SMAD6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMAD6
Entrez Gene ID	4091
Full Name	SMAD family member 6
Synonyms	AOVD2,HsT17432,MADH6,MADH7
General protein information	Preferred Names SMAD family member 6 Names mothers against decapentaplegic homolog 6 MAD homolog 6 SMAD, mothers against DPP homolog 6 mothers against decapentaplegic, drosophila, homolog of, 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.31
Summary	The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014].
Disorder MIM:	602931
Disorder Html:	Aortic valve disease 2, 614823 (3); {Craniosynostosis 7, susceptibility to}, 617439 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005585.4	NP_005576.3	mothers against decapentaplegic homolog 6
NM_005585.5	NP_005576.3	mothers against decapentaplegic homolog 6
XM_011521561.2	XP_011519863.1	mothers against decapentaplegic homolog 6 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Smad6	NP_032568.3
Rattus norvegicus (Norway rat)	Smad6	NP_001102472.1
	SMAD6	XP_001104638.2
Bos taurus (cattle)	SMAD6	NP_001193074.1
Homo sapiens (human)	SMAD6	NP_005576.3
Pan troglodytes (chimpanzee)	SMAD6	XP_523105.2
Gallus gallus (chicken)	SMAD6	NP_989579.1
Canis lupus familiaris (dog)	SMAD6	XP_544737.2
Danio rerio (zebrafish)	LOC564395	NP_001038516.1

Gene Ontology
Bibliography

Related articles in PubMed

Two locus inheritance of non-syndromic midline craniosynostosis via rare
Timberlake AT, Choi J, Zaidi S, Lu Q, Nelson-Williams C, Brooks ED, Bilguvar K, Tikhonova I, Mane S, Yang JF, Sawh-Martinez R, Persing S, Zellner EG, Loring E, Chuang C, Galm A, Hashim PW, Steinbacher DM, DiLuna ML, Duncan CC, Pelphrey KA, Zhao H, Persing JA, Lifton RP
eLife5(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This search revealed that rare mutations that disable one copy of a gene called SMAD6 in combination with a common DNA variant near another gene called BMP2 account for about 7% of infants with midline forms of craniosynostosis.
Title: Two locus inheritance of non-syndromic midline craniosynostosis via rare

monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis
Title: Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.

Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Title: Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells.

Congenital cardiovascular malformation is related to genetic variation in SMAD6
Title: Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation.

Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
Title: SNPs in the TGF-? signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.

The following SMAD6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMAD6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15318	XM_011521561.2 Latest version!	Homo sapiens SMAD family member 6 (SMAD6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu17815	NM_005585.5 Latest version!	Homo sapiens SMAD family member 6 (SMAD6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu17815	NM_005585.4	Homo sapiens SMAD family member 6 (SMAD6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMAD6 ( XM_011521561.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519863.1 Homo sapiens SMAD family member 6 (SMAD6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu15318
Clone ID Related Accession (Same CDS sequence)	XM_011521561.2
Accession Version	XM_011521561.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	mothers against decapentaplegic homolog 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521561.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGAA TGGGCAAACC CATAGAGACA CAAAAATCTC CGCCACCTCC CTACTCTCGG 
CTGTCTCCTC GCGACGAGTA CAAGCCACTG GATCTGTCCG ATTCCACATT GTCTTACACT 
GAAACGGAGG CTACCAACTC CCTCATCACT GCTCCGGGTG AATTCTCAGA CGCCAGCATG 
TCTCCGGACG CCACCAAGCC GAGCCACTGG TGCAGCGTGG CGTACTGGGA GCACCGGACG 
CGCGTGGGCC GCCTCTATGC GGTGTACGAC CAGGCCGTCA GCATCTTCTA CGACCTACCT 
CAGGGCAGCG GCTTCTGCCT GGGCCAGCTC AACCTGGAGC AGCGCAGCGA GTCGGTGCGG 
CGAACGCGCA GCAAGATCGG CTTCGGCATC CTGCTCAGCA AGGAGCCCGA CGGCGTGTGG 
GCCTACAACC GCGGCGAGCA CCCCATCTTC GTCAACTCCC CGACGCTGGA CGCGCCCGGC 
GGCCGCGCCC TGGTCGTGCG CAAGGTGCCC CCCGGCTACT CCATCAAGGT GTTCGACTTC 
GAGCGCTCGG GCCTGCAGCA CGCGCCCGAG CCCGACGCCG CCGACGGCCC CTACGACCCC 
AACAGCGTCC GCATCAGCTT CGCCAAGGGC TGGGGGCCCT GCTACTCCCG GCAGTTCATC 
ACCTCCTGCC CCTGCTGGCT GGAGATCCTC CTCAACAACC CCAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519863.1
CDS	4618..5325
Translation	MSRMGKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR

Target ORF information:

RefSeq Version	XM_011521561.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SMAD family member 6 (SMAD6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521561.2

ORF Insert Sequence:

ATGTCCAGAA TGGGCAAACC CATAGAGACA CAAAAATCTC CGCCACCTCC CTACTCTCGG 
CTGTCTCCTC GCGACGAGTA CAAGCCACTG GATCTGTCCG ATTCCACATT GTCTTACACT 
GAAACGGAGG CTACCAACTC CCTCATCACT GCTCCGGGTG AATTCTCAGA CGCCAGCATG 
TCTCCGGACG CCACCAAGCC GAGCCACTGG TGCAGCGTGG CGTACTGGGA GCACCGGACG 
CGCGTGGGCC GCCTCTATGC GGTGTACGAC CAGGCCGTCA GCATCTTCTA CGACCTACCT 
CAGGGCAGCG GCTTCTGCCT GGGCCAGCTC AACCTGGAGC AGCGCAGCGA GTCGGTGCGG 
CGAACGCGCA GCAAGATCGG CTTCGGCATC CTGCTCAGCA AGGAGCCCGA CGGCGTGTGG 
GCCTACAACC GCGGCGAGCA CCCCATCTTC GTCAACTCCC CGACGCTGGA CGCGCCCGGC 
GGCCGCGCCC TGGTCGTGCG CAAGGTGCCC CCCGGCTACT CCATCAAGGT GTTCGACTTC 
GAGCGCTCGG GCCTGCAGCA CGCGCCCGAG CCCGACGCCG CCGACGGCCC CTACGACCCC 
AACAGCGTCC GCATCAGCTT CGCCAAGGGC TGGGGGCCCT GCTACTCCCG GCAGTTCATC 
ACCTCCTGCC CCTGCTGGCT GGAGATCCTC CTCAACAACC CCAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMAD6 ( NM_005585.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005576.3 Homo sapiens SMAD family member 6 (SMAD6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17815
Clone ID Related Accession (Same CDS sequence)	NM_005585.4 , NM_005585.5
Accession Version	NM_005585.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	mothers against decapentaplegic homolog 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF035528.1, CA406301.1, CN314455.1, BC029288.1, BC012986.2, U59914.1 and CN314453.1. This sequence is a reference standard in the RefSeqGene project. On May 13, 2009 this sequence version replaced NM_005585.3. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035528.1, ERR279875.5003.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCAGGT CCAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCC 
GACCGGGAGG AAGGCGGCAG CGGCGGCGGC GGTGGCGGCG ACGAGGATGG GAGCTTGGGC 
AGCCGAGCTG AGCCGGCCCC GCGGGCAAGA GAGGGCGGAG GCTGCGGCCG CTCCGAAGTC 
CGCCCGGTAG CCCCGCGGCG GCCCCGGGAC GCAGTGGGAC AGCGAGGCGC CCAGGGCGCG 
GGGAGGCGCC GGCGCGCAGG GGGCCCCCCG AGGCCCATGT CGGAGCCAGG GGCCGGCGCT 
GGGAGCTCCC TGCTGGACGT GGCGGAGCCG GGAGGCCCGG GCTGGCTGCC CGAGAGTGAC 
TGCGAGACGG TGACCTGCTG TCTCTTTTCG GAGCGGGACG CCGCCGGCGC GCCCCGGGAC 
GCCAGCGACC CCCTGGCCGG GGCGGCCCTG GAGCCGGCGG GCGGCGGGCG GAGTCGCGAA 
GCGCGCTCGC GGCTGCTGCT GCTGGAGCAG GAACTCAAAA CCGTCACGTA CTCGCTGCTG 
AAGCGGCTCA AGGAGCGCTC GCTGGACACG CTGCTGGAGG CGGTGGAGTC CCGCGGCGGC 
GTGCCGGGCG GCTGCGTGCT GGTGCCGCGC GCCGACCTCC GCCTGGGCGG CCAGCCCGCG 
CCGCCGCAGC TGCTGCTCGG CCGCCTCTTT CGCTGGCCCG ACCTGCAGCA CGCCGTGGAG 
CTGAAGCCCC TGTGCGGCTG CCACAGCTTC GCCGCCGCCG CCGACGGCCC TACCGTGTGC 
TGCAACCCCT ACCACTTCAG CCGGCTCTGC GGGCCCGAAT CTCCGCCACC TCCCTACTCT 
CGGCTGTCTC CTCGCGACGA GTACAAGCCA CTGGATCTGT CCGATTCCAC ATTGTCTTAC 
ACTGAAACGG AGGCTACCAA CTCCCTCATC ACTGCTCCGG GTGAATTCTC AGACGCCAGC 
ATGTCTCCGG ACGCCACCAA GCCGAGCCAC TGGTGCAGCG TGGCGTACTG GGAGCACCGG 
ACGCGCGTGG GCCGCCTCTA TGCGGTGTAC GACCAGGCCG TCAGCATCTT CTACGACCTA 
CCTCAGGGCA GCGGCTTCTG CCTGGGCCAG CTCAACCTGG AGCAGCGCAG CGAGTCGGTG 
CGGCGAACGC GCAGCAAGAT CGGCTTCGGC ATCCTGCTCA GCAAGGAGCC CGACGGCGTG 
TGGGCCTACA ACCGCGGCGA GCACCCCATC TTCGTCAACT CCCCGACGCT GGACGCGCCC 
GGCGGCCGCG CCCTGGTCGT GCGCAAGGTG CCCCCCGGCT ACTCCATCAA GGTGTTCGAC 
TTCGAGCGCT CGGGCCTGCA GCACGCGCCC GAGCCCGACG CCGCCGACGG CCCCTACGAC 
CCCAACAGCG TCCGCATCAG CTTCGCCAAG GGCTGGGGGC CCTGCTACTC CCGGCAGTTC 
ATCACCTCCT GCCCCTGCTG GCTGGAGATC CTCCTCAACA ACCCCAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005576.3
CDS	924..2414
Translation	MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR

Target ORF information:

RefSeq Version	NM_005585.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SMAD family member 6 (SMAD6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005585.4

ORF Insert Sequence:

ATGTTCAGGT CCAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCC 
GACCGGGAGG AAGGCGGCAG CGGCGGCGGC GGTGGCGGCG ACGAGGATGG GAGCTTGGGC 
AGCCGAGCTG AGCCGGCCCC GCGGGCAAGA GAGGGCGGAG GCTGCGGCCG CTCCGAAGTC 
CGCCCGGTAG CCCCGCGGCG GCCCCGGGAC GCAGTGGGAC AGCGAGGCGC CCAGGGCGCG 
GGGAGGCGCC GGCGCGCAGG GGGCCCCCCG AGGCCCATGT CGGAGCCAGG GGCCGGCGCT 
GGGAGCTCCC TGCTGGACGT GGCGGAGCCG GGAGGCCCGG GCTGGCTGCC CGAGAGTGAC 
TGCGAGACGG TGACCTGCTG TCTCTTTTCG GAGCGGGACG CCGCCGGCGC GCCCCGGGAC 
GCCAGCGACC CCCTGGCCGG GGCGGCCCTG GAGCCGGCGG GCGGCGGGCG GAGTCGCGAA 
GCGCGCTCGC GGCTGCTGCT GCTGGAGCAG GAACTCAAAA CCGTCACGTA CTCGCTGCTG 
AAGCGGCTCA AGGAGCGCTC GCTGGACACG CTGCTGGAGG CGGTGGAGTC CCGCGGCGGC 
GTGCCGGGCG GCTGCGTGCT GGTGCCGCGC GCCGACCTCC GCCTGGGCGG CCAGCCCGCG 
CCGCCGCAGC TGCTGCTCGG CCGCCTCTTT CGCTGGCCCG ACCTGCAGCA CGCCGTGGAG 
CTGAAGCCCC TGTGCGGCTG CCACAGCTTC GCCGCCGCCG CCGACGGCCC TACCGTGTGC 
TGCAACCCCT ACCACTTCAG CCGGCTCTGC GGGCCCGAAT CTCCGCCACC TCCCTACTCT 
CGGCTGTCTC CTCGCGACGA GTACAAGCCA CTGGATCTGT CCGATTCCAC ATTGTCTTAC 
ACTGAAACGG AGGCTACCAA CTCCCTCATC ACTGCTCCGG GTGAATTCTC AGACGCCAGC 
ATGTCTCCGG ACGCCACCAA GCCGAGCCAC TGGTGCAGCG TGGCGTACTG GGAGCACCGG 
ACGCGCGTGG GCCGCCTCTA TGCGGTGTAC GACCAGGCCG TCAGCATCTT CTACGACCTA 
CCTCAGGGCA GCGGCTTCTG CCTGGGCCAG CTCAACCTGG AGCAGCGCAG CGAGTCGGTG 
CGGCGAACGC GCAGCAAGAT CGGCTTCGGC ATCCTGCTCA GCAAGGAGCC CGACGGCGTG 
TGGGCCTACA ACCGCGGCGA GCACCCCATC TTCGTCAACT CCCCGACGCT GGACGCGCCC 
GGCGGCCGCG CCCTGGTCGT GCGCAAGGTG CCCCCCGGCT ACTCCATCAA GGTGTTCGAC 
TTCGAGCGCT CGGGCCTGCA GCACGCGCCC GAGCCCGACG CCGCCGACGG CCCCTACGAC 
CCCAACAGCG TCCGCATCAG CTTCGCCAAG GGCTGGGGGC CCTGCTACTC CCGGCAGTTC 
ATCACCTCCT GCCCCTGCTG GCTGGAGATC CTCCTCAACA ACCCCAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMAD6 ( NM_005585.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005576.3 Homo sapiens SMAD family member 6 (SMAD6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17815
Clone ID Related Accession (Same CDS sequence)	NM_005585.4 , NM_005585.5
