Map2k2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map2k2
Entrez Gene ID	26396
Full Name	mitogen-activated protein kinase kinase 2
Synonyms	AA589381,MEK2,MK2,Prkmk2
General protein information	Preferred Names mitogen-activated protein kinase kinase 2 Names dual specificity mitogen-activated protein kinase kinase 2 ERK activator kinase 2 MAP kinase kinase 2 MAP kinase/Erk kinase MAPK/ERK kinase 2 MAPKK 2 MEK 2 protein kinase, mitogen activated, kinase 2, p45
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.72 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006513684.3	XP_006513747.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X3
NM_001358539.1	NP_001345468.1	dual specificity mitogen-activated protein kinase kinase 2 isoform 3
XM_006513683.3	XP_006513746.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X2
NM_001347144.1	NP_001334073.1	dual specificity mitogen-activated protein kinase kinase 2 isoform 2
NM_023138.5	NP_075627.2	dual specificity mitogen-activated protein kinase kinase 2 isoform 1
XM_006513683.4	XP_006513746.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MAP2K2	NP_001041601.1
Eremothecium gossypii	AGOS_ACR196C	NP_983598.1
	MAP2K2	XP_001118016.2
Gallus gallus (chicken)	MAP2K2	NP_990719.1
Danio rerio (zebrafish)	map2k2b	NP_001121753.1
Saccharomyces cerevisiae (baker's yeast)	STE7	NP_010122.1
Danio rerio (zebrafish)	map2k2a	NP_001032468.2
Arabidopsis thaliana (thale cress)	MKK6	NP_200469.1
Pan troglodytes (chimpanzee)	LOC100611792	XP_003318859.1
Bos taurus (cattle)	MAP2K2	NP_001033160.2
Kluyveromyces lactis	KLLA0C16577g	XP_452941.1
Oryza sativa (rice)	Os01g0510100	NP_001043164.1
Homo sapiens (human)	MAP2K2	NP_109587.1
Mus musculus (house mouse)	Map2k2	NP_075627.2
Rattus norvegicus (Norway rat)	Map2k2	NP_579817.1

Gene Ontology
Bibliography

Related articles in PubMed

Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.
Garg A, Bansal M, Gotoh N, Feng GS, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X
PLoS genetics13(10)e1007047(2017 Oct)

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.
Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K
Nature548(7666)219-223(2017 08)

Fluid shear stress-induced TGF-?/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Kunnen SJ, Leonhard WN, Semeins C, Hawinkels LJAC, Poelma C, Ten Dijke P, Bakker A, Hierck BP, Peters DJM
Cellular and molecular life sciences : CMLS74(12)2283-2298(2017 Jun)

Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
Dungan CM, Williamson DL
Biochemical and biophysical research communications482(4)1067-1072(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that, although short-term suppression of Mek1/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Title: Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

fluid shear stress induces autocrine TGF-beta/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
Title: Fluid shear stress-induced TGF-?/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.

REDD1 is required for normal insulin-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1, and mTOR
Title: Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.

Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
Title: Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.

FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation
Title: FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells.

