MAP2K2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAP2K2
Entrez Gene ID	5605
Full Name	mitogen-activated protein kinase kinase 2
Synonyms	CFC4,MAPKK2,MEK2,MKK2,PRKMK2
General protein information	Preferred Names mitogen-activated protein kinase kinase 2 Names dual specificity mitogen-activated protein kinase kinase 2 ERK activator kinase 2 MAP kinase kinase 2 MAPK/ERK kinase 2 mitogen-activated protein kinase kinase 2, p45
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	601263
Disorder Html:	Cardiofaciocutaneous syndrome 4, 615280 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_030662.3	NP_109587.1	dual specificity mitogen-activated protein kinase kinase 2
XM_017026989.1	XP_016882478.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X1
XM_017026991.1	XP_016882480.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X4
XM_017026990.1	XP_016882479.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X2
NM_030662.4	NP_109587.1	dual specificity mitogen-activated protein kinase kinase 2
XM_006722799.2	XP_006722862.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MAP2K2	NP_001041601.1
Eremothecium gossypii	AGOS_ACR196C	NP_983598.1
	MAP2K2	XP_001118016.2
Gallus gallus (chicken)	MAP2K2	NP_990719.1
Danio rerio (zebrafish)	map2k2b	NP_001121753.1
Saccharomyces cerevisiae (baker's yeast)	STE7	NP_010122.1
Danio rerio (zebrafish)	map2k2a	NP_001032468.2
Arabidopsis thaliana (thale cress)	MKK6	NP_200469.1
Pan troglodytes (chimpanzee)	LOC100611792	XP_003318859.1
Bos taurus (cattle)	MAP2K2	NP_001033160.2
Kluyveromyces lactis	KLLA0C16577g	XP_452941.1
Oryza sativa (rice)	Os01g0510100	NP_001043164.1
Homo sapiens (human)	MAP2K2	NP_109587.1
Mus musculus (house mouse)	Map2k2	NP_075627.2
Rattus norvegicus (Norway rat)	Map2k2	NP_579817.1

Gene Ontology
Bibliography

Related articles in PubMed

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation.
Zhou D, Kuang Z, Zeng X, Wang K, Ma J, Luo H, Chen M, Li Y, Zeng J, Li S, Luan F, He Y, Dai H, Liu B, Li H, He L, Xing Q
Journal of cellular and molecular medicine21(10)2465-2480(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High MEK2 expression is associated with inflammation.
Title: Lactoferrin interacts with SPLUNC1 to attenuate lipopolysaccharide-induced inflammation of human nasal epithelial cells via down-regulated MEK1/2-MAPK signaling.

There are no other biomarkers correlated with treatment responses following MEK1/2 inhibition.
Title: Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas.

The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC) syndrome
Title: Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis.

MEK2 was essential for the phosphorylation of MKK3/MKK6 and p38 MAPK that directly impacted on cyclin D1 expression.
Title: MEK2 controls the activation of MKK3/MKK6-p38 axis involved in the MDA-MB-231 breast cancer cell survival: Correlation with cyclin D1 expression.

the purpose of this paper was to investigate MAPK downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
Title: ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56 dim CD16+ and CD56 bright CD16 dim/- natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

The following MAP2K2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAP2K2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26203	NM_030662.4 Latest version!	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu51701	XM_006722799.2 Latest version!	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu88562	XM_017026990.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu88563	XM_017026991.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu88561	XM_017026989.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu26203	NM_030662.3	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAP2K2 ( NM_030662.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_109587.1 Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.

