NEUROD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEUROD2
Entrez Gene ID	4761
Full Name	neuronal differentiation 2
Synonyms	NDRF,bHLHa1
General protein information	Preferred Names neuronal differentiation 2 Names neurogenic differentiation factor 2 class A basic helix-loop-helix protein 1 neuroD-related factor neurogenic basic-helix-loop-helix protein neurogenic differentiation 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008].
Disorder MIM:	601725

mRNA and Protein(s)

mRNA	Protein	Name
XM_011524851.1	XP_011523153.1	neurogenic differentiation factor 2 isoform X1
NM_006160.4	NP_006151.3	neurogenic differentiation factor 2
NM_006160.3	NP_006151.3	neurogenic differentiation factor 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NEUROD2	XP_005624617.1
Gallus gallus (chicken)	LOC100859203	XP_003643468.1
Danio rerio (zebrafish)	neurod2	NP_571157.1
Homo sapiens (human)	NEUROD2	NP_006151.3
Bos taurus (cattle)	NEUROD2	NP_001192887.1
Mus musculus (house mouse)	Neurod2	NP_035025.3
Pan troglodytes (chimpanzee)	NEUROD2	XP_511456.2
	NEUROD2	XP_001088823.1
Xenopus tropicalis (tropical clawed frog)	neurod2	NP_001072486.1
Rattus norvegicus (Norway rat)	Neurod2	NP_062199.1

Gene Ontology
Bibliography

Related articles in PubMed

p53 and miR-210 regulated NeuroD2, a neuronal basic helix-loop-helix transcription factor, is downregulated in glioblastoma patients and functions as a tumor suppressor under hypoxic microenvironment.
Agrawal R, Garg A, Benny Malgulwar P, Sharma V, Sarkar C, Kulshreshtha R
International journal of cancer(2017 Dec)

Associations of NEUROD2 polymorphisms and change of cognitive dysfunctions in schizophrenia and schizoaffective disorder after eight weeks of antipsychotic treatment.
Spellmann I, Riedel M, St?dtler J, Zill P, Obermeier M, Cerovecki A, Dehning S, Schennach R, Epple M, Opgen-Rhein M, M?ller N, Bondy B, M?ller HJ, Musil R
Cognitive neuropsychiatry22(4)280-297(2017 Jul)

Novel neurodevelopmental information revealed in amniotic fluid supernatant transcripts from fetuses with trisomies 18 and 21.
Hui L, Slonim DK, Wick HC, Johnson KL, Koide K, Bianchi DW
Human genetics131(11)1751-9(2012 Nov)

Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.
Zill P, Preuss UW, Koller G, Bondy B, Soyka M
Psychiatry research187(1-2)220-3(2011 May)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of NEUROD2 is associated with neurodevelopmental defects in trisomies 18.
Title: Novel neurodevelopmental information revealed in amniotic fluid supernatant transcripts from fetuses with trisomies 18 and 21.

The results of this study did not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence.
Title: Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

Observational study of gene-disease association. (HuGE Navigator)
Title: Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer.

The following NEUROD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEUROD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30371	NM_006160.4 Latest version!	Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30371	XM_011524851.1 Latest version!	Homo sapiens neuronal differentiation 2 (NEUROD2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu30371	NM_006160.3	Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEUROD2 ( NM_006160.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006151.3 Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA.