The following Map2k2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map2k2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu44520	NM_001347144.1 Latest version!	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu44522	NM_001358539.1 Latest version!	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu44522	XM_006513684.3 Latest version!	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu22053	NM_023138.5 Latest version!	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu44521	XM_006513683.4 Latest version!	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu44521	XM_006513683.3	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map2k2 ( NM_001347144.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334073.1 Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu44520
Clone ID Related Accession (Same CDS sequence)	NM_001347144.1
Accession Version	NM_001347144.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX204173.1, AK171584.1, AK036822.1, BQ032953.1 and AW123542.1. On Nov 16, 2016 this sequence version replaced XM_006513682.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one amino acid shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.171966.1, SRR1660813.260493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCC GGAGGAAGCC GGTGTTACCG GCACTCACTA TCAACCCTAC CATCGCCGAG 
GGCCCGTCCC CCACCAGCGA GGGCGCCTCT GAGGCAAACC TGGTGGACCT CCAGAAGAAG 
CTGGAAGAGC TGGACCTGGA TGAGCAGCAA AGGAAGCGGC TGGAGGCCTT CCTTACCCAG 
AAGGCTAAGG TCGGTGAGCT CAAGGACGAC GACTTTGAGA GGATCTCAGA GCTGGGTGCC 
GGCAATGGCG GAGTGGTCAC CAAGGCCCGG CATAGGCCGT CAGGCCTCAT CATGGCCAGA 
AAGCTGATCC ACCTGGAGAT CAAACCGGCC GTGCGCAACC AGATCATCCG GGAGCTGCAG 
GTGCTGCACG AGTGCAACTC GCCCTACATC GTGGGCTTCT ATGGGGCCTT CTACAGCGAC 
GGCGAGATCA GCATCTGCAT GGAGCACATG GATGGTGGCT CACTGGACCA GGTACTGAAG 
GAGGCCAAGC GGATTCCTGA AGACATCTTG GGGAAGGTCA GCATTGCGGT GCTCCGGGGC 
CTGGCCTACC TCCGAGAGAA GCACCAGATC ATGCACAGAG ATGTGAAGCC CTCCAACATC 
CTGGTGAACT CTCGCGGGGA GATTAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTGATC 
GACTCCATGG CCAACTCGTT TGTAGGGACG CGCTCCTACA TGTCCCCAGA GCGGCTGCAG 
GGCACCCACT ACTCTGTGCA GTCGGACATC TGGAGCATGG GGCTGTCGCT GGTGGAGCTG 
GCCATCGGGA GGTATCCCAT TCCCCCACCT GATGCCAAGG AACTAGAGGC CAGCTTTGGC 
CGGCCTGTGG TGGACGGGGC AGACGGAGAA CCCCATAGTG TCTCCCCGAG GCCCAGGCCC 
CCTGGACGCC CCATCAGTGG TCATGGGATG GACAGCCGAC CGGCCATGGC CATCTTTGAG 
CTGCTGGACT ACATAGTGAA CGAGCCACCT CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA 
GACTTCCAGG AGTTTGTGAA TAAATGTCTC ATTAAGAACC CAGCAGAGCG AGCAGATCTG 
AAGCTGCTGA TGAACCACGC CTTCATCAAG CGCTCTGAGG GGGAGGAAGT GGACTTCGCC 
GGCTGGCTGT GCAGAACCCT GCGGCTGAAG CAGCCCAGCA CACCCACGCG GACTGCAGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334073.1
CDS	233..1435
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Target ORF information:

RefSeq Version	NM_001347144.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347144.1