Accession Version	NM_005585.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	mothers against decapentaplegic homolog 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC013564.7, AF035528.1, CA406301.1, CN314455.1, BC029288.1, BC012986.2, U59914.1, CN314453.1 and AC110048.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005585.4. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035528.1, ERR279875.5003.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000288840.10/ ENSP00000288840.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCAGGT CCAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCC 
GACCGGGAGG AAGGCGGCAG CGGCGGCGGC GGTGGCGGCG ACGAGGATGG GAGCTTGGGC 
AGCCGAGCTG AGCCGGCCCC GCGGGCAAGA GAGGGCGGAG GCTGCGGCCG CTCCGAAGTC 
CGCCCGGTAG CCCCGCGGCG GCCCCGGGAC GCAGTGGGAC AGCGAGGCGC CCAGGGCGCG 
GGGAGGCGCC GGCGCGCAGG GGGCCCCCCG AGGCCCATGT CGGAGCCAGG GGCCGGCGCT 
GGGAGCTCCC TGCTGGACGT GGCGGAGCCG GGAGGCCCGG GCTGGCTGCC CGAGAGTGAC 
TGCGAGACGG TGACCTGCTG TCTCTTTTCG GAGCGGGACG CCGCCGGCGC GCCCCGGGAC 
GCCAGCGACC CCCTGGCCGG GGCGGCCCTG GAGCCGGCGG GCGGCGGGCG GAGTCGCGAA 
GCGCGCTCGC GGCTGCTGCT GCTGGAGCAG GAACTCAAAA CCGTCACGTA CTCGCTGCTG 
AAGCGGCTCA AGGAGCGCTC GCTGGACACG CTGCTGGAGG CGGTGGAGTC CCGCGGCGGC 
GTGCCGGGCG GCTGCGTGCT GGTGCCGCGC GCCGACCTCC GCCTGGGCGG CCAGCCCGCG 
CCGCCGCAGC TGCTGCTCGG CCGCCTCTTT CGCTGGCCCG ACCTGCAGCA CGCCGTGGAG 
CTGAAGCCCC TGTGCGGCTG CCACAGCTTC GCCGCCGCCG CCGACGGCCC TACCGTGTGC 
TGCAACCCCT ACCACTTCAG CCGGCTCTGC GGGCCCGAAT CTCCGCCACC TCCCTACTCT 
CGGCTGTCTC CTCGCGACGA GTACAAGCCA CTGGATCTGT CCGATTCCAC ATTGTCTTAC 
ACTGAAACGG AGGCTACCAA CTCCCTCATC ACTGCTCCGG GTGAATTCTC AGACGCCAGC 
ATGTCTCCGG ACGCCACCAA GCCGAGCCAC TGGTGCAGCG TGGCGTACTG GGAGCACCGG 
ACGCGCGTGG GCCGCCTCTA TGCGGTGTAC GACCAGGCCG TCAGCATCTT CTACGACCTA 
CCTCAGGGCA GCGGCTTCTG CCTGGGCCAG CTCAACCTGG AGCAGCGCAG CGAGTCGGTG 
CGGCGAACGC GCAGCAAGAT CGGCTTCGGC ATCCTGCTCA GCAAGGAGCC CGACGGCGTG 
TGGGCCTACA ACCGCGGCGA GCACCCCATC TTCGTCAACT CCCCGACGCT GGACGCGCCC 
GGCGGCCGCG CCCTGGTCGT GCGCAAGGTG CCCCCCGGCT ACTCCATCAA GGTGTTCGAC 
TTCGAGCGCT CGGGCCTGCA GCACGCGCCC GAGCCCGACG CCGCCGACGG CCCCTACGAC 
CCCAACAGCG TCCGCATCAG CTTCGCCAAG GGCTGGGGGC CCTGCTACTC CCGGCAGTTC 
ATCACCTCCT GCCCCTGCTG GCTGGAGATC CTCCTCAACA ACCCCAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005576.3
CDS	1024..2514
Translation	MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR

Target ORF information:

RefSeq Version	NM_005585.5
Organism	Homo sapiens(human)
Definition	Homo sapiens SMAD family member 6 (SMAD6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005585.5

ORF Insert Sequence:

ATGTTCAGGT CCAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCC 
GACCGGGAGG AAGGCGGCAG CGGCGGCGGC GGTGGCGGCG ACGAGGATGG GAGCTTGGGC 
AGCCGAGCTG AGCCGGCCCC GCGGGCAAGA GAGGGCGGAG GCTGCGGCCG CTCCGAAGTC 
CGCCCGGTAG CCCCGCGGCG GCCCCGGGAC GCAGTGGGAC AGCGAGGCGC CCAGGGCGCG 
GGGAGGCGCC GGCGCGCAGG GGGCCCCCCG AGGCCCATGT CGGAGCCAGG GGCCGGCGCT 
GGGAGCTCCC TGCTGGACGT GGCGGAGCCG GGAGGCCCGG GCTGGCTGCC CGAGAGTGAC 
TGCGAGACGG TGACCTGCTG TCTCTTTTCG GAGCGGGACG CCGCCGGCGC GCCCCGGGAC 
GCCAGCGACC CCCTGGCCGG GGCGGCCCTG GAGCCGGCGG GCGGCGGGCG GAGTCGCGAA 
GCGCGCTCGC GGCTGCTGCT GCTGGAGCAG GAACTCAAAA CCGTCACGTA CTCGCTGCTG 
AAGCGGCTCA AGGAGCGCTC GCTGGACACG CTGCTGGAGG CGGTGGAGTC CCGCGGCGGC 
GTGCCGGGCG GCTGCGTGCT GGTGCCGCGC GCCGACCTCC GCCTGGGCGG CCAGCCCGCG 
CCGCCGCAGC TGCTGCTCGG CCGCCTCTTT CGCTGGCCCG ACCTGCAGCA CGCCGTGGAG 
CTGAAGCCCC TGTGCGGCTG CCACAGCTTC GCCGCCGCCG CCGACGGCCC TACCGTGTGC 
TGCAACCCCT ACCACTTCAG CCGGCTCTGC GGGCCCGAAT CTCCGCCACC TCCCTACTCT 
CGGCTGTCTC CTCGCGACGA GTACAAGCCA CTGGATCTGT CCGATTCCAC ATTGTCTTAC 
ACTGAAACGG AGGCTACCAA CTCCCTCATC ACTGCTCCGG GTGAATTCTC AGACGCCAGC 
ATGTCTCCGG ACGCCACCAA GCCGAGCCAC TGGTGCAGCG TGGCGTACTG GGAGCACCGG 
ACGCGCGTGG GCCGCCTCTA TGCGGTGTAC GACCAGGCCG TCAGCATCTT CTACGACCTA 
CCTCAGGGCA GCGGCTTCTG CCTGGGCCAG CTCAACCTGG AGCAGCGCAG CGAGTCGGTG 
CGGCGAACGC GCAGCAAGAT CGGCTTCGGC ATCCTGCTCA GCAAGGAGCC CGACGGCGTG 
TGGGCCTACA ACCGCGGCGA GCACCCCATC TTCGTCAACT CCCCGACGCT GGACGCGCCC 
GGCGGCCGCG CCCTGGTCGT GCGCAAGGTG CCCCCCGGCT ACTCCATCAA GGTGTTCGAC 
TTCGAGCGCT CGGGCCTGCA GCACGCGCCC GAGCCCGACG CCGCCGACGG CCCCTACGAC 
CCCAACAGCG TCCGCATCAG CTTCGCCAAG GGCTGGGGGC CCTGCTACTC CCGGCAGTTC 
ATCACCTCCT GCCCCTGCTG GCTGGAGATC CTCCTCAACA ACCCCAGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Two locus inheritance of non-syndromic midline craniosynostosis via rare
eLife5(2016 Sep)
Timberlake AT,Choi J,Zaidi S,Lu Q,Nelson-Williams C,Brooks ED,Bilguvar K,Tikhonova I,Mane S,Yang JF,Sawh-Martinez R,Persing S,Zellner EG,Loring E,Chuang C,Galm A,Hashim PW,Steinbacher DM,DiLuna ML,Duncan CC,Pelphrey KA,Zhao H,Persing JA,Lifton RP

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SMAD6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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