NXF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NXF2
Entrez Gene ID	56001
Full Name	nuclear RNA export factor 2
Synonyms	CT39,TAPL-2,TCP11X2
General protein information	Preferred Names nuclear RNA export factor 2 Names nuclear RNA export factor 2 TAP-like protein 2 cancer/testis antigen 39 t-complex protein 11 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq22.1
Summary	This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013].
Disorder MIM:	300315

mRNA and Protein(s)

mRNA	Protein	Name
NM_022053.3	NP_071336.1	nuclear RNA export factor 2
NM_022053.4	NP_071336.1	nuclear RNA export factor 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	NXF2	NP_071336.1
Canis lupus familiaris (dog)	NXF2	XP_005641648.1
Pan troglodytes (chimpanzee)	NXF2B	XP_001134843.2
Rattus norvegicus (Norway rat)	Nxf2	XP_002730329.2
Canis lupus familiaris (dog)	LOC492024	XP_005641633.1
Homo sapiens (human)	NXF2B	NP_001093156.1
	LOC706029	XP_001094356.1
Canis lupus familiaris (dog)	NXF2B	XP_005641651.1
Mus musculus (house mouse)	Nxf2	NP_112549.1

Gene Ontology
Bibliography

Related articles in PubMed

Luzp4 defines a new mRNA export pathway in cancer cells.
Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA
Nucleic acids research43(4)2353-66(2015 Feb)

The cancer?testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.
Zhou J, Li Y, Yao Y, Wang L, Gao L, Gao X, Luo X, Li J, Jiang M, Zhou M, Wang L, Yu L
Molecular medicine reports8(5)1549-55(2013 Nov)

Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma.
Chen YT, Chiu R, Lee P, Beneck D, Jin B, Old LJ
Human reproduction (Oxford, England)26(12)3232-43(2011 Dec)

De novo duplication of Xq22.1?q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure.
Chen CP, Su YN, Lin HH, Chern SR, Tsai FJ, Wu PC, Lee CC, Chen YT, Wang W
Taiwanese journal of obstetrics & gynecology50(3)339-44(2011 Sep)

Familial 1.1 Mb deletion in chromosome Xq22.1 associated with mental retardation and behavioural disorders in female patients.
Grillo L, Reitano S, Belfiore G, Spalletta A, Amata S, Bottitta M, Barone C, Falco M, Fichera M, Romano C
European journal of medical genetics53(2)113-6(2010 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low NXF2 expression is associated with leukemia.
Title: The cancer?testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.

Data do not support role for NXF2 in male infertility.
Title: Is there a role for the nuclear export factor 2 gene in male infertility?

The following NXF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NXF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10343	NM_022053.4 Latest version!	Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu10343	NM_022053.3	Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NXF2 ( NM_022053.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071336.1 Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.

