NPPB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NPPB
Entrez Gene ID	4879
Full Name	natriuretic peptide B
Synonyms	BNP
General protein information	Preferred Names natriuretic peptide B Names natriuretic peptides B brain type natriuretic peptide gamma-brain natriuretic peptide natriuretic peptide precursor B natriuretic protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.22
Summary	This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014].
Disorder MIM:	600295

mRNA and Protein(s)

mRNA	Protein	Name
NM_002521.2	NP_002512.1	natriuretic peptides B preproprotein
NM_002521.3	NP_002512.1	natriuretic peptides B preproprotein

Pathways from BioSystems

Homologies

	NPPB	XP_001115574.2
Pan troglodytes (chimpanzee)	NPPB	XP_525186.2
Homo sapiens (human)	NPPB	NP_002512.1
Bos taurus (cattle)	NPPB	NP_001160042.1
Canis lupus familiaris (dog)	NPPB	XP_005618075.1

Gene Ontology
Bibliography

Related articles in PubMed

Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents.
Legaz-Arrese A, Carranza-Garc?a LE, Navarro-Orocio R, Valadez-Lira A, Mayolas-Pi C, Mungu?a-Izquierdo D, Reverter-Mas?a J, George K
The Journal of pediatrics19196-102(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NT-proBNP showed an incremental prognostic value for prediction of adverse outcomes when added to the clinical and echocardiographic parameters in patients with left ventricular dysfunction.
Title: Long-term outcome of patients with triphasic mitral flow with a mid-diastolic L wave: prognostic role of left atrial volume and N-terminal pro-brain natriuretic peptide.

NT-proBNP is increased in differentiated thyroid carcinoma patients and may predict cardiovascular risk.
Title: NT-proBNP is increased in differentiated thyroid carcinoma patients and may predict cardiovascular risk.

Plasma BNP levels were independently associated with functional outcomes 3 months after stroke onset in atrial fibrillation patients.
Title: Brain Natriuretic Peptide Is a Powerful Predictor of Outcome in Stroke Patients with Atrial Fibrillation .

Blood BNP is a significant independent predictor of 6-month left ventricle remodeling in myocardial infarction patients.
Title: Predictors of Left Ventricle Remodeling: Combined Plasma B-type Natriuretic Peptide Decreasing Ratio and Peak Creatine Kinase-MB.

It has been shown that NT-proBNP level may be not only a marker of severity of condition and poor outcome in patients with severe TRAUMATIC BRAIN INJURY, but also can be used as a good predictor of exhaustion of compensatory myocardial capacity in these patients.
Title: [BRAIN NATRIURETIC PEPTIDE AS A MARKER OF SEVERITY OF PATIENT'S CONDITION AFTER SEVERE TRAUMATIC BRAIN INJURY].

The following NPPB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPPB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27344	NM_002521.3 Latest version!	Homo sapiens natriuretic peptide B (NPPB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27344	NM_002521.2	Homo sapiens natriuretic peptide B (NPPB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NPPB ( NM_002521.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002512.1 Homo sapiens natriuretic peptide B (NPPB), mRNA.

Price & Availability↑

CloneID	OHu27344
Clone ID Related Accession (Same CDS sequence)	NM_002521.2 , NM_002521.3
Accession Version	NM_002521.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	natriuretic peptides B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ708502.1, M25296.1 and BC025785.1. On Dec 16, 2005 this sequence version replaced NM_002521.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025785.1, ERR279856.3578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 11410403 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCCCC AGACAGCACC TTCCCGGGCG CTCCTGCTCC TGCTCTTCTT GCATCTGGCT 
TTCCTGGGAG GTCGTTCCCA CCCGCTGGGC AGCCCCGGTT CAGCCTCGGA CTTGGAAACG 
TCCGGGTTAC AGGAGCAGCG CAACCATTTG CAGGGCAAAC TGTCGGAGCT GCAGGTGGAG 
CAGACATCCC TGGAGCCCCT CCAGGAGAGC CCCCGTCCCA CAGGTGTCTG GAAGTCCCGG 
GAGGTAGCCA CCGAGGGCAT CCGTGGGCAC CGCAAAATGG TCCTCTACAC CCTGCGGGCA 
CCACGAAGCC CCAAGATGGT GCAAGGGTCT GGCTGCTTTG GGAGGAAGAT GGACCGGATC 
AGCTCCTCCA GTGGCCTGGG CTGCAAAGTG CTGAGGCGGC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002512.1
CDS	103..507
Translation	MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Target ORF information:

RefSeq Version	NM_002521.2
Organism	Homo sapiens(human)
Definition	Homo sapiens natriuretic peptide B (NPPB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002521.2

ORF Insert Sequence:

ATGGATCCCC AGACAGCACC TTCCCGGGCG CTCCTGCTCC TGCTCTTCTT GCATCTGGCT 
TTCCTGGGAG GTCGTTCCCA CCCGCTGGGC AGCCCCGGTT CAGCCTCGGA CTTGGAAACG 
TCCGGGTTAC AGGAGCAGCG CAACCATTTG CAGGGCAAAC TGTCGGAGCT GCAGGTGGAG 
CAGACATCCC TGGAGCCCCT CCAGGAGAGC CCCCGTCCCA CAGGTGTCTG GAAGTCCCGG 
GAGGTAGCCA CCGAGGGCAT CCGTGGGCAC CGCAAAATGG TCCTCTACAC CCTGCGGGCA 
CCACGAAGCC CCAAGATGGT GCAAGGGTCT GGCTGCTTTG GGAGGAAGAT GGACCGGATC 
AGCTCCTCCA GTGGCCTGGG CTGCAAAGTG CTGAGGCGGC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NPPB ( NM_002521.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002512.1 Homo sapiens natriuretic peptide B (NPPB), mRNA.

Price & Availability↑

CloneID	OHu27344
Clone ID Related Accession (Same CDS sequence)	NM_002521.2 , NM_002521.3
Accession Version	NM_002521.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	natriuretic peptides B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL021155.1, AJ708502.1, M25296.1 and BC025785.1. On Nov 22, 2018 this sequence version replaced NM_002521.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025785.1, SRR5189655.214911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376468.4/ ENSP00000365651.3 Protein has antimicrobial activity :: PMID: 11410403 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCCCC AGACAGCACC TTCCCGGGCG CTCCTGCTCC TGCTCTTCTT GCATCTGGCT 
TTCCTGGGAG GTCGTTCCCA CCCGCTGGGC AGCCCCGGTT CAGCCTCGGA CTTGGAAACG 
TCCGGGTTAC AGGAGCAGCG CAACCATTTG CAGGGCAAAC TGTCGGAGCT GCAGGTGGAG 
CAGACATCCC TGGAGCCCCT CCAGGAGAGC CCCCGTCCCA CAGGTGTCTG GAAGTCCCGG 
GAGGTAGCCA CCGAGGGCAT CCGTGGGCAC CGCAAAATGG TCCTCTACAC CCTGCGGGCA 
CCACGAAGCC CCAAGATGGT GCAAGGGTCT GGCTGCTTTG GGAGGAAGAT GGACCGGATC 
AGCTCCTCCA GTGGCCTGGG CTGCAAAGTG CTGAGGCGGC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002512.1
CDS	113..517
Translation	MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Target ORF information:

RefSeq Version	NM_002521.3
Organism	Homo sapiens(human)
Definition	Homo sapiens natriuretic peptide B (NPPB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002521.3

ORF Insert Sequence:

ATGGATCCCC AGACAGCACC TTCCCGGGCG CTCCTGCTCC TGCTCTTCTT GCATCTGGCT 
TTCCTGGGAG GTCGTTCCCA CCCGCTGGGC AGCCCCGGTT CAGCCTCGGA CTTGGAAACG 
TCCGGGTTAC AGGAGCAGCG CAACCATTTG CAGGGCAAAC TGTCGGAGCT GCAGGTGGAG 
CAGACATCCC TGGAGCCCCT CCAGGAGAGC CCCCGTCCCA CAGGTGTCTG GAAGTCCCGG 
GAGGTAGCCA CCGAGGGCAT CCGTGGGCAC CGCAAAATGG TCCTCTACAC CCTGCGGGCA 
CCACGAAGCC CCAAGATGGT GCAAGGGTCT GGCTGCTTTG GGAGGAAGAT GGACCGGATC 
AGCTCCTCCA GTGGCCTGGG CTGCAAAGTG CTGAGGCGGC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents.
The Journal of pediatrics19196-102(2017 Dec)
Legaz-Arrese A,Carranza-Garc?a LE,Navarro-Orocio R,Valadez-Lira A,Mayolas-Pi C,Mungu?a-Izquierdo D,Reverter-Mas?a J,George K

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NPPB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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