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGTTACCG GCACTCACTA TCAACCCTAC CATCGCCGAG 
GGCCCGTCCC CCACCAGCGA GGGCGCCTCT GAGGCAAACC TGGTGGACCT CCAGAAGAAG 
CTGGAAGAGC TGGACCTGGA TGAGCAGCAA AGGAAGCGGC TGGAGGCCTT CCTTACCCAG 
AAGGCTAAGG TCGGTGAGCT CAAGGACGAC GACTTTGAGA GGATCTCAGA GCTGGGTGCC 
GGCAATGGCG GAGTGGTCAC CAAGGCCCGG CATAGGCCGT CAGGCCTCAT CATGGCCAGA 
AAGCTGATCC ACCTGGAGAT CAAACCGGCC GTGCGCAACC AGATCATCCG GGAGCTGCAG 
GTGCTGCACG AGTGCAACTC GCCCTACATC GTGGGCTTCT ATGGGGCCTT CTACAGCGAC 
GGCGAGATCA GCATCTGCAT GGAGCACATG GATGGTGGCT CACTGGACCA GGTACTGAAG 
GAGGCCAAGC GGATTCCTGA AGACATCTTG GGGAAGGTCA GCATTGCGGT GCTCCGGGGC 
CTGGCCTACC TCCGAGAGAA GCACCAGATC ATGCACAGAG ATGTGAAGCC CTCCAACATC 
CTGGTGAACT CTCGCGGGGA GATTAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTGATC 
GACTCCATGG CCAACTCGTT TGTAGGGACG CGCTCCTACA TGTCCCCAGA GCGGCTGCAG 
GGCACCCACT ACTCTGTGCA GTCGGACATC TGGAGCATGG GGCTGTCGCT GGTGGAGCTG 
GCCATCGGGA GGTATCCCAT TCCCCCACCT GATGCCAAGG AACTAGAGGC CAGCTTTGGC 
CGGCCTGTGG TGGACGGGGC AGACGGAGAA CCCCATAGTG TCTCCCCGAG GCCCAGGCCC 
CCTGGACGCC CCATCAGTGG TCATGGGATG GACAGCCGAC CGGCCATGGC CATCTTTGAG 
CTGCTGGACT ACATAGTGAA CGAGCCACCT CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA 
GACTTCCAGG AGTTTGTGAA TAAATGTCTC ATTAAGAACC CAGCAGAGCG AGCAGATCTG 
AAGCTGCTGA TGAACCACGC CTTCATCAAG CGCTCTGAGG GGGAGGAAGT GGACTTCGCC 
GGCTGGCTGT GCAGAACCCT GCGGCTGAAG CAGCCCAGCA CACCCACGCG GACTGCAGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k2 ( NM_001358539.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001345468.1 Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu44522
Clone ID Related Accession (Same CDS sequence)	XM_006513684.3 , NM_001358539.1
Accession Version	NM_001358539.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX204173.1, AK171584.1, AK138130.1, AK036822.1, BQ032953.1 and AW123542.1. On Dec 1, 2017 this sequence version replaced XM_006513684.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK138130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGG TCATGGGATG 
GACAGCCGAC CGGCCATGGC CATCTTTGAG CTGCTGGACT ACATAGTGAA CGAGCCACCT 
CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA GACTTCCAGG AGTTTGTGAA TAAATGTCTC 
ATTAAGAACC CAGCAGAGCG AGCAGATCTG AAGCTGCTGA TGAACCACGC CTTCATCAAG 
CGCTCTGAGG GGGAGGAAGT GGACTTCGCC GGCTGGCTGT GCAGAACCCT GCGGCTGAAG 
CAGCCCAGCA CACCCACGCG GACTGCAGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001345468.1
CDS	935..1567
Translation	MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Target ORF information:

RefSeq Version	NM_001358539.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001358539.1

ORF Insert Sequence:

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGG TCATGGGATG 
GACAGCCGAC CGGCCATGGC CATCTTTGAG CTGCTGGACT ACATAGTGAA CGAGCCACCT 
CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA GACTTCCAGG AGTTTGTGAA TAAATGTCTC 
ATTAAGAACC CAGCAGAGCG AGCAGATCTG AAGCTGCTGA TGAACCACGC CTTCATCAAG 
CGCTCTGAGG GGGAGGAAGT GGACTTCGCC GGCTGGCTGT GCAGAACCCT GCGGCTGAAG 
CAGCCCAGCA CACCCACGCG GACTGCAGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k2 ( XM_006513684.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513747.1 Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu44522
Clone ID Related Accession (Same CDS sequence)	XM_006513684.3 , NM_001358539.1
Accession Version	XM_006513684.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X3
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513684.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGG TCATGGGATG 
GACAGCCGAC CGGCCATGGC CATCTTTGAG CTGCTGGACT ACATAGTGAA CGAGCCACCT 
CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA GACTTCCAGG AGTTTGTGAA TAAATGTCTC 
ATTAAGAACC CAGCAGAGCG AGCAGATCTG AAGCTGCTGA TGAACCACGC CTTCATCAAG 
CGCTCTGAGG GGGAGGAAGT GGACTTCGCC GGCTGGCTGT GCAGAACCCT GCGGCTGAAG 
CAGCCCAGCA CACCCACGCG GACTGCAGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513747.1
CDS	878..1510
Translation	MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Target ORF information:

RefSeq Version	XM_006513684.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513684.3

ORF Insert Sequence:

