LYZ cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LYZ
Entrez Gene ID	4069
Full Name	lysozyme
Synonyms	LYZF1,LZM
General protein information	Preferred Names lysozyme Names lysozyme C 1,4-beta-N-acetylmuramidase C c-type lysozyme lysozyme F1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q15
Summary	This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014].
Disorder MIM:	153450
Disorder Html:	Amyloidosis, renal, 105200 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000239.2	NP_000230.1	lysozyme C precursor
NM_000239.3	NP_000230.1	lysozyme C precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LYZ	XP_531672.1
Rattus norvegicus (Norway rat)	Lyz2	NP_036903.2
	LYZ	NP_001095203.1
Gallus gallus (chicken)	LYZ	NP_990612.1
Xenopus tropicalis (tropical clawed frog)	LOC100492798	XP_002938553.1
Pan troglodytes (chimpanzee)	LYZ	NP_001009073.1
Mus musculus (house mouse)	Lyz2	NP_059068.1
Bos taurus (cattle)	LYZ	NP_001071627.1
Mus musculus (house mouse)	Lyz1	NP_038618.1
Homo sapiens (human)	LYZ	NP_000230.1

Gene Ontology
Bibliography

Related articles in PubMed

Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.
Andersen KK, Vad BS, Scavenius C, Enghild JJ, Otzen DE
Biochemistry56(1)260-270(2017 Jan)

A comparative study of fibrillation kinetics of two homologous proteins under identical solution condition.
Chaudhary AP, Vispute NH, Shukla VK, Ahmad B
Biochimie13275-84(2017 Jan)

Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy.
Aass C, Norheim I, Eriksen EF, B?rnick EC, Thorsby PM, Pepaj M
PloS one12(4)e0175274(2017)

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
Ahn M, Hagan CL, Bernardo-Gancedo A, De Genst E, Newby FN, Christodoulou J, Dhulesia A, Dumoulin M, Robinson CV, Dobson CM, Kumita JR
Biophysical journal111(11)2358-2367(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

rhamnolipid (RL) secreted by Pseudomonas aeruginosa (PA) accelerates proteolysis of lysozyme.
Title: Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.

Data show that hen lysozyme aggregates faster than the human lysozyme.
Title: A comparative study of fibrillation kinetics of two homologous proteins under identical solution condition.

Data show increased levels of lysozyme C (LYZ), lacritin (LACRT) and zinc-alpha-2 glycoprotein 1 (AZGP1) in pooled tear fluid sample from Graves' disease (GD) patients with moderate-to-severe Graves' orbitopathy (GO) compared with GD patients without clinical signs of GO.
Title: Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy.

the location of specific mutations is an important factor in determining the native-state dynamical properties of human lysozyme
Title: The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.

The findings suggest that the F57I mutation affects the aggregation process of lysozyme resulting in the formation of cytotoxic species and that SAP is able to prevent cell death in the F57I flies by preventing accumulation of toxic F57I structures.
Title: Serum Amyloid P Component Ameliorates Neurological Damage Caused by Expressing a Lysozyme Variant in the Central Nervous System of Drosophila melanogaster.

The following LYZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LYZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26163	NM_000239.3 Latest version!	Homo sapiens lysozyme (LYZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26163	NM_000239.2	Homo sapiens lysozyme (LYZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LYZ ( NM_000239.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000230.1 Homo sapiens lysozyme (LYZ), mRNA.

Price & Availability↑

CloneID	OHu26163
Clone ID Related Accession (Same CDS sequence)	NM_000239.2 , NM_000239.3
Accession Version	NM_000239.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	lysozyme C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK130149.1 and J03801.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2008 this sequence version replaced NM_000239.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK130149.1, BC004147.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16416029 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCTC TCATTGTTCT GGGGCTTGTC CTCCTTTCTG TTACGGTCCA GGGCAAGGTC 
TTTGAAAGGT GTGAGTTGGC CAGAACTCTG AAAAGATTGG GAATGGATGG CTACAGGGGA 
ATCAGCCTAG CAAACTGGAT GTGTTTGGCC AAATGGGAGA GTGGTTACAA CACACGAGCT 
ACAAACTACA ATGCTGGAGA CAGAAGCACT GATTATGGGA TATTTCAGAT CAATAGCCGC 
TACTGGTGTA ATGATGGCAA AACCCCAGGA GCAGTTAATG CCTGTCATTT ATCCTGCAGT 
GCTTTGCTGC AAGATAACAT CGCTGATGCT GTAGCTTGTG CAAAGAGGGT TGTCCGTGAT 
CCACAAGGCA TTAGAGCATG GGTGGCATGG AGAAATCGTT GTCAAAACAG AGATGTCCGT 
CAGTATGTTC AAGGTTGTGG AGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000230.1
CDS	56..502
Translation	MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV

Target ORF information:

RefSeq Version	NM_000239.2
Organism	Homo sapiens(human)
Definition	Homo sapiens lysozyme (LYZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000239.2

ORF Insert Sequence:

ATGAAGGCTC TCATTGTTCT GGGGCTTGTC CTCCTTTCTG TTACGGTCCA GGGCAAGGTC 
TTTGAAAGGT GTGAGTTGGC CAGAACTCTG AAAAGATTGG GAATGGATGG CTACAGGGGA 
ATCAGCCTAG CAAACTGGAT GTGTTTGGCC AAATGGGAGA GTGGTTACAA CACACGAGCT 
ACAAACTACA ATGCTGGAGA CAGAAGCACT GATTATGGGA TATTTCAGAT CAATAGCCGC 
TACTGGTGTA ATGATGGCAA AACCCCAGGA GCAGTTAATG CCTGTCATTT ATCCTGCAGT 
GCTTTGCTGC AAGATAACAT CGCTGATGCT GTAGCTTGTG CAAAGAGGGT TGTCCGTGAT 
CCACAAGGCA TTAGAGCATG GGTGGCATGG AGAAATCGTT GTCAAAACAG AGATGTCCGT 
CAGTATGTTC AAGGTTGTGG AGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LYZ ( NM_000239.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000230.1 Homo sapiens lysozyme (LYZ), mRNA.

Price & Availability↑

CloneID	OHu26163
Clone ID Related Accession (Same CDS sequence)	NM_000239.2 , NM_000239.3
Accession Version	NM_000239.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	lysozyme C precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK130149.1, J03801.1 and AC020656.33. On Aug 31, 2019 this sequence version replaced NM_000239.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004147.2, AK130149.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16416029 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCTC TCATTGTTCT GGGGCTTGTC CTCCTTTCTG TTACGGTCCA GGGCAAGGTC 
TTTGAAAGGT GTGAGTTGGC CAGAACTCTG AAAAGATTGG GAATGGATGG CTACAGGGGA 
ATCAGCCTAG CAAACTGGAT GTGTTTGGCC AAATGGGAGA GTGGTTACAA CACACGAGCT 
ACAAACTACA ATGCTGGAGA CAGAAGCACT GATTATGGGA TATTTCAGAT CAATAGCCGC 
TACTGGTGTA ATGATGGCAA AACCCCAGGA GCAGTTAATG CCTGTCATTT ATCCTGCAGT 
GCTTTGCTGC AAGATAACAT CGCTGATGCT GTAGCTTGTG CAAAGAGGGT TGTCCGTGAT 
CCACAAGGCA TTAGAGCATG GGTGGCATGG AGAAATCGTT GTCAAAACAG AGATGTCCGT 
CAGTATGTTC AAGGTTGTGG AGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000230.1
CDS	29..475
Translation	MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV

Target ORF information:

RefSeq Version	NM_000239.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lysozyme (LYZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000239.3

ORF Insert Sequence:

ATGAAGGCTC TCATTGTTCT GGGGCTTGTC CTCCTTTCTG TTACGGTCCA GGGCAAGGTC 
TTTGAAAGGT GTGAGTTGGC CAGAACTCTG AAAAGATTGG GAATGGATGG CTACAGGGGA 
ATCAGCCTAG CAAACTGGAT GTGTTTGGCC AAATGGGAGA GTGGTTACAA CACACGAGCT 
ACAAACTACA ATGCTGGAGA CAGAAGCACT GATTATGGGA TATTTCAGAT CAATAGCCGC 
TACTGGTGTA ATGATGGCAA AACCCCAGGA GCAGTTAATG CCTGTCATTT ATCCTGCAGT 
GCTTTGCTGC AAGATAACAT CGCTGATGCT GTAGCTTGTG CAAAGAGGGT TGTCCGTGAT 
CCACAAGGCA TTAGAGCATG GGTGGCATGG AGAAATCGTT GTCAAAACAG AGATGTCCGT 
CAGTATGTTC AAGGTTGTGG AGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.
Biochemistry56(1)260-270(2017 Jan)
Andersen KK,Vad BS,Scavenius C,Enghild JJ,Otzen DE

A comparative study of fibrillation kinetics of two homologous proteins under identical solution condition.
Biochimie13275-84(2017 Jan)
Chaudhary AP,Vispute NH,Shukla VK,Ahmad B

Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy.
PloS one12(4)e0175274(2017)
Aass C,Norheim I,Eriksen EF,B?rnick EC,Thorsby PM,Pepaj M

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
Biophysical journal111(11)2358-2367(2016 Dec)
Ahn M,Hagan CL,Bernardo-Gancedo A,De Genst E,Newby FN,Christodoulou J,Dhulesia A,Dumoulin M,Robinson CV,Dobson CM,Kumita JR

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LYZ cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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