GDF6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GDF6
Entrez Gene ID	392255
Full Name	growth differentiation factor 6
Synonyms	BMP-13,BMP13,CDMP2,KFM,KFS,KFS1,KFSL,SGM1
General protein information	Preferred Names growth differentiation factor 6 Names growth/differentiation factor 6 bone morphogenetic protein 13 growth/differentiation factor 16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q22.1
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis. [provided by RefSeq, Sep 2016].
Disorder MIM:	601147
Disorder Html:	Klippel-Feil syndrome 1, autosomal dominant, 118100 (3); Microphthalmia, isolated 4, 613094 (3); Microphthalmia with coloboma 6, digenic, 613703 (3); Leber congenital amaurosis 17, 615360 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001557.2	NP_001001557.1	growth/differentiation factor 6 precursor
NM_001001557.3	NP_001001557.1	growth/differentiation factor 6 preproprotein
NM_001001557.4	NP_001001557.1	growth/differentiation factor 6 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GDF6	NP_001001557.1
Mus musculus (house mouse)	Gdf6	NP_038554.1
Danio rerio (zebrafish)	gdf6a	NP_001153466.1
Xenopus tropicalis (tropical clawed frog)	gdf6	NP_001016077.1
Bos taurus (cattle)	GDF6	NP_001001140.1
Pan troglodytes (chimpanzee)	GDF6	XP_003311926.1
	GDF6	XP_001090825.1
Rattus norvegicus (Norway rat)	Gdf6	NP_001013056.1

Gene Ontology
Bibliography

Related articles in PubMed

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
Krispin S, Stratman AN, Melick CH, Stan RV, Malinverno M, Gleklen J, Castranova D, Dejana E, Weinstein BM
Arteriosclerosis, thrombosis, and vascular biology(2017 Dec)

A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.
Wang J, Yu T, Wang Z, Ohte S, Yao RE, Zheng Z, Geng J, Cai H, Ge Y, Li Y, Xu Y, Zhang Q, Gusella JF, Fu Q, Pregizer S, Rosen V, Shen Y
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research31(4)882-9(2016 Apr)

Expression of growth differentiation factor 6 in the human developing fetal spine retreats from vertebral ossifying regions and is restricted to cartilaginous tissues.
Wei A, Shen B, Williams LA, Bhargav D, Gulati T, Fang Z, Pathmanandavel S, Diwan AD
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(2)279-89(2016 Feb)

Localization of bone morphogenetic protein 13 in human intervertebral disc and its molecular and functional effects in vitro in 3D culture.
Gulati T, Chung SA, Wei AQ, Diwan AD
Journal of orthopaedic research : official publication of the Orthopaedic Research Society33(12)1769-75(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings indicate that increased BMP signaling owing to a GDF6 gain-of-function mutation is responsible for loss of joint formation and profound functional impairment in patients with Multiple Synostoses Syndrome 4.
Title: A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.

As fetal age increased, the expression of growth differentiation factor 6 was decreased correspondingly with the progress of ossification in vertebral bodies and restricted to cartilaginous regions.
Title: Expression of growth differentiation factor 6 in the human developing fetal spine retreats from vertebral ossifying regions and is restricted to cartilaginous tissues.

BMP13 has a role in enhancing extracellular matrix accumulation and inducing cell migration in certain intervertebral disc cells
Title: Localization of bone morphogenetic protein 13 in human intervertebral disc and its molecular and functional effects in vitro in 3D culture.

GDF6 is overexpressed in Leri's pleonosteosis.
Title: Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.

There was a possible weak association between the rs6982567 near GDF6 and polypoidal choroidal vasculopathy in this replication study with an independent Han Chinese cohort.
Title: Association of rs6982567 near GDF6 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese cohort.