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGG TCATGGGATG 
GACAGCCGAC CGGCCATGGC CATCTTTGAG CTGCTGGACT ACATAGTGAA CGAGCCACCT 
CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA GACTTCCAGG AGTTTGTGAA TAAATGTCTC 
ATTAAGAACC CAGCAGAGCG AGCAGATCTG AAGCTGCTGA TGAACCACGC CTTCATCAAG 
CGCTCTGAGG GGGAGGAAGT GGACTTCGCC GGCTGGCTGT GCAGAACCCT GCGGCTGAAG 
CAGCCCAGCA CACCCACGCG GACTGCAGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k2 ( NM_023138.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075627.2 Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22053
Clone ID Related Accession (Same CDS sequence)	NM_023138.5
Accession Version	NM_023138.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX204173.1, AK080574.1, AK036822.1, BQ032953.1 and AW123542.1. On Nov 16, 2016 this sequence version replaced NM_023138.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK009392.1, AK080574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGCCC GGAGGAAGCC GGTGTTACCG GCACTCACTA TCAACCCTAC CATCGCCGAG 
GGCCCGTCCC CCACCAGCGA GGGCGCCTCT GAGGCAAACC TGGTGGACCT CCAGAAGAAG 
CTGGAAGAGC TGGACCTGGA TGAGCAGCAA AGGAAGCGGC TGGAGGCCTT CCTTACCCAG 
AAGGCTAAGG TCGGTGAGCT CAAGGACGAC GACTTTGAGA GGATCTCAGA GCTGGGTGCC 
GGCAATGGCG GAGTGGTCAC CAAGGCCCGG CATAGGCCGT CAGGCCTCAT CATGGCCAGA 
AAGCTGATCC ACCTGGAGAT CAAACCGGCC GTGCGCAACC AGATCATCCG GGAGCTGCAG 
GTGCTGCACG AGTGCAACTC GCCCTACATC GTGGGCTTCT ATGGGGCCTT CTACAGCGAC 
GGCGAGATCA GCATCTGCAT GGAGCACATG GATGGTGGCT CACTGGACCA GGTACTGAAG 
GAGGCCAAGC GGATTCCTGA AGACATCTTG GGGAAGGTCA GCATTGCGGT GCTCCGGGGC 
CTGGCCTACC TCCGAGAGAA GCACCAGATC ATGCACAGAG ATGTGAAGCC CTCCAACATC 
CTGGTGAACT CTCGCGGGGA GATTAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTGATC 
GACTCCATGG CCAACTCGTT TGTAGGGACG CGCTCCTACA TGTCCCCAGA GCGGCTGCAG 
GGCACCCACT ACTCTGTGCA GTCGGACATC TGGAGCATGG GGCTGTCGCT GGTGGAGCTG 
GCCATCGGGA GGTATCCCAT TCCCCCACCT GATGCCAAGG AACTAGAGGC CAGCTTTGGC 
CGGCCTGTGG TGGACGGGGC AGACGGAGAA CCCCATAGTG TCTCCCCGAG GCCCAGGCCC 
CCTGGACGCC CCATCAGTGT AGGTCATGGG ATGGACAGCC GACCGGCCAT GGCCATCTTT 
GAGCTGCTGG ACTACATAGT GAACGAGCCA CCTCCCAAGC TGCCCAGTGG TGTGTTCAGC 
TCAGACTTCC AGGAGTTTGT GAATAAATGT CTCATTAAGA ACCCAGCAGA GCGAGCAGAT 
CTGAAGCTGC TGATGAACCA CGCCTTCATC AAGCGCTCTG AGGGGGAGGA AGTGGACTTC 
GCCGGCTGGC TGTGCAGAAC CCTGCGGCTG AAGCAGCCCA GCACACCCAC GCGGACTGCA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075627.2
CDS	233..1438
Translation	MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Target ORF information:

RefSeq Version	NM_023138.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023138.5

ORF Insert Sequence:

