LYZ cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	LYZ
Entrez Gene ID	474442
Full Name	lysozyme
Synonyms	LYZF1
General protein information	Preferred Names lysozyme Names lysozyme C lysozyme (renal amyloidosis) lysozyme F1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001300876.1	NP_001287805.1	lysozyme C, spleen isozyme precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LYZ	XP_531672.1
Rattus norvegicus (Norway rat)	Lyz2	NP_036903.2
	LYZ	NP_001095203.1
Gallus gallus (chicken)	LYZ	NP_990612.1
Xenopus tropicalis (tropical clawed frog)	LOC100492798	XP_002938553.1
Pan troglodytes (chimpanzee)	LYZ	NP_001009073.1
Mus musculus (house mouse)	Lyz2	NP_059068.1
Bos taurus (cattle)	LYZ	NP_001071627.1
Mus musculus (house mouse)	Lyz1	NP_038618.1
Homo sapiens (human)	LYZ	NP_000230.1

Gene Ontology
Bibliography

Related articles in PubMed

Lysozyme, a mediator of sepsis that deposits in the systemic vasculature and kidney as a possible mechanism of acute organ dysfunction.
Gotes J, Kasian K, Jacobs H, Cheng ZQ, Mink SN
Shock (Augusta, Ga.)41(3)256-65(2014 Mar)

Lysozyme, a mediator of sepsis that intrinsically generates hydrogen peroxide to cause cardiovascular dysfunction.
Mink SN, Jacobs H, Cheng ZQ, Kasian K, Santos-Martinez LE, Light RB
American journal of physiology. Heart and circulatory physiology297(3)H930-48(2009 Sep)

Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditions.
Nonaka Y, Aizawa T, Akieda D, Yasui M, Watanabe M, Watanabe N, Tanaka I, Kamiya M, Mizuguchi M, Demura M, Kawano K
Proteins72(1)313-22(2008 Jul)

Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
Mink SN, Kasian K, Santos Martinez LE, Jacobs H, Bose R, Cheng ZQ, Light RB
American journal of physiology. Heart and circulatory physiology294(4)H1724-35(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lzm-S can deposit in the systemic vasculature and kidneys in SS, where this deposition could lead to acute organ dysfunction.
Title: Lysozyme, a mediator of sepsis that deposits in the systemic vasculature and kidney as a possible mechanism of acute organ dysfunction.

generation of H(2)O(2) by lysozyyme may activate H(2)O(2)-dependent pathways leading to cardiovascular collapse in septic shock
Title: Lysozyme, a mediator of sepsis that intrinsically generates hydrogen peroxide to cause cardiovascular dysfunction.

Canine milk lysozyme (CML), a useful model for the study of the molten globule state, exhibited charge heterogeneity after sample purification. Four Asn residues in CML deamidated rapidly under mild conditions.
Title: Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditions.

Lysozyme may contribute to the vasodilation that occurs in septic shock.
Title: Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.

The following LYZ gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LYZ cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe13172	NM_001300876.1 Latest version!	Canis lupus familiaris lysozyme (LYZ), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LYZ ( NM_001300876.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001287805.1 Canis lupus familiaris lysozyme (LYZ), mRNA.

Price & Availability↑

CloneID	OCe13172
Clone ID Related Accession (Same CDS sequence)	NM_001300876.1
Accession Version	NM_001300876.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Canis lupus familiaris(dog)
Product	lysozyme C, spleen isozyme precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from KJ700878.1. On Jul 16, 2014 this sequence version replaced XM_531672.4. ##Evidence-Data-START## Transcript exon combination :: BU747257.1, DN270188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGAAGACTC TCCTTTTCCT TGGGCTCCTC CTCCTTTCCA TCACCGTCCA GGGCAAGATC 
TTTGAAAGGT GTGAGCTGGC CAGAACTCTG AAAAACCTTG GGCTGGCTGG CTATAAGGGC 
GTCAGCCTGG CAAACTGGGT GTGTTTGGCC AAGTGGGAAA GTAATTATAA TACAAGGGCT 
ACGAACTACA ATCCCGGAAG CAAAAGCACT GATTATGGGA TATTTCAAAT CAATAGCCGC 
TACTGGTGTA ATGATGGCAA AACGCCCAGA GCAGTGAACG CCTGTCACAT ATCCTGCAGC 
GCTTTGCTGC AAGATGACAT CACTCAAGCC GTAGCATGTG CAAAGAGGGT TGTCAGTGAT 
CCAAATGGCA TTCGAGCATG GGTGGCATGG AGAGCACACT GTGAAAACCG AGATGTCTCT 
CAGTATGTTC GGAATTGTGG AGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287805.1
CDS	1..447
Translation	MKTLLFLGLLLLSITVQGKIFERCELARTLKNLGLAGYKGVSLANWVCLAKWESNYNTRATNYNPGSKSTDYGIFQINSRYWCNDGKTPRAVNACHISCSALLQDDITQAVACAKRVVSDPNGIRAWVAWRAHCENRDVSQYVRNCGV

Target ORF information:

RefSeq Version	NM_001300876.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris lysozyme (LYZ), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300876.1

ORF Insert Sequence:

ATGAAGACTC TCCTTTTCCT TGGGCTCCTC CTCCTTTCCA TCACCGTCCA GGGCAAGATC 
TTTGAAAGGT GTGAGCTGGC CAGAACTCTG AAAAACCTTG GGCTGGCTGG CTATAAGGGC 
GTCAGCCTGG CAAACTGGGT GTGTTTGGCC AAGTGGGAAA GTAATTATAA TACAAGGGCT 
ACGAACTACA ATCCCGGAAG CAAAAGCACT GATTATGGGA TATTTCAAAT CAATAGCCGC 
TACTGGTGTA ATGATGGCAA AACGCCCAGA GCAGTGAACG CCTGTCACAT ATCCTGCAGC 
GCTTTGCTGC AAGATGACAT CACTCAAGCC GTAGCATGTG CAAAGAGGGT TGTCAGTGAT 
CCAAATGGCA TTCGAGCATG GGTGGCATGG AGAGCACACT GTGAAAACCG AGATGTCTCT 
CAGTATGTTC GGAATTGTGG AGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysozyme, a mediator of sepsis that deposits in the systemic vasculature and kidney as a possible mechanism of acute organ dysfunction.
Shock (Augusta, Ga.)41(3)256-65(2014 Mar)
Gotes J,Kasian K,Jacobs H,Cheng ZQ,Mink SN

Lysozyme, a mediator of sepsis that intrinsically generates hydrogen peroxide to cause cardiovascular dysfunction.
American journal of physiology. Heart and circulatory physiology297(3)H930-48(2009 Sep)
Mink SN,Jacobs H,Cheng ZQ,Kasian K,Santos-Martinez LE,Light RB

Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditions.
Proteins72(1)313-22(2008 Jul)
Nonaka Y,Aizawa T,Akieda D,Yasui M,Watanabe M,Watanabe N,Tanaka I,Kamiya M,Mizuguchi M,Demura M,Kawano K

Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
American journal of physiology. Heart and circulatory physiology294(4)H1724-35(2008 Apr)
Mink SN,Kasian K,Santos Martinez LE,Jacobs H,Bose R,Cheng ZQ,Light RB

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LYZ cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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