PANX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PANX2
Entrez Gene ID	56666
Full Name	pannexin 2
Synonyms	PX2,hPANX2
General protein information	Preferred Names pannexin 2 Names pannexin-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.33
Summary	The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Disorder MIM:	608421

mRNA and Protein(s)

mRNA	Protein	Name
NM_001160300.1	NP_001153772.1	pannexin-2 isoform 2
NM_052839.4	NP_443071.2	pannexin-2 isoform 1
NM_001160300.2	NP_001153772.1	pannexin-2 isoform 2
NM_052839.3	NP_443071.2	pannexin-2 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PANX2	NP_443071.2
Xenopus tropicalis (tropical clawed frog)	LOC100486454	XP_002932244.1
	LOC720613	XP_001116218.2
Mus musculus (house mouse)	Panx2	NP_001002005.2
Pan troglodytes (chimpanzee)	PANX2	XP_001140508.1
Gallus gallus (chicken)	PANX2	XP_424545.3
Canis lupus familiaris (dog)	PANX2	XP_538316.4
Bos taurus (cattle)	PANX2	NP_001095695.1
Danio rerio (zebrafish)	panx2	NP_001243570.1
Rattus norvegicus (Norway rat)	Panx2	NP_955441.2

Gene Ontology
Bibliography

Related articles in PubMed

Human stem cells express pannexins.
Hainz N, Beckmann A, Schubert M, Haase A, Martin U, Tschernig T, Meier C
BMC research notes11(1)54(2018 Jan)

Pannexin-2-deficiency sensitizes pancreatic ?-cells to cytokine-induced apoptosis in?vitro and impairs glucose tolerance in?vivo.
Berchtold LA, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, St?rling J
Molecular and cellular endocrinology448108-121(2017 Jun)

Expression of pannexin 1 and 2 in cortical lesions from intractable epilepsy patients with focal cortical dysplasia.
Li S, Zang Z, He J, Chen X, Yu S, Pei Y, Hou Z, An N, Yang H, Zhang C, Liu S
Oncotarget8(4)6883-6895(2017 Jan)

The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes.
Gawlik M, Wagner M, Pfuhlmann B, St?ber G
European archives of psychiatry and clinical neuroscience266(5)433-7(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells.
Title: Pannexin-2-deficiency sensitizes pancreatic ?-cells to cytokine-induced apoptosis in?vitro and impairs glucose tolerance in?vivo.

The results of this study do not support a major contribution of PANX1-3 to disease risk of schizophrenia according to DSM-5.
Title: The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes.

There is dense expression of Panx2 in the enteric nervous system. The substantial increase in Panx2 mRNA in ulcerative colitis (UC) muscle but not protein suggests that the Panx2 translation process may be disrupted in UC.
Title: Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system.

Data suggest that both up-regulation and down-regulation of expression of pannexins (PANX1, PANX2, PANX3) are associated with disease onset and/or progression; examples include neoplasms, multiple sclerosis, migraine, and hypertension. [REVIEW]
Title: Pannexin channels and their links to human disease.

Panx1 and Panx2 expression was detected in the temporal lobe cortex of patients with temporal lobe epilepsy and in the control tissues.
Title: Altered expression of pannexin proteins in patients with temporal lobe epilepsy.

The following PANX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PANX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03113	NM_001160300.2 Latest version!	Homo sapiens pannexin 2 (PANX2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
OHu31364	NM_052839.4 Latest version!	Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$482.30 $689.00
View Old Accession Versions >>
OHu03113	NM_001160300.1	Homo sapiens pannexin 2 (PANX2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
OHu31364	NM_052839.3	Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$482.30 $689.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PANX2 ( NM_001160300.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001153772.1 Homo sapiens pannexin 2 (PANX2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03113
Clone ID Related Accession (Same CDS sequence)	NM_001160300.1 , NM_001160300.2
Accession Version	NM_001160300.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	pannexin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA116770.1, AF398510.1, AK123508.1 and BU734128.1. Transcript Variant: This variant (2), also known as PANX2alt1, lacks an alternate segment in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF398510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMN01820687 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTATCCTCAT CGCCACCTTC GACGAGCCGA 
GAACGGTCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153772.1
CDS	1..1932
Translation	MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLSSSPPSTSRERS

Target ORF information:

RefSeq Version	NM_001160300.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pannexin 2 (PANX2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001160300.1

ORF Insert Sequence:

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTATCCTCAT CGCCACCTTC GACGAGCCGA 
GAACGGTCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PANX2 ( NM_001160300.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001153772.1 Homo sapiens pannexin 2 (PANX2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03113
Clone ID Related Accession (Same CDS sequence)	NM_001160300.1 , NM_001160300.2
Accession Version	NM_001160300.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	pannexin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA116770.1, AF398510.1, AK123508.1 and BU734128.1. On May 31, 2019 this sequence version replaced NM_001160300.1. Transcript Variant: This variant (2), also known as PANX2alt1, lacks an alternate segment in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF398510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMN01820687 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTATCCTCAT CGCCACCTTC GACGAGCCGA 
GAACGGTCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153772.1
CDS	1..1932
Translation	MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLSSSPPSTSRERS

Target ORF information:

RefSeq Version	NM_001160300.2
Organism	Homo sapiens(human)
Definition	Homo sapiens pannexin 2 (PANX2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001160300.2

ORF Insert Sequence:

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTATCCTCAT CGCCACCTTC GACGAGCCGA 
GAACGGTCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PANX2 ( NM_052839.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_443071.2 Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31364
Clone ID Related Accession (Same CDS sequence)	NM_052839.4 , NM_052839.3
Accession Version	NM_052839.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	pannexin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA127683.1, AK096019.1, AK123508.1, BC101023.2 and BU732466.1. On May 17, 2019 this sequence version replaced NM_052839.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299910.1, AK096019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000395842.3/ ENSP00000379183.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTGTACGAGG CCCGGGAGGA GGAGGACGGG 
GGCCCCCGCC TGCCGCAGGA CGTGGGGGAC CTCATCGCCA TCCCTGCCCC ACAGCAGATC 
CTCATCGCCA CCTTCGACGA GCCGAGAACG GTCGTGAGTA CTGTGGAGTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443071.2
CDS	1..2034
Translation	MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF

Target ORF information:

RefSeq Version	NM_052839.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052839.4

ORF Insert Sequence:

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTGTACGAGG CCCGGGAGGA GGAGGACGGG 
GGCCCCCGCC TGCCGCAGGA CGTGGGGGAC CTCATCGCCA TCCCTGCCCC ACAGCAGATC 
CTCATCGCCA CCTTCGACGA GCCGAGAACG GTCGTGAGTA CTGTGGAGTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PANX2 ( NM_052839.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443071.2 Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.

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CloneID	OHu31364
Clone ID Related Accession (Same CDS sequence)	NM_052839.4 , NM_052839.3
Accession Version	NM_052839.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	pannexin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA127683.1, AK096019.1, AK123508.1, BC101023.2 and BU732466.1. On Dec 20, 2007 this sequence version replaced NM_052839.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299910.1, AK096019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTGTACGAGG CCCGGGAGGA GGAGGACGGG 
GGCCCCCGCC TGCCGCAGGA CGTGGGGGAC CTCATCGCCA TCCCTGCCCC ACAGCAGATC 
CTCATCGCCA CCTTCGACGA GCCGAGAACG GTCGTGAGTA CTGTGGAGTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443071.2
CDS	1..2034
Translation	MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF

Target ORF information:

RefSeq Version	NM_052839.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pannexin 2 (PANX2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052839.3

ORF Insert Sequence:

ATGCACCACC TCCTGGAGCA GTCGGCGGAC ATGGCGACCG CGCTGCTGGC GGGAGAGAAG 
CTGCGGGAGC TGATCCTGCC GGGCGCGCAG GACGACAAGG CGGGCGCGCT GGCCGCGCTG 
CTTCTGCAGC TGAAGCTGGA GCTGCCGTTC GACCGGGTGG TCACCATCGG CACCGTGCTG 
GTGCCCATCC TGCTGGTCAC CCTGGTCTTC ACCAAGAACT TCGCAGAGGA ACCCATTTAC 
TGTTACACCC CGCACAACTT CACGCGCGAC CAGGCGCTGT ACGCCCGCGG CTACTGCTGG 
ACGGAGCTGC GGGACGCGCT GCCCGGCGTG GACGCCAGCC TGTGGCCGTC GCTGTTTGAG 
CACAAGTTCC TGCCCTACGC GCTGCTGGCC TTCGCCGCCA TCATGTACGT GCCCGCGCTG 
GGCTGGGAGT TCCTGGCCTC CACGCGCCTC ACCTCCGAGC TCAACTTCCT GCTGCAGGAG 
ATCGACAACT GTTACCACCG GGCGGCCGAG GGCCGCGCGC CCAAGATCGA GAAGCAGATC 
CAGTCCAAGG GCCCGGGCAT CACGGAGCGC GAGAAGCGCG AGATCATCGA GAACGCGGAG 
AAGGAGAAGA GCCCGGAGCA GAACCTGTTC GAGAAGTACC TGGAGCGCCG CGGCCGCAGC 
AACTTCCTGG CCAAGCTGTA CCTGGCGCGG CACGTGCTGA TCCTGCTGCT GAGCGCCGTG 
CCCATCTCCT ACCTGTGCAC CTACTACGCC ACGCAGAAGC AGAACGAGTT CACCTGCGCG 
CTGGGCGCGT CCCCGGACGG GGCGGCAGGT GCGGGGCCCG CGGTGCGCGT GAGCTGCAAG 
CTCCCGTCCG TGCAACTGCA GCGCATCATC GCGGGCGTGG ACATCGTGCT GCTGTGCGTC 
ATGAACCTCA TCATCCTCGT CAACCTCATC CACCTCTTCA TCTTCCGCAA GAGCAACTTC 
ATCTTCGACA AGCTGCACAA GGTGGGCATC AAGACGCGCC GGCAGTGGCG CCGCTCGCAG 
TTCTGCGACA TCAACATCCT GGCCATGTTC TGCAACGAGA ACCGCGACCA CATCAAGTCG 
CTCAACCGGC TGGACTTCAT CACCAACGAG AGCGACCTCA TGTACGACAA CGTGGTCCGG 
CAGCTGCTGG CGGCGCTGGC GCAGTCCAAC CACGACGCCA CCCCCACGGT GCGCGACTCG 
GGGGTGCAGA CCGTGGACCC CAGCGCCAAC CCCGCCGAGC CCGACGGCGC CGCCGAGCCG 
CCCGTGGTCA AGCGGCCGCG CAAGAAGATG AAGTGGATCC CCACCAGCAA CCCGCTTCCG 
CAGCCCTTCA AGGAGCCGCT GGCCATCATG CGCGTGGAGA ACAGCAAGGC GGAGAAGCCG 
AAGCCCGCGC GCAGGAAGAC GGCCACGGAC ACGCTGATCG CGCCGCTGCT GGACCGCTCC 
GCCCACCACT ACAAGGGCGG AGGGGGCGAC CCGGGCCCCG GCCCCGCCCC TGCCCCCGCC 
CCGCCGCCCG CCCCTGACAA GAAGCACGCG CGCCACTTCT CCCTGGACGT GCACCCCTAC 
ATCCTCGGCA CCAAGAAGGC CAAGGCCGAG GCGGTGCCCG CCGCCCTGCC CGCCTCCCGG 
AGCCAGGAGG GGGGCTTCCT GTCCCAGGCG GAGGACTGTG GGCTAGGCCT GGCCCCGGCG 
CCCATCAAAG ATGCTCCGCT CCCCGAGAAG GAAATCCCGT ACCCCACAGA GCCAGCCCGG 
GCAGGGCTTC CCTCGGGGGG CCCGTTCCAC GTCCGCTCAC CTCCCGCCGC CCCTGCTGTG 
GCCCCTCTGA CACCAGCCAG CCTGGGCAAG GCGGAGCCCC TCACCATCCT GAGCCGAAAC 
GCCACACACC CGCTGCTGCA CATCAACACG CTGTACGAGG CCCGGGAGGA GGAGGACGGG 
GGCCCCCGCC TGCCGCAGGA CGTGGGGGAC CTCATCGCCA TCCCTGCCCC ACAGCAGATC 
CTCATCGCCA CCTTCGACGA GCCGAGAACG GTCGTGAGTA CTGTGGAGTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human stem cells express pannexins.
BMC research notes11(1)54(2018 Jan)
Hainz N,Beckmann A,Schubert M,Haase A,Martin U,Tschernig T,Meier C

Pannexin-2-deficiency sensitizes pancreatic ?-cells to cytokine-induced apoptosis in?vitro and impairs glucose tolerance in?vivo.
Molecular and cellular endocrinology448108-121(2017 Jun)
Berchtold LA,Miani M,Diep TA,Madsen AN,Cigliola V,Colli M,Krivokapic JM,Pociot F,Eizirik DL,Meda P,Holst B,Billestrup N,St?rling J

Expression of pannexin 1 and 2 in cortical lesions from intractable epilepsy patients with focal cortical dysplasia.
Oncotarget8(4)6883-6895(2017 Jan)
Li S,Zang Z,He J,Chen X,Yu S,Pei Y,Hou Z,An N,Yang H,Zhang C,Liu S

The role of Pannexin gene variants in schizophrenia: systematic analysis of phenotypes.
European archives of psychiatry and clinical neuroscience266(5)433-7(2016 Aug)
Gawlik M,Wagner M,Pfuhlmann B,St?ber G

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PANX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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