ATGCTGGCCC GGAGGAAGCC GGTGTTACCG GCACTCACTA TCAACCCTAC CATCGCCGAG 
GGCCCGTCCC CCACCAGCGA GGGCGCCTCT GAGGCAAACC TGGTGGACCT CCAGAAGAAG 
CTGGAAGAGC TGGACCTGGA TGAGCAGCAA AGGAAGCGGC TGGAGGCCTT CCTTACCCAG 
AAGGCTAAGG TCGGTGAGCT CAAGGACGAC GACTTTGAGA GGATCTCAGA GCTGGGTGCC 
GGCAATGGCG GAGTGGTCAC CAAGGCCCGG CATAGGCCGT CAGGCCTCAT CATGGCCAGA 
AAGCTGATCC ACCTGGAGAT CAAACCGGCC GTGCGCAACC AGATCATCCG GGAGCTGCAG 
GTGCTGCACG AGTGCAACTC GCCCTACATC GTGGGCTTCT ATGGGGCCTT CTACAGCGAC 
GGCGAGATCA GCATCTGCAT GGAGCACATG GATGGTGGCT CACTGGACCA GGTACTGAAG 
GAGGCCAAGC GGATTCCTGA AGACATCTTG GGGAAGGTCA GCATTGCGGT GCTCCGGGGC 
CTGGCCTACC TCCGAGAGAA GCACCAGATC ATGCACAGAG ATGTGAAGCC CTCCAACATC 
CTGGTGAACT CTCGCGGGGA GATTAAGCTG TGTGACTTCG GGGTGAGCGG CCAGCTGATC 
GACTCCATGG CCAACTCGTT TGTAGGGACG CGCTCCTACA TGTCCCCAGA GCGGCTGCAG 
GGCACCCACT ACTCTGTGCA GTCGGACATC TGGAGCATGG GGCTGTCGCT GGTGGAGCTG 
GCCATCGGGA GGTATCCCAT TCCCCCACCT GATGCCAAGG AACTAGAGGC CAGCTTTGGC 
CGGCCTGTGG TGGACGGGGC AGACGGAGAA CCCCATAGTG TCTCCCCGAG GCCCAGGCCC 
CCTGGACGCC CCATCAGTGT AGGTCATGGG ATGGACAGCC GACCGGCCAT GGCCATCTTT 
GAGCTGCTGG ACTACATAGT GAACGAGCCA CCTCCCAAGC TGCCCAGTGG TGTGTTCAGC 
TCAGACTTCC AGGAGTTTGT GAATAAATGT CTCATTAAGA ACCCAGCAGA GCGAGCAGAT 
CTGAAGCTGC TGATGAACCA CGCCTTCATC AAGCGCTCTG AGGGGGAGGA AGTGGACTTC 
GCCGGCTGGC TGTGCAGAAC CCTGCGGCTG AAGCAGCCCA GCACACCCAC GCGGACTGCA 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k2 ( XM_006513683.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513746.1 Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu44521
Clone ID Related Accession (Same CDS sequence)	XM_006513683.3 , XM_006513683.4
Accession Version	XM_006513683.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513683.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGT AGGTCATGGG 
ATGGACAGCC GACCGGCCAT GGCCATCTTT GAGCTGCTGG ACTACATAGT GAACGAGCCA 
CCTCCCAAGC TGCCCAGTGG TGTGTTCAGC TCAGACTTCC AGGAGTTTGT GAATAAATGT 
CTCATTAAGA ACCCAGCAGA GCGAGCAGAT CTGAAGCTGC TGATGAACCA CGCCTTCATC 
AAGCGCTCTG AGGGGGAGGA AGTGGACTTC GCCGGCTGGC TGTGCAGAAC CCTGCGGCTG 
AAGCAGCCCA GCACACCCAC GCGGACTGCA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513746.1
CDS	587..1222
Translation	MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Target ORF information:

RefSeq Version	XM_006513683.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513683.3

ORF Insert Sequence:

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGT AGGTCATGGG 
ATGGACAGCC GACCGGCCAT GGCCATCTTT GAGCTGCTGG ACTACATAGT GAACGAGCCA 
CCTCCCAAGC TGCCCAGTGG TGTGTTCAGC TCAGACTTCC AGGAGTTTGT GAATAAATGT 
CTCATTAAGA ACCCAGCAGA GCGAGCAGAT CTGAAGCTGC TGATGAACCA CGCCTTCATC 
AAGCGCTCTG AGGGGGAGGA AGTGGACTTC GCCGGCTGGC TGTGCAGAAC CCTGCGGCTG 
AAGCAGCCCA GCACACCCAC GCGGACTGCA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k2 ( XM_006513683.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006513746.1 Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu44521
Clone ID Related Accession (Same CDS sequence)	XM_006513683.3 , XM_006513683.4
Accession Version	XM_006513683.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	dual specificity mitogen-activated protein kinase kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006513683.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGT AGGTCATGGG 
ATGGACAGCC GACCGGCCAT GGCCATCTTT GAGCTGCTGG ACTACATAGT GAACGAGCCA 
CCTCCCAAGC TGCCCAGTGG TGTGTTCAGC TCAGACTTCC AGGAGTTTGT GAATAAATGT 
CTCATTAAGA ACCCAGCAGA GCGAGCAGAT CTGAAGCTGC TGATGAACCA CGCCTTCATC 
AAGCGCTCTG AGGGGGAGGA AGTGGACTTC GCCGGCTGGC TGTGCAGAAC CCTGCGGCTG 
AAGCAGCCCA GCACACCCAC GCGGACTGCA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006513746.1
CDS	937..1572
Translation	MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV

Target ORF information:

RefSeq Version	XM_006513683.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006513683.4

ORF Insert Sequence:

ATGCACAGAG ATGTGAAGCC CTCCAACATC CTGGTGAACT CTCGCGGGGA GATTAAGCTG 
TGTGACTTCG GGGTGAGCGG CCAGCTGATC GACTCCATGG CCAACTCGTT TGTAGGGACG 
CGCTCCTACA TGTCCCCAGA GCGGCTGCAG GGCACCCACT ACTCTGTGCA GTCGGACATC 
TGGAGCATGG GGCTGTCGCT GGTGGAGCTG GCCATCGGGA GGTATCCCAT TCCCCCACCT 
GATGCCAAGG AACTAGAGGC CAGCTTTGGC CGGCCTGTGG TGGACGGGGC AGACGGAGAA 
CCCCATAGTG TCTCCCCGAG GCCCAGGCCC CCTGGACGCC CCATCAGTGT AGGTCATGGG 
ATGGACAGCC GACCGGCCAT GGCCATCTTT GAGCTGCTGG ACTACATAGT GAACGAGCCA 
CCTCCCAAGC TGCCCAGTGG TGTGTTCAGC TCAGACTTCC AGGAGTTTGT GAATAAATGT 
CTCATTAAGA ACCCAGCAGA GCGAGCAGAT CTGAAGCTGC TGATGAACCA CGCCTTCATC 
AAGCGCTCTG AGGGGGAGGA AGTGGACTTC GCCGGCTGGC TGTGCAGAAC CCTGCGGCTG 
AAGCAGCCCA GCACACCCAC GCGGACTGCA GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.
PLoS genetics13(10)e1007047(2017 Oct)
Garg A,Bansal M,Gotoh N,Feng GS,Zhong J,Wang F,Kariminejad A,Brooks S,Zhang X

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.
Nature548(7666)219-223(2017 08)
Choi J,Huebner AJ,Clement K,Walsh RM,Savol A,Lin K,Gu H,Di Stefano B,Brumbaugh J,Kim SY,Sharif J,Rose CM,Mohammad A,Odajima J,Charron J,Shioda T,Gnirke A,Gygi S,Koseki H,Sadreyev RI,Xiao A,Meissner A,Hochedlinger K

Fluid shear stress-induced TGF-?/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Cellular and molecular life sciences : CMLS74(12)2283-2298(2017 Jun)
Kunnen SJ,Leonhard WN,Semeins C,Hawinkels LJAC,Poelma C,Ten Dijke P,Bakker A,Hierck BP,Peters DJM

Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
Biochemical and biophysical research communications482(4)1067-1072(2017 Jan)
Dungan CM,Williamson DL

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Map2k2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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