Price & Availability↑

CloneID	OHu10343
Clone ID Related Accession (Same CDS sequence)	NM_022053.3 , NM_022053.4
Accession Version	NM_022053.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	nuclear RNA export factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC234791.5, AJ277526.1 and BC015020.1. On Aug 24, 2013 this sequence version replaced NM_022053.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015020.1, AJ277526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCTCTA CTCTAAAGAA GTGTGGGACA TACAGAACTG AAGTTGCAGA ATGCCATGAC 
CATGGTAGCA CTTTTCAAGG AAGAAAGAAA GGTGGGAGTT CTTTCCGGGA TAATTTTGAC 
AAGAGGAGCT GTCATTATGA ACATGGTGGG TATGAGCGCC CGCCTTCACA CTGCCAGGAG 
AATGATGGAA GCGTGGAGAT GAGGGATGTC CACAAGGACC AACAACTAAG ACACACTCCT 
TATAGCATCC GATGCGAAAG AAGAATGAAA TGGCATAGTG AAGACGAAAT CCGTATTACC 
ACGTGGAGAA ATAGAAAACC TCCGGAGAGA AAAATGAGTC AGAACACACA GGATGGATAC 
ACAAGGAACT GGTTTAAGGT CACAATTCCT TACGGGATAA AGTATGACAA GGCATGGCTA 
ATGAATTCAA TCCAGAGCCA TTGCAGTGAC CGCTTCACTC CGGTTGATTT CCACTACGTC 
CGAAATCGGG CATGCTTCTT TGTCCAGGAT GCTAGCGCTG CCTCCGCATT GAAGGATGTC 
AGTTATAAGA TTTATGATGA TGAGAACCAA AAGATATGTA TATTTGTCAA TCATTCTACT 
GCGCCCTACT CTGTGAAGAA TAAGTTGAAG CCAGGCCAAA TGGAGATGCT AAAGCTGACC 
ATGAACAAAC GGTACAATGT CTCCCAGCAA GCTCTTGATC TCCAGAATCT CCGCTTTGAC 
CCAGACTTGA TGGGCCGTGA CATTGATATA ATCCTGAATC GAAGAAACTG CATGGCTGCC 
ACCCTGAAGA TCATTGAAAG AAATTTCCCT GAGCTGTTGT CTTTGAACTT GTGCAACAAC 
AAGCTGTACC AGCTGGATGG CCTTTCTGAC ATTACAGAGA AGGCTCCCAA AGTCAAGACC 
CTGAATCTCT CCAAAAATAA GCTGGAGTCG GCGTGGGAGT TGGGCAAGGT GAAAGGGCTG 
AAGCTCGAAG AGCTATGGCT AGAAGGGAAC CCGTTGTGCA GCACCTTCTC GGACCAGTCC 
GCCTATGTAA GTGCCATCCG GGATTGTTTC CCCAAGTTGT TACGCCTGGA CGGCCGAGAG 
TTATCCGCAC CAGTGATTGT TGACATTGAC AGCTCTGAGA CAATGAAACC CTGCAAGGAA 
AACTTTACTG GATCTGAGAC CCTAAAGCAT TTAGTCCTGC AATTCCTGCA GCAGTATTAC 
TCGATCTATG ACTCTGGAGA TCGACAGGGT CTCCTCGGTG CTTACCACGA TGAGGCCTGC 
TTCTCCTTGG CTATTCCCTT CGACCCCAAG GACTCAGCCC CGAGCAGCTT GTGCAAGTAC 
TTTGAGGATA GCAGGAATAT GAAAACACTC AAGGACCCCT ACCTGAAGGG GGAACTGCTG 
AGGCGCACAA AACGTGACAT TGTGGACTCC CTCAGTGCGT TGCCCAAAAC TCAGCATGAC 
CTCAGCTCCA TCCTGGTGGA CGTGTGGTGC CAGACGGAAA GGATGCTCTG CTTTTCTGTC 
AATGGGGTTT TCAAGGAAGT GGAAGGACAG TCTCAGGGTT CTGTTCTCGC CTTCACCCGG 
ACCTTCATTG CTACCCCTGG CAGCAGTTCC AGTCTGTGCA TCGTGAATGA CGAGCTGTTT 
GTGAGGGATG CCAGCCCCCA AGAGACTCAG AGTGCCTTCT CCATCCCAGT GTCCACACTC 
TCCTCCAGCT CTGAGCCCTC CCTCTCCCAG GAGCAGCAGG AAATGGTGCA GGCTTTCTCT 
GCCCAGTCTG GGATGAAACT GGAGTGGTCT CAGAAGTGCC TTCAGGACAA TGAGTGGAAC 
TACACTAGAG CTGGCCAGGC CTTCACTATG CTCCAGACCG AGGGCAAGAT CCCCGCGGAG 
GCCTTCAAGC AAATCTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071336.1
CDS	315..2195
Translation	MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSCHYEHGGYERPPSHCQENDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTWRNRKPPERKMSQNTQDGYTRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYVRNRACFFVQDASAASALKDVSYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAPSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSSSSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWNYTRAGQAFTMLQTEGKIPAEAFKQIS

