PBOV1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PBOV1
Entrez Gene ID	59351
Full Name	prostate and breast cancer overexpressed 1
Synonyms	UC28,UROC28,dJ171N11.2
General protein information	Preferred Names prostate and breast cancer overexpressed 1 Names prostate and breast cancer overexpressed gene 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q23.3
Summary	This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011].
Disorder MIM:	605669

mRNA and Protein(s)

mRNA	Protein	Name
NM_021635.2	NP_067648.1	prostate and breast cancer overexpressed gene 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PBOV1	XP_003954512.1
Homo sapiens (human)	PBOV1	NP_067648.1

Gene Ontology
Bibliography

Related articles in PubMed

PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells.
Wang L, Niu CH, Wu S, Wu HM, Ouyang F, He M, He SY
Oncology reports35(1)488-96(2016 Jan)

PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer.
Samusik N, Krukovskaya L, Meln I, Shilov E, Kozlov AP
PloS one8(2)e56162(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows that patients with high PBOV1 expression had longer overall survival; patients with low PBOV1 expression had shorter survival suggesting that PBOV1 may play an important role in suppressing ovarian cancer proliferation and carcinogenesis.
Title: PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells.

Data indicate that analysis of public microarray data suggests that PBOV1 activation in tumors could be dependent on the Hedgehog signaling pathway.
Title: PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

Approximately half of the prostate tumors displayed increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci, which may account for their abnormal gene expression patterns in neoplastic prostate tissue.
Title: Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer.

UROC28 mRNA expression was greater in breast cancers than in noncancerous tissues (p < 0.0001), as was ERBB2 mRNA.
Title: Enhanced expression of the UROC28 gene in human breast cancer: relationship to ERBB2 gene expression.

The following PBOV1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PBOV1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18351	NM_021635.2 Latest version!	Homo sapiens prostate and breast cancer overexpressed 1 (PBOV1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PBOV1 ( NM_021635.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_067648.1 Homo sapiens prostate and breast cancer overexpressed 1 (PBOV1), mRNA.

Price & Availability↑

CloneID	OHu18351
Clone ID Related Accession (Same CDS sequence)	NM_021635.2
Accession Version	NM_021635.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	prostate and breast cancer overexpressed gene 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069109.1 and AF189269.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2006 this sequence version replaced NM_021635.1. ##Evidence-Data-START## Transcript is intronless :: AF189269.1, BC069109.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGGCCT TCTTAAGGAA CCAGAAATAT GAGGATATGC ACAATATTAT TCACATTTTA 
CAGATCAGAA AATTGAGGCA CAGATTAAGT AACTTCCCAA GGCTACCAGG CATTCTAGCT 
CCAGAAACTG TGCTCTTACC ATTCTGCTAC AAGGTATTTC GAAAAAAAGA AAAAGTAAAA 
AGAAGTCAAA AGGCAACAGA GTTCATTGAT TATTCCATAG AACAGTCACA CCATGCAATT 
CTCACACCCT TGCAGACACA CTTGACCATG AAAGGTTCCT CAATGAAATG TTCCTCATTA 
TCTTCAGAAG CCATATTATT CACATTGACT TTGCAGTTAA CTCAGACCCT AGGTCTGGAA 
TGCTGTCTTC TCTACTTATC CAAAACTATA CATCCACAGA TCATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067648.1
CDS	96..503
Translation	MRAFLRNQKYEDMHNIIHILQIRKLRHRLSNFPRLPGILAPETVLLPFCYKVFRKKEKVKRSQKATEFIDYSIEQSHHAILTPLQTHLTMKGSSMKCSSLSSEAILFTLTLQLTQTLGLECCLLYLSKTIHPQII

Target ORF information:

RefSeq Version	NM_021635.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prostate and breast cancer overexpressed 1 (PBOV1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021635.2

ORF Insert Sequence:

ATGAGGGCCT TCTTAAGGAA CCAGAAATAT GAGGATATGC ACAATATTAT TCACATTTTA 
CAGATCAGAA AATTGAGGCA CAGATTAAGT AACTTCCCAA GGCTACCAGG CATTCTAGCT 
CCAGAAACTG TGCTCTTACC ATTCTGCTAC AAGGTATTTC GAAAAAAAGA AAAAGTAAAA 
AGAAGTCAAA AGGCAACAGA GTTCATTGAT TATTCCATAG AACAGTCACA CCATGCAATT 
CTCACACCCT TGCAGACACA CTTGACCATG AAAGGTTCCT CAATGAAATG TTCCTCATTA 
TCTTCAGAAG CCATATTATT CACATTGACT TTGCAGTTAA CTCAGACCCT AGGTCTGGAA 
TGCTGTCTTC TCTACTTATC CAAAACTATA CATCCACAGA TCATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells.
Oncology reports35(1)488-96(2016 Jan)
Wang L,Niu CH,Wu S,Wu HM,Ouyang F,He M,He SY

PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer.
PloS one8(2)e56162(2013)
Samusik N,Krukovskaya L,Meln I,Shilov E,Kozlov AP

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PBOV1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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