Gdf6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gdf6
Entrez Gene ID	242316
Full Name	growth differentiation factor 6
Synonyms	BMP-13,BMP13,GDF16
General protein information	Preferred Names growth differentiation factor 6 Names growth/differentiation factor 6 GDF-6 bone morphogenetic protein 13 growth/differentiation factor 16
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 A1
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mice lacking a functional copy of this gene exhibit joint and skeletal defects. [provided by RefSeq, Sep 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013526.1	NP_038554.1	growth/differentiation factor 6 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GDF6	NP_001001557.1
Mus musculus (house mouse)	Gdf6	NP_038554.1
Danio rerio (zebrafish)	gdf6a	NP_001153466.1
Xenopus tropicalis (tropical clawed frog)	gdf6	NP_001016077.1
Bos taurus (cattle)	GDF6	NP_001001140.1
Pan troglodytes (chimpanzee)	GDF6	XP_003311926.1
	GDF6	XP_001090825.1
Rattus norvegicus (Norway rat)	Gdf6	NP_001013056.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.
Hisamatsu D, Ohno-Oishi M, Nakamura S, Mabuchi Y, Naka-Kaneda H
Aging8(6)1259-75(2016 Jun)

Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.
Indjeian VB, Kingman GA, Jones FC, Guenther CA, Grimwood J, Schmutz J, Myers RM, Kingsley DM
Cell164(1-2)45-56(2016 Jan)

Bmp4 from the optic vesicle specifies murine retina formation.
Huang J, Liu Y, Oltean A, Beebe DC
Developmental biology402(1)119-26(2015 Jun)

Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.
Maga AM, Navarro N, Cunningham ML, Cox TC
Frontiers in physiology692(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Upregulation of Gdf6 restored the osteogenic capacity of old mesenchymal stem cells in vitro and exerted positive effects in vivo on aging-associated pathologies such as reduced lymphopoiesis, insufficient muscle repair, reduced numbers of neural progenitors in the brain, and chronic inflammation.
Title: Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.

data indicate that BMP9 and BMP13 (BMP9 might be more effective) promoted the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells
Title: Bone Morphogenetic Protein 9 and 13 Induce C3H10T1/2 Cell Differentiation to Cardiomyocyte-Like Cells In Vitro.

Over-expression of Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.
Title: Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.

a critical role of HTRA1 in the regulation of angiogenesis via TGF-beta signaling and identified GDF6 as a novel disease gene for AMD.
Title: High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-? family member growth differentiation factor 6.

Gdf6 plays an inhibitory role to prevent the osteogenic differentiation of the coronal suture mesenchyme
Title: The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development.

The following Gdf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gdf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18062	NM_013526.1 Latest version!	Mus musculus growth differentiation factor 6 (Gdf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gdf6 ( NM_013526.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038554.1 Mus musculus growth differentiation factor 6 (Gdf6), mRNA.

Price & Availability↑

CloneID	OMu18062
Clone ID Related Accession (Same CDS sequence)	NM_013526.1
Accession Version	NM_013526.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	growth/differentiation factor 6 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL732476.12 and BC141339.1. On Feb 3, 2004 this sequence version replaced XM_143637.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ537425.1, BC141339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGACACTC CTAGGGTCCT TCTCTGGGCG ATCTTCCTCA TTAGCTTCCT CTGGGATTTG 
CCGGGTTTCC AGCAGGCTTC CATCTCCTCG TCCTCCTCCT CCTCCACCGA ATTGGACTCC 
ACCAAAGACG TGGGGAACCG CAAAGAAGGG AAGATGCAGC GAACTCCACA AGAGAGTGCC 
GAGGGCCGGA CGCCCCCGGA GCACGGGCTG CGGCAGAAGG ACCTCCGGCG GCGGCCGCCC 
GGACAACATC AGGGGCAGGA GCCGCCGGGC AGGGGGCTGC GCGTGGTGCC TCACGAGTAC 
ATGCTGTCAA TCTACAAGAC TTACTCCATT GCCGAGAAGC TGGGCATCAA TGCCAGCTTT 
TTCCAGTCTT CCAAGTCAGC TAATACGATC ACTAGCTTTG TAGACAGAGG ACTGGACGAT 
CTCTCGCACA CTCCTCTCCG GAGACAGAAG TATTTGTTTG ATGTGTCCAC ACTCTCAGAC 
AAAGAAGAGC TGGTGGGCGC AGAGCTAAGG CTTTATCGCC AGGCGCCCCC AACGCCCTGG 
GGGCTACCGG CCCGACCGCT GCACTTGCAG CTCTTCCCTT GTTTATCCCC ATTGCTACTG 
GACGCCAGGA CCCTGGATCC TCAGGGACCA ACCCAGGCCG GCTGGGAAGT CTTCGACGTG 
TGGCAGGGCC TGCGCCCTCA GCCTTGGAAG CAGCTGTGCC TGGAGTTGCG GGCAGCCTGG 
GGTGAGCTGG ACGCCGGGGA TACGGGGGCG CGCGCGAGGG GTCCCCAGCA GCCACCGCCT 
CTGGACCTGC GGAGTCTGGG CTTCGGTCGG AGGGTGAGGC CGCCCCAGGA GCGCGCCCTG 
CTTGTAGTGT TCACCAGATC GCAGCGCAAG AACCTGTTCA CTGAGATGCA TGAGCAGCTG 
GGCTCTGCAG AGGCTGCGGG AGCCGAGGGG TCATGGCCAG CGCCGTCGGG CTCCCCAGAC 
GCCGGGTCTT GGCTGCCCTC GCCCGGCCGC CGGCGGCGAC GCACCGCCTT CGCCAGCCGT 
CACGGCAAGC GACATGGCAA GAAGTCCAGG CTGCGCTGCA GCAGAAAGCC TCTGCACGTG 
AATTTTAAGG AGTTAGGCTG GGACGACTGG ATTATCGCGC CCCTAGAGTA CGAGGCCTAT 
CACTGCGAGG GCGTGTGCGA CTTTCCGCTG CGCTCGCACC TTGAGCCCAC TAACCATGCC 
ATCATTCAGA CGCTGATGAA CTCCATGGAC CCGGGCTCCA CCCCGCCTAG CTGCTGCGTT 
CCCACCAAAC TGACTCCCAT TAGCATCCTG TACATCGACG CGGGCAATAA TGTAGTCTAC 
AAGCAGTATG AGGACATGGT GGTGGAGTCC TGCGGCTGTA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038554.1
CDS	107..1471
Translation	MDTPRVLLWAIFLISFLWDLPGFQQASISSSSSSSTELDSTKDVGNRKEGKMQRTPQESAEGRTPPEHGLRQKDLRRRPPGQHQGQEPPGRGLRVVPHEYMLSIYKTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVGAELRLYRQAPPTPWGLPARPLHLQLFPCLSPLLLDARTLDPQGPTQAGWEVFDVWQGLRPQPWKQLCLELRAAWGELDAGDTGARARGPQQPPPLDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGSPDAGSWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR

