KCNA5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNA5
Entrez Gene ID	3741
Full Name	potassium voltage-gated channel subfamily A member 5
Synonyms	ATFB7,HCK1,HK2,HPCN1,KV1.5,PCN1
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 5 Names potassium voltage-gated channel subfamily A member 5 cardiac potassium channel insulinoma and islet potassium channel potassium channel 1 potassium channel, voltage gated shaker related subfamily A, member 5 potassium voltage-gated channel, shaker-related subfamily, member 5 voltage-gated potassium channel HK2 voltage-gated potassium channel protein Kv1.5 voltage-gated potassium channel subunit Kv1.5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.32
Summary	Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012].
Disorder MIM:	176267
Disorder Html:	Atrial fibrillation, familial, 7, 612240 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002234.4	NP_002225.2	potassium voltage-gated channel subfamily A member 5
NM_002234.3	NP_002225.2	potassium voltage-gated channel subfamily A member 5

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC100004160	XP_005171764.1
Bos taurus (cattle)	KCNA5	NP_001015552.1
Mus musculus (house mouse)	Kcna5	NP_666095.1
Rattus norvegicus (Norway rat)	Kcna5	NP_037104.1
Gallus gallus (chicken)	KCNA5	XP_417226.3
Pan troglodytes (chimpanzee)	KCNA5	XP_522330.1
Canis lupus familiaris (dog)	KCNA5	NP_001006646.1
Xenopus tropicalis (tropical clawed frog)	kcna5	XP_004912856.1
Homo sapiens (human)	KCNA5	NP_002225.2
	KCNA5	XP_001102294.1

Gene Ontology
Bibliography

Related articles in PubMed

In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics.
Ni H, Adeniran I, Zhang H
Journal of molecular and cellular cardiology11186-95(2017 Oct)

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.
Colman MA, Ni H, Liang B, Schmitt N, Zhang H
PLoS computational biology13(6)e1005587(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In addition, as IKur is an atrial-specific channel and a number of IKur-selective blockers have been developed as anti-AF agents, this study also helps to understand some contradictory results on both pro- and anti-arrhythmic effects of blocking IKur.
Title: In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.

our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells.
Title: Expression of KCNA5 Protein in Human Mammary Epithelial Cell Line Associated with Caveolin-1.

demonstrate that PK treatment cleaved mature membrane-bound (75kDa) Kv1.5 channels at a single locus in the S1-S2 linker, producing 42-kDa N-terminal fragments and 33-kDa C-terminal fragments
Title: Proteolytic cleavage in the S1-S2 linker of the Kv1.5 channel does not affect channel function.

Studies demonstrate that DNA hypermethylation contributes to epigenetic repression of the KCNA5 locus and that the resulting suppression of the Kv1.5 ion channel supports cancer cell proliferation.
Title: Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.

Kv1.5 expression is increased in osteosarcoma cells and tissues and shRNA mediated silencing of Kv1.5 results in cell proliferation inhibition, cell cycle arrest, and induces cell apoptosis.
Title: Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells.

The following KCNA5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21909	NM_002234.4 Latest version!	Homo sapiens potassium voltage-gated channel subfamily A member 5 (KCNA5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu21909	NM_002234.3	Homo sapiens potassium voltage-gated channel subfamily A member 5 (KCNA5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNA5 ( NM_002234.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002225.2 Homo sapiens potassium voltage-gated channel subfamily A member 5 (KCNA5), mRNA.