Target ORF information:

RefSeq Version	NM_022053.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022053.3

ORF Insert Sequence:

ATGTGCTCTA CTCTAAAGAA GTGTGGGACA TACAGAACTG AAGTTGCAGA ATGCCATGAC 
CATGGTAGCA CTTTTCAAGG AAGAAAGAAA GGTGGGAGTT CTTTCCGGGA TAATTTTGAC 
AAGAGGAGCT GTCATTATGA ACATGGTGGG TATGAGCGCC CGCCTTCACA CTGCCAGGAG 
AATGATGGAA GCGTGGAGAT GAGGGATGTC CACAAGGACC AACAACTAAG ACACACTCCT 
TATAGCATCC GATGCGAAAG AAGAATGAAA TGGCATAGTG AAGACGAAAT CCGTATTACC 
ACGTGGAGAA ATAGAAAACC TCCGGAGAGA AAAATGAGTC AGAACACACA GGATGGATAC 
ACAAGGAACT GGTTTAAGGT CACAATTCCT TACGGGATAA AGTATGACAA GGCATGGCTA 
ATGAATTCAA TCCAGAGCCA TTGCAGTGAC CGCTTCACTC CGGTTGATTT CCACTACGTC 
CGAAATCGGG CATGCTTCTT TGTCCAGGAT GCTAGCGCTG CCTCCGCATT GAAGGATGTC 
AGTTATAAGA TTTATGATGA TGAGAACCAA AAGATATGTA TATTTGTCAA TCATTCTACT 
GCGCCCTACT CTGTGAAGAA TAAGTTGAAG CCAGGCCAAA TGGAGATGCT AAAGCTGACC 
ATGAACAAAC GGTACAATGT CTCCCAGCAA GCTCTTGATC TCCAGAATCT CCGCTTTGAC 
CCAGACTTGA TGGGCCGTGA CATTGATATA ATCCTGAATC GAAGAAACTG CATGGCTGCC 
ACCCTGAAGA TCATTGAAAG AAATTTCCCT GAGCTGTTGT CTTTGAACTT GTGCAACAAC 
AAGCTGTACC AGCTGGATGG CCTTTCTGAC ATTACAGAGA AGGCTCCCAA AGTCAAGACC 
CTGAATCTCT CCAAAAATAA GCTGGAGTCG GCGTGGGAGT TGGGCAAGGT GAAAGGGCTG 
AAGCTCGAAG AGCTATGGCT AGAAGGGAAC CCGTTGTGCA GCACCTTCTC GGACCAGTCC 
GCCTATGTAA GTGCCATCCG GGATTGTTTC CCCAAGTTGT TACGCCTGGA CGGCCGAGAG 
TTATCCGCAC CAGTGATTGT TGACATTGAC AGCTCTGAGA CAATGAAACC CTGCAAGGAA 
AACTTTACTG GATCTGAGAC CCTAAAGCAT TTAGTCCTGC AATTCCTGCA GCAGTATTAC 
TCGATCTATG ACTCTGGAGA TCGACAGGGT CTCCTCGGTG CTTACCACGA TGAGGCCTGC 
TTCTCCTTGG CTATTCCCTT CGACCCCAAG GACTCAGCCC CGAGCAGCTT GTGCAAGTAC 
TTTGAGGATA GCAGGAATAT GAAAACACTC AAGGACCCCT ACCTGAAGGG GGAACTGCTG 
AGGCGCACAA AACGTGACAT TGTGGACTCC CTCAGTGCGT TGCCCAAAAC TCAGCATGAC 
CTCAGCTCCA TCCTGGTGGA CGTGTGGTGC CAGACGGAAA GGATGCTCTG CTTTTCTGTC 
AATGGGGTTT TCAAGGAAGT GGAAGGACAG TCTCAGGGTT CTGTTCTCGC CTTCACCCGG 
ACCTTCATTG CTACCCCTGG CAGCAGTTCC AGTCTGTGCA TCGTGAATGA CGAGCTGTTT 
GTGAGGGATG CCAGCCCCCA AGAGACTCAG AGTGCCTTCT CCATCCCAGT GTCCACACTC 
TCCTCCAGCT CTGAGCCCTC CCTCTCCCAG GAGCAGCAGG AAATGGTGCA GGCTTTCTCT 
GCCCAGTCTG GGATGAAACT GGAGTGGTCT CAGAAGTGCC TTCAGGACAA TGAGTGGAAC 
TACACTAGAG CTGGCCAGGC CTTCACTATG CTCCAGACCG AGGGCAAGAT CCCCGCGGAG 
GCCTTCAAGC AAATCTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NXF2 ( NM_022053.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_071336.1 Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.

