same CDS sequence)	NM_002993.3 , NM_002993.4
Accession Version	NM_002993.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	C-X-C motif chemokine 6 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP204144.1, AC108029.3 and U81234.1. On Nov 22, 2018 this sequence version replaced NM_002993.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U81234.1, ERR279869.1807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000226317.10/ ENSP00000226317.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCTCC CGTCCAGCCG CGCGGCCCGT GTCCCGGGTC CTTCGGGCTC CTTGTGCGCG 
CTGCTCGCGC TGCTGCTCCT GCTGACGCCG CCGGGGCCCC TCGCCAGCGC TGGTCCTGTC 
TCTGCTGTGC TGACAGAGCT GCGTTGCACT TGTTTACGCG TTACGCTGAG AGTAAACCCC 
AAAACGATTG GTAAACTGCA GGTGTTCCCC GCAGGCCCGC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGCAAGTT TGTCTGGACC CGGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACAGTGGA AACAAGAAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002984.1
CDS	74..418
Translation	MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN

Target ORF information:

RefSeq Version	NM_002993.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X-C motif chemokine ligand 6 (CXCL6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002993.4

ORF Insert Sequence:

ATGAGCCTCC CGTCCAGCCG CGCGGCCCGT GTCCCGGGTC CTTCGGGCTC CTTGTGCGCG 
CTGCTCGCGC TGCTGCTCCT GCTGACGCCG CCGGGGCCCC TCGCCAGCGC TGGTCCTGTC 
TCTGCTGTGC TGACAGAGCT GCGTTGCACT TGTTTACGCG TTACGCTGAG AGTAAACCCC 
AAAACGATTG GTAAACTGCA GGTGTTCCCC GCAGGCCCGC AGTGCTCCAA GGTGGAAGTG 
GTAGCCTCCC TGAAGAACGG GAAGCAAGTT TGTCTGGACC CGGAAGCCCC TTTTCTAAAG 
AAAGTCATCC AGAAAATTTT GGACAGTGGA AACAAGAAAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie971182-1188(2018 Jan)
Li J,Tang Z,Wang H,Wu W,Zhou F,Ke H,Lu W,Zhang S,Zhang Y,Yang S,Ni S,Huang J

CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome.
Scientific reports7(1)12490(2017 Oct)
Tor?n JL,Aguilar S,L?pez JA,Torroja C,Quintana JA,Santiago C,Abad JL,Gomes-Alves P,Gonzalez A,Bernal JA,Jim?nez-Borreguero LJ,Alves PM,R-Borlado L,V?zquez J,Bernad A

Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
The Journal of rheumatology44(8)1198-1205(2017 Aug)
Taniguchi T,Asano Y,Nakamura K,Yamashita T,Saigusa R,Ichimura Y,Takahashi T,Toyama T,Yoshizaki A,Sato S

Fibroblast-derived CXCL12/SDF-1? promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer.
World journal of gastroenterology23(28)5167-5178(2017 Jul)
Ma JC,Sun XW,Su H,Chen Q,Guo TK,Li Y,Chen XC,Guo J,Gong ZQ,Zhao XD,Qi JB