BRF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BRF2
Entrez Gene ID	55290
Full Name	BRF2, RNA polymerase III transcription initiation factor subunit
Synonyms	BRFU,TFIIIB50
General protein information	Preferred Names BRF2, RNA polymerase III transcription initiation factor subunit Names transcription factor IIIB 50 kDa subunit B-related factor 2 BRF-2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RNA polymerase III transcription initiation factor BRFU hBRFU hTFIIIB50 transcription factor IIB- related factor, TFIIIB50
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.23
Summary	This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	607013

mRNA and Protein(s)

mRNA	Protein	Name
NM_018310.3	NP_060780.2	transcription factor IIIB 50 kDa subunit
NM_018310.4	NP_060780.2	transcription factor IIIB 50 kDa subunit

Pathways from BioSystems

Homologies

	BRF2	XP_001089435.1
Canis lupus familiaris (dog)	BRF2	XP_850010.1
Xenopus tropicalis (tropical clawed frog)	brf2	NP_001096549.1
Danio rerio (zebrafish)	brf2	NP_001003536.1
Danio rerio (zebrafish)	LOC100536580	XP_003201813.1
Homo sapiens (human)	BRF2	NP_060780.2
Pan troglodytes (chimpanzee)	BRF2	XP_001169914.1
Mus musculus (house mouse)	Brf2	NP_079962.1
Rattus norvegicus (Norway rat)	Brf2	NP_001019944.1
Bos taurus (cattle)	BRF2	NP_001015582.1
Gallus gallus (chicken)	LOC100859102	XP_003643371.2
Gallus gallus (chicken)	BRF2	XP_424383.3

Gene Ontology
Bibliography

Related articles in PubMed

New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
Gouge J, Vannini A
Transcription9(1)61-66(2018)

MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line.
Wang L, Qu J, Zhou L, Liao F, Wang J
Cancer research and treatment : official journal of Korean Cancer Association(2017 Oct)

Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Gouge J, Guthertz N, Kramm K, Dergai O, Abascal-Palacios G, Satia K, Cousin P, Hernandez N, Grohmann D, Vannini A
Nature communications8(1)130(2017 07)

Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.
Gouge J, Satia K, Guthertz N, Widya M, Thompson AJ, Cousin P, Dergai O, Hernandez N, Vannini A
Cell163(6)1375-87(2015 Dec)

hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
Reznik B, Clement SL, Lykke-Andersen J
PloS one9(6)e100992(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter.
Title: Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.

Study solved crystal structures of a human Brf2-TATA-binding complex bound to natural promoters, obtaining a detailed view of the molecular interactions occurring at Brf2-dependent Pol III promoters and highlighting the general structural and functional conservation of human Pol II and Pol III pre-initiation complexes.
Title: Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.

These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program.
Title: TFIIB-related factor 2 is associated with poor prognosis of nonsmall cell lung cancer patients through promoting tumor epithelial-mesenchymal transition.

hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay.
Title: hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.

BRF2 may have a role in poor prognosis and anti-angiogenic therapy for early-stage non-small cell lung cancer
Title: TFIIB-related factor 2 over expression is a prognosis marker for early-stage non-small cell lung cancer correlated with tumor angiogenesis.

The following BRF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BRF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09346	NM_018310.4 Latest version!	Homo sapiens BRF2 RNA polymerase III transcription initiation factor subunit (BRF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu09346	NM_018310.3	Homo sapiens BRF2 RNA polymerase III transcription initiation factor subunit (BRF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BRF2 ( NM_018310.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060780.2 Homo sapiens BRF2 RNA polymerase III transcription initiation factor subunit (BRF2), mRNA.