Price & Availability↑

CloneID	OHu10343
Clone ID Related Accession (Same CDS sequence)	NM_022053.3 , NM_022053.4
Accession Version	NM_022053.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	nuclear RNA export factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC234791.5. On Dec 4, 2019 this sequence version replaced NM_022053.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015020.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGCTCTA CTCTAAAGAA GTGTGGGACA TACAGAACTG AAGTTGCAGA ATGCCATGAC 
CATGGTAGCA CTTTTCAAGG AAGAAAGAAA GGTGGGAGTT CTTTCCGGGA TAATTTTGAC 
AAGAGGAGCT GTCATTATGA ACATGGTGGG TATGAGCGCC CGCCTTCACA CTGCCAGGAG 
AATGATGGAA GCGTGGAGAT GAGGGATGTC CACAAGGACC AACAACTAAG ACACACTCCT 
TATAGCATCC GATGCGAAAG AAGAATGAAA TGGCATAGTG AAGACGAAAT CCGTATTACC 
ACGTGGAGAA ATAGAAAACC TCCGGAGAGA AAAATGAGTC AGAACACACA GGATGGATAC 
ACAAGGAACT GGTTTAAGGT CACAATTCCT TACGGGATAA AGTATGACAA GGCATGGCTA 
ATGAATTCAA TCCAGAGCCA TTGCAGTGAC CGCTTCACTC CGGTTGATTT CCACTACGTC 
CGAAATCGGG CATGCTTCTT TGTCCAGGAT GCTAGCGCTG CCTCCGCATT GAAGGATGTC 
AGTTATAAGA TTTATGATGA TGAGAACCAA AAGATATGTA TATTTGTCAA TCATTCTACT 
GCGCCCTACT CTGTGAAGAA TAAGTTGAAG CCAGGCCAAA TGGAGATGCT AAAGCTGACC 
ATGAACAAAC GGTACAATGT CTCCCAGCAA GCTCTTGATC TCCAGAATCT CCGCTTTGAC 
CCAGACTTGA TGGGCCGTGA CATTGATATA ATCCTGAATC GAAGAAACTG CATGGCTGCC 
ACCCTGAAGA TCATTGAAAG AAATTTCCCT GAGCTGTTGT CTTTGAACTT GTGCAACAAC 
AAGCTGTACC AGCTGGATGG CCTTTCTGAC ATTACAGAGA AGGCTCCCAA AGTCAAGACC 
CTGAATCTCT CCAAAAATAA GCTGGAGTCG GCGTGGGAGT TGGGCAAGGT GAAAGGGCTG 
AAGCTCGAAG AGCTATGGCT AGAAGGGAAC CCGTTGTGCA GCACCTTCTC GGACCAGTCC 
GCCTATGTAA GTGCCATCCG GGATTGTTTC CCCAAGTTGT TACGCCTGGA CGGCCGAGAG 
TTATCCGCAC CAGTGATTGT TGACATTGAC AGCTCTGAGA CAATGAAACC CTGCAAGGAA 
AACTTTACTG GATCTGAGAC CCTAAAGCAT TTAGTCCTGC AATTCCTGCA GCAGTATTAC 
TCGATCTATG ACTCTGGAGA TCGACAGGGT CTCCTCGGTG CTTACCACGA TGAGGCCTGC 
TTCTCCTTGG CTATTCCCTT CGACCCCAAG GACTCAGCCC CGAGCAGCTT GTGCAAGTAC 
TTTGAGGATA GCAGGAATAT GAAAACACTC AAGGACCCCT ACCTGAAGGG GGAACTGCTG 
AGGCGCACAA AACGTGACAT TGTGGACTCC CTCAGTGCGT TGCCCAAAAC TCAGCATGAC 
CTCAGCTCCA TCCTGGTGGA CGTGTGGTGC CAGACGGAAA GGATGCTCTG CTTTTCTGTC 
AATGGGGTTT TCAAGGAAGT GGAAGGACAG TCTCAGGGTT CTGTTCTCGC CTTCACCCGG 
ACCTTCATTG CTACCCCTGG CAGCAGTTCC AGTCTGTGCA TCGTGAATGA CGAGCTGTTT 
GTGAGGGATG CCAGCCCCCA AGAGACTCAG AGTGCCTTCT CCATCCCAGT GTCCACACTC 
TCCTCCAGCT CTGAGCCCTC CCTCTCCCAG GAGCAGCAGG AAATGGTGCA GGCTTTCTCT 
GCCCAGTCTG GGATGAAACT GGAGTGGTCT CAGAAGTGCC TTCAGGACAA TGAGTGGAAC 
TACACTAGAG CTGGCCAGGC CTTCACTATG CTCCAGACCG AGGGCAAGAT CCCCGCGGAG 
GCCTTCAAGC AAATCTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071336.1
CDS	248..2128
Translation	MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSCHYEHGGYERPPSHCQENDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTWRNRKPPERKMSQNTQDGYTRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYVRNRACFFVQDASAASALKDVSYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAPSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSSSSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWNYTRAGQAFTMLQTEGKIPAEAFKQIS