The following GDF6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18538	NM_001001557.4 Latest version!	Homo sapiens growth differentiation factor 6 (GDF6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu18538	NM_001001557.2	Homo sapiens growth differentiation factor 6 (GDF6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu18538	NM_001001557.3	Homo sapiens growth differentiation factor 6 (GDF6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GDF6 ( NM_001001557.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001557.1 Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Price & Availability↑

CloneID	OHu18538
Clone ID Related Accession (Same CDS sequence)	NM_001001557.2 , NM_001001557.3 , NM_001001557.4
Accession Version	NM_001001557.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	growth/differentiation factor 6 precursor
Comment

ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC 
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG 
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC 
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA 
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT 
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC 
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG 
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA 
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG 
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC 
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG 
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG 
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA 
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC 
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG 
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT 
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC 
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC 
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC 
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC 
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC 
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001001557.1

Translation

MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR

Target ORF information:

RefSeq Version	NM_001001557.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001557.2

ORF Insert Sequence:

ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC 
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG 
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC 
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA 
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT 
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC 
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG 
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA 
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG 
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC 
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG 
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG 
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA 
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC 
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG 
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT 
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC 
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC 
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC 
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC 
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC 
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF6 ( NM_001001557.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001557.1 Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Price & Availability↑

CloneID	OHu18538
Clone ID Related Accession (Same CDS sequence)	NM_001001557.2 , NM_001001557.3 , NM_001001557.4
Accession Version	NM_001001557.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-03
Organism	Homo sapiens(human)
Product	growth/differentiation factor 6 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ537424.1 and CA423567.1. This sequence is a reference standard in the RefSeqGene project. On Sep 3, 2016 this sequence version replaced NM_001001557.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ537424.1, CN282698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC 
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG 
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC 
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA 
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT 
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC 
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG 
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA 
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG 
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC 
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG 
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG 
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA 
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC 
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG 
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT 
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC 
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC 
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC 
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC 
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC 
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001557.1
CDS	101..1468
Translation	MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR

Target ORF information:

RefSeq Version	NM_001001557.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001557.3

ORF Insert Sequence:

ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC 
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG 
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC 
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA 
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT 
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC 
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG 
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA 
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG 
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC 
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG 
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG 
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA 
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC 
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG 
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT 
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC 
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC 
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC 
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC 
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC 
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF6 ( NM_001001557.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001001557.1 Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Price & Availability↑

CloneID	OHu18538
Clone ID Related Accession (Same CDS sequence)	NM_001001557.2 , NM_001001557.3 , NM_001001557.4
Accession Version	NM_001001557.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	growth/differentiation factor 6 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003465.2, AJ537424.1 and CA423567.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001001557.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ537424.1, CN282698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000287020.7/ ENSP00000287020.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC 
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG 
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC 
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA 
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT 
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC 
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG 
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA 
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG 
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC 
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG 
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG 
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA 
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC 
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG 
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT 
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC 
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC 
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC 
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC 
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC 
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001557.1
CDS	115..1482
Translation	MDTPRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR

Target ORF information:

RefSeq Version	NM_001001557.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001557.4

ORF Insert Sequence:

ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC 
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG 
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC 
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA 
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT 
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC 
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG 
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA 
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG 
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC 
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG 
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG 
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA 
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC 
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG 
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT 
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC 
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC 
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC 
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC 
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC 
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
Arteriosclerosis, thrombosis, and vascular biology(2017 Dec)
Krispin S,Stratman AN,Melick CH,Stan RV,Malinverno M,Gleklen J,Castranova D,Dejana E,Weinstein BM

A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research31(4)882-9(2016 Apr)
Wang J,Yu T,Wang Z,Ohte S,Yao RE,Zheng Z,Geng J,Cai H,Ge Y,Li Y,Xu Y,Zhang Q,Gusella JF,Fu Q,Pregizer S,Rosen V,Shen Y

Expression of growth differentiation factor 6 in the human developing fetal spine retreats from vertebral ossifying regions and is restricted to cartilaginous tissues.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(2)279-89(2016 Feb)
Wei A,Shen B,Williams LA,Bhargav D,Gulati T,Fang Z,Pathmanandavel S,Diwan AD

Localization of bone morphogenetic protein 13 in human intervertebral disc and its molecular and functional effects in vitro in 3D culture.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society33(12)1769-75(2015 Dec)
Gulati T,Chung SA,Wei AQ,Diwan AD

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GDF6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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