Price & Availability↑

CloneID	OHu26203
Clone ID Related Accession (Same CDS sequence)	NM_030662.3 , NM_030662.4
Accession Version	NM_030662.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	dual specificity mitogen-activated protein kinase kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000471.2 and AA312322.1. This sequence is a reference standard in the RefSeqGene project. On May 1, 2008 this sequence version replaced NM_030662.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000471.2, SRR1163655.466140.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 
GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 
GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 
CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 
CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CTGCCATGGC CATCTTTGAA 
CTCCTGGACT ATATTGTGAA CGAGCCACCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 
GACTTCCAGG AGTTTGTCAA TAAATGCCTC ATCAAGAACC CAGCGGAGCG GGCGGACCTG 
AAGATGCTCA CAAACCACAC CTTCATCAAG CGGTCCGAGG TGGAAGAAGT GGATTTTGCC 
GGCTGGTTGT GTAAAACCCT GCGGCTGAAC CAGCCCGGCA CACCCACGCG CACCGCCGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109587.1
CDS	255..1457
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV

Target ORF information:

RefSeq Version	NM_030662.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030662.3

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 
GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 
GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 
CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 
CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CTGCCATGGC CATCTTTGAA 
CTCCTGGACT ATATTGTGAA CGAGCCACCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 
GACTTCCAGG AGTTTGTCAA TAAATGCCTC ATCAAGAACC CAGCGGAGCG GGCGGACCTG 
AAGATGCTCA CAAACCACAC CTTCATCAAG CGGTCCGAGG TGGAAGAAGT GGATTTTGCC 
GGCTGGTTGT GTAAAACCCT GCGGCTGAAC CAGCCCGGCA CACCCACGCG CACCGCCGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP2K2 ( NM_030662.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_109587.1 Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.

Price & Availability↑

CloneID	OHu26203
Clone ID Related Accession (Same CDS sequence)	NM_030662.3 , NM_030662.4
Accession Version	NM_030662.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	dual specificity mitogen-activated protein kinase kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000471.2 and AA312322.1. On Dec 4, 2019 this sequence version replaced NM_030662.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000471.2, ERR279836.1707.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 
GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 
GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 
CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 
CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CTGCCATGGC CATCTTTGAA 
CTCCTGGACT ATATTGTGAA CGAGCCACCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 
GACTTCCAGG AGTTTGTCAA TAAATGCCTC ATCAAGAACC CAGCGGAGCG GGCGGACCTG 
AAGATGCTCA CAAACCACAC CTTCATCAAG CGGTCCGAGG TGGAAGAAGT GGATTTTGCC 
GGCTGGTTGT GTAAAACCCT GCGGCTGAAC CAGCCCGGCA CACCCACGCG CACCGCCGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109587.1
CDS	248..1450
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV

Target ORF information:

RefSeq Version	NM_030662.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030662.4

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 
GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 
GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 
CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 
CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CTGCCATGGC CATCTTTGAA 
CTCCTGGACT ATATTGTGAA CGAGCCACCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 
GACTTCCAGG AGTTTGTCAA TAAATGCCTC ATCAAGAACC CAGCGGAGCG GGCGGACCTG 
AAGATGCTCA CAAACCACAC CTTCATCAAG CGGTCCGAGG TGGAAGAAGT GGATTTTGCC 
GGCTGGTTGT GTAAAACCCT GCGGCTGAAC CAGCCCGGCA CACCCACGCG CACCGCCGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP2K2 ( XM_006722799.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006722862.1 Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu51701
Clone ID Related Accession (Same CDS sequence)	XM_006722799.2
Accession Version	XM_006722799.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006722799.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCACC TCCTAAGCTG 
CCCAACGGTG TGTTCACCCC CGACTTCCAG GAGTTTGTCA ATAAATGCCT CATCAAGAAC 
CCAGCGGAGC GGGCGGACCT GAAGATGCTC ACAAACCACA CCTTCATCAA GCGGTCCGAG 
GTGGAAGAAG TGGATTTTGC CGGCTGGTTG TGTAAAACCC TGCGGCTGAA CCAGCCCGGC 
ACACCCACGC GCACCGCCGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006722862.1
CDS	310..1233
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV

Target ORF information:

RefSeq Version	XM_006722799.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006722799.2

