Cxcl5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl5
Entrez Gene ID	20311
Full Name	chemokine (C-X-C motif) ligand 5
Synonyms	AMCF-II,Cxcl6,ENA-78,GCP-2,LIX,Scyb5,Scyb6
General protein information	Preferred Names chemokine (C-X-C motif) ligand 5 Names C-X-C motif chemokine 5 cytokine LIX granulocyte chemotactic protein-2 small inducible cytokine B subfamily, member 5 small inducible cytokine subfamily B, member 15 small-inducible cytokine B5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 E1\|5 44.78 cM
Summary	This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009141.3	NP_033167.2	C-X-C motif chemokine 5 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cxcl5	NP_033167.2
Rattus norvegicus (Norway rat)	Cxcl5	NP_071550.1
Pan troglodytes (chimpanzee)	CXCL6	XP_001156255.1
	CXCL6	XP_001103136.1
Homo sapiens (human)	CXCL6	NP_002984.1

Gene Ontology
Bibliography

Related articles in PubMed

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone.
Roca H, Jones JD, Purica MC, Weidner S, Koh AJ, Kuo R, Wilkinson JE, Wang Y, Daignault-Newton S, Pienta KJ, Morgan TM, Keller ET, N?r JE, Shea LD, McCauley LK
The Journal of clinical investigation128(1)248-266(2018 Jan)

Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection.
Mancuso RI, Miyaji EN, Silva CCF, Portaro FV, Soares-Schanoski A, Ribeiro OG, Oliveira MLS
Immunity, inflammation and disease(2017 Nov)

Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.
Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH
Toxicological sciences : an official journal of the Society of Toxicology160(1)83-94(2017 Nov)

CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.
Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS
Immunity33(1)106-17(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data identify suppression of CXCL2 and CXCL5 chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury.
Title: 11?-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI.

IL-17RA regulates CXL-1 and 5 production in the lungs during the adaptive response.
Title: IL-17RA in Non-Hematopoietic Cells Controls CXCL-1 and 5 Critical to Recruit Neutrophils to the Lung of Mycobacteria-Infected Mice during the Adaptive Immune Response.

STAT3 is required for maximal OSM-induced CXCL5 expression.
Title: Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia.

CXCL5 regulates pulmonary responses to infection and plays a central role in conferring clock control of inflammation.
Title: An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.

findings demonstrated that CXCL1 and CXCL5 are increased in circulation with onset of T2D, are produced by islets under stress, and synergistically affect islet function, suggesting that these chemokines participate in pathogenesis of T2D.
Title: Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function.

The following Cxcl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20538	NM_009141.3 Latest version!	Mus musculus chemokine (C-X-C motif) ligand 5 (Cxcl5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl5 ( NM_009141.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033167.2 Mus musculus chemokine (C-X-C motif) ligand 5 (Cxcl5), mRNA.

Price & Availability↑

CloneID	OMu20538
Clone ID Related Accession (Same CDS sequence)	NM_009141.3
Accession Version	NM_009141.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	C-X-C motif chemokine 5 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC105995.9 and BQ829929.1. On May 2, 2013 this sequence version replaced NM_009141.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U27267.1, BC024392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCC AGCTCCGCAG CTCCGCCCGC ATCCCCAGCG GTTCCATCTC GCCATTCATG 
CGGATGGCGC CGCTGGCATT TCTGTTGCTG TTCACGCTGC CGCAGCATCT AGCTGAAGCT 
GCCCCTTCCT CAGTCATAGC CGCAACGGAG CTGCGTTGTG TTTGCTTAAC CGTAACTCCA 
AAAATTAATC CCAAATTGAT CGCTAATTTG GAGGTGATCC CTGCAGGTCC ACAGTGCCCT 
ACGGTGGAAG TCATAGCTAA ACTGAAAAAC CAGAAGGAGG TCTGTCTGGA TCCAGAAGCT 
CCTGTGATAA AGAAAATCAT TCAGAAAATA TTGGGCAGTG ACAAAAAGAA AGCTAAGCGG 
AATGCACTCG CAGTGGAAAG AACGGCCAGT GTTCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033167.2
CDS	146..544
Translation	MSLQLRSSARIPSGSISPFMRMAPLAFLLLFTLPQHLAEAAPSSVIAATELRCVCLTVTPKINPKLIANLEVIPAGPQCPTVEVIAKLKNQKEVCLDPEAPVIKKIIQKILGSDKKKAKRNALAVERTASVQ

Target ORF information:

RefSeq Version	NM_009141.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-X-C motif) ligand 5 (Cxcl5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009141.3

ORF Insert Sequence:

ATGAGCCTCC AGCTCCGCAG CTCCGCCCGC ATCCCCAGCG GTTCCATCTC GCCATTCATG 
CGGATGGCGC CGCTGGCATT TCTGTTGCTG TTCACGCTGC CGCAGCATCT AGCTGAAGCT 
GCCCCTTCCT CAGTCATAGC CGCAACGGAG CTGCGTTGTG TTTGCTTAAC CGTAACTCCA 
AAAATTAATC CCAAATTGAT CGCTAATTTG GAGGTGATCC CTGCAGGTCC ACAGTGCCCT 
ACGGTGGAAG TCATAGCTAA ACTGAAAAAC CAGAAGGAGG TCTGTCTGGA TCCAGAAGCT 
CCTGTGATAA AGAAAATCAT TCAGAAAATA TTGGGCAGTG ACAAAAAGAA AGCTAAGCGG 
AATGCACTCG CAGTGGAAAG AACGGCCAGT GTTCAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone.
The Journal of clinical investigation128(1)248-266(2018 Jan)
Roca H,Jones JD,Purica MC,Weidner S,Koh AJ,Kuo R,Wilkinson JE,Wang Y,Daignault-Newton S,Pienta KJ,Morgan TM,Keller ET,N?r JE,Shea LD,McCauley LK

Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection.
Immunity, inflammation and disease(2017 Nov)
Mancuso RI,Miyaji EN,Silva CCF,Portaro FV,Soares-Schanoski A,Ribeiro OG,Oliveira MLS

Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.
Toxicological sciences : an official journal of the Society of Toxicology160(1)83-94(2017 Nov)
Smith KJ,Boyer JA,Muku GE,Murray IA,Gowda K,Desai D,Amin SG,Glick AB,Perdew GH

CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.
Immunity33(1)106-17(2010 Jul)
Mei J,Liu Y,Dai N,Favara M,Greene T,Jeyaseelan S,Poncz M,Lee JS,Worthen GS

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Cxcl5 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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