Price & Availability↑

CloneID	OHu09346
Clone ID Related Accession (Same CDS sequence)	NM_018310.3 , NM_018310.4
Accession Version	NM_018310.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	transcription factor IIIB 50 kDa subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA688249.1, AF206673.2, AK001914.1 and AA496239.1. This sequence is a reference standard in the RefSeqGene project. On Jul 31, 2010 this sequence version replaced NM_018310.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.79496.1, AF206673.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAGGCA GAGGCCGCTG CCCGGACTGC GGCTCCACGG AGCTGGTGGA AGACTCGCAC 
TATTCGCAGA GCCAGCTGGT GTGCTCCGAC TGCGGCTGCG TGGTCACCGA GGGGGTCCTT 
ACCACTACCT TCAGCGACGA GGGCAATCTC CGAGAGGTAA CATATTCCCG AAGCACAGGG 
GAAAACGAAC AAGTTAGTCG CAGCCAGCAA CGAGGTCTCC GGCGAGTGAG AGACCTTTGT 
CGAGTTCTGC AGTTGCCACC AACATTTGAG GATACCGCGG TTGCCTACTA CCAACAGGCA 
TATCGGCACT CTGGCATCCG AGCGGCCAGG CTGCAAAAGA AGGAGGTGTT GGTTGGGTGC 
TGCGTCTTAA TCACCTGCCG ACAGCATAAC TGGCCCCTAA CAATGGGGGC CATCTGCACG 
CTGTTGTATG CAGATTTGGA TGTGTTTTCT AGCACTTACA TGCAGATAGT GAAGCTCCTG 
GGACTGGATG TGCCATCTCT GTGCTTGGCA GAACTGGTGA AGACCTATTG CAGCAGCTTC 
AAACTGTTCC AAGCTTCACC TTCTGTGCCA GCCAAATACG TGGAAGACAA AGAGAAGATG 
CTGTCTCGAA CAATGCAGTT GGTGGAGCTG GCAAATGAGA CGTGGCTGGT GACCGGGAGG 
CATCCCTTGC CCGTCATCAC TGCTGCGACT TTCCTGGCTT GGCAGTCGCT GCAGCCTGCA 
GATCGGCTTT CATGTTCCCT TGCCCGATTT TGTAAATTGG CAAATGTGGA CCTGCCCTAC 
CCGGCGTCCT CCCGCCTGCA GGAGCTGCTG GCTGTGCTGC TGCGGATGGC TGAGCAGCTG 
GCCTGGTTAC GAGTTCTGAG ACTTGACAAA CGGTCTGTGG TGAAGCACAT CGGTGACCTT 
CTCCAGCACC GCCAGTCACT GGTCCGCTCT GCCTTTCGGG ATGGGACAGC AGAAGTGGAG 
ACCCGAGAGA AGGAGCCACC GGGGTGGGGA CAGGGGCAAG GAGAAGGGGA GGTGGGAAAT 
AATTCCTTAG GTTTACCCCA GGGGAAGCGG CCGGCCAGTC CTGCCCTTCT CTTGCCACCC 
TGCATGTTGA AGTCCCCGAA GCGGATCTGC CCTGTACCCC CTGTCTCCAC TGTCACTGGA 
GATGAGAACA TTTCTGATAG TGAAATAGAA CAGTATTTGC GTACCCCTCA GGAAGTTAGG 
GACTTTCAGA GAGCCCAGGC TGCTAGACAG GCTGCCACGA GTGTCCCTAA CCCTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060780.2
CDS	131..1390
Translation	MPGRGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTMQLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLANVDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQSLVRSAFRDGTAEVETREKEPPGWGQGQGEGEVGNNSLGLPQGKRPASPALLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTPQEVRDFQRAQAARQAATSVPNPP

Target ORF information:

RefSeq Version	NM_018310.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BRF2 RNA polymerase III transcription initiation factor subunit (BRF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018310.3

ORF Insert Sequence:

ATGCCAGGCA GAGGCCGCTG CCCGGACTGC GGCTCCACGG AGCTGGTGGA AGACTCGCAC 
TATTCGCAGA GCCAGCTGGT GTGCTCCGAC TGCGGCTGCG TGGTCACCGA GGGGGTCCTT 
ACCACTACCT TCAGCGACGA GGGCAATCTC CGAGAGGTAA CATATTCCCG AAGCACAGGG 
GAAAACGAAC AAGTTAGTCG CAGCCAGCAA CGAGGTCTCC GGCGAGTGAG AGACCTTTGT 
CGAGTTCTGC AGTTGCCACC AACATTTGAG GATACCGCGG TTGCCTACTA CCAACAGGCA 
TATCGGCACT CTGGCATCCG AGCGGCCAGG CTGCAAAAGA AGGAGGTGTT GGTTGGGTGC 
TGCGTCTTAA TCACCTGCCG ACAGCATAAC TGGCCCCTAA CAATGGGGGC CATCTGCACG 
CTGTTGTATG CAGATTTGGA TGTGTTTTCT AGCACTTACA TGCAGATAGT GAAGCTCCTG 
GGACTGGATG TGCCATCTCT GTGCTTGGCA GAACTGGTGA AGACCTATTG CAGCAGCTTC 
AAACTGTTCC AAGCTTCACC TTCTGTGCCA GCCAAATACG TGGAAGACAA AGAGAAGATG 
CTGTCTCGAA CAATGCAGTT GGTGGAGCTG GCAAATGAGA CGTGGCTGGT GACCGGGAGG 
CATCCCTTGC CCGTCATCAC TGCTGCGACT TTCCTGGCTT GGCAGTCGCT GCAGCCTGCA 
GATCGGCTTT CATGTTCCCT TGCCCGATTT TGTAAATTGG CAAATGTGGA CCTGCCCTAC 
CCGGCGTCCT CCCGCCTGCA GGAGCTGCTG GCTGTGCTGC TGCGGATGGC TGAGCAGCTG 
GCCTGGTTAC GAGTTCTGAG ACTTGACAAA CGGTCTGTGG TGAAGCACAT CGGTGACCTT 
CTCCAGCACC GCCAGTCACT GGTCCGCTCT GCCTTTCGGG ATGGGACAGC AGAAGTGGAG 
ACCCGAGAGA AGGAGCCACC GGGGTGGGGA CAGGGGCAAG GAGAAGGGGA GGTGGGAAAT 
AATTCCTTAG GTTTACCCCA GGGGAAGCGG CCGGCCAGTC CTGCCCTTCT CTTGCCACCC 
TGCATGTTGA AGTCCCCGAA GCGGATCTGC CCTGTACCCC CTGTCTCCAC TGTCACTGGA 
GATGAGAACA TTTCTGATAG TGAAATAGAA CAGTATTTGC GTACCCCTCA GGAAGTTAGG 
GACTTTCAGA GAGCCCAGGC TGCTAGACAG GCTGCCACGA GTGTCCCTAA CCCTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BRF2 ( NM_018310.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060780.2 Homo sapiens BRF2 RNA polymerase III transcription initiation factor subunit (BRF2), mRNA.

