UGT1A10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UGT1A10
Entrez Gene ID	54575
Full Name	UDP glucuronosyltransferase family 1 member A10
Synonyms	UDPGT,UGT-1J,UGT1-10,UGT1.10,UGT1J
General protein information	Preferred Names UDP glucuronosyltransferase family 1 member A10 Names UDP-glucuronosyltransferase 1-10 UDP glucuronosyltransferase 1 family, polypeptide A10 UDP glycosyltransferase 1 family, polypeptide A10 UDP-glucuronosyltransferase 1-J UDP-glucuronosyltransferase 1A10 UDPGT 1-10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Summary	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008].
Disorder MIM:	606435

mRNA and Protein(s)

mRNA	Protein	Name
NM_019075.2	NP_061948.1	UDP-glucuronosyltransferase 1-10 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ugt1a10	NP_964003.2
Homo sapiens (human)	UGT1A10	NP_061948.1
Homo sapiens (human)	UGT1A8	NP_061949.3
Homo sapiens (human)	UGT1A9	NP_066307.1
Mus musculus (house mouse)	Ugt1a9	NP_964006.2
Homo sapiens (human)	UGT1A7	NP_061950.2
Rattus norvegicus (Norway rat)	Ugt1a8	NP_787040.2

Gene Ontology
Bibliography

Related articles in PubMed

Glucuronidation of estrone and 16?-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.
Kallionp?? RA, J?rvinen E, Finel M
The Journal of steroid biochemistry and molecular biology154104-11(2015 Nov)

Genome-wide analysis of hepatic lipid content in extreme obesity.
DiStefano JK, Kingsley C, Craig Wood G, Chu X, Argyropoulos G, Still CD, Don? SC, Legendre C, Tembe W, Gerhard GS
Acta diabetologica52(2)373-82(2015 Apr)

Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.
Gramec Skledar D, Troberg J, Lavdas J, Peterlin Ma?i? L, Finel M
Xenobiotica; the fate of foreign compounds in biological systems45(6)511-9(2015)

Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.
Lu J, Zhang Y, Li H, Yu J, Liu S
Chemical communications (Cambridge, England)50(90)13896-9(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In further studies with UGT1A10, mutant F93G exhibited increased glucuronidation rates of 16alpha-hydroxyestrone, but not estrone
Title: Glucuronidation of estrone and 16?-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.

UGT1A10 exhibited somewhat higher BPA glucuronidation activity than UGT1A9, but it was lower than UGT2A1 and UGT2B15. 4.
Title: Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.

A graphene nanocage with regulatable space for the assembly of a CYP1A2-UGT1A10 bienzyme complex has been constructed via a click reaction, and used to study drug sequential metabolism using an electrochemically-driven method.
Title: Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.

DNA hypermethylation results in defective expression of UGT1A10 in the liver.
Title: Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.

Suggest that extrahepatic UGT1A10 plays an important role in the metabolism and the bioactivation of the antitumor agent C-1305.
Title: Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.

The following UGT1A10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UGT1A10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25033	NM_019075.2 Latest version!	Homo sapiens UDP glucuronosyltransferase family 1 member A10 (UGT1A10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UGT1A10 ( NM_019075.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_061948.1 Homo sapiens UDP glucuronosyltransferase family 1 member A10 (UGT1A10), mRNA.