Target ORF information:

RefSeq Version	NM_013526.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus growth differentiation factor 6 (Gdf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013526.1

ORF Insert Sequence:

ATGGACACTC CTAGGGTCCT TCTCTGGGCG ATCTTCCTCA TTAGCTTCCT CTGGGATTTG 
CCGGGTTTCC AGCAGGCTTC CATCTCCTCG TCCTCCTCCT CCTCCACCGA ATTGGACTCC 
ACCAAAGACG TGGGGAACCG CAAAGAAGGG AAGATGCAGC GAACTCCACA AGAGAGTGCC 
GAGGGCCGGA CGCCCCCGGA GCACGGGCTG CGGCAGAAGG ACCTCCGGCG GCGGCCGCCC 
GGACAACATC AGGGGCAGGA GCCGCCGGGC AGGGGGCTGC GCGTGGTGCC TCACGAGTAC 
ATGCTGTCAA TCTACAAGAC TTACTCCATT GCCGAGAAGC TGGGCATCAA TGCCAGCTTT 
TTCCAGTCTT CCAAGTCAGC TAATACGATC ACTAGCTTTG TAGACAGAGG ACTGGACGAT 
CTCTCGCACA CTCCTCTCCG GAGACAGAAG TATTTGTTTG ATGTGTCCAC ACTCTCAGAC 
AAAGAAGAGC TGGTGGGCGC AGAGCTAAGG CTTTATCGCC AGGCGCCCCC AACGCCCTGG 
GGGCTACCGG CCCGACCGCT GCACTTGCAG CTCTTCCCTT GTTTATCCCC ATTGCTACTG 
GACGCCAGGA CCCTGGATCC TCAGGGACCA ACCCAGGCCG GCTGGGAAGT CTTCGACGTG 
TGGCAGGGCC TGCGCCCTCA GCCTTGGAAG CAGCTGTGCC TGGAGTTGCG GGCAGCCTGG 
GGTGAGCTGG ACGCCGGGGA TACGGGGGCG CGCGCGAGGG GTCCCCAGCA GCCACCGCCT 
CTGGACCTGC GGAGTCTGGG CTTCGGTCGG AGGGTGAGGC CGCCCCAGGA GCGCGCCCTG 
CTTGTAGTGT TCACCAGATC GCAGCGCAAG AACCTGTTCA CTGAGATGCA TGAGCAGCTG 
GGCTCTGCAG AGGCTGCGGG AGCCGAGGGG TCATGGCCAG CGCCGTCGGG CTCCCCAGAC 
GCCGGGTCTT GGCTGCCCTC GCCCGGCCGC CGGCGGCGAC GCACCGCCTT CGCCAGCCGT 
CACGGCAAGC GACATGGCAA GAAGTCCAGG CTGCGCTGCA GCAGAAAGCC TCTGCACGTG 
AATTTTAAGG AGTTAGGCTG GGACGACTGG ATTATCGCGC CCCTAGAGTA CGAGGCCTAT 
CACTGCGAGG GCGTGTGCGA CTTTCCGCTG CGCTCGCACC TTGAGCCCAC TAACCATGCC 
ATCATTCAGA CGCTGATGAA CTCCATGGAC CCGGGCTCCA CCCCGCCTAG CTGCTGCGTT 
CCCACCAAAC TGACTCCCAT TAGCATCCTG TACATCGACG CGGGCAATAA TGTAGTCTAC 
AAGCAGTATG AGGACATGGT GGTGGAGTCC TGCGGCTGTA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.
Aging8(6)1259-75(2016 Jun)
Hisamatsu D,Ohno-Oishi M,Nakamura S,Mabuchi Y,Naka-Kaneda H

Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.
Cell164(1-2)45-56(2016 Jan)
Indjeian VB,Kingman GA,Jones FC,Guenther CA,Grimwood J,Schmutz J,Myers RM,Kingsley DM

Bmp4 from the optic vesicle specifies murine retina formation.
Developmental biology402(1)119-26(2015 Jun)
Huang J,Liu Y,Oltean A,Beebe DC

Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.
Frontiers in physiology692(2015)
Maga AM,Navarro N,Cunningham ML,Cox TC

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Gdf6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報