UGT1A8 cDNA ORF clone, Homo sapiens(human)

Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study.
Falkowski S, Woillard JB, Postil D, Tubiana-Mathieu N, Terrebonne E, Pariente A, Smith D, Guimbaud R, Thalamas C, Rouguieg-Malki K, Marquet P, Picard N
BMC cancer17(1)901(2017 12)

In Vitro Study on Influences of UGT1A8 Gene Polymorphisms on Mycophenolate Mofetil Metabolism.
Zhou Z, Lu Y, Song G, Wang Y, Chen J, Xiao C, Zhong L, Sun X, Peng Z, Wang X
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation(2017 Oct)

Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.
Kishi N, Takasuka A, Kokawa Y, Isobe T, Taguchi M, Shigeyama M, Murata M, Suno M, Hanioka N
Xenobiotica; the fate of foreign compounds in biological systems46(4)289-95(2016)

Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes.
Dai P, Luo F, Wang Y, Jiang H, Wang L, Zhang G, Zhu L, Hu M, Wang X, Lu L, Liu Z
Biopharmaceutics & drug disposition36(9)622-35(2015 Dec)

the in vitro glucuronidation of raloxifene in humans and monkeys was examined using liver and intestinal microsomes and recombinant UGT enzymes (UGT1A1, UGT1A8 and UGT1A9).
Title: Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.

Data suggest UGT1A8 is involved in differential metabolism of dietary flavonoids (glucosides and aglycones); glucuronidation of flavonoid glucosides is considerably slower than glucuronidation of flavonoid aglycones in microsomes of intestine/liver.
Title: Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes.

Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1alpha and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.
Title: Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1? and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.

UGT1A8 Polymorphism is associated with response to raloxifene in breast cancer.
Title: Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo.

A much higher frequency of UGT1A8*2 variant allele was found in Chinese than in Caucasians and Africans
Title: Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.