CCL15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL15
Entrez Gene ID	6359
Full Name	C-C motif chemokine ligand 15
Synonyms	HCC-2,HMRP-2B,LKN-1,LKN1,MIP-1 delta,MIP-1D,MIP-5,MRP-2B,NCC-3,NCC3,SCYA15,SCYL3,SY15
General protein information	Preferred Names C-C motif chemokine ligand 15 Names C-C motif chemokine 15 chemokine (C-C motif) ligand 15 chemokine CC-2 leukotactin 1 macrophage inflammatory protein 5 new CC chemokine 3 small inducible cytokine subfamily A (Cys-Cys), member 15 small-inducible cytokine A15
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013].
Disorder MIM:	601393

mRNA and Protein(s)

mRNA	Protein	Name
NM_032965.6	NP_116741.2	C-C motif chemokine 15 preproprotein
NM_032965.5	NP_116741.2	C-C motif chemokine 15 preproprotein

Pathways from BioSystems

Homologies

	LOC100430368	XP_002800425.1
Pan troglodytes (chimpanzee)	CCL15	XP_003315560.1
Homo sapiens (human)	CCL15	NP_116741.1

Gene Ontology
Bibliography

Related articles in PubMed

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients.
Du J, Flynn R, Paz K, Ren HG, Ogata Y, Zhang Q, Gafken PR, Storer BE, Roy NH, Burkhardt JK, Mathews W, Tolar J, Lee SJ, Blazar BR, Paczesny S
Blood(2018 Jan)

Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15.
Huang FJ, Zhou XY, Ye L, Fei XC, Wang S, Wang W, Ning G
BMC cancer1698(2016 Feb)

Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16.
Starr AE, Dufour A, Maier J, Overall CM
The Journal of biological chemistry287(8)5848-60(2012 Feb)

Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness.
Richter R, Bistrian R, Escher S, Forssmann WG, Vakili J, Henschler R, Spodsberg N, Frimpong-Boateng A, Forssmann U
Journal of immunology (Baltimore, Md. : 1950)175(3)1599-608(2005 Aug)

Proteolytic activation of alternative CCR1 ligands in inflammation.
Berahovich RD, Miao Z, Wang Y, Premack B, Howard MC, Schall TJ
Journal of immunology (Baltimore, Md. : 1950)174(11)7341-51(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis.
Title: CCL15/CCR1 axis is involved in hepatocellular carcinoma cells migration and invasion.

Orthotopic animal models of HCC were established to investigate the role of CCL15 in hMSCs migration toward HCC in vivo. Both histological and flow cytometric analysis showed that significantly fewer hMSCs localized within 97H-CCL15-shRNA xenografts compared with 97H-green fluorescent protein xenografts after intravenous delivery
Title: Chemokine CCL15 Mediates Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Hepatocellular Carcinoma.

follicular thyroid carcinoma (FTC) might induce tumor associated macrophages (TAMs) infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from follicular adenoma
Title: Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15.

Loss of SMAD4 was significantly associated with CCL15 expression.
Title: Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15-CCR1 Chemokine Axis.

two inflammatory cytokines, MIP-1delta and MIP-3alpha, are able to increase mesenchymal stromal cells migration in vitro
Title: Inflammatory Chemokines MIP-1? and MIP-3? Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells.

The following CCL15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13760	NM_032965.6 Latest version!	Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13760	NM_032965.5	Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL15 ( NM_032965.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_116741.2 Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.

Price & Availability↑

CloneID	OHu13760
Clone ID Related Accession (Same CDS sequence)	NM_032965.6 , NM_032965.5
Accession Version	NM_032965.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	C-C motif chemokine 15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX098368.1 and AI244164.1. On Nov 23, 2018 this sequence version replaced NM_032965.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U58914.1, ERR279836.87.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000617897.2/ ENSP00000484078.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGTCT CCGTGGCTGC CCTCTCCTGC CTCATGCTTG TTGCTGTCCT TGGATCCCAG 
GCCCAGTTCA CAAATGATGC AGAGACAGAG TTAATGATGT CAAAGCTTCC ACTGGAAAAT 
CCAGTAGTTC TGAACAGCTT TCACTTTGCT GCTGACTGCT GCACCTCCTA CATCTCACAA 
AGCATCCCGT GTTCACTCAT GAAAAGTTAT TTTGAAACGA GCAGCGAGTG CTCCAAGCCA 
GGTGTCATAT TCCTCACCAA GAAGGGGCGG CAAGTCTGTG CCAAACCCAG TGGTCCGGGA 
GTTCAGGATT GCATGAAAAA GCTGAAGCCC TACTCAATAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116741.2
CDS	62..403
Translation	MKVSVAALSCLMLVAVLGSQAQFTNDAETELMMSKLPLENPVVLNSFHFAADCCTSYISQSIPCSLMKSYFETSSECSKPGVIFLTKKGRQVCAKPSGPGVQDCMKKLKPYSI