Price & Availability↑

CloneID	OHu30371
Clone ID Related Accession (Same CDS sequence)	XM_011524851.1 , NM_006160.4 , NM_006160.3
Accession Version	NM_006160.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	neurogenic differentiation factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC022481.1, AC087491.5 and AW134767.1. On Nov 23, 2018 this sequence version replaced NM_006160.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022481.1, SRR3476690.757441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302584.5/ ENSP00000306754.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGACCC GCCTGTTCAG CGAGCCCGGC CTTCTCTCGG ACGTGCCCAA GTTCGCCAGC 
TGGGGCGACG GCGAAGACGA CGAGCCGAGG AGCGACAAGG GCGACGCGCC GCCACCGCCA 
CCGCCTGCGC CCGGGCCAGG GGCTCCGGGG CCAGCCCGGG CGGCCAAGCC AGTCCCTCTC 
CGTGGAGAAG AGGGGACGGA GGCCACGTTG GCCGAGGTCA AGGAGGAAGG CGAGCTGGGG 
GGAGAGGAGG AGGAGGAAGA GGAGGAGGAA GAAGGACTGG ACGAGGCGGA GGGCGAGCGG 
CCCAAGAAGC GCGGGCCCAA GAAGCGCAAG ATGACCAAGG CGCGCTTGGA GCGCTCCAAG 
CTTCGGCGGC AGAAGGCGAA CGCGCGGGAG CGCAACCGCA TGCACGACCT GAACGCAGCC 
CTGGACAACC TGCGCAAGGT GGTGCCCTGC TACTCCAAGA CGCAGAAGCT GTCCAAGATC 
GAGACGCTGC GCCTAGCCAA GAACTATATC TGGGCGCTCT CGGAGATCCT GCGCTCCGGC 
AAGCGGCCAG ACCTAGTGTC CTACGTGCAG ACTCTGTGCA AGGGTCTGTC GCAGCCCACC 
ACCAATCTGG TGGCCGGCTG TCTGCAGCTC AACTCTCGCA ACTTCCTCAC GGAGCAAGGC 
GCCGACGGTG CCGGCCGCTT CCACGGCTCG GGCGGCCCGT TCGCCATGCA CCCCTACCCG 
TACCCGTGCT CGCGCCTGGC GGGCGCACAG TGCCAGGCGG CCGGCGGCCT GGGCGGCGGC 
GCGGCGCACG CCCTGCGGAC CCACGGCTAC TGCGCCGCCT ACGAGACGCT GTATGCGGCG 
GCAGGCGGTG GCGGCGCGAG CCCGGACTAC AACAGCTCCG AGTACGAGGG CCCGCTCAGC 
CCCCCGCTCT GTCTCAATGG CAACTTCTCA CTCAAGCAGG ACTCCTCGCC CGACCACGAG 
AAAAGCTACC ACTACTCTAT GCACTACTCG GCGCTGCCCG GTTCGCGGCC CACGGGCCAC 
GGGCTAGTCT TCGGCTCGTC GGCTGTGCGC GGGGGCGTCC ACTCGGAGAA TCTCTTGTCT 
TACGATATGC ACCTTCACCA CGACCGGGGC CCCATGTACG AGGAGCTCAA TGCGTTTTTT 
CATAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006151.3
CDS	199..1347
Translation	MLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN

Target ORF information:

RefSeq Version	NM_006160.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006160.4

ORF Insert Sequence:

ATGCTGACCC GCCTGTTCAG CGAGCCCGGC CTTCTCTCGG ACGTGCCCAA GTTCGCCAGC 
TGGGGCGACG GCGAAGACGA CGAGCCGAGG AGCGACAAGG GCGACGCGCC GCCACCGCCA 
CCGCCTGCGC CCGGGCCAGG GGCTCCGGGG CCAGCCCGGG CGGCCAAGCC AGTCCCTCTC 
CGTGGAGAAG AGGGGACGGA GGCCACGTTG GCCGAGGTCA AGGAGGAAGG CGAGCTGGGG 
GGAGAGGAGG AGGAGGAAGA GGAGGAGGAA GAAGGACTGG ACGAGGCGGA GGGCGAGCGG 
CCCAAGAAGC GCGGGCCCAA GAAGCGCAAG ATGACCAAGG CGCGCTTGGA GCGCTCCAAG 
CTTCGGCGGC AGAAGGCGAA CGCGCGGGAG CGCAACCGCA TGCACGACCT GAACGCAGCC 
CTGGACAACC TGCGCAAGGT GGTGCCCTGC TACTCCAAGA CGCAGAAGCT GTCCAAGATC 
GAGACGCTGC GCCTAGCCAA GAACTATATC TGGGCGCTCT CGGAGATCCT GCGCTCCGGC 
AAGCGGCCAG ACCTAGTGTC CTACGTGCAG ACTCTGTGCA AGGGTCTGTC GCAGCCCACC 
ACCAATCTGG TGGCCGGCTG TCTGCAGCTC AACTCTCGCA ACTTCCTCAC GGAGCAAGGC 
GCCGACGGTG CCGGCCGCTT CCACGGCTCG GGCGGCCCGT TCGCCATGCA CCCCTACCCG 
TACCCGTGCT CGCGCCTGGC GGGCGCACAG TGCCAGGCGG CCGGCGGCCT GGGCGGCGGC 
GCGGCGCACG CCCTGCGGAC CCACGGCTAC TGCGCCGCCT ACGAGACGCT GTATGCGGCG 
GCAGGCGGTG GCGGCGCGAG CCCGGACTAC AACAGCTCCG AGTACGAGGG CCCGCTCAGC 
CCCCCGCTCT GTCTCAATGG CAACTTCTCA CTCAAGCAGG ACTCCTCGCC CGACCACGAG 
AAAAGCTACC ACTACTCTAT GCACTACTCG GCGCTGCCCG GTTCGCGGCC CACGGGCCAC 
GGGCTAGTCT TCGGCTCGTC GGCTGTGCGC GGGGGCGTCC ACTCGGAGAA TCTCTTGTCT 
TACGATATGC ACCTTCACCA CGACCGGGGC CCCATGTACG AGGAGCTCAA TGCGTTTTTT 
CATAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEUROD2 ( NM_006160.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006151.3 Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA.

Price & Availability↑

CloneID	OHu30371
Clone ID Related Accession (Same CDS sequence)	XM_011524851.1 , NM_006160.4 , NM_006160.3
Accession Version	NM_006160.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	neurogenic differentiation factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087491.5, BC022481.1 and AW134767.1. On May 19, 2006 this sequence version replaced NM_006160.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022481.1, AL538289.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCTGACCC GCCTGTTCAG CGAGCCCGGC CTTCTCTCGG ACGTGCCCAA GTTCGCCAGC 
TGGGGCGACG GCGAAGACGA CGAGCCGAGG AGCGACAAGG GCGACGCGCC GCCACCGCCA 
CCGCCTGCGC CCGGGCCAGG GGCTCCGGGG CCAGCCCGGG CGGCCAAGCC AGTCCCTCTC 
CGTGGAGAAG AGGGGACGGA GGCCACGTTG GCCGAGGTCA AGGAGGAAGG CGAGCTGGGG 
GGAGAGGAGG AGGAGGAAGA GGAGGAGGAA GAAGGACTGG ACGAGGCGGA GGGCGAGCGG 
CCCAAGAAGC GCGGGCCCAA GAAGCGCAAG ATGACCAAGG CGCGCTTGGA GCGCTCCAAG 
CTTCGGCGGC AGAAGGCGAA CGCGCGGGAG CGCAACCGCA TGCACGACCT GAACGCAGCC 
CTGGACAACC TGCGCAAGGT GGTGCCCTGC TACTCCAAGA CGCAGAAGCT GTCCAAGATC 
GAGACGCTGC GCCTAGCCAA GAACTATATC TGGGCGCTCT CGGAGATCCT GCGCTCCGGC 
AAGCGGCCAG ACCTAGTGTC CTACGTGCAG ACTCTGTGCA AGGGTCTGTC GCAGCCCACC 
ACCAATCTGG TGGCCGGCTG TCTGCAGCTC AACTCTCGCA ACTTCCTCAC GGAGCAAGGC 
GCCGACGGTG CCGGCCGCTT CCACGGCTCG GGCGGCCCGT TCGCCATGCA CCCCTACCCG 
TACCCGTGCT CGCGCCTGGC GGGCGCACAG TGCCAGGCGG CCGGCGGCCT GGGCGGCGGC 
GCGGCGCACG CCCTGCGGAC CCACGGCTAC TGCGCCGCCT ACGAGACGCT GTATGCGGCG 
GCAGGCGGTG GCGGCGCGAG CCCGGACTAC AACAGCTCCG AGTACGAGGG CCCGCTCAGC 
CCCCCGCTCT GTCTCAATGG CAACTTCTCA CTCAAGCAGG ACTCCTCGCC CGACCACGAG 
AAAAGCTACC ACTACTCTAT GCACTACTCG GCGCTGCCCG GTTCGCGGCC CACGGGCCAC 
GGGCTAGTCT TCGGCTCGTC GGCTGTGCGC GGGGGCGTCC ACTCGGAGAA TCTCTTGTCT 
TACGATATGC ACCTTCACCA CGACCGGGGC CCCATGTACG AGGAGCTCAA TGCGTTTTTT 
CATAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006151.3
CDS	201..1349
Translation	MLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN

Target ORF information:

RefSeq Version	NM_006160.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006160.3

ORF Insert Sequence:

ATGCTGACCC GCCTGTTCAG CGAGCCCGGC CTTCTCTCGG ACGTGCCCAA GTTCGCCAGC 
TGGGGCGACG GCGAAGACGA CGAGCCGAGG AGCGACAAGG GCGACGCGCC GCCACCGCCA 
CCGCCTGCGC CCGGGCCAGG GGCTCCGGGG CCAGCCCGGG CGGCCAAGCC AGTCCCTCTC 
CGTGGAGAAG AGGGGACGGA GGCCACGTTG GCCGAGGTCA AGGAGGAAGG CGAGCTGGGG 
GGAGAGGAGG AGGAGGAAGA GGAGGAGGAA GAAGGACTGG ACGAGGCGGA GGGCGAGCGG 
CCCAAGAAGC GCGGGCCCAA GAAGCGCAAG ATGACCAAGG CGCGCTTGGA GCGCTCCAAG 
CTTCGGCGGC AGAAGGCGAA CGCGCGGGAG CGCAACCGCA TGCACGACCT GAACGCAGCC 
CTGGACAACC TGCGCAAGGT GGTGCCCTGC TACTCCAAGA CGCAGAAGCT GTCCAAGATC 
GAGACGCTGC GCCTAGCCAA GAACTATATC TGGGCGCTCT CGGAGATCCT GCGCTCCGGC 
AAGCGGCCAG ACCTAGTGTC CTACGTGCAG ACTCTGTGCA AGGGTCTGTC GCAGCCCACC 
ACCAATCTGG TGGCCGGCTG TCTGCAGCTC AACTCTCGCA ACTTCCTCAC GGAGCAAGGC 
GCCGACGGTG CCGGCCGCTT CCACGGCTCG GGCGGCCCGT TCGCCATGCA CCCCTACCCG 
TACCCGTGCT CGCGCCTGGC GGGCGCACAG TGCCAGGCGG CCGGCGGCCT GGGCGGCGGC 
GCGGCGCACG CCCTGCGGAC CCACGGCTAC TGCGCCGCCT ACGAGACGCT GTATGCGGCG 
GCAGGCGGTG GCGGCGCGAG CCCGGACTAC AACAGCTCCG AGTACGAGGG CCCGCTCAGC 
CCCCCGCTCT GTCTCAATGG CAACTTCTCA CTCAAGCAGG ACTCCTCGCC CGACCACGAG 
AAAAGCTACC ACTACTCTAT GCACTACTCG GCGCTGCCCG GTTCGCGGCC CACGGGCCAC 
GGGCTAGTCT TCGGCTCGTC GGCTGTGCGC GGGGGCGTCC ACTCGGAGAA TCTCTTGTCT 
TACGATATGC ACCTTCACCA CGACCGGGGC CCCATGTACG AGGAGCTCAA TGCGTTTTTT 
CATAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEUROD2 ( XM_011524851.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523153.1 Homo sapiens neuronal differentiation 2 (NEUROD2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu30371
Clone ID Related Accession (Same CDS sequence)	XM_011524851.1 , NM_006160.4 , NM_006160.3
Accession Version	XM_011524851.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	neurogenic differentiation factor 2 isoform X1
Comment

