Smad6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Smad6
Entrez Gene ID	367100
Full Name	SMAD family member 6
General protein information	Preferred Names SMAD family member 6 Names mothers against decapentaplegic homolog 6 MAD homolog 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243241.3	XP_006243303.1	mothers against decapentaplegic homolog 6 isoform X1
NM_001109002.2	NP_001102472.1	mothers against decapentaplegic homolog 6
XM_006243242.3	XP_006243304.1	mothers against decapentaplegic homolog 6 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Smad6	NP_032568.3
Rattus norvegicus (Norway rat)	Smad6	NP_001102472.1
	SMAD6	XP_001104638.2
Bos taurus (cattle)	SMAD6	NP_001193074.1
Homo sapiens (human)	SMAD6	NP_005576.3
Pan troglodytes (chimpanzee)	SMAD6	XP_523105.2
Gallus gallus (chicken)	SMAD6	NP_989579.1
Canis lupus familiaris (dog)	SMAD6	XP_544737.2
Danio rerio (zebrafish)	LOC564395	NP_001038516.1

Gene Ontology
Bibliography

Related articles in PubMed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)

Smad6 suppresses the growth and self-renewal of hepatic progenitor cells.
Ding ZY, Liang HF, Jin GN, Chen WX, Wang W, Datta PK, Zhang MZ, Zhang B, Chen XP
Journal of cellular physiology229(5)651-60(2014 May)

The effects of Smad6 via small RNA pathways on the ischemic injury in PC12 cells.
Mei CL, Zhang LJ, Fan ZW, Song Y, Zhang M, Liu HM
Clinical laboratory60(12)2063-71(2014)

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.
Kelly CE, Thymiakou E, Dixon JE, Tanaka S, Godwin J, Episkopou V
PLoS biology11(4)e1001538(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that Smad6 is a regulatory molecule which regulates the proliferation, self-renewal and Wnt/beta-catenin signaling in HPCs.
Title: Smad6 suppresses the growth and self-renewal of hepatic progenitor cells.

Suggest role for Smad6 signaling in cerebral ischemia.
Title: The effects of Smad6 via small RNA pathways on the ischemic injury in PC12 cells.

stretch decreased Smad6 mRNA
Title: Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells.

Smad6 most potently functions to block dI1 axon outgrowth.
Title: Inhibitory Smads differentially regulate cell fate specification and axon dynamics in the dorsal spinal cord.

JNK1 activation decreases binding of inhibitory Smad6 to the type I BMP receptor.
Title: Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor.

The following Smad6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Smad6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12657	NM_001109002.2 Latest version!	Rattus norvegicus SMAD family member 6 (Smad6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00
ORa31287	XM_006243241.3 Latest version!	Rattus norvegicus SMAD family member 6 (Smad6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
ORa31287	XM_006243242.3 Latest version!	Rattus norvegicus SMAD family member 6 (Smad6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Smad6 ( NM_001109002.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102472.1 Rattus norvegicus SMAD family member 6 (Smad6), mRNA.

