P2RY4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	P2RY4
Entrez Gene ID	5030
Full Name	pyrimidinergic receptor P2Y4
Synonyms	NRU,P2P,P2Y4,UNR
General protein information	Preferred Names pyrimidinergic receptor P2Y4 Names P2Y purinoceptor 4 pyrimidinergic receptor P2Y, G-protein coupled, 4 uridine nucleotide receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq13.1
Summary	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008].
Disorder MIM:	300038

mRNA and Protein(s)

mRNA	Protein	Name
NM_002565.3	NP_002556.1	P2Y purinoceptor 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	P2RY4	NP_001243486.1
Mus musculus (house mouse)	P2ry4	NP_065646.1
Pan troglodytes (chimpanzee)	P2RY4	XP_003317560.1
	P2RY4	XP_001083871.1
Canis lupus familiaris (dog)	P2RY4	XP_003640305.1
Xenopus tropicalis (tropical clawed frog)	p2ry4	NP_001025633.1
Homo sapiens (human)	P2RY4	NP_002556.1
Rattus norvegicus (Norway rat)	P2ry4	NP_113868.1
Gallus gallus (chicken)	LOC100857687	XP_004940598.1
Danio rerio (zebrafish)	pr2y4l	XP_005173325.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.
Sukigara S, Dai H, Nabatame S, Otsuki T, Hanai S, Honda R, Saito T, Nakagawa E, Kaido T, Sato N, Kaneko Y, Takahashi A, Sugai K, Saito Y, Sasaki M, Goto Y, Koizumi S, Itoh M
Journal of neuropathology and experimental neurology73(8)798-806(2014 Aug)

Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Tran MD, Furones-Alonso O, Sanchez-Molano J, Bramlett HM
Neuroreport23(12)721-6(2012 Aug)

Purinergic receptors expressed in human skeletal muscle fibres.
Born? A, Ploug T, Bune LT, Rosenmeier JB, Thaning P
Purinergic signalling8(2)255-64(2012 Jun)

Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
Luo W, Wang Y, Reiser G
Journal of neurochemistry117(1)71-81(2011 Apr)

ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells.
Scodelaro Bilbao P, Boland R, Santill?n G
Archives of biochemistry and biophysics494(1)7-14(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

reflected in the immunoblotting data P2RY4 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.
Title: Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.

show that P2 receptors and protein kinases are also involved in regulating injury-induced expression and the release of TSP-1 in injured astrocytes
Title: Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.

P2Y4 receptors are expressed in intracellular vesicles and sarcolemma of skeletal muscle fibers.
Title: Purinergic receptors expressed in human skeletal muscle fibres.

Nucleotide P2Y4 receptor binding is arrested in post-Golgi trafficking by type I transmembrane proteins p23 and p24A.
Title: Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.

Taken together, our data indicate that the high expression and activation of the P2Y4 receptor participates in the neuronal differentiation and commitment to death of SH-SY5Y cells.
Title: The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.

The following P2RY4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P2RY4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18494	NM_002565.3 Latest version!	Homo sapiens pyrimidinergic receptor P2Y4 (P2RY4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P2RY4 ( NM_002565.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002556.1 Homo sapiens pyrimidinergic receptor P2Y4 (P2RY4), mRNA.

Price & Availability↑

CloneID	OHu18494
Clone ID Related Accession (Same CDS sequence)	NM_002565.3
Accession Version	NM_002565.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	P2Y purinoceptor 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X91852.1 and BC095503.1. This sequence is a reference standard in the RefSeqGene project. On Jun 3, 2005 this sequence version replaced NM_002565.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCAGTA CAGAGTCCTC CCTGTTGAGA TCCCTAGGCC TCAGCCCAGG TCCTGGCAGC 
AGTGAGGTGG AGCTGGACTG TTGGTTTGAT GAGGATTTCA AGTTCATCCT GCTGCCTGTG 
AGCTATGCAG TTGTCTTTGT GCTGGGCTTG GGCCTTAACG CCCCAACCCT ATGGCTCTTC 
ATCTTCCGCC TCCGACCCTG GGATGCAACG GCCACCTACA TGTTCCACCT GGCATTGTCA 
GACACCTTGT ATGTGCTGTC GCTGCCCACC CTCATCTACT ATTATGCAGC CCACAACCAC 
TGGCCCTTTG GCACTGAGAT CTGCAAGTTC GTCCGCTTTC TTTTCTATTG GAACCTCTAC 
TGCAGTGTCC TTTTCCTCAC CTGCATCAGC GTGCACCGCT ACCTGGGCAT CTGCCACCCA 
CTTCGGGCAC TACGCTGGGG CCGCCCTCGC CTCGCAGGCC TTCTCTGCCT GGCAGTTTGG 
TTGGTCGTAG CCGGCTGCCT CGTGCCCAAC CTGTTCTTTG TCACAACCAG CAACAAAGGG 
ACCACCGTCC TGTGCCATGA CACCACTCGG CCTGAAGAGT TTGACCACTA TGTGCACTTC 
AGCTCGGCGG TCATGGGGCT GCTCTTTGGC GTGCCCTGCC TGGTCACTCT TGTTTGCTAT 
GGACTCATGG CTCGTCGCCT GTATCAGCCC TTGCCAGGCT CTGCACAGTC GTCTTCTCGC 
CTCCGCTCTC TCCGCACCAT AGCTGTGGTG CTGACTGTCT TTGCTGTCTG CTTCGTGCCT 
TTCCACATCA CCCGCACCAT TTACTACCTG GCCAGGCTGT TGGAAGCTGA CTGCCGAGTA 
CTGAACATTG TCAACGTGGT CTATAAAGTG ACTCGGCCCC TGGCCAGTGC CAACAGCTGC 
CTGGATCCTG TGCTCTACTT GCTCACTGGG GACAAATATC GACGTCAGCT CCGTCAGCTC 
TGTGGTGGTG GCAAGCCCCA GCCCCGCACG GCTGCCTCTT CCCTGGCACT AGTGTCCCTG 
CCTGAGGATA GCAGCTGCAG GTGGGCGGCC ACCCCCCAGG ACAGTAGCTG CTCTACTCCT 
AGGGCAGATA GATTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002556.1
CDS	181..1278
Translation	MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL

Target ORF information:

RefSeq Version	NM_002565.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pyrimidinergic receptor P2Y4 (P2RY4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002565.3

ORF Insert Sequence:

ATGGCCAGTA CAGAGTCCTC CCTGTTGAGA TCCCTAGGCC TCAGCCCAGG TCCTGGCAGC 
AGTGAGGTGG AGCTGGACTG TTGGTTTGAT GAGGATTTCA AGTTCATCCT GCTGCCTGTG 
AGCTATGCAG TTGTCTTTGT GCTGGGCTTG GGCCTTAACG CCCCAACCCT ATGGCTCTTC 
ATCTTCCGCC TCCGACCCTG GGATGCAACG GCCACCTACA TGTTCCACCT GGCATTGTCA 
GACACCTTGT ATGTGCTGTC GCTGCCCACC CTCATCTACT ATTATGCAGC CCACAACCAC 
TGGCCCTTTG GCACTGAGAT CTGCAAGTTC GTCCGCTTTC TTTTCTATTG GAACCTCTAC 
TGCAGTGTCC TTTTCCTCAC CTGCATCAGC GTGCACCGCT ACCTGGGCAT CTGCCACCCA 
CTTCGGGCAC TACGCTGGGG CCGCCCTCGC CTCGCAGGCC TTCTCTGCCT GGCAGTTTGG 
TTGGTCGTAG CCGGCTGCCT CGTGCCCAAC CTGTTCTTTG TCACAACCAG CAACAAAGGG 
ACCACCGTCC TGTGCCATGA CACCACTCGG CCTGAAGAGT TTGACCACTA TGTGCACTTC 
AGCTCGGCGG TCATGGGGCT GCTCTTTGGC GTGCCCTGCC TGGTCACTCT TGTTTGCTAT 
GGACTCATGG CTCGTCGCCT GTATCAGCCC TTGCCAGGCT CTGCACAGTC GTCTTCTCGC 
CTCCGCTCTC TCCGCACCAT AGCTGTGGTG CTGACTGTCT TTGCTGTCTG CTTCGTGCCT 
TTCCACATCA CCCGCACCAT TTACTACCTG GCCAGGCTGT TGGAAGCTGA CTGCCGAGTA 
CTGAACATTG TCAACGTGGT CTATAAAGTG ACTCGGCCCC TGGCCAGTGC CAACAGCTGC 
CTGGATCCTG TGCTCTACTT GCTCACTGGG GACAAATATC GACGTCAGCT CCGTCAGCTC 
TGTGGTGGTG GCAAGCCCCA GCCCCGCACG GCTGCCTCTT CCCTGGCACT AGTGTCCCTG 
CCTGAGGATA GCAGCTGCAG GTGGGCGGCC ACCCCCCAGG ACAGTAGCTG CTCTACTCCT 
AGGGCAGATA GATTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.
Journal of neuropathology and experimental neurology73(8)798-806(2014 Aug)
Sukigara S,Dai H,Nabatame S,Otsuki T,Hanai S,Honda R,Saito T,Nakagawa E,Kaido T,Sato N,Kaneko Y,Takahashi A,Sugai K,Saito Y,Sasaki M,Goto Y,Koizumi S,Itoh M

Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Neuroreport23(12)721-6(2012 Aug)
Tran MD,Furones-Alonso O,Sanchez-Molano J,Bramlett HM

Purinergic receptors expressed in human skeletal muscle fibres.
Purinergic signalling8(2)255-64(2012 Jun)
Born? A,Ploug T,Bune LT,Rosenmeier JB,Thaning P

Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
Journal of neurochemistry117(1)71-81(2011 Apr)
Luo W,Wang Y,Reiser G

ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells.
Archives of biochemistry and biophysics494(1)7-14(2010 Feb)
Scodelaro Bilbao P,Boland R,Santill?n G

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P2RY4 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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