Target ORF information:

RefSeq Version	NM_032965.6
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032965.6

ORF Insert Sequence:

ATGAAGGTCT CCGTGGCTGC CCTCTCCTGC CTCATGCTTG TTGCTGTCCT TGGATCCCAG 
GCCCAGTTCA CAAATGATGC AGAGACAGAG TTAATGATGT CAAAGCTTCC ACTGGAAAAT 
CCAGTAGTTC TGAACAGCTT TCACTTTGCT GCTGACTGCT GCACCTCCTA CATCTCACAA 
AGCATCCCGT GTTCACTCAT GAAAAGTTAT TTTGAAACGA GCAGCGAGTG CTCCAAGCCA 
GGTGTCATAT TCCTCACCAA GAAGGGGCGG CAAGTCTGTG CCAAACCCAG TGGTCCGGGA 
GTTCAGGATT GCATGAAAAA GCTGAAGCCC TACTCAATAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL15 ( NM_032965.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_116741.2 Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.

Price & Availability↑

CloneID	OHu13760
Clone ID Related Accession (Same CDS sequence)	NM_032965.6 , NM_032965.5
Accession Version	NM_032965.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	C-C motif chemokine 15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX098368.1 and AI244164.1. On Mar 25, 2014 this sequence version replaced NM_032965.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DR005483.1, U58914.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGTCT CCGTGGCTGC CCTCTCCTGC CTCATGCTTG TTGCTGTCCT TGGATCCCAG 
GCCCAGTTCA CAAATGATGC AGAGACAGAG TTAATGATGT CAAAGCTTCC ACTGGAAAAT 
CCAGTAGTTC TGAACAGCTT TCACTTTGCT GCTGACTGCT GCACCTCCTA CATCTCACAA 
AGCATCCCGT GTTCACTCAT GAAAAGTTAT TTTGAAACGA GCAGCGAGTG CTCCAAGCCA 
GGTGTCATAT TCCTCACCAA GAAGGGGCGG CAAGTCTGTG CCAAACCCAG TGGTCCGGGA 
GTTCAGGATT GCATGAAAAA GCTGAAGCCC TACTCAATAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116741.2
CDS	547..888
Translation	MKVSVAALSCLMLVAVLGSQAQFTNDAETELMMSKLPLENPVVLNSFHFAADCCTSYISQSIPCSLMKSYFETSSECSKPGVIFLTKKGRQVCAKPSGPGVQDCMKKLKPYSI

Target ORF information:

RefSeq Version	NM_032965.5
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032965.5

ORF Insert Sequence:

ATGAAGGTCT CCGTGGCTGC CCTCTCCTGC CTCATGCTTG TTGCTGTCCT TGGATCCCAG 
GCCCAGTTCA CAAATGATGC AGAGACAGAG TTAATGATGT CAAAGCTTCC ACTGGAAAAT 
CCAGTAGTTC TGAACAGCTT TCACTTTGCT GCTGACTGCT GCACCTCCTA CATCTCACAA 
AGCATCCCGT GTTCACTCAT GAAAAGTTAT TTTGAAACGA GCAGCGAGTG CTCCAAGCCA 
GGTGTCATAT TCCTCACCAA GAAGGGGCGG CAAGTCTGTG CCAAACCCAG TGGTCCGGGA 
GTTCAGGATT GCATGAAAAA GCTGAAGCCC TACTCAATAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients.
Blood(2018 Jan)
Du J,Flynn R,Paz K,Ren HG,Ogata Y,Zhang Q,Gafken PR,Storer BE,Roy NH,Burkhardt JK,Mathews W,Tolar J,Lee SJ,Blazar BR,Paczesny S

Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15.
BMC cancer1698(2016 Feb)
Huang FJ,Zhou XY,Ye L,Fei XC,Wang S,Wang W,Ning G

Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16.
The Journal of biological chemistry287(8)5848-60(2012 Feb)
Starr AE,Dufour A,Maier J,Overall CM

Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness.
Journal of immunology (Baltimore, Md. : 1950)175(3)1599-608(2005 Aug)
Richter R,Bistrian R,Escher S,Forssmann WG,Vakili J,Henschler R,Spodsberg N,Frimpong-Boateng A,Forssmann U

Proteolytic activation of alternative CCR1 ligands in inflammation.
Journal of immunology (Baltimore, Md. : 1950)174(11)7341-51(2005 Jun)
Berahovich RD,Miao Z,Wang Y,Premack B,Howard MC,Schall TJ

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CCL15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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