Price & Availability↑

CloneID	ORa12657
Clone ID Related Accession (Same CDS sequence)	NM_001109002.2
Accession Version	NM_001109002.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Rattus norvegicus(Norway rat)
Product	mothers against decapentaplegic homolog 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473975.1. On Mar 3, 2011 this sequence version replaced NM_001109002.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FM056091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGTTCAGGT CTAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCT 
GATCGGGAGG AAGGCAGCGG CGGCGGCTGT GGTGGCGACG AGGATGGGAG CCTGGGCAGC 
CGAGCTGAGC CTGCCCCGCG GGCACGAGAG GGCGGAGGTT GCGGCCGCTC CGAAGTCCGC 
TCGGTAGCCC CGCGGCGGCT CCGGGACGCG GTGGGACCGC GAGGCGCCCT GATCGCGGGC 
AGGCGCCGGC GCACAGGGGG CCCCCCGAGG CCCGTGTCGG AGCCGGGGGC CGGAGCTGGG 
GGCTCCCCGC TGGATGTGGT GGAGCCTGGA GGCCCGGGCT GGCTGCCTGA GAGTGACTGC 
GAGACGGTGA CTTGCTGTCT CTTCTCCGAG CGGGACGCTG CAGGCGCGCC CCGGGACTCT 
GGCGATCCCC AAGCCAGGCA GTCCCCGGAG CCGGAGGAGG GCGGCGGGCC TCGGAGTCGC 
GAAGCCCGCT CGCGGCTGCT GCTTCTGGAG CAGGAGCTCA AGACAGTCAC GTACTCGCTG 
CTCAAGCGGC TCAAGGAGCG TTCGCTGGAC ACACTGTTGG AGGCTGTAGA GTCCCGAGGC 
GGCGTGCCGG GCGGCTGCGT GCTGGTGCCG CGCGCCGACC TCCGTCTGGG CGGCCAGCCC 
GCGCCACCGC AGCTGCTGCT CGGTCGCCTG TTCCGCTGGC CAGACCTGCA GCACGCAGTG 
GAGCTGAAAC CCCTGTGCGG CTGCCACAGC TTTGCCGCCG CCGCTGACGG GCCCACGGTG 
TGTTGCAACC CCTACCACTT CAGCCGGCTC TGCGGGCCAG AATCACCGCC GCCCCCCTAT 
TCTCGGCTGT CTCCTCCTGA CCAGCACAAG CCACTGGATC TGTCCGATTC TACATTGTCT 
TACACTGAAA CCGAGGCCAC CAACTCCCTC ATCACTGCTC CGGGTGAATT CTCAGATGCC 
AGCATGTCTC CAGATGCCAC CAAGCCAAGC CACTGGTGCA GCGTGGCATA CTGGGAGCAC 
CGGACACGCG TGGGCCGCCT CTATGCGGTG TATGACCAGG CTGTCAGCAT CTTCTACGAC 
CTACCTCAGG GCAGCGGCTT CTGCCTGGGC CAGCTCAACC TGGAGCAGCG CAGTGAGTCG 
GTGCGGCGCA CACGGAGCAA GATCGGTTTT GGCATCCTGC TCAGCAAGGA GCCCGATGGC 
GTGTGGGCCT ACAACCGGGG CGAGCACCCC ATCTTCGTCA ACTCCCCGAC GCTGGATGCG 
CCCGGAGGCC GCGCCCTGGT CGTGCGCAAG GTGCCACCGG GCTACTCCAT CAAGGTGTTC 
GACTTTGAGC GCTCAGGGCT GCTGCAGCAC GCAGACGCCG CTCATGGGCC CCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102472.1
CDS	1..1377
Translation	MFRSKRSGLVRRLWRSRVVPDREEGSGGGCGGDEDGSLGSRAEPAPRAREGGGCGRSEVRSVAPRRLRDAVGPRGALIAGRRRRTGGPPRPVSEPGAGAGGSPLDVVEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPPDQHKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAHGPL

Target ORF information:

RefSeq Version	NM_001109002.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SMAD family member 6 (Smad6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109002.2

ORF Insert Sequence:

ATGTTCAGGT CTAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCT 
GATCGGGAGG AAGGCAGCGG CGGCGGCTGT GGTGGCGACG AGGATGGGAG CCTGGGCAGC 
CGAGCTGAGC CTGCCCCGCG GGCACGAGAG GGCGGAGGTT GCGGCCGCTC CGAAGTCCGC 
TCGGTAGCCC CGCGGCGGCT CCGGGACGCG GTGGGACCGC GAGGCGCCCT GATCGCGGGC 
AGGCGCCGGC GCACAGGGGG CCCCCCGAGG CCCGTGTCGG AGCCGGGGGC CGGAGCTGGG 
GGCTCCCCGC TGGATGTGGT GGAGCCTGGA GGCCCGGGCT GGCTGCCTGA GAGTGACTGC 
GAGACGGTGA CTTGCTGTCT CTTCTCCGAG CGGGACGCTG CAGGCGCGCC CCGGGACTCT 
GGCGATCCCC AAGCCAGGCA GTCCCCGGAG CCGGAGGAGG GCGGCGGGCC TCGGAGTCGC 
GAAGCCCGCT CGCGGCTGCT GCTTCTGGAG CAGGAGCTCA AGACAGTCAC GTACTCGCTG 
CTCAAGCGGC TCAAGGAGCG TTCGCTGGAC ACACTGTTGG AGGCTGTAGA GTCCCGAGGC 
GGCGTGCCGG GCGGCTGCGT GCTGGTGCCG CGCGCCGACC TCCGTCTGGG CGGCCAGCCC 
GCGCCACCGC AGCTGCTGCT CGGTCGCCTG TTCCGCTGGC CAGACCTGCA GCACGCAGTG 
GAGCTGAAAC CCCTGTGCGG CTGCCACAGC TTTGCCGCCG CCGCTGACGG GCCCACGGTG 
TGTTGCAACC CCTACCACTT CAGCCGGCTC TGCGGGCCAG AATCACCGCC GCCCCCCTAT 
TCTCGGCTGT CTCCTCCTGA CCAGCACAAG CCACTGGATC TGTCCGATTC TACATTGTCT 
TACACTGAAA CCGAGGCCAC CAACTCCCTC ATCACTGCTC CGGGTGAATT CTCAGATGCC 
AGCATGTCTC CAGATGCCAC CAAGCCAAGC CACTGGTGCA GCGTGGCATA CTGGGAGCAC 
CGGACACGCG TGGGCCGCCT CTATGCGGTG TATGACCAGG CTGTCAGCAT CTTCTACGAC 
CTACCTCAGG GCAGCGGCTT CTGCCTGGGC CAGCTCAACC TGGAGCAGCG CAGTGAGTCG 
GTGCGGCGCA CACGGAGCAA GATCGGTTTT GGCATCCTGC TCAGCAAGGA GCCCGATGGC 
GTGTGGGCCT ACAACCGGGG CGAGCACCCC ATCTTCGTCA ACTCCCCGAC GCTGGATGCG 
CCCGGAGGCC GCGCCCTGGT CGTGCGCAAG GTGCCACCGG GCTACTCCAT CAAGGTGTTC 
GACTTTGAGC GCTCAGGGCT GCTGCAGCAC GCAGACGCCG CTCATGGGCC CCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Smad6 ( XM_006243241.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243303.1 Rattus norvegicus SMAD family member 6 (Smad6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31287
Clone ID Related Accession (Same CDS sequence)	XM_006243241.3 , XM_006243242.3
Accession Version	XM_006243241.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mothers against decapentaplegic homolog 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243241.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCAGGT CTAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCT 