Price & Availability↑

CloneID	OHu09346
Clone ID Related Accession (Same CDS sequence)	NM_018310.3 , NM_018310.4
Accession Version	NM_018310.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	transcription factor IIIB 50 kDa subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF206673.2, AK001914.1, AA496239.1 and AC138356.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_018310.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.427703.1, DRR138522.14564.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000220659.11/ ENSP00000220659.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCAGGCA GAGGCCGCTG CCCGGACTGC GGCTCCACGG AGCTGGTGGA AGACTCGCAC 
TATTCGCAGA GCCAGCTGGT GTGCTCCGAC TGCGGCTGCG TGGTCACCGA GGGGGTCCTT 
ACCACTACCT TCAGCGACGA GGGCAATCTC CGAGAGGTAA CATATTCCCG AAGCACAGGG 
GAAAACGAAC AAGTTAGTCG CAGCCAGCAA CGAGGTCTCC GGCGAGTGAG AGACCTTTGT 
CGAGTTCTGC AGTTGCCACC AACATTTGAG GATACCGCGG TTGCCTACTA CCAACAGGCA 
TATCGGCACT CTGGCATCCG AGCGGCCAGG CTGCAAAAGA AGGAGGTGTT GGTTGGGTGC 
TGCGTCTTAA TCACCTGCCG ACAGCATAAC TGGCCCCTAA CAATGGGGGC CATCTGCACG 
CTGTTGTATG CAGATTTGGA TGTGTTTTCT AGCACTTACA TGCAGATAGT GAAGCTCCTG 
GGACTGGATG TGCCATCTCT GTGCTTGGCA GAACTGGTGA AGACCTATTG CAGCAGCTTC 
AAACTGTTCC AAGCTTCACC TTCTGTGCCA GCCAAATACG TGGAAGACAA AGAGAAGATG 
CTGTCTCGAA CAATGCAGTT GGTGGAGCTG GCAAATGAGA CGTGGCTGGT GACCGGGAGG 
CATCCCTTGC CCGTCATCAC TGCTGCGACT TTCCTGGCTT GGCAGTCGCT GCAGCCTGCA 
GATCGGCTTT CATGTTCCCT TGCCCGATTT TGTAAATTGG CAAATGTGGA CCTGCCCTAC 
CCGGCGTCCT CCCGCCTGCA GGAGCTGCTG GCTGTGCTGC TGCGGATGGC TGAGCAGCTG 
GCCTGGTTAC GAGTTCTGAG ACTTGACAAA CGGTCTGTGG TGAAGCACAT CGGTGACCTT 
CTCCAGCACC GCCAGTCACT GGTCCGCTCT GCCTTTCGGG ATGGGACAGC AGAAGTGGAG 
ACCCGAGAGA AGGAGCCACC GGGGTGGGGA CAGGGGCAAG GAGAAGGGGA GGTGGGAAAT 
AATTCCTTAG GTTTACCCCA GGGGAAGCGG CCGGCCAGTC CTGCCCTTCT CTTGCCACCC 
TGCATGTTGA AGTCCCCGAA GCGGATCTGC CCTGTACCCC CTGTCTCCAC TGTCACTGGA 
GATGAGAACA TTTCTGATAG TGAAATAGAA CAGTATTTGC GTACCCCTCA GGAAGTTAGG 
GACTTTCAGA GAGCCCAGGC TGCTAGACAG GCTGCCACGA GTGTCCCTAA CCCTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060780.2
CDS	79..1338
Translation	MPGRGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTMQLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLANVDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQSLVRSAFRDGTAEVETREKEPPGWGQGQGEGEVGNNSLGLPQGKRPASPALLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTPQEVRDFQRAQAARQAATSVPNPP