Price & Availability↑

CloneID	OHu21909
Clone ID Related Accession (Same CDS sequence)	NM_002234.4 , NM_002234.3
Accession Version	NM_002234.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005906.1, BC099665.3, BM692565.1 and BM663787.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_002234.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR1803613.198188.1, SRR1660807.110520.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252321.5/ ENSP00000252321.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGATCG CCCTGGTGCC CCTGGAGAAC GGCGGTGCCA TGACCGTCAG AGGAGGCGAT 
GAGGCCCGGG CAGGCTGCGG CCAGGCCACA GGGGGAGAGC TCCAGTGTCC CCCGACGGCT 
GGGCTCAGCG ATGGGCCCAA GGAGCCGGCG CCAAAGGGGC GCGGCGCGCA GAGAGACGCG 
GACTCGGGAG TGCGGCCCTT GCCTCCGCTG CCGGACCCGG GAGTGCGGCC CTTGCCTCCG 
CTGCCAGAGG AGCTGCCACG GCCTCGACGG CCGCCTCCCG AGGACGAGGA GGAAGAAGGC 
GATCCCGGCC TGGGCACGGT GGAGGACCAG GCTCTGGGCA CGGCGTCCCT GCACCACCAG 
CGCGTCCACA TCAACATCTC CGGGCTGCGC TTTGAGACGC AGCTGGGCAC CCTGGCGCAG 
TTCCCCAACA CACTCCTGGG GGACCCCGCC AAGCGCCTGC GCTACTTCGA CCCCCTGAGG 
AACGAGTACT TCTTCGACCG CAACCGGCCC AGCTTCGACG GTATCCTCTA CTACTACCAG 
TCCGGGGGCC GCCTGCGGAG GCCGGTCAAC GTCTCCCTGG ACGTGTTCGC GGACGAGATA 
CGCTTCTACC AGCTGGGGGA CGAGGCCATG GAGCGCTTCC GCGAGGATGA GGGCTTCATT 
AAAGAAGAGG AGAAGCCCCT GCCCCGCAAC GAGTTCCAGC GCCAGGTGTG GCTTATCTTC 
GAGTATCCGG AGAGCTCTGG GTCCGCGCGG GCCATCGCCA TCGTCTCGGT CTTGGTTATC 
CTCATCTCCA TCATCACCTT CTGCTTGGAG ACCCTGCCTG AGTTCAGGGA TGAACGTGAG 
CTGCTCCGCC ACCCTCCGGC GCCCCACCAG CCTCCCGCGC CCGCCCCTGG GGCCAACGGC 
AGCGGGGTCA TGGCCCCGCC CTCTGGCCCT ACGGTGGCAC CGCTCCTGCC CAGGACCCTG 
GCCGACCCCT TCTTCATCGT GGAGACCACG TGCGTCATCT GGTTCACCTT CGAGCTGCTC 
GTGCGCTTCT TCGCCTGCCC CAGCAAGGCA GGGTTCTCCC GGAACATCAT GAACATCATC 
GATGTGGTGG CCATCTTCCC CTACTTCATC ACCCTGGGCA CCGAACTGGC AGAGCAGCAG 
CCAGGGGGTG GAGGAGGCGG CCAGAATGGG CAGCAGGCCA TGTCCCTGGC CATCCTCCGA 
GTCATCCGCC TGGTCCGGGT GTTCCGCATC TTCAAGCTCT CCCGCCACTC CAAGGGGCTG 
CAGATCCTGG GCAAGACCTT GCAGGCCTCC ATGAGGGAGC TGGGGCTGCT CATCTTCTTC 
CTCTTCATCG GGGTCATCCT CTTCTCCAGT GCCGTCTACT TCGCAGAGGC TGACAACCAG 
GGAACCCATT TCTCTAGCAT CCCTGACGCC TTCTGGTGGG CAGTGGTCAC CATGACCACT 
GTGGGCTACG GGGACATGAG GCCCATCACT GTTGGGGGCA AGATCGTGGG CTCGCTGTGT 
GCCATCGCCG GGGTCCTCAC CATTGCCCTG CCTGTGCCCG TCATCGTCTC CAACTTCAAC 
TACTTCTACC ACCGGGAAAC GGATCACGAG GAGCCGGCAG TCCTTAAGGA AGAGCAGGGC 
ACTCAGAGCC AGGGGCCGGG GCTGGACAGA GGAGTCCAGC GGAAGGTCAG CGGGAGCAGG 
GGATCCTTCT GCAAGGCTGG GGGGACCCTG GAGAATGCAG ACAGTGCCCG AAGGGGCAGC 
TGCCCCCTAG AGAAGTGTAA CGTCAAGGCC AAGAGCAACG TGGACTTGCG GAGGTCCCTT 
TATGCCCTCT GCCTGGACAC CAGCCGGGAA ACAGATTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002225.2
CDS	270..2111
Translation	MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL

Target ORF information:

RefSeq Version	NM_002234.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 5 (KCNA5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002234.4

ORF Insert Sequence:

ATGGAGATCG CCCTGGTGCC CCTGGAGAAC GGCGGTGCCA TGACCGTCAG AGGAGGCGAT 
GAGGCCCGGG CAGGCTGCGG CCAGGCCACA GGGGGAGAGC TCCAGTGTCC CCCGACGGCT 
GGGCTCAGCG ATGGGCCCAA GGAGCCGGCG CCAAAGGGGC GCGGCGCGCA GAGAGACGCG 
GACTCGGGAG TGCGGCCCTT GCCTCCGCTG CCGGACCCGG GAGTGCGGCC CTTGCCTCCG 
CTGCCAGAGG AGCTGCCACG GCCTCGACGG CCGCCTCCCG AGGACGAGGA GGAAGAAGGC 
GATCCCGGCC TGGGCACGGT GGAGGACCAG GCTCTGGGCA CGGCGTCCCT GCACCACCAG 
CGCGTCCACA TCAACATCTC CGGGCTGCGC TTTGAGACGC AGCTGGGCAC CCTGGCGCAG 
TTCCCCAACA CACTCCTGGG GGACCCCGCC AAGCGCCTGC GCTACTTCGA CCCCCTGAGG 
AACGAGTACT TCTTCGACCG CAACCGGCCC AGCTTCGACG GTATCCTCTA CTACTACCAG 
TCCGGGGGCC GCCTGCGGAG GCCGGTCAAC GTCTCCCTGG ACGTGTTCGC GGACGAGATA 
CGCTTCTACC AGCTGGGGGA CGAGGCCATG GAGCGCTTCC GCGAGGATGA GGGCTTCATT 
AAAGAAGAGG AGAAGCCCCT GCCCCGCAAC GAGTTCCAGC GCCAGGTGTG GCTTATCTTC 
GAGTATCCGG AGAGCTCTGG GTCCGCGCGG GCCATCGCCA TCGTCTCGGT CTTGGTTATC 
CTCATCTCCA TCATCACCTT CTGCTTGGAG ACCCTGCCTG AGTTCAGGGA TGAACGTGAG 
CTGCTCCGCC ACCCTCCGGC GCCCCACCAG CCTCCCGCGC CCGCCCCTGG GGCCAACGGC 
AGCGGGGTCA TGGCCCCGCC CTCTGGCCCT ACGGTGGCAC CGCTCCTGCC CAGGACCCTG 
GCCGACCCCT TCTTCATCGT GGAGACCACG TGCGTCATCT GGTTCACCTT CGAGCTGCTC 
GTGCGCTTCT TCGCCTGCCC CAGCAAGGCA GGGTTCTCCC GGAACATCAT GAACATCATC 
GATGTGGTGG CCATCTTCCC CTACTTCATC ACCCTGGGCA CCGAACTGGC AGAGCAGCAG 
CCAGGGGGTG GAGGAGGCGG CCAGAATGGG CAGCAGGCCA TGTCCCTGGC CATCCTCCGA 
GTCATCCGCC TGGTCCGGGT GTTCCGCATC TTCAAGCTCT CCCGCCACTC CAAGGGGCTG 
CAGATCCTGG GCAAGACCTT GCAGGCCTCC ATGAGGGAGC TGGGGCTGCT CATCTTCTTC 
CTCTTCATCG GGGTCATCCT CTTCTCCAGT GCCGTCTACT TCGCAGAGGC TGACAACCAG 
GGAACCCATT TCTCTAGCAT CCCTGACGCC TTCTGGTGGG CAGTGGTCAC CATGACCACT 
GTGGGCTACG GGGACATGAG GCCCATCACT GTTGGGGGCA AGATCGTGGG CTCGCTGTGT 
GCCATCGCCG GGGTCCTCAC CATTGCCCTG CCTGTGCCCG TCATCGTCTC CAACTTCAAC 
TACTTCTACC ACCGGGAAAC GGATCACGAG GAGCCGGCAG TCCTTAAGGA AGAGCAGGGC 
ACTCAGAGCC AGGGGCCGGG GCTGGACAGA GGAGTCCAGC GGAAGGTCAG CGGGAGCAGG 
GGATCCTTCT GCAAGGCTGG GGGGACCCTG GAGAATGCAG ACAGTGCCCG AAGGGGCAGC 
TGCCCCCTAG AGAAGTGTAA CGTCAAGGCC AAGAGCAACG TGGACTTGCG GAGGTCCCTT 
TATGCCCTCT GCCTGGACAC CAGCCGGGAA ACAGATTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNA5 ( NM_002234.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002225.2 Homo sapiens potassium voltage-gated channel subfamily A member 5 (KCNA5), mRNA.