GATCGGGAGG AAGGCAGCGG CGGCGGCTGT GGTGGCGACG AGGATGGGAG CCTGGGCAGC 
CGAGCTGAGC CTGCCCCGCG GGCACGAGAG GGCGGAGGTT GCGGCCGCTC CGAAGTCCGC 
TCGGTAGCCC CGCGGCGGCT CCGGGACGCG GTGGGACCGC GAGGCGCCCT GATCGCGGGC 
AGGCGCCGGC GCACAGGGGG CCCCCCGAGG CCCGTGTCGG AGCCGGGGGC CGGAGCTGGG 
GGCTCCCCGC TGGATGTGGT GGAGCCTGGA GGCCCGGGCT GGCTGCCTGA GAGTGACTGC 
GAGACGGTGA CTTGCTGTCT CTTCTCCGAG CGGGACGCTG CAGGCGCGCC CCGGGACTCT 
GGCGATCCCC AAGCCAGGCA GTCCCCGGAG CCGGAGGAGG GCGGCGGGCC TCGGAGTCGC 
GAAGCCCGCT CGCGGCTGCT GCTTCTGGAG CAGGAGCTCA AGACAGTCAC GTACTCGCTG 
CTCAAGCGGC TCAAGGAGCG TTCGCTGGAC ACACTGTTGG AGGCTGTAGA GTCCCGAGGC 
GGCGTGCCGG GCGGCTGCGT GCTGGTGCCG CGCGCCGACC TCCGTCTGGG CGGCCAGCCC 
GCGCCACCGC AGCTGCTGCT CGGTCGCCTG TTCCGCTGGC CAGACCTGCA GCACGCAGTG 
GAGCTGAAAC CCCTGTGCGG CTGCCACAGC TTTGCCGCCG CCGCTGACGG GCCCACGGTG 
TGTTGCAACC CCTACCACTT CAGCCGGCTC TGCGGGCCAG AATCACCGCC GCCCCCCTAT 
TCTCGGCTGT CTCCTCCTGA CCAGCACAAG CCACTGGATC TGTCCGATTC TACATTGTCT 
TACACTGAAA CCGAGGCCAC CAACTCCCTC ATCACTGCTC CGGGTGAATT CTCAGATGCC 
AGCATGTCTC CAGATGCCAC CAAGCCAAGC CACTGGTGCA GCGTGGCATA CTGGGAGCAC 
CGGACACGCG TGGGCCGCCT CTATGCGGTG TATGACCAGG CTGTCAGCAT CTTCTACGAC 
CTACCTCAGG GCAGCGGCTT CTGCCTGGGC CAGCTCAACC TGGAGCAGCG CAGTGAGTCG 
GTGCGGCGCA CACGGAGCAA GATCGGTTTT GGCATCCTGC TCAGCAAGGA GCCCGATGGC 
GTGTGGGCCT ACAACCGGGG CGAGCACCCC ATCTTCGTCA ACTCCCCGAC GCTGGATGCG 
CCCGGAGGCC GCGCCCTGGT CGTGCGCAAG GTGCCACCGG GCTACTCCAT CAAGGTGTTC 
GACTTTGAGC GCTCAGGGCT GCTGCAGCAC GCAGACGCCG CTCATGGCCC CTATGACCCG 
CACAGCGTGC GCATCAGCTT CGCCAAGGGC TGGGGACCCT GCTACTCGCG ACAGTTCATC 
ACCTCCTGCC CCTGTTGGCT GGAGATCCTC CTCAACAACC ACAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243303.1
CDS	1114..2601
Translation	MFRSKRSGLVRRLWRSRVVPDREEGSGGGCGGDEDGSLGSRAEPAPRAREGGGCGRSEVRSVAPRRLRDAVGPRGALIAGRRRRTGGPPRPVSEPGAGAGGSPLDVVEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPPDQHKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR

Target ORF information:

RefSeq Version	XM_006243241.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SMAD family member 6 (Smad6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243241.3

ORF Insert Sequence:

ATGTTCAGGT CTAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCT 
GATCGGGAGG AAGGCAGCGG CGGCGGCTGT GGTGGCGACG AGGATGGGAG CCTGGGCAGC 
CGAGCTGAGC CTGCCCCGCG GGCACGAGAG GGCGGAGGTT GCGGCCGCTC CGAAGTCCGC 
TCGGTAGCCC CGCGGCGGCT CCGGGACGCG GTGGGACCGC GAGGCGCCCT GATCGCGGGC 
AGGCGCCGGC GCACAGGGGG CCCCCCGAGG CCCGTGTCGG AGCCGGGGGC CGGAGCTGGG 
GGCTCCCCGC TGGATGTGGT GGAGCCTGGA GGCCCGGGCT GGCTGCCTGA GAGTGACTGC 
GAGACGGTGA CTTGCTGTCT CTTCTCCGAG CGGGACGCTG CAGGCGCGCC CCGGGACTCT 
GGCGATCCCC AAGCCAGGCA GTCCCCGGAG CCGGAGGAGG GCGGCGGGCC TCGGAGTCGC 
GAAGCCCGCT CGCGGCTGCT GCTTCTGGAG CAGGAGCTCA AGACAGTCAC GTACTCGCTG 
CTCAAGCGGC TCAAGGAGCG TTCGCTGGAC ACACTGTTGG AGGCTGTAGA GTCCCGAGGC 
GGCGTGCCGG GCGGCTGCGT GCTGGTGCCG CGCGCCGACC TCCGTCTGGG CGGCCAGCCC 
GCGCCACCGC AGCTGCTGCT CGGTCGCCTG TTCCGCTGGC CAGACCTGCA GCACGCAGTG 
GAGCTGAAAC CCCTGTGCGG CTGCCACAGC TTTGCCGCCG CCGCTGACGG GCCCACGGTG 
TGTTGCAACC CCTACCACTT CAGCCGGCTC TGCGGGCCAG AATCACCGCC GCCCCCCTAT 
TCTCGGCTGT CTCCTCCTGA CCAGCACAAG CCACTGGATC TGTCCGATTC TACATTGTCT 
TACACTGAAA CCGAGGCCAC CAACTCCCTC ATCACTGCTC CGGGTGAATT CTCAGATGCC 
AGCATGTCTC CAGATGCCAC CAAGCCAAGC CACTGGTGCA GCGTGGCATA CTGGGAGCAC 
CGGACACGCG TGGGCCGCCT CTATGCGGTG TATGACCAGG CTGTCAGCAT CTTCTACGAC 
CTACCTCAGG GCAGCGGCTT CTGCCTGGGC CAGCTCAACC TGGAGCAGCG CAGTGAGTCG 
GTGCGGCGCA CACGGAGCAA GATCGGTTTT GGCATCCTGC TCAGCAAGGA GCCCGATGGC 
GTGTGGGCCT ACAACCGGGG CGAGCACCCC ATCTTCGTCA ACTCCCCGAC GCTGGATGCG 
CCCGGAGGCC GCGCCCTGGT CGTGCGCAAG GTGCCACCGG GCTACTCCAT CAAGGTGTTC 
GACTTTGAGC GCTCAGGGCT GCTGCAGCAC GCAGACGCCG CTCATGGCCC CTATGACCCG 
CACAGCGTGC GCATCAGCTT CGCCAAGGGC TGGGGACCCT GCTACTCGCG ACAGTTCATC 
ACCTCCTGCC CCTGTTGGCT GGAGATCCTC CTCAACAACC ACAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Smad6 ( XM_006243242.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243304.1 Rattus norvegicus SMAD family member 6 (Smad6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa31287
Clone ID Related Accession (Same CDS sequence)	XM_006243241.3 , XM_006243242.3