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCACC TCCTAAGCTG 
CCCAACGGTG TGTTCACCCC CGACTTCCAG GAGTTTGTCA ATAAATGCCT CATCAAGAAC 
CCAGCGGAGC GGGCGGACCT GAAGATGCTC ACAAACCACA CCTTCATCAA GCGGTCCGAG 
GTGGAAGAAG TGGATTTTGC CGGCTGGTTG TGTAAAACCC TGCGGCTGAA CCAGCCCGGC 
ACACCCACGC GCACCGCCGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP2K2 ( XM_017026990.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882479.1 Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu88562
Clone ID Related Accession (Same CDS sequence)	XM_017026990.1
Accession Version	XM_017026990.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCACC TCCTAAGCTG 
CCCAACGGTG TGTTCACCCC CGACTTCCAG GAGTTTGTCA ATAAATGGTT CTGGGAGGGT 
CGCCAGCCCC ACTCCATTCT CCTGCCCCCA AGCACCCAGC AGCACCTGTG GCGTGGGCTT 
CACAGGCATG TGCCGCAGAC CACGGGGAAG GAGCTGCGGA CACCCCGCTG CCCACAGGGC 
CGGTCCATGT GTGTGAGCTC GGGACGCCGT GGAACGGCAC CGCACTCCTG GTGCCGGAGT 
TGCCCCGGGC CCTTGGCGTG CGCTCCGGCG ATGTTGCCCC GGGCCTGGGG TTTTATTAGA 
CAGTTAGCTG GGGTTGCGTC CAGGCTTCTG ACCCACCAGG CGGGGTTTCC CACCCTCTTT 
CCCTCTCACC CTCCCGCTGG GGGGTGTCCT GCCCCTGGCA CCAAAGTGCA GAGGTGGATC 
CCTCGTCCTC TGCCAGGAGG CAGAACAGAG CAGCCACTCT GTGCCACTCT CTCTGGTCGG 
AGAGATCCAG GCCCCCTCCG ACCACGGCCC ACACGCGGGT GCCCCGGGGC CACCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882479.1
CDS	310..1569
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPPPKLPNGVFTPDFQEFVNKWFWEGRQPHSILLPPSTQQHLWRGLHRHVPQTTGKELRTPRCPQGRSMCVSSGRRGTAPHSWCRSCPGPLACAPAMLPRAWGFIRQLAGVASRLLTHQAGFPTLFPSHPPAGGCPAPGTKVQRWIPRPLPGGRTEQPLCATLSGRRDPGPLRPRPTRGCPGATS

Target ORF information:

RefSeq Version	XM_017026990.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026990.1

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCACC TCCTAAGCTG 
CCCAACGGTG TGTTCACCCC CGACTTCCAG GAGTTTGTCA ATAAATGGTT CTGGGAGGGT 
CGCCAGCCCC ACTCCATTCT CCTGCCCCCA AGCACCCAGC AGCACCTGTG GCGTGGGCTT 
CACAGGCATG TGCCGCAGAC CACGGGGAAG GAGCTGCGGA CACCCCGCTG CCCACAGGGC 
CGGTCCATGT GTGTGAGCTC GGGACGCCGT GGAACGGCAC CGCACTCCTG GTGCCGGAGT 
TGCCCCGGGC CCTTGGCGTG CGCTCCGGCG ATGTTGCCCC GGGCCTGGGG TTTTATTAGA 
CAGTTAGCTG GGGTTGCGTC CAGGCTTCTG ACCCACCAGG CGGGGTTTCC CACCCTCTTT 
CCCTCTCACC CTCCCGCTGG GGGGTGTCCT GCCCCTGGCA CCAAAGTGCA GAGGTGGATC 
CCTCGTCCTC TGCCAGGAGG CAGAACAGAG CAGCCACTCT GTGCCACTCT CTCTGGTCGG 
AGAGATCCAG GCCCCCTCCG ACCACGGCCC ACACGCGGGT GCCCCGGGGC CACCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP2K2 ( XM_017026991.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882480.1 Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu88563
Clone ID Related Accession (Same CDS sequence)	XM_017026991.1
Accession Version	XM_017026991.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTGAAAC GACTGGGGAT 
TCAGCAACCT GCCAAATTGA GCCTTGGAGC AGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882480.1
CDS	310..1068
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAETTGDSATCQIEPWSSL

Target ORF information:

RefSeq Version	XM_017026991.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026991.1