ATGCTGACCC GCCTGTTCAG CGAGCCCGGC CTTCTCTCGG ACGTGCCCAA GTTCGCCAGC 
TGGGGCGACG GCGAAGACGA CGAGCCGAGG AGCGACAAGG GCGACGCGCC GCCACCGCCA 
CCGCCTGCGC CCGGGCCAGG GGCTCCGGGG CCAGCCCGGG CGGCCAAGCC AGTCCCTCTC 
CGTGGAGAAG AGGGGACGGA GGCCACGTTG GCCGAGGTCA AGGAGGAAGG CGAGCTGGGG 
GGAGAGGAGG AGGAGGAAGA GGAGGAGGAA GAAGGACTGG ACGAGGCGGA GGGCGAGCGG 
CCCAAGAAGC GCGGGCCCAA GAAGCGCAAG ATGACCAAGG CGCGCTTGGA GCGCTCCAAG 
CTTCGGCGGC AGAAGGCGAA CGCGCGGGAG CGCAACCGCA TGCACGACCT GAACGCAGCC 
CTGGACAACC TGCGCAAGGT GGTGCCCTGC TACTCCAAGA CGCAGAAGCT GTCCAAGATC 
GAGACGCTGC GCCTAGCCAA GAACTATATC TGGGCGCTCT CGGAGATCCT GCGCTCCGGC 
AAGCGGCCAG ACCTAGTGTC CTACGTGCAG ACTCTGTGCA AGGGTCTGTC GCAGCCCACC 
ACCAATCTGG TGGCCGGCTG TCTGCAGCTC AACTCTCGCA ACTTCCTCAC GGAGCAAGGC 
GCCGACGGTG CCGGCCGCTT CCACGGCTCG GGCGGCCCGT TCGCCATGCA CCCCTACCCG 
TACCCGTGCT CGCGCCTGGC GGGCGCACAG TGCCAGGCGG CCGGCGGCCT GGGCGGCGGC 
GCGGCGCACG CCCTGCGGAC CCACGGCTAC TGCGCCGCCT ACGAGACGCT GTATGCGGCG 
GCAGGCGGTG GCGGCGCGAG CCCGGACTAC AACAGCTCCG AGTACGAGGG CCCGCTCAGC 
CCCCCGCTCT GTCTCAATGG CAACTTCTCA CTCAAGCAGG ACTCCTCGCC CGACCACGAG 
AAAAGCTACC ACTACTCTAT GCACTACTCG GCGCTGCCCG GTTCGCGGCC CACGGGCCAC 
GGGCTAGTCT TCGGCTCGTC GGCTGTGCGC GGGGGCGTCC ACTCGGAGAA TCTCTTGTCT 
TACGATATGC ACCTTCACCA CGACCGGGGC CCCATGTACG AGGAGCTCAA TGCGTTTTTT 
CATAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523153.1
Translation	MLTRLFSEPGLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN

Target ORF information:

RefSeq Version	XM_011524851.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens neuronal differentiation 2 (NEUROD2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524851.1

ORF Insert Sequence:

ATGCTGACCC GCCTGTTCAG CGAGCCCGGC CTTCTCTCGG ACGTGCCCAA GTTCGCCAGC 
TGGGGCGACG GCGAAGACGA CGAGCCGAGG AGCGACAAGG GCGACGCGCC GCCACCGCCA 
CCGCCTGCGC CCGGGCCAGG GGCTCCGGGG CCAGCCCGGG CGGCCAAGCC AGTCCCTCTC 
CGTGGAGAAG AGGGGACGGA GGCCACGTTG GCCGAGGTCA AGGAGGAAGG CGAGCTGGGG 
GGAGAGGAGG AGGAGGAAGA GGAGGAGGAA GAAGGACTGG ACGAGGCGGA GGGCGAGCGG 
CCCAAGAAGC GCGGGCCCAA GAAGCGCAAG ATGACCAAGG CGCGCTTGGA GCGCTCCAAG 
CTTCGGCGGC AGAAGGCGAA CGCGCGGGAG CGCAACCGCA TGCACGACCT GAACGCAGCC 
CTGGACAACC TGCGCAAGGT GGTGCCCTGC TACTCCAAGA CGCAGAAGCT GTCCAAGATC 
GAGACGCTGC GCCTAGCCAA GAACTATATC TGGGCGCTCT CGGAGATCCT GCGCTCCGGC 
AAGCGGCCAG ACCTAGTGTC CTACGTGCAG ACTCTGTGCA AGGGTCTGTC GCAGCCCACC 
ACCAATCTGG TGGCCGGCTG TCTGCAGCTC AACTCTCGCA ACTTCCTCAC GGAGCAAGGC 
GCCGACGGTG CCGGCCGCTT CCACGGCTCG GGCGGCCCGT TCGCCATGCA CCCCTACCCG 
TACCCGTGCT CGCGCCTGGC GGGCGCACAG TGCCAGGCGG CCGGCGGCCT GGGCGGCGGC 
GCGGCGCACG CCCTGCGGAC CCACGGCTAC TGCGCCGCCT ACGAGACGCT GTATGCGGCG 
GCAGGCGGTG GCGGCGCGAG CCCGGACTAC AACAGCTCCG AGTACGAGGG CCCGCTCAGC 
CCCCCGCTCT GTCTCAATGG CAACTTCTCA CTCAAGCAGG ACTCCTCGCC CGACCACGAG 
AAAAGCTACC ACTACTCTAT GCACTACTCG GCGCTGCCCG GTTCGCGGCC CACGGGCCAC 
GGGCTAGTCT TCGGCTCGTC GGCTGTGCGC GGGGGCGTCC ACTCGGAGAA TCTCTTGTCT 
TACGATATGC ACCTTCACCA CGACCGGGGC CCCATGTACG AGGAGCTCAA TGCGTTTTTT 
CATAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p53 and miR-210 regulated NeuroD2, a neuronal basic helix-loop-helix transcription factor, is downregulated in glioblastoma patients and functions as a tumor suppressor under hypoxic microenvironment.
International journal of cancer(2017 Dec)
Agrawal R,Garg A,Benny Malgulwar P,Sharma V,Sarkar C,Kulshreshtha R

Associations of NEUROD2 polymorphisms and change of cognitive dysfunctions in schizophrenia and schizoaffective disorder after eight weeks of antipsychotic treatment.
Cognitive neuropsychiatry22(4)280-297(2017 Jul)
Spellmann I,Riedel M,St?dtler J,Zill P,Obermeier M,Cerovecki A,Dehning S,Schennach R,Epple M,Opgen-Rhein M,M?ller N,Bondy B,M?ller HJ,Musil R

Novel neurodevelopmental information revealed in amniotic fluid supernatant transcripts from fetuses with trisomies 18 and 21.
Human genetics131(11)1751-9(2012 Nov)
Hui L,Slonim DK,Wick HC,Johnson KL,Koide K,Bianchi DW

Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.
Psychiatry research187(1-2)220-3(2011 May)
Zill P,Preuss UW,Koller G,Bondy B,Soyka M

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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NEUROD2 cDNA ORF clone, Homo sapiens(human)

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