Accession Version	XM_006243242.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mothers against decapentaplegic homolog 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243242.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCAGGT CTAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCT 
GATCGGGAGG AAGGCAGCGG CGGCGGCTGT GGTGGCGACG AGGATGGGAG CCTGGGCAGC 
CGAGCTGAGC CTGCCCCGCG GGCACGAGAG GGCGGAGGTT GCGGCCGCTC CGAAGTCCGC 
TCGGTAGCCC CGCGGCGGCT CCGGGACGCG GTGGGACCGC GAGGCGCCCT GATCGCGGGC 
AGGCGCCGGC GCACAGGGGG CCCCCCGAGG CCCGTGTCGG AGCCGGGGGC CGGAGCTGGG 
GGCTCCCCGC TGGATGTGGT GGAGCCTGGA GGCCCGGGCT GGCTGCCTGA GAGTGACTGC 
GAGACGGTGA CTTGCTGTCT CTTCTCCGAG CGGGACGCTG CAGGCGCGCC CCGGGACTCT 
GGCGATCCCC AAGCCAGGCA GTCCCCGGAG CCGGAGGAGG GCGGCGGGCC TCGGAGTCGC 
GAAGCCCGCT CGCGGCTGCT GCTTCTGGAG CAGGAGCTCA AGACAGTCAC GTACTCGCTG 
CTCAAGCGGC TCAAGGAGCG TTCGCTGGAC ACACTGTTGG AGGCTGTAGA GTCCCGAGGC 
GGCGTGCCGG GCGGCTGCGT GCTGGTGCCG CGCGCCGACC TCCGTCTGGG CGGCCAGCCC 
GCGCCACCGC AGCTGCTGCT CGGTCGCCTG TTCCGCTGGC CAGACCTGCA GCACGCAGTG 
GAGCTGAAAC CCCTGTGCGG CTGCCACAGC TTTGCCGCCG CCGCTGACGG GCCCACGGTG 
TGTTGCAACC CCTACCACTT CAGCCGGCTC TGCGGGCCAG AATCACCGCC GCCCCCCTAT 
TCTCGGCTGT CTCCTCCTGA CCAGCACAAG CCACTGGATC TGTCCGATTC TACATTGTCT 
TACACTGAAA CCGAGGCCAC CAACTCCCTC ATCACTGCTC CGGGTGAATT CTCAGATGCC 
AGCATGTCTC CAGATGCCAC CAAGCCAAGC CACTGGTGCA GCGTGGCATA CTGGGAGCAC 
CGGACACGCG TGGGCCGCCT CTATGCGGTG TATGACCAGG CTGTCAGCAT CTTCTACGAC 
CTACCTCAGG GCAGCGGCTT CTGCCTGGGC CAGCTCAACC TGGAGCAGCG CAGTGAGTCG 
GTGCGGCGCA CACGGAGCAA GATCGGTTTT GGCATCCTGC TCAGCAAGGA GCCCGATGGC 
GTGTGGGCCT ACAACCGGGG CGAGCACCCC ATCTTCGTCA ACTCCCCGAC GCTGGATGCG 
CCCGGAGGCC GCGCCCTGGT CGTGCGCAAG GTGCCACCGG GCTACTCCAT CAAGGTGTTC 
GACTTTGAGC GCTCAGGGCT GCTGCAGCAC GCAGACGCCG CTCATGGCCC CTATGACCCG 
CACAGCGTGC GCATCAGCTT CGCCAAGGGC TGGGGACCCT GCTACTCGCG ACAGTTCATC 
ACCTCCTGCC CCTGTTGGCT GGAGATCCTC CTCAACAACC ACAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243304.1
CDS	1031..2518
Translation	MFRSKRSGLVRRLWRSRVVPDREEGSGGGCGGDEDGSLGSRAEPAPRAREGGGCGRSEVRSVAPRRLRDAVGPRGALIAGRRRRTGGPPRPVSEPGAGAGGSPLDVVEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPPDQHKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR

Target ORF information:

RefSeq Version	XM_006243242.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SMAD family member 6 (Smad6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243242.3

ORF Insert Sequence:

ATGTTCAGGT CTAAACGCTC GGGGCTGGTG CGGCGACTTT GGCGAAGTCG TGTGGTCCCT 
GATCGGGAGG AAGGCAGCGG CGGCGGCTGT GGTGGCGACG AGGATGGGAG CCTGGGCAGC 
CGAGCTGAGC CTGCCCCGCG GGCACGAGAG GGCGGAGGTT GCGGCCGCTC CGAAGTCCGC 
TCGGTAGCCC CGCGGCGGCT CCGGGACGCG GTGGGACCGC GAGGCGCCCT GATCGCGGGC 
AGGCGCCGGC GCACAGGGGG CCCCCCGAGG CCCGTGTCGG AGCCGGGGGC CGGAGCTGGG 
GGCTCCCCGC TGGATGTGGT GGAGCCTGGA GGCCCGGGCT GGCTGCCTGA GAGTGACTGC 
GAGACGGTGA CTTGCTGTCT CTTCTCCGAG CGGGACGCTG CAGGCGCGCC CCGGGACTCT 
GGCGATCCCC AAGCCAGGCA GTCCCCGGAG CCGGAGGAGG GCGGCGGGCC TCGGAGTCGC 
GAAGCCCGCT CGCGGCTGCT GCTTCTGGAG CAGGAGCTCA AGACAGTCAC GTACTCGCTG 
CTCAAGCGGC TCAAGGAGCG TTCGCTGGAC ACACTGTTGG AGGCTGTAGA GTCCCGAGGC 
GGCGTGCCGG GCGGCTGCGT GCTGGTGCCG CGCGCCGACC TCCGTCTGGG CGGCCAGCCC 
GCGCCACCGC AGCTGCTGCT CGGTCGCCTG TTCCGCTGGC CAGACCTGCA GCACGCAGTG 
GAGCTGAAAC CCCTGTGCGG CTGCCACAGC TTTGCCGCCG CCGCTGACGG GCCCACGGTG 
TGTTGCAACC CCTACCACTT CAGCCGGCTC TGCGGGCCAG AATCACCGCC GCCCCCCTAT 
TCTCGGCTGT CTCCTCCTGA CCAGCACAAG CCACTGGATC TGTCCGATTC TACATTGTCT 
TACACTGAAA CCGAGGCCAC CAACTCCCTC ATCACTGCTC CGGGTGAATT CTCAGATGCC 
AGCATGTCTC CAGATGCCAC CAAGCCAAGC CACTGGTGCA GCGTGGCATA CTGGGAGCAC 
CGGACACGCG TGGGCCGCCT CTATGCGGTG TATGACCAGG CTGTCAGCAT CTTCTACGAC 
CTACCTCAGG GCAGCGGCTT CTGCCTGGGC CAGCTCAACC TGGAGCAGCG CAGTGAGTCG 
GTGCGGCGCA CACGGAGCAA GATCGGTTTT GGCATCCTGC TCAGCAAGGA GCCCGATGGC 
GTGTGGGCCT ACAACCGGGG CGAGCACCCC ATCTTCGTCA ACTCCCCGAC GCTGGATGCG 
CCCGGAGGCC GCGCCCTGGT CGTGCGCAAG GTGCCACCGG GCTACTCCAT CAAGGTGTTC 
GACTTTGAGC GCTCAGGGCT GCTGCAGCAC GCAGACGCCG CTCATGGCCC CTATGACCCG 
CACAGCGTGC GCATCAGCTT CGCCAAGGGC TGGGGACCCT GCTACTCGCG ACAGTTCATC 
ACCTCCTGCC CCTGTTGGCT GGAGATCCTC CTCAACAACC ACAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Nature521(7553)520-4(2015 May)
Li Y,Klena NT,Gabriel GC,Liu X,Kim AJ,Lemke K,Chen Y,Chatterjee B,Devine W,Damerla RR,Chang C,Yagi H,San Agustin JT,Thahir M,Anderton S,Lawhead C,Vescovi A,Pratt H,Morgan J,Haynes L,Smith CL,Eppig JT,Reinholdt L,Francis R,Leatherbury L,Ganapathiraju MK,Tobita K,Pazour GJ,Lo CW

Smad6 suppresses the growth and self-renewal of hepatic progenitor cells.
Journal of cellular physiology229(5)651-60(2014 May)
Ding ZY,Liang HF,Jin GN,Chen WX,Wang W,Datta PK,Zhang MZ,Zhang B,Chen XP

The effects of Smad6 via small RNA pathways on the ischemic injury in PC12 cells.
Clinical laboratory60(12)2063-71(2014)
Mei CL,Zhang LJ,Fan ZW,Song Y,Zhang M,Liu HM

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.
PLoS biology11(4)e1001538(2013)
Kelly CE,Thymiakou E,Dixon JE,Tanaka S,Godwin J,Episkopou V

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Smad6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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