IFNK cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNK
Entrez Gene ID	56832
Full Name	interferon kappa
Synonyms	IFNT1,INFE1
General protein information	Preferred Names interferon kappa Names interferon kappa IFN-kappa interferon-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.2
Summary	This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008].
Disorder MIM:	615326

mRNA and Protein(s)

mRNA	Protein	Name
NM_020124.2	NP_064509.2	interferon kappa precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IFNK	NP_064509.2
Pan troglodytes (chimpanzee)	IFNK	XP_528490.1
Canis lupus familiaris (dog)	IFNK	XP_003639432.2
Bos taurus (cattle)	IFNK	NP_001193352.1
Rattus norvegicus (Norway rat)	Ifnk	NP_001101395.1
	IFNK	XP_001104958.1
Mus musculus (house mouse)	Ifnk	NP_954608.1

Gene Ontology
Bibliography

Related articles in PubMed

Limited role of interferon-kappa (IFNK) truncating mutations in common variable immunodeficiency.
Atschekzei F, D?rk T, Sch?rmann P, Geffers R, Witte T, Schmidt RE
Cytokine9671-74(2017 Aug)

Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins.
Habiger C, J?ger G, Walter M, Iftner T, Stubenrauch F
Journal of virology90(2)694-704(2015 Oct)

E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-? transcription in keratinocytes.
Sunthamala N, Thierry F, Teissier S, Pientong C, Kongyingyoes B, Tangsiriwatthana T, Sangkomkamhang U, Ekalaksananan T
PloS one9(3)e91473(2014)

A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
Kerns SL, Stone NN, Stock RG, Rath L, Ostrer H, Rosenstein BS
The Journal of urology190(1)102-8(2013 07)

High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression.
Reiser J, Hurst J, Voges M, Krauss P, M?nch P, Iftner T, Stubenrauch F
Journal of virology85(21)11372-80(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that high-risk human papillomavirus 31 target interferon kappa to prevent Sp100 expression and identify Sp100 as an interferon-stimulated gene with anti-human papillomavirus activity.
Title: Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins.

This study demonstrates that E2 proteins of high risk human papillomavirus reduce STING and IFN-kappa transcription.
Title: E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-? transcription in keratinocytes.

The viral E6 and E7 oncogenes are sufficient for interferon-kappa repression, with E6 being mainly responsible.
Title: High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of genetic variation near interferon-kappa in systemic lupus erythematosus.

The following IFNK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13357	NM_020124.2 Latest version!	Homo sapiens interferon kappa (IFNK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNK ( NM_020124.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_064509.2 Homo sapiens interferon kappa (IFNK), mRNA.

Price & Availability↑

CloneID	OHu13357
Clone ID Related Accession (Same CDS sequence)	NM_020124.2
Accession Version	NM_020124.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	interferon kappa precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF315688.1 and AL451123.12. On Aug 18, 2006 this sequence version replaced NM_020124.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF315688.1, BF379925.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCACCA AACCTGATAT GATTCAAAAG TGTTTGTGGC TTGAGATCCT TATGGGTATA 
TTCATTGCTG GCACCCTATC CCTGGACTGT AACTTACTGA ACGTTCACCT GAGAAGAGTC 
ACCTGGCAAA ATCTGAGACA TCTGAGTAGT ATGAGCAATT CATTTCCTGT AGAATGTCTA 
CGAGAAAACA TAGCTTTTGA GTTGCCCCAA GAGTTTCTGC AATACACCCA ACCTATGAAG 
AGGGACATCA AGAAGGCCTT CTATGAAATG TCCCTACAGG CCTTCAACAT CTTCAGCCAA 
CACACCTTCA AATATTGGAA AGAGAGACAC CTCAAACAAA TCCAAATAGG ACTTGATCAG 
CAAGCAGAGT ACCTGAACCA ATGCTTGGAG GAAGACAAGA ATGAAAATGA AGACATGAAA 
GAAATGAAAG AGAATGAGAT GAAACCCTCA GAAGCCAGGG TCCCCCAGCT GAGCAGCCTG 
GAACTGAGGA GATATTTCCA CAGGATAGAC AATTTCCTGA AAGAAAAGAA ATACAGTGAC 
TGTGCCTGGG AGATTGTCCG AGTGGAAATC AGAAGATGTT TGTATTACTT TTACAAATTT 
ACAGCTCTAT TCAGGAGGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064509.2
CDS	24..647
Translation	MSTKPDMIQKCLWLEILMGIFIAGTLSLDCNLLNVHLRRVTWQNLRHLSSMSNSFPVECLRENIAFELPQEFLQYTQPMKRDIKKAFYEMSLQAFNIFSQHTFKYWKERHLKQIQIGLDQQAEYLNQCLEEDKNENEDMKEMKENEMKPSEARVPQLSSLELRRYFHRIDNFLKEKKYSDCAWEIVRVEIRRCLYYFYKFTALFRRK

Target ORF information:

RefSeq Version	NM_020124.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon kappa (IFNK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020124.2

ORF Insert Sequence:

ATGAGCACCA AACCTGATAT GATTCAAAAG TGTTTGTGGC TTGAGATCCT TATGGGTATA 
TTCATTGCTG GCACCCTATC CCTGGACTGT AACTTACTGA ACGTTCACCT GAGAAGAGTC 
ACCTGGCAAA ATCTGAGACA TCTGAGTAGT ATGAGCAATT CATTTCCTGT AGAATGTCTA 
CGAGAAAACA TAGCTTTTGA GTTGCCCCAA GAGTTTCTGC AATACACCCA ACCTATGAAG 
AGGGACATCA AGAAGGCCTT CTATGAAATG TCCCTACAGG CCTTCAACAT CTTCAGCCAA 
CACACCTTCA AATATTGGAA AGAGAGACAC CTCAAACAAA TCCAAATAGG ACTTGATCAG 
CAAGCAGAGT ACCTGAACCA ATGCTTGGAG GAAGACAAGA ATGAAAATGA AGACATGAAA 
GAAATGAAAG AGAATGAGAT GAAACCCTCA GAAGCCAGGG TCCCCCAGCT GAGCAGCCTG 
GAACTGAGGA GATATTTCCA CAGGATAGAC AATTTCCTGA AAGAAAAGAA ATACAGTGAC 
TGTGCCTGGG AGATTGTCCG AGTGGAAATC AGAAGATGTT TGTATTACTT TTACAAATTT 
ACAGCTCTAT TCAGGAGGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Limited role of interferon-kappa (IFNK) truncating mutations in common variable immunodeficiency.
Cytokine9671-74(2017 Aug)
Atschekzei F,D?rk T,Sch?rmann P,Geffers R,Witte T,Schmidt RE

Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins.
Journal of virology90(2)694-704(2015 Oct)
Habiger C,J?ger G,Walter M,Iftner T,Stubenrauch F

E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-? transcription in keratinocytes.
PloS one9(3)e91473(2014)
Sunthamala N,Thierry F,Teissier S,Pientong C,Kongyingyoes B,Tangsiriwatthana T,Sangkomkamhang U,Ekalaksananan T

A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
The Journal of urology190(1)102-8(2013 07)
Kerns SL,Stone NN,Stock RG,Rath L,Ostrer H,Rosenstein BS

High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression.
Journal of virology85(21)11372-80(2011 Nov)
Reiser J,Hurst J,Voges M,Krauss P,M?nch P,Iftner T,Stubenrauch F

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IFNK cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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