Target ORF information:

RefSeq Version	NM_022053.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear RNA export factor 2 (NXF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022053.4

ORF Insert Sequence:

ATGTGCTCTA CTCTAAAGAA GTGTGGGACA TACAGAACTG AAGTTGCAGA ATGCCATGAC 
CATGGTAGCA CTTTTCAAGG AAGAAAGAAA GGTGGGAGTT CTTTCCGGGA TAATTTTGAC 
AAGAGGAGCT GTCATTATGA ACATGGTGGG TATGAGCGCC CGCCTTCACA CTGCCAGGAG 
AATGATGGAA GCGTGGAGAT GAGGGATGTC CACAAGGACC AACAACTAAG ACACACTCCT 
TATAGCATCC GATGCGAAAG AAGAATGAAA TGGCATAGTG AAGACGAAAT CCGTATTACC 
ACGTGGAGAA ATAGAAAACC TCCGGAGAGA AAAATGAGTC AGAACACACA GGATGGATAC 
ACAAGGAACT GGTTTAAGGT CACAATTCCT TACGGGATAA AGTATGACAA GGCATGGCTA 
ATGAATTCAA TCCAGAGCCA TTGCAGTGAC CGCTTCACTC CGGTTGATTT CCACTACGTC 
CGAAATCGGG CATGCTTCTT TGTCCAGGAT GCTAGCGCTG CCTCCGCATT GAAGGATGTC 
AGTTATAAGA TTTATGATGA TGAGAACCAA AAGATATGTA TATTTGTCAA TCATTCTACT 
GCGCCCTACT CTGTGAAGAA TAAGTTGAAG CCAGGCCAAA TGGAGATGCT AAAGCTGACC 
ATGAACAAAC GGTACAATGT CTCCCAGCAA GCTCTTGATC TCCAGAATCT CCGCTTTGAC 
CCAGACTTGA TGGGCCGTGA CATTGATATA ATCCTGAATC GAAGAAACTG CATGGCTGCC 
ACCCTGAAGA TCATTGAAAG AAATTTCCCT GAGCTGTTGT CTTTGAACTT GTGCAACAAC 
AAGCTGTACC AGCTGGATGG CCTTTCTGAC ATTACAGAGA AGGCTCCCAA AGTCAAGACC 
CTGAATCTCT CCAAAAATAA GCTGGAGTCG GCGTGGGAGT TGGGCAAGGT GAAAGGGCTG 
AAGCTCGAAG AGCTATGGCT AGAAGGGAAC CCGTTGTGCA GCACCTTCTC GGACCAGTCC 
GCCTATGTAA GTGCCATCCG GGATTGTTTC CCCAAGTTGT TACGCCTGGA CGGCCGAGAG 
TTATCCGCAC CAGTGATTGT TGACATTGAC AGCTCTGAGA CAATGAAACC CTGCAAGGAA 
AACTTTACTG GATCTGAGAC CCTAAAGCAT TTAGTCCTGC AATTCCTGCA GCAGTATTAC 
TCGATCTATG ACTCTGGAGA TCGACAGGGT CTCCTCGGTG CTTACCACGA TGAGGCCTGC 
TTCTCCTTGG CTATTCCCTT CGACCCCAAG GACTCAGCCC CGAGCAGCTT GTGCAAGTAC 
