ROM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ROM1
Entrez Gene ID	6094
Full Name	retinal outer segment membrane protein 1
Synonyms	ROM,ROSP1,RP7,TSPAN23
General protein information	Preferred Names retinal outer segment membrane protein 1 Names rod outer segment membrane protein 1 tetraspanin-23 tspan-23
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008].
Disorder MIM:	180721
Disorder Html:	Retinitis pigmentosa 7, digenic, 608133 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000327.3	NP_000318.1	rod outer segment membrane protein 1

Pathways from BioSystems

Homologies

	ROM1	XP_002799528.1
Bos taurus (cattle)	ROM1	NP_776599.2
Mus musculus (house mouse)	Rom1	NP_033099.3
Canis lupus familiaris (dog)	ROM1	XP_540907.3
Homo sapiens (human)	ROM1	NP_000318.1
Pan troglodytes (chimpanzee)	ROM1	XP_001142314.3
Rattus norvegicus (Norway rat)	Rom1	NP_001009690.1

Gene Ontology
Bibliography

Related articles in PubMed

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.
B?hm S, Riedmayr LM, Nguyen ONP, Gie?l A, Liebscher T, Butz ES, Sch?n C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E
Scientific reports7(1)2321(2017 May)

Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.
Conley SM, Stuck MW, Watson JN, Naash MI
Human molecular genetics26(3)509-518(2017 02)

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.
Booij JC, Bakker A, Kulumbetova J, Moutaoukil Y, Smeets B, Verheij J, Kroes HY, Klaver CC, van Schooneveld M, Bergen AA, Florijn RJ
Ophthalmology118(1)160-167.e1-3(2011 Jan)

ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype.
Poloschek CM, Bach M, Lagr?ze WA, Glaus E, Lemke JR, Berger W, Neidhardt J
Investigative ophthalmology & visual science51(8)4253-65(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ablation of Rom1 results in the conversion of an MD/PD phenotype characterized by cone functional defects and the formation of abnormal Prph2/Rom1 complexes to an RP phenotype characterized by rod-dominant functional defects and reductions in total Prph2 protein. Thus one method by which ROM1 may act as a disease modifier is by contributing to the large variability in PRPH2-associated disease phenotype
Title: Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.

Observational study of genetic testing. (HuGE Navigator)
Title: Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

Families showing a variable macular dystrophy phenotype caused by mutations in PRPH2 should be tested for additional mutations in ABCA4 and ROM1, as they may alter the progression of the PRPH2 phenotype.
Title: ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype.

The following ROM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ROM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19020	NM_000327.3 Latest version!	Homo sapiens retinal outer segment membrane protein 1 (ROM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ROM1 ( NM_000327.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000318.1 Homo sapiens retinal outer segment membrane protein 1 (ROM1), mRNA.

Price & Availability↑

CloneID	OHu19020
Clone ID Related Accession (Same CDS sequence)	NM_000327.3
Accession Version	NM_000327.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	rod outer segment membrane protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC335199.1, AK313674.1, L07894.1 and BU731899.1. This sequence is a reference standard in the RefSeqGene project. On Feb 12, 2009 this sequence version replaced NM_000327.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313674.1, BC008100.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGG TGTTGCCCCT GGTGCTGCCC CTGCAGCCCC GCATCCGCCT GGCACAAGGG 
CTCTGGCTCC TCTCCTGGCT GCTGGCGCTG GCTGGTGGCG TCATCCTCCT CTGTAGTGGG 
CACCTCCTGG TCCAGCTAAG GCACCTTGGC ACCTTCCTGG CTCCCTCCTG TCAGTTCCCT 
GTCCTGCCCC AGGCTGCCCT GGCAGCGGGC GCGGTGGCTC TGGGCACAGG ACTAGTGGGT 
GTAGGAGCCA GCCGGGCAAG TCTGAATGCA GCTCTATACC CTCCCTGGCG AGGGGTCCTG 
GGCCCGCTGC TGGTGGCTGG CACGGCTGGT GGGGGGGGGC TCCTGGTCGT CGCCCTCGGG 
CTAGCCCTGG CTTTGCCTGG GAGTCTGGAT GAGGCGCTGG AGGAGGGCCT GGTGACTGCC 
TTGGCTCACT ACAAGGACAC AGAGGTGCCT GGGCACTGTC AGGCCAAAAG GCTGGTGGAT 
GAGCTGCAAC TGAGGTACCA CTGCTGCGGG CGCCACGGGT ACAAGGATTG GTTTGGGGTC 
CAGTGGGTCA GCAGCCGTTA CCTGGATCCC GGTGACCGGG ATGTGGCTGA CCGGATCCAG 
AGCAATGTAG AAGGCCTATA CCTGACTGAT GGGGTCCCTT TCTCCTGTTG CAACCCCCAC 
TCACCCCGGC CTTGCCTGCA AAACCGTCTT TCAGACTCCT ACGCCCACCC CCTGTTCGAT 
CCCCGACAAC CCAACCAAAA CCTCTGGGCC CAAGGGTGCC ATGAGGTGCT GCTGGAGCAC 
TTGCAGGACT TGGCAGGCAC ACTGGGTAGC ATGCTGGCTG TCACCTTCCT ACTGCAGGCT 
CTGGTGCTCC TTGGCCTGCG GTACCTGCAA ACAGCACTGG AGGGGCTTGG AGGGGTCATT 
GATGCGGGAG GAGAGACCCA GGGCTATCTC TTTCCCAGTG GGCTGAAAGA TATGCTGAAA 
ACAGCATGGC TACAGGGAGG GGTTGCCTGC AGGCCAGCAC CTGAGGAGGC CCCACCAGGA 
GAAGCACCTC CCAAGGAGGA TCTATCTGAG GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000318.1
CDS	542..1597
Translation	MAPVLPLVLPLQPRIRLAQGLWLLSWLLALAGGVILLCSGHLLVQLRHLGTFLAPSCQFPVLPQAALAAGAVALGTGLVGVGASRASLNAALYPPWRGVLGPLLVAGTAGGGGLLVVALGLALALPGSLDEALEEGLVTALAHYKDTEVPGHCQAKRLVDELQLRYHCCGRHGYKDWFGVQWVSSRYLDPGDRDVADRIQSNVEGLYLTDGVPFSCCNPHSPRPCLQNRLSDSYAHPLFDPRQPNQNLWAQGCHEVLLEHLQDLAGTLGSMLAVTFLLQALVLLGLRYLQTALEGLGGVIDAGGETQGYLFPSGLKDMLKTAWLQGGVACRPAPEEAPPGEAPPKEDLSEA