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTGAAAC GACTGGGGAT 
TCAGCAACCT GCCAAATTGA GCCTTGGAGC AGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP2K2 ( XM_017026989.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882478.1 Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88561
Clone ID Related Accession (Same CDS sequence)	XM_017026989.1
Accession Version	XM_017026989.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 
GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 
GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 
CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 
CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CTGCCATGGC CATCTTTGAA 
CTCCTGGACT ATATTGTGAA CGAGCCACCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 
GACTTCCAGG AGTTTGTCAA TAAATGGTTC TGGGAGGGTC GCCAGCCCCA CTCCATTCTC 
CTGCCCCCAA GCACCCAGCA GCACCTGTGG CGTGGGCTTC ACAGGCATGT GCCGCAGACC 
ACGGGGAAGG AGCTGCGGAC ACCCCGCTGC CCACAGGGCC GGTCCATGTG TGTGAGCTCG 
GGACGCCGTG GAACGGCACC GCACTCCTGG TGCCGGAGTT GCCCCGGGCC CTTGGCGTGC 
GCTCCGGCGA TGTTGCCCCG GGCCTGGGGT TTTATTAGAC AGTTAGCTGG GGTTGCGTCC 
AGGCTTCTGA CCCACCAGGC GGGGTTTCCC ACCCTCTTTC CCTCTCACCC TCCCGCTGGG 
GGGTGTCCTG CCCCTGGCAC CAAAGTGCAG AGGTGGATCC CTCGTCCTCT GCCAGGAGGC 
AGAACAGAGC AGCCACTCTG TGCCACTCTC TCTGGTCGGA GAGATCCAGG CCCCCTCCGA 
CCACGGCCCA CACGCGGGTG CCCCGGGGCC ACCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882478.1
CDS	310..1848
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKWFWEGRQPHSILLPPSTQQHLWRGLHRHVPQTTGKELRTPRCPQGRSMCVSSGRRGTAPHSWCRSCPGPLACAPAMLPRAWGFIRQLAGVASRLLTHQAGFPTLFPSHPPAGGCPAPGTKVQRWIPRPLPGGRTEQPLCATLSGRRDPGPLRPRPTRGCPGATS

Target ORF information:

RefSeq Version	XM_017026989.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026989.1

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 
GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 
CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 
AAAGCCAAGG TCGGCGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCG 
GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 
AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 
GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 
GGGGAGATCA GCATTTGCAT GGAACACATG GACGGCGGCT CCCTGGACCA GGTGCTGAAA 
GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 
TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 
CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTCATC 
GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 
GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 
GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 
CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 
CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CTGCCATGGC CATCTTTGAA 
CTCCTGGACT ATATTGTGAA CGAGCCACCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 
GACTTCCAGG AGTTTGTCAA TAAATGGTTC TGGGAGGGTC GCCAGCCCCA CTCCATTCTC 
CTGCCCCCAA GCACCCAGCA GCACCTGTGG CGTGGGCTTC ACAGGCATGT GCCGCAGACC 
ACGGGGAAGG AGCTGCGGAC ACCCCGCTGC CCACAGGGCC GGTCCATGTG TGTGAGCTCG 
GGACGCCGTG GAACGGCACC GCACTCCTGG TGCCGGAGTT GCCCCGGGCC CTTGGCGTGC 
GCTCCGGCGA TGTTGCCCCG GGCCTGGGGT TTTATTAGAC AGTTAGCTGG GGTTGCGTCC 
AGGCTTCTGA CCCACCAGGC GGGGTTTCCC ACCCTCTTTC CCTCTCACCC TCCCGCTGGG 
GGGTGTCCTG CCCCTGGCAC CAAAGTGCAG AGGTGGATCC CTCGTCCTCT GCCAGGAGGC 
AGAACAGAGC AGCCACTCTG TGCCACTCTC TCTGGTCGGA GAGATCCAGG CCCCCTCCGA 
CCACGGCCCA CACGCGGGTG CCCCGGGGCC ACCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation.
Journal of cellular and molecular medicine21(10)2465-2480(2017 Oct)
Zhou D,Kuang Z,Zeng X,Wang K,Ma J,Luo H,Chen M,Li Y,Zeng J,Li S,Luan F,He Y,Dai H,Liu B,Li H,He L,Xing Q

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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MAP2K2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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