Price & Availability↑

CloneID	OHu21909
Clone ID Related Accession (Same CDS sequence)	NM_002234.4 , NM_002234.3
Accession Version	NM_002234.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily A member 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005906.1, BC099665.3, BM692565.1 and BM663787.1. This sequence is a reference standard in the RefSeqGene project. On May 9, 2012 this sequence version replaced NM_002234.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGAGATCG CCCTGGTGCC CCTGGAGAAC GGCGGTGCCA TGACCGTCAG AGGAGGCGAT 
GAGGCCCGGG CAGGCTGCGG CCAGGCCACA GGGGGAGAGC TCCAGTGTCC CCCGACGGCT 
GGGCTCAGCG ATGGGCCCAA GGAGCCGGCG CCAAAGGGGC GCGGCGCGCA GAGAGACGCG 
GACTCGGGAG TGCGGCCCTT GCCTCCGCTG CCGGACCCGG GAGTGCGGCC CTTGCCTCCG 
CTGCCAGAGG AGCTGCCACG GCCTCGACGG CCGCCTCCCG AGGACGAGGA GGAAGAAGGC 
GATCCCGGCC TGGGCACGGT GGAGGACCAG GCTCTGGGCA CGGCGTCCCT GCACCACCAG 
CGCGTCCACA TCAACATCTC CGGGCTGCGC TTTGAGACGC AGCTGGGCAC CCTGGCGCAG 
TTCCCCAACA CACTCCTGGG GGACCCCGCC AAGCGCCTGC GCTACTTCGA CCCCCTGAGG 
AACGAGTACT TCTTCGACCG CAACCGGCCC AGCTTCGACG GTATCCTCTA CTACTACCAG 
TCCGGGGGCC GCCTGCGGAG GCCGGTCAAC GTCTCCCTGG ACGTGTTCGC GGACGAGATA 
CGCTTCTACC AGCTGGGGGA CGAGGCCATG GAGCGCTTCC GCGAGGATGA GGGCTTCATT 
AAAGAAGAGG AGAAGCCCCT GCCCCGCAAC GAGTTCCAGC GCCAGGTGTG GCTTATCTTC 
GAGTATCCGG AGAGCTCTGG GTCCGCGCGG GCCATCGCCA TCGTCTCGGT CTTGGTTATC 
CTCATCTCCA TCATCACCTT CTGCTTGGAG ACCCTGCCTG AGTTCAGGGA TGAACGTGAG 
CTGCTCCGCC ACCCTCCGGC GCCCCACCAG CCTCCCGCGC CCGCCCCTGG GGCCAACGGC 
AGCGGGGTCA TGGCCCCGCC CTCTGGCCCT ACGGTGGCAC CGCTCCTGCC CAGGACCCTG 
GCCGACCCCT TCTTCATCGT GGAGACCACG TGCGTCATCT GGTTCACCTT CGAGCTGCTC 
GTGCGCTTCT TCGCCTGCCC CAGCAAGGCA GGGTTCTCCC GGAACATCAT GAACATCATC 
GATGTGGTGG CCATCTTCCC CTACTTCATC ACCCTGGGCA CCGAACTGGC AGAGCAGCAG 
CCAGGGGGTG GAGGAGGCGG CCAGAATGGG CAGCAGGCCA TGTCCCTGGC CATCCTCCGA 
GTCATCCGCC TGGTCCGGGT GTTCCGCATC TTCAAGCTCT CCCGCCACTC CAAGGGGCTG 
CAGATCCTGG GCAAGACCTT GCAGGCCTCC ATGAGGGAGC TGGGGCTGCT CATCTTCTTC 
CTCTTCATCG GGGTCATCCT CTTCTCCAGT GCCGTCTACT TCGCAGAGGC TGACAACCAG 
GGAACCCATT TCTCTAGCAT CCCTGACGCC TTCTGGTGGG CAGTGGTCAC CATGACCACT 
GTGGGCTACG GGGACATGAG GCCCATCACT GTTGGGGGCA AGATCGTGGG CTCGCTGTGT 
GCCATCGCCG GGGTCCTCAC CATTGCCCTG CCTGTGCCCG TCATCGTCTC CAACTTCAAC 
TACTTCTACC ACCGGGAAAC GGATCACGAG GAGCCGGCAG TCCTTAAGGA AGAGCAGGGC 
ACTCAGAGCC AGGGGCCGGG GCTGGACAGA GGAGTCCAGC GGAAGGTCAG CGGGAGCAGG 
GGATCCTTCT GCAAGGCTGG GGGGACCCTG GAGAATGCAG ACAGTGCCCG AAGGGGCAGC 
TGCCCCCTAG AGAAGTGTAA CGTCAAGGCC AAGAGCAACG TGGACTTGCG GAGGTCCCTT 
TATGCCCTCT GCCTGGACAC CAGCCGGGAA ACAGATTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002225.2
CDS	230..2071
Translation	MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL

Target ORF information:

RefSeq Version	NM_002234.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily A member 5 (KCNA5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002234.3

ORF Insert Sequence:

ATGGAGATCG CCCTGGTGCC CCTGGAGAAC GGCGGTGCCA TGACCGTCAG AGGAGGCGAT 
GAGGCCCGGG CAGGCTGCGG CCAGGCCACA GGGGGAGAGC TCCAGTGTCC CCCGACGGCT 
GGGCTCAGCG ATGGGCCCAA GGAGCCGGCG CCAAAGGGGC GCGGCGCGCA GAGAGACGCG 
GACTCGGGAG TGCGGCCCTT GCCTCCGCTG CCGGACCCGG GAGTGCGGCC CTTGCCTCCG 
CTGCCAGAGG AGCTGCCACG GCCTCGACGG CCGCCTCCCG AGGACGAGGA GGAAGAAGGC 
GATCCCGGCC TGGGCACGGT GGAGGACCAG GCTCTGGGCA CGGCGTCCCT GCACCACCAG 
CGCGTCCACA TCAACATCTC CGGGCTGCGC TTTGAGACGC AGCTGGGCAC CCTGGCGCAG 
TTCCCCAACA CACTCCTGGG GGACCCCGCC AAGCGCCTGC GCTACTTCGA CCCCCTGAGG 
AACGAGTACT TCTTCGACCG CAACCGGCCC AGCTTCGACG GTATCCTCTA CTACTACCAG 
TCCGGGGGCC GCCTGCGGAG GCCGGTCAAC GTCTCCCTGG ACGTGTTCGC GGACGAGATA 
CGCTTCTACC AGCTGGGGGA CGAGGCCATG GAGCGCTTCC GCGAGGATGA GGGCTTCATT 
AAAGAAGAGG AGAAGCCCCT GCCCCGCAAC GAGTTCCAGC GCCAGGTGTG GCTTATCTTC 
GAGTATCCGG AGAGCTCTGG GTCCGCGCGG GCCATCGCCA TCGTCTCGGT CTTGGTTATC 
CTCATCTCCA TCATCACCTT CTGCTTGGAG ACCCTGCCTG AGTTCAGGGA TGAACGTGAG 
CTGCTCCGCC ACCCTCCGGC GCCCCACCAG CCTCCCGCGC CCGCCCCTGG GGCCAACGGC 
AGCGGGGTCA TGGCCCCGCC CTCTGGCCCT ACGGTGGCAC CGCTCCTGCC CAGGACCCTG 
GCCGACCCCT TCTTCATCGT GGAGACCACG TGCGTCATCT GGTTCACCTT CGAGCTGCTC 
GTGCGCTTCT TCGCCTGCCC CAGCAAGGCA GGGTTCTCCC GGAACATCAT GAACATCATC 
GATGTGGTGG CCATCTTCCC CTACTTCATC ACCCTGGGCA CCGAACTGGC AGAGCAGCAG 
CCAGGGGGTG GAGGAGGCGG CCAGAATGGG CAGCAGGCCA TGTCCCTGGC CATCCTCCGA 
GTCATCCGCC TGGTCCGGGT GTTCCGCATC TTCAAGCTCT CCCGCCACTC CAAGGGGCTG 
CAGATCCTGG GCAAGACCTT GCAGGCCTCC ATGAGGGAGC TGGGGCTGCT CATCTTCTTC 
CTCTTCATCG GGGTCATCCT CTTCTCCAGT GCCGTCTACT TCGCAGAGGC TGACAACCAG 
GGAACCCATT TCTCTAGCAT CCCTGACGCC TTCTGGTGGG CAGTGGTCAC CATGACCACT 
GTGGGCTACG GGGACATGAG GCCCATCACT GTTGGGGGCA AGATCGTGGG CTCGCTGTGT 
GCCATCGCCG GGGTCCTCAC CATTGCCCTG CCTGTGCCCG TCATCGTCTC CAACTTCAAC 
TACTTCTACC ACCGGGAAAC GGATCACGAG GAGCCGGCAG TCCTTAAGGA AGAGCAGGGC 
ACTCAGAGCC AGGGGCCGGG GCTGGACAGA GGAGTCCAGC GGAAGGTCAG CGGGAGCAGG 
GGATCCTTCT GCAAGGCTGG GGGGACCCTG GAGAATGCAG ACAGTGCCCG AAGGGGCAGC 
TGCCCCCTAG AGAAGTGTAA CGTCAAGGCC AAGAGCAACG TGGACTTGCG GAGGTCCCTT 
TATGCCCTCT GCCTGGACAC CAGCCGGGAA ACAGATTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics.
Journal of molecular and cellular cardiology11186-95(2017 Oct)
Ni H,Adeniran I,Zhang H

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.
PLoS computational biology13(6)e1005587(2017 Jun)
Colman MA,Ni H,Liang B,Schmitt N,Zhang H

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KCNA5 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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