Target ORF information:

RefSeq Version	NM_018310.4
Organism	Homo sapiens(human)
Definition	Homo sapiens BRF2 RNA polymerase III transcription initiation factor subunit (BRF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018310.4

ORF Insert Sequence:

ATGCCAGGCA GAGGCCGCTG CCCGGACTGC GGCTCCACGG AGCTGGTGGA AGACTCGCAC 
TATTCGCAGA GCCAGCTGGT GTGCTCCGAC TGCGGCTGCG TGGTCACCGA GGGGGTCCTT 
ACCACTACCT TCAGCGACGA GGGCAATCTC CGAGAGGTAA CATATTCCCG AAGCACAGGG 
GAAAACGAAC AAGTTAGTCG CAGCCAGCAA CGAGGTCTCC GGCGAGTGAG AGACCTTTGT 
CGAGTTCTGC AGTTGCCACC AACATTTGAG GATACCGCGG TTGCCTACTA CCAACAGGCA 
TATCGGCACT CTGGCATCCG AGCGGCCAGG CTGCAAAAGA AGGAGGTGTT GGTTGGGTGC 
TGCGTCTTAA TCACCTGCCG ACAGCATAAC TGGCCCCTAA CAATGGGGGC CATCTGCACG 
CTGTTGTATG CAGATTTGGA TGTGTTTTCT AGCACTTACA TGCAGATAGT GAAGCTCCTG 
GGACTGGATG TGCCATCTCT GTGCTTGGCA GAACTGGTGA AGACCTATTG CAGCAGCTTC 
AAACTGTTCC AAGCTTCACC TTCTGTGCCA GCCAAATACG TGGAAGACAA AGAGAAGATG 
CTGTCTCGAA CAATGCAGTT GGTGGAGCTG GCAAATGAGA CGTGGCTGGT GACCGGGAGG 
CATCCCTTGC CCGTCATCAC TGCTGCGACT TTCCTGGCTT GGCAGTCGCT GCAGCCTGCA 
GATCGGCTTT CATGTTCCCT TGCCCGATTT TGTAAATTGG CAAATGTGGA CCTGCCCTAC 
CCGGCGTCCT CCCGCCTGCA GGAGCTGCTG GCTGTGCTGC TGCGGATGGC TGAGCAGCTG 
GCCTGGTTAC GAGTTCTGAG ACTTGACAAA CGGTCTGTGG TGAAGCACAT CGGTGACCTT 
CTCCAGCACC GCCAGTCACT GGTCCGCTCT GCCTTTCGGG ATGGGACAGC AGAAGTGGAG 
ACCCGAGAGA AGGAGCCACC GGGGTGGGGA CAGGGGCAAG GAGAAGGGGA GGTGGGAAAT 
AATTCCTTAG GTTTACCCCA GGGGAAGCGG CCGGCCAGTC CTGCCCTTCT CTTGCCACCC 
TGCATGTTGA AGTCCCCGAA GCGGATCTGC CCTGTACCCC CTGTCTCCAC TGTCACTGGA 
GATGAGAACA TTTCTGATAG TGAAATAGAA CAGTATTTGC GTACCCCTCA GGAAGTTAGG 
GACTTTCAGA GAGCCCAGGC TGCTAGACAG GCTGCCACGA GTGTCCCTAA CCCTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
Transcription9(1)61-66(2018)
Gouge J,Vannini A

MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line.
Cancer research and treatment : official journal of Korean Cancer Association(2017 Oct)
Wang L,Qu J,Zhou L,Liao F,Wang J

Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Nature communications8(1)130(2017 07)
Gouge J,Guthertz N,Kramm K,Dergai O,Abascal-Palacios G,Satia K,Cousin P,Hernandez N,Grohmann D,Vannini A

Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.
Cell163(6)1375-87(2015 Dec)
Gouge J,Satia K,Guthertz N,Widya M,Thompson AJ,Cousin P,Dergai O,Hernandez N,Vannini A

hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
PloS one9(6)e100992(2014)
Reznik B,Clement SL,Lykke-Andersen J

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BRF2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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