TTTGAGGATA GCAGGAATAT GAAAACACTC AAGGACCCCT ACCTGAAGGG GGAACTGCTG 
AGGCGCACAA AACGTGACAT TGTGGACTCC CTCAGTGCGT TGCCCAAAAC TCAGCATGAC 
CTCAGCTCCA TCCTGGTGGA CGTGTGGTGC CAGACGGAAA GGATGCTCTG CTTTTCTGTC 
AATGGGGTTT TCAAGGAAGT GGAAGGACAG TCTCAGGGTT CTGTTCTCGC CTTCACCCGG 
ACCTTCATTG CTACCCCTGG CAGCAGTTCC AGTCTGTGCA TCGTGAATGA CGAGCTGTTT 
GTGAGGGATG CCAGCCCCCA AGAGACTCAG AGTGCCTTCT CCATCCCAGT GTCCACACTC 
TCCTCCAGCT CTGAGCCCTC CCTCTCCCAG GAGCAGCAGG AAATGGTGCA GGCTTTCTCT 
GCCCAGTCTG GGATGAAACT GGAGTGGTCT CAGAAGTGCC TTCAGGACAA TGAGTGGAAC 
TACACTAGAG CTGGCCAGGC CTTCACTATG CTCCAGACCG AGGGCAAGAT CCCCGCGGAG 
GCCTTCAAGC AAATCTCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Luzp4 defines a new mRNA export pathway in cancer cells.
Nucleic acids research43(4)2353-66(2015 Feb)
Viphakone N,Cumberbatch MG,Livingstone MJ,Heath PR,Dickman MJ,Catto JW,Wilson SA

The cancer?testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.
Molecular medicine reports8(5)1549-55(2013 Nov)
Zhou J,Li Y,Yao Y,Wang L,Gao L,Gao X,Luo X,Li J,Jiang M,Zhou M,Wang L,Yu L

Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma.
Human reproduction (Oxford, England)26(12)3232-43(2011 Dec)
Chen YT,Chiu R,Lee P,Beneck D,Jin B,Old LJ

De novo duplication of Xq22.1?q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure.
Taiwanese journal of obstetrics & gynecology50(3)339-44(2011 Sep)
Chen CP,Su YN,Lin HH,Chern SR,Tsai FJ,Wu PC,Lee CC,Chen YT,Wang W

Familial 1.1 Mb deletion in chromosome Xq22.1 associated with mental retardation and behavioural disorders in female patients.
European journal of medical genetics53(2)113-6(2010 Mar-Apr)
Grillo L,Reitano S,Belfiore G,Spalletta A,Amata S,Bottitta M,Barone C,Falco M,Fichera M,Romano C