Price & Availability↑

CloneID	OHu25033
Clone ID Related Accession (Same CDS sequence)	NM_019075.2
Accession Version	NM_019075.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	UDP-glucuronosyltransferase 1-10 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020971.1 and AY435137.1. This sequence is a reference standard in the RefSeqGene project. On Mar 30, 2004 this sequence version replaced NM_019075.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020971.1, BC069210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCGCG CAGGGTGGAC CAGCCCCGTT CCTTTATGTG TGTGTCTACT GCTGACCTGT 
GGCTTTGCCG AGGCAGGGAA GCTGCTGGTA GTGCCCATGG ATGGGAGTCA CTGGTTCACC 
ATGCAGTCGG TGGTGGAGAA ACTTATCCTC AGGGGGCATG AGGTGGTTGT AGTCATGCCA 
GAGGTGAGTT GGCAACTGGA AAGATCACTG AATTGCACAG TGAAGACTTA CTCAACCTCG 
TACACTCTGG AAGATCAGAA CCGGGAATTC ATGGTTTTCG CCCATGCTCA ATGGAAAGCA 
CAGGCACAAA GTATATTTTC TCTATTAATG AGTTCATCCA GTGGTTTTCT TGACTTATTT 
TTTTCGCATT GCAGGAGTTT GTTTAATGAC CGAAAATTAG TAGAATACTT AAAGGAGAGT 
TCTTTTGATG CAGTGTTTCT GGATCCTTTT GATACCTGTG GCTTAATTGT TGCTAAATAT 
TTCTCCCTCC CCTCTGTGGT CTTCACCAGG GGAATATTTT GCCACCATCT TGAAGAAGGT 
GCACAGTGCC CTGCTCCTCT TTCCTATGTC CCCAATGATC TCTTAGGGTT CTCAGATGCC 
ATGACTTTCA AGGAGAGAGT ATGGAACCAC ATCGTGCACT TGGAGGACCA TTTATTTTGC 
CAGTATCTTT TTAGAAATGC CCTAGAAATA GCCTCTGAAA TTCTCCAAAC CCCTGTCACG 
GCATATGATC TCTACAGTCA CACATCAATT TGGTTGTTGC GAACGGACTT TGTTTTGGAC 
TATCCCAAAC CCGTGATGCC CAACATGATC TTCATTGGTG GTATCAACTG TCATCAGGGA 
AAGCCATTGC CTATGGAATT TGAAGCCTAC ATTAATGCTT CTGGAGAACA TGGAATTGTG 
GTTTTCTCTT TGGGATCAAT GGTCTCAGAA ATTCCAGAGA AGAAAGCTAT GGCAATTGCT 
GATGCTTTGG GCAAAATCCC TCAGACAGTC CTGTGGCGGT ACACTGGAAC CCGACCATCG 
AATCTTGCGA ACAACACGAT ACTTGTTAAG TGGCTACCCC AAAACGATCT GCTTGGTCAC 
CCGATGACCC GTGCCTTTAT CACCCATGCT GGTTCCCATG GTGTTTATGA AAGCATATGC 
AATGGCGTTC CCATGGTGAT GATGCCCTTG TTTGGTGATC AGATGGACAA TGCAAAGCGC 
ATGGAGACTA AGGGAGCTGG AGTGACCCTG AATGTTCTGG AAATGACTTC TGAAGATTTA 
GAAAATGCTC TAAAAGCAGT CATCAATGAC AAAAGTTACA AGGAGAACAT CATGCGCCTC 
TCCAGCCTTC ACAAGGACCG CCCGGTGGAG CCGCTGGACC TGGCCGTGTT CTGGGTGGAG 
TTTGTGATGA GGCACAAGGG CGCGCCACAC CTGCGCCCCG CAGCCCACGA CCTCACCTGG 
TACCAGTACC ATTCCTTGGA CGTGATTGGT TTCCTCTTGG CCGTCGTGCT GACAGTGGCC 
TTCATCACCT TTAAATGTTG TGCTTATGGC TACCGGAAAT GCTTGGGGAA AAAAGGGCGA 
GTTAAGAAAG CCCACAAATC CAAGACCCAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061948.1
CDS	47..1639
Translation	MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Target ORF information:

RefSeq Version	NM_019075.2
Organism	Homo sapiens(human)
Definition	Homo sapiens UDP glucuronosyltransferase family 1 member A10 (UGT1A10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019075.2

ORF Insert Sequence:

ATGGCTCGCG CAGGGTGGAC CAGCCCCGTT CCTTTATGTG TGTGTCTACT GCTGACCTGT 
GGCTTTGCCG AGGCAGGGAA GCTGCTGGTA GTGCCCATGG ATGGGAGTCA CTGGTTCACC 
ATGCAGTCGG TGGTGGAGAA ACTTATCCTC AGGGGGCATG AGGTGGTTGT AGTCATGCCA 
GAGGTGAGTT GGCAACTGGA AAGATCACTG AATTGCACAG TGAAGACTTA CTCAACCTCG 
TACACTCTGG AAGATCAGAA CCGGGAATTC ATGGTTTTCG CCCATGCTCA ATGGAAAGCA 
CAGGCACAAA GTATATTTTC TCTATTAATG AGTTCATCCA GTGGTTTTCT TGACTTATTT 
TTTTCGCATT GCAGGAGTTT GTTTAATGAC CGAAAATTAG TAGAATACTT AAAGGAGAGT 
TCTTTTGATG CAGTGTTTCT GGATCCTTTT GATACCTGTG GCTTAATTGT TGCTAAATAT 
TTCTCCCTCC CCTCTGTGGT CTTCACCAGG GGAATATTTT GCCACCATCT TGAAGAAGGT 
GCACAGTGCC CTGCTCCTCT TTCCTATGTC CCCAATGATC TCTTAGGGTT CTCAGATGCC 
ATGACTTTCA AGGAGAGAGT ATGGAACCAC ATCGTGCACT TGGAGGACCA TTTATTTTGC 
CAGTATCTTT TTAGAAATGC CCTAGAAATA GCCTCTGAAA TTCTCCAAAC CCCTGTCACG 
GCATATGATC TCTACAGTCA CACATCAATT TGGTTGTTGC GAACGGACTT TGTTTTGGAC 
TATCCCAAAC CCGTGATGCC CAACATGATC TTCATTGGTG GTATCAACTG TCATCAGGGA 
AAGCCATTGC CTATGGAATT TGAAGCCTAC ATTAATGCTT CTGGAGAACA TGGAATTGTG 
GTTTTCTCTT TGGGATCAAT GGTCTCAGAA ATTCCAGAGA AGAAAGCTAT GGCAATTGCT 
GATGCTTTGG GCAAAATCCC TCAGACAGTC CTGTGGCGGT ACACTGGAAC CCGACCATCG 
AATCTTGCGA ACAACACGAT ACTTGTTAAG TGGCTACCCC AAAACGATCT GCTTGGTCAC 
CCGATGACCC GTGCCTTTAT CACCCATGCT GGTTCCCATG GTGTTTATGA AAGCATATGC 
AATGGCGTTC CCATGGTGAT GATGCCCTTG TTTGGTGATC AGATGGACAA TGCAAAGCGC 
ATGGAGACTA AGGGAGCTGG AGTGACCCTG AATGTTCTGG AAATGACTTC TGAAGATTTA 
GAAAATGCTC TAAAAGCAGT CATCAATGAC AAAAGTTACA AGGAGAACAT CATGCGCCTC 
TCCAGCCTTC ACAAGGACCG CCCGGTGGAG CCGCTGGACC TGGCCGTGTT CTGGGTGGAG 
TTTGTGATGA GGCACAAGGG CGCGCCACAC CTGCGCCCCG CAGCCCACGA CCTCACCTGG 
TACCAGTACC ATTCCTTGGA CGTGATTGGT TTCCTCTTGG CCGTCGTGCT GACAGTGGCC 
TTCATCACCT TTAAATGTTG TGCTTATGGC TACCGGAAAT GCTTGGGGAA AAAAGGGCGA 
GTTAAGAAAG CCCACAAATC CAAGACCCAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glucuronidation of estrone and 16?-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.
The Journal of steroid biochemistry and molecular biology154104-11(2015 Nov)
Kallionp?? RA,J?rvinen E,Finel M

Genome-wide analysis of hepatic lipid content in extreme obesity.
Acta diabetologica52(2)373-82(2015 Apr)
DiStefano JK,Kingsley C,Craig Wood G,Chu X,Argyropoulos G,Still CD,Don? SC,Legendre C,Tembe W,Gerhard GS

Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.
Xenobiotica; the fate of foreign compounds in biological systems45(6)511-9(2015)
Gramec Skledar D,Troberg J,Lavdas J,Peterlin Ma?i? L,Finel M

Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.
Chemical communications (Cambridge, England)50(90)13896-9(2014 Nov)
Lu J,Zhang Y,Li H,Yu J,Liu S

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

UGT1A10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報