Target ORF information:

RefSeq Version	NM_000327.3
Organism	Homo sapiens(human)
Definition	Homo sapiens retinal outer segment membrane protein 1 (ROM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000327.3

ORF Insert Sequence:

ATGGCGCCGG TGTTGCCCCT GGTGCTGCCC CTGCAGCCCC GCATCCGCCT GGCACAAGGG 
CTCTGGCTCC TCTCCTGGCT GCTGGCGCTG GCTGGTGGCG TCATCCTCCT CTGTAGTGGG 
CACCTCCTGG TCCAGCTAAG GCACCTTGGC ACCTTCCTGG CTCCCTCCTG TCAGTTCCCT 
GTCCTGCCCC AGGCTGCCCT GGCAGCGGGC GCGGTGGCTC TGGGCACAGG ACTAGTGGGT 
GTAGGAGCCA GCCGGGCAAG TCTGAATGCA GCTCTATACC CTCCCTGGCG AGGGGTCCTG 
GGCCCGCTGC TGGTGGCTGG CACGGCTGGT GGGGGGGGGC TCCTGGTCGT CGCCCTCGGG 
CTAGCCCTGG CTTTGCCTGG GAGTCTGGAT GAGGCGCTGG AGGAGGGCCT GGTGACTGCC 
TTGGCTCACT ACAAGGACAC AGAGGTGCCT GGGCACTGTC AGGCCAAAAG GCTGGTGGAT 
GAGCTGCAAC TGAGGTACCA CTGCTGCGGG CGCCACGGGT ACAAGGATTG GTTTGGGGTC 
CAGTGGGTCA GCAGCCGTTA CCTGGATCCC GGTGACCGGG ATGTGGCTGA CCGGATCCAG 
AGCAATGTAG AAGGCCTATA CCTGACTGAT GGGGTCCCTT TCTCCTGTTG CAACCCCCAC 
TCACCCCGGC CTTGCCTGCA AAACCGTCTT TCAGACTCCT ACGCCCACCC CCTGTTCGAT 
CCCCGACAAC CCAACCAAAA CCTCTGGGCC CAAGGGTGCC ATGAGGTGCT GCTGGAGCAC 
TTGCAGGACT TGGCAGGCAC ACTGGGTAGC ATGCTGGCTG TCACCTTCCT ACTGCAGGCT 
CTGGTGCTCC TTGGCCTGCG GTACCTGCAA ACAGCACTGG AGGGGCTTGG AGGGGTCATT 
GATGCGGGAG GAGAGACCCA GGGCTATCTC TTTCCCAGTG GGCTGAAAGA TATGCTGAAA 
ACAGCATGGC TACAGGGAGG GGTTGCCTGC AGGCCAGCAC CTGAGGAGGC CCCACCAGGA 
GAAGCACCTC CCAAGGAGGA TCTATCTGAG GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.
Scientific reports7(1)2321(2017 May)
B?hm S,Riedmayr LM,Nguyen ONP,Gie?l A,Liebscher T,Butz ES,Sch?n C,Michalakis S,Wahl-Schott C,Biel M,Becirovic E

Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.
Human molecular genetics26(3)509-518(2017 02)
Conley SM,Stuck MW,Watson JN,Naash MI

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.
Ophthalmology118(1)160-167.e1-3(2011 Jan)
Booij JC,Bakker A,Kulumbetova J,Moutaoukil Y,Smeets B,Verheij J,Kroes HY,Klaver CC,van Schooneveld M,Bergen AA,Florijn RJ

ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype.
Investigative ophthalmology & visual science51(8)4253-65(2010 Aug)
Poloschek CM,Bach M,Lagr?ze WA,Glaus E,Lemke JR,Berger W,